{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T03:59:27Z","timestamp":1754193567177},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["pathophysiologyjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathophysiology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.pathophys.2016.09.001","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T20:31:07Z","timestamp":1474489867000},"page":"275-283","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular mechanisms underlying fibrosis and elastin destruction in childhood interstitial lung diseases"],"prefix":"10.1016","volume":"23","author":[{"given":"Enas A.","family":"Hamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa M.","family":"El-Saied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem Abu-Zeid","family":"Yousef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany O.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Sabry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pathophys.2016.09.001_bib0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ppul.10125","article-title":"Idiopathic interstitial pneumonitis in children: a national survey in the United Kingdom and Ireland","volume":"34","author":"Dinwiddie","year":"2002","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1471-2466-8-24","article-title":"The incidence of interstitial lung disease 1995\u20132005: a Danish nationwide population\u2013based study","volume":"8","author":"Kornum","year":"2008","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0015","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1750-1172-4-26","article-title":"Incidence and classification of pediatric diffuse parenchymal lung diseases in Germany","volume":"4","author":"Griese","year":"2009","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0020","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1164\/ajrccm.156.3.9703051","article-title":"Factors influencing survival in children with chronic interstitial lung disease","volume":"156","author":"Fan","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.pathophys.2016.09.001_bib0025","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1034\/j.1399-3003.1999.14d16.x","article-title":"Open lung biopsy for diffuse interstitial lung disease in children","volume":"14","author":"Coren","year":"1999","journal-title":"Eur. Respir. J."},{"issue":"10","key":"10.1016\/j.pathophys.2016.09.001_bib0030","first-page":"899","article-title":"Pediatric interstitial lung disease","volume":"43","author":"Vijayasekaran","year":"2006","journal-title":"Indian Pediatr."},{"issue":"3","key":"10.1016\/j.pathophys.2016.09.001_bib0035","first-page":"233","article-title":"Chronic interstitial lung disease in children","volume":"83","author":"Paiva","year":"2007","journal-title":"J. Pediatr. (Rio. J)"},{"issue":"4","key":"10.1016\/j.pathophys.2016.09.001_bib0040","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1542\/peds.2013-1780","article-title":"Childhood interstitial lung diseases: an 18-year retrospective analysis","volume":"132","author":"Soares","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.pathophys.2016.09.001_bib0045","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1183\/09031936.04.00089803","article-title":"ERS Task Force Task Force on Chronic Interstitial Lung Disease in Immunocompetent Children","volume":"24","author":"Clement","year":"2004","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0050","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1164\/rccm.201305-0923ST","volume":"188","author":"Kurland","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0055","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1164\/rccm.200810-1615OC","article-title":"Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis","volume":"181","author":"Sisson","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.pupt.2006.01.002","article-title":"Pathogenetic pathways, and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis","volume":"20","author":"Antoniou","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0065","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12079-009-0037-7","article-title":"Connective tissue growth factor (CTGF CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?","volume":"3","author":"Leask","year":"2009","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0070","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1183\/09031936.00174807","article-title":"Desmosine as a biomarker of elastin degradation in COPD: current status and future directions","volume":"32","author":"Luisetti","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0075","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.molcel.2013.02.010","article-title":"Dogma derailed: the many influences of RNA on the genome","volume":"49","author":"Sabin","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.pathophys.2016.09.001_bib0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ccr.2007.07.027","article-title":"Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas","volume":"12","author":"Calin","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pathophys.2016.09.001_bib0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-4608(01)00634-3","article-title":"Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas","volume":"133","author":"Pibouin","year":"2002","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0090","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/dna.2006.25.135","article-title":"Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1","volume":"25","author":"Fu","year":"2006","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0095","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2164-10-163","article-title":"A transcriptional sketch of a primary human breast cancer by 454 deep sequencing","volume":"10","author":"Guffanti","year":"2009","journal-title":"BMC Genom."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0100","doi-asserted-by":"crossref","first-page":"24159","DOI":"10.1074\/jbc.M501704200","article-title":"Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS","volume":"280","author":"Sonkoly","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0105","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s10038-006-0070-9","article-title":"Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction","volume":"51","author":"Ishii","year":"2006","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0110","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nm1784","article-title":"Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of \u03b2-secretase","volume":"14","author":"Faghihi","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0115","doi-asserted-by":"crossref","first-page":"e1000600","DOI":"10.1371\/journal.pgen.1000600","article-title":"RNA gain-of-function in spinocerebellar ataxia type 8","volume":"5","author":"Daughters","year":"2009","journal-title":"PLoS Genet."},{"issue":"7","key":"10.1016\/j.pathophys.2016.09.001_bib0120","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/jcmm.12783","article-title":"Integrated long non-coding RNA analyses identify novel regulators of epithelial-mesenchymal transition in the mouse model of pulmonary fibrosis","volume":"20","author":"Sun","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0125","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0022-3476(05)80330-0","article-title":"Clinical spectrum of chronic interstitial lung disease in children","volume":"121","author":"Fan","year":"1992","journal-title":"J. Pediatr."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.prrv.2004.01.003","article-title":"Clinical presentation of interstitial lung disease in children","volume":"5","author":"Fauroux","year":"2004","journal-title":"Paediatr. Respir. Rev."},{"issue":"2","key":"10.1016\/j.pathophys.2016.09.001_bib0135","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.prrv.2004.01.002","article-title":"The pathogenesis of interstitial lung diseases in children","volume":"5","author":"Clement","year":"2004","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/ppul.20114","article-title":"Pediatric interstitial lung disease revisited","volume":"38","author":"Fan","year":"2004","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0145","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1136\/thoraxjnl-2013-204132","article-title":"A cluster of lung injury cases associated with home humidifier use: an epidemiological investigation","volume":"69","author":"Kim","year":"2014","journal-title":"Thorax"},{"key":"10.1016\/j.pathophys.2016.09.001_bib0150","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1164\/rccm.200703-393OC","article-title":"ChILD Research Co-operative, Diffuse lung disease in young children: application of a novel classification scheme","volume":"176","author":"Deutsch","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0155","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1034\/j.1399-3003.2000.016003509.x","article-title":"Interstitial lung disease in children: a multicentre survey on diagnostic approach","volume":"16","author":"Barbato","year":"2000","journal-title":"Eur. Respir. J."},{"issue":"5","key":"10.1016\/j.pathophys.2016.09.001_bib0160","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1053\/j.sult.2005.07.004","article-title":"High-resolution CT in diagnosis of diffuse infiltrative lung disease","volume":"2","author":"Zompatori","year":"2005","journal-title":"Semin. Ultrasound CT MR"},{"key":"10.1016\/j.pathophys.2016.09.001_bib0165","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s13312-013-0034-z","article-title":"Clinical profile of interstitial lung disease in Indian children","volume":"50","author":"Sankar","year":"2013","journal-title":"Indian Pediatr."},{"issue":"3","key":"10.1016\/j.pathophys.2016.09.001_bib0170","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1183\/09031936.00166508","article-title":"Medicines used in respiratory diseases only seen in children","volume":"34","author":"Lenney","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0175","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/ppul.23183","article-title":"Childhood interstitial lung disease: a systematic review","volume":"50","author":"Hime","year":"2015","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0180","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1084\/jem.170.3.727","article-title":"Macrophage production of transforming growth factor \u03b2 and fibroblast collagen synthesis in chronic pulmonary inflammation","volume":"170","author":"Khalil","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0185","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/ppul.20365","article-title":"Safety of endobronchial biopsy in children with cystic fibrosis","volume":"41","author":"Molina\u2013Teran","year":"2006","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0190","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2350-14-66","article-title":"Cytokine gene polymorphisms and serum cytokine levels in patients with idiopathic pulmonary fibrosis","volume":"14","author":"Alhamad","year":"2013","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0195","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.cellbi.2004.09.003","article-title":"Connective tissue growth factor regulates the key events in tubular epithelial to myofibroblast transition in vitro","volume":"28","author":"Zhang","year":"2004","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0200","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1165\/ajrcmb.21.6.3719","article-title":"Enhanced insulin\u2013like growth factor binding protein\u2013related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis","volume":"21","author":"Allen","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0205","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3892\/ijmm.2013.1565","article-title":"CCN5 overexpression inhibits profibrotic phenotypes via the P13K\/Akt signaling pathway in the lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis and in an in vivo model of lung fibrosis","volume":"33","author":"Zhang","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0210","doi-asserted-by":"crossref","first-page":"e21911","DOI":"10.1371\/journal.pone.0021911","article-title":"CCN2 is required for the TGF\u2013\u03b2 induced activation of Smad1\u2013Erk1\/2 signaling network","volume":"6","author":"Nakerakanti","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pathophys.2016.09.001_bib0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1465-9921-6-37","article-title":"Altered expression of membrane\u2013bound and soluble CD95\/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL-induced apoptosis","volume":"6","author":"Buhling","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0220","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.resp.2011.04.016","article-title":"Dual role of TGF\u2013\u03b21 on Fas- induced apoptosis in lung epithelial cells","volume":"177","author":"Bai","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0225","doi-asserted-by":"crossref","first-page":"E2048","DOI":"10.1073\/pnas.1415111112","article-title":"Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-\u03b2 signaling","volume":"112","author":"Oruqaj","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.pathophys.2016.09.001_bib0230","first-page":"952","article-title":"Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease","volume":"151","author":"Stone","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0235","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ppul.20646","article-title":"The effect of treatment of cystic fibrosis pulmonary exacerbations on airways and systemic inflammation","volume":"42","author":"Downey","year":"2007","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.pathophys.2016.09.001_bib0240","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2466-2-5","article-title":"Amyloid-associated with elastin\u2013staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome","volume":"2","author":"Fan","year":"2002","journal-title":"BMC Pulm. Med."}],"container-title":["Pathophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928468016300657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928468016300657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T21:23:45Z","timestamp":1568409825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928468016300657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0928468016300657"],"URL":"https:\/\/doi.org\/10.1016\/j.pathophys.2016.09.001","relation":{},"ISSN":["0928-4680"],"issn-type":[{"value":"0928-4680","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular mechanisms underlying fibrosis and elastin destruction in childhood interstitial lung diseases","name":"articletitle","label":"Article Title"},{"value":"Pathophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathophys.2016.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}