{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:05:28Z","timestamp":1784322328443,"version":"3.55.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.pathol.2026.03.006","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:17:18Z","timestamp":1778739438000},"page":"579-585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detecting T-cell clones of uncertain significance using anti-TRBC1-based flow cytometry"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-9656","authenticated-orcid":false,"given":"Tessa","family":"Potezny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip C.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-5558","authenticated-orcid":false,"given":"Kah-Lok","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2771-8827","authenticated-orcid":false,"given":"Surender","family":"Juneja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-3886","authenticated-orcid":false,"given":"Neil","family":"Came","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuong","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Westerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2026.03.006_bib1","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.3390\/ijms22041817","article-title":"Emerging role of T-cell receptor constant \u03b2 chain-1 (TRBC1) expression in the flow cytometric diagnosis of T-cell malignancies","volume":"22","author":"Horna","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.pathol.2026.03.006_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/cyto.b.22175","article-title":"TRBC1 in flow cytometry: assay development, validation, and reporting considerations","volume":"106","author":"Devitt","year":"2024","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.pathol.2026.03.006_bib3","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1038\/s41379-020-0568-2","article-title":"T-cell clones of uncertain significance are highly prevalent and show close resemblance to T-cell large granular lymphocytic leukemia. Implications for laboratory diagnostics","volume":"33","author":"Shi","year":"2020","journal-title":"Mod Pathol"},{"key":"10.1016\/j.pathol.2026.03.006_bib4","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jid.2020.09.011","article-title":"Utility of TRBC1 expression in the diagnosis of peripheral blood involvement by cutaneous T-cell lymphoma","volume":"141","author":"Horna","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.pathol.2026.03.006_bib5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/ajcp\/aqy173","article-title":"Utility of a simple and robust flow cytometry assay for rapid clonality testing in mature peripheral T-cell lymphomas","volume":"151","author":"Novikov","year":"2019","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.pathol.2026.03.006_bib6","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/ijlh.14525","article-title":"Assessing the persistence and relevance of small T-LGL clones via TRBC1 in a flowcytometric lymphoid screening tube","volume":"47","author":"Debunne","year":"2025","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.pathol.2026.03.006_bib7","volume":"vol. 11","year":"2024"},{"key":"10.1016\/j.pathol.2026.03.006_bib8","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/nm.4444","article-title":"Targeting the T cell receptor \u03b2-chain constant region for immunotherapy of T cell malignancies","volume":"23","author":"Maciocia","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.pathol.2026.03.006_bib9","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/bjh.19252","article-title":"Evaluation of T-cell clonality by anti-TRBC1 antibody-based flow cytometry and correlation with T-cell receptor sequencing","volume":"204","author":"Nguyen","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.pathol.2026.03.006_bib10","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1080\/10428194.2025.2484643","article-title":"Computational flow cytometry reveals a high prevalence of TRBC1-restricted CD8+ T-cell subsets","volume":"66","author":"Nguyen","year":"2025","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.pathol.2026.03.006_bib11","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1182\/blood-2011-05-357251","article-title":"General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL","volume":"118","author":"Fazi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2026.03.006_bib12","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1182\/blood.V84.7.2315.2315","article-title":"CD3+, CD56+ aggressive variant of large granular lymphocyte leukemia","volume":"84","author":"Gentile","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2026.03.006_bib13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fonc.2020.00152","article-title":"Insights into genetic landscape of large granular lymphocyte leukemia","volume":"10","author":"Teramo","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.pathol.2026.03.006_bib14","first-page":"37","article-title":"T-cell clones of uncertain significance. When is the rogue clone dangerous?","volume":"110","author":"Semenzato","year":"2025","journal-title":"Haematol"},{"key":"10.1016\/j.pathol.2026.03.006_bib15","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cyto.b.22204","article-title":"Appropriate interpretation of TRBC1-dim positive subsets in T-cell immunophenotyping by flow cytometry","volume":"108","author":"Shi","year":"2025","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.pathol.2026.03.006_bib16","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.3390\/cancers13174379","article-title":"Anti-TRBC1 antibody-based flow cytometric detection of T-cell clonality: standardization of sample preparation and diagnostic implementation","volume":"13","author":"Munoz-Garcia","year":"2021","journal-title":"Cancers (Basel)"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302526005118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302526005118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:35:31Z","timestamp":1784320531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302526005118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0031302526005118"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2026.03.006","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detecting T-cell clones of uncertain significance using anti-TRBC1-based flow cytometry","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2026.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}