{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:11:17Z","timestamp":1789593077488,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","pathologyjournal.rcpa.edu.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.pathol.2026.06.004","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:44:48Z","timestamp":1783061088000},"page":"697-706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Structural complexity and mechanistic diversity of MECOM rearrangements in myeloid neoplasms"],"prefix":"10.1016","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-1091","authenticated-orcid":false,"given":"Jia-Chi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Oo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmon","family":"Enriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pathol.2026.06.004_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2141.1993.tb04647.x","article-title":"Clinical, haematological and cytogenetic features in 24 patients with structural rearrangements of the Q arm of chromosome 3","volume":"83","author":"Grigg","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1016\/j.pathol.2026.06.004_bib2","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1182\/blood.V84.8.2681.2681","article-title":"Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26)","volume":"84","author":"Suzukawa","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2026.06.004_bib3","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.pathol.2026.06.004_bib4","series-title":"WHO classification of tumours: haematolymphoid tumours","first-page":"85","year":"2022"},{"key":"10.1016\/j.pathol.2026.06.004_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cell.2014.02.019","article-title":"A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia","volume":"157","author":"Gr\u00f6schel","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2026.06.004_bib6","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.3324\/haematol.2022.282030","article-title":"Characteristics and clinical outcomes of patients with acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)","volume":"108","author":"Richard-Carpentier","year":"2023","journal-title":"Haematologica"},{"key":"10.1016\/j.pathol.2026.06.004_bib7","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1200\/JCO.2010.29.2771","article-title":"Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)\/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia","volume":"28","author":"Lugthart","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.pathol.2026.06.004_bib8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1182\/blood.2019003701","article-title":"Atypical 3q26\/MECOM rearrangements genocopy inv(3)\/t(3;3) in acute myeloid leukemia","volume":"136","author":"Ottema","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.pathol.2026.06.004_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2019.104025","article-title":"Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies","volume":"24","author":"Tang","year":"2019","journal-title":"Data Brief"},{"key":"10.1016\/j.pathol.2026.06.004_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cancergen.2019.03.002","article-title":"Deciphering the complexities of MECOM rearrangement-driven chromosomal aberrations","volume":"233\u2013234","author":"Tang","year":"2019","journal-title":"Cancer Genet"},{"key":"10.1016\/j.pathol.2026.06.004_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/gcc.23004","article-title":"Comparison of myeloid neoplasms with nonclassic 3q26.2\/MECOM versus classic inv(3)\/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and molecular mechanisms of MECOM activation","volume":"61","author":"Gao","year":"2022","journal-title":"Genes Chrom Cancer"},{"key":"10.1016\/j.pathol.2026.06.004_bib12","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3390\/cancers15020458","article-title":"3q26.2\/MECOM rearrangements by pericentric inv(3): diagnostic challenges and clinicopathologic features","volume":"15","author":"Tang","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.pathol.2026.06.004_bib13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41379-020-00663-z","article-title":"Myeloid neoplasms associated with t(3;12)(q26.2;p13) are clinically aggressive, show myelodysplasia, and frequently harbor chromosome 7 abnormalities","volume":"34","author":"Ronaghy","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.pathol.2026.06.004_bib14","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.2217\/fon.15.64","article-title":"3q26\/EVI1 rearrangements in myeloid hemopathies: a cytogenetic review","volume":"11","author":"De Braekeleer","year":"2015","journal-title":"Future Oncol"},{"key":"10.1016\/j.pathol.2026.06.004_bib15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41408-022-00718-1","article-title":"Optical genome mapping refines cytogenetic diagnostics, prognostic stratification and provides new molecular insights in adult MDS\/AML patients","volume":"12","author":"Balducci","year":"2022","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.pathol.2026.06.004_bib16","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.ajhg.2021.06.001","article-title":"Next-generation cytogenetics: comprehensive assessment of 52 hematological malignancy genomes by optical genome mapping","volume":"108","author":"Neveling","year":"2021","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.pathol.2026.06.004_bib17","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/ijc.33942","article-title":"Optical genome mapping reveals additional prognostic information compared to conventional cytogenetics in AML\/MDS patients","volume":"150","author":"Gerding","year":"2022","journal-title":"Int J Cancer"},{"key":"10.1016\/j.pathol.2026.06.004_bib18","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.3390\/cancers15072131","article-title":"Optical genome mapping in routine cytogenetic diagnosis of acute leukemia","volume":"15","author":"Soler","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.pathol.2026.06.004_bib19","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1182\/bloodadvances.2022007583","article-title":"Optical genome mapping in acute myeloid leukemia: a multicenter evaluation","volume":"7","author":"Levy","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.pathol.2026.06.004_bib20","series-title":"ISCN 2024: an international system for human cytogenomic nomenclature","author":"McGowan-Jordan","year":"2024"},{"key":"10.1016\/j.pathol.2026.06.004_bib21","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1038\/s41467-020-19119-8","article-title":"Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics","volume":"11","author":"Morita","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.pathol.2026.06.004_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/genetics\/26.2.234","article-title":"The stability of broken ends of chromosomes in zea mays","volume":"26","author":"McClintock","year":"1941","journal-title":"Genetics"},{"key":"10.1016\/j.pathol.2026.06.004_bib23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.tig.2022.03.008","article-title":"Breakage in breakage-fusion-bridge cycle: an 80-year-old mystery","volume":"38","author":"Gu\u00e9rin","year":"2022","journal-title":"Trends Genet"},{"key":"10.1016\/j.pathol.2026.06.004_bib24","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1073\/pnas.67.4.1934","article-title":"The rolling circle for phiX DNA replication. II. Synthesis of single-stranded circles","volume":"67","author":"Dressler","year":"1970","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pathol.2026.06.004_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11082","article-title":"Topological domains in mammalian genomes identified by analysis of chromatin interactions","volume":"485","author":"Dixon","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.pathol.2026.06.004_bib26","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","article-title":"3D map of the human genome at kilobase resolution reveals principles of chromatin looping","volume":"159","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.pathol.2026.06.004_bib27","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1038\/s41467-021-25862-3","article-title":"The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops","volume":"12","author":"Ottema","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.pathol.2026.06.004_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.biochem.052308.093131","article-title":"The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway","volume":"79","author":"Lieber","year":"2010","journal-title":"Ann Rev Biochem"},{"key":"10.1016\/j.pathol.2026.06.004_bib29","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"Chang","year":"2017","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302526005702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302526005702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:57:39Z","timestamp":1789592259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302526005702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0031302526005702"],"URL":"https:\/\/doi.org\/10.1016\/j.pathol.2026.06.004","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural complexity and mechanistic diversity of MECOM rearrangements in myeloid neoplasms","name":"articletitle","label":"Article Title"},{"value":"Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathol.2026.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}