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Chem."},{"key":"10.1016\/j.pathophys.2003.10.007_BIB82","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/cvr\/28.7.980","article-title":"Superoxide dismutase and N-2-mercaptopropionyl glycine attenuate infarct size limitation effect of ischaemic preconditioning in the rabbit","volume":"28","author":"Tanaka","year":"1994","journal-title":"Cardiovasc. 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