{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T18:45:40Z","timestamp":1775328340280,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["pathophysiologyjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pathophysiology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.pathophys.2018.02.002","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T16:49:23Z","timestamp":1521391763000},"page":"89-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Revisiting colorectal cancer animal model \u2013 An improved metastatic model for distal rectosigmoid colon carcinoma"],"prefix":"10.1016","volume":"25","author":[{"given":"Rui","family":"Caetano-Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Ant\u00f3nio","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Margarida","family":"Abrantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Tavares-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Carvalho","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-6007","authenticated-orcid":false,"given":"Mafalda","family":"Laranjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Bas\u00edlio","family":"Queir\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Casalta-Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-4650","authenticated-orcid":false,"given":"Salom\u00e9","family":"Pires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Gouveia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Rodrigues","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Gon\u00e7alves","family":"Priolli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Guilherme","family":"Tralh\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.pathophys.2018.02.002_bib0005","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012","volume":"49","author":"Ferlay","year":"2013","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0010","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nbt0610-561","article-title":"Raising the bar for cancer therapy models","volume":"28","author":"Francia","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000085342","article-title":"Mouse models of colorectal cancer and liver metastases","volume":"22","author":"Heijstek","year":"2005","journal-title":"Dig. Surg."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0020","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s12094-006-0177-7","article-title":"Mouse models in oncogenesis and cancer therapy","volume":"8","author":"C\u00e9spedes","year":"2006","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0025","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1038\/sj.onc.1203036","article-title":"Mouse models for colorectal cancer","volume":"18","author":"Heyer","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0030","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1053\/j.gastro.2008.12.049","article-title":"Mouse models of colon cancer","volume":"136","author":"Taketo","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0035","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/carcin\/bgh261","article-title":"Modeling metastasis in vivo","volume":"26","author":"Khanna","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0040","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/ijc.2910390514","article-title":"A new animal model for human colon cancer metastasis","volume":"39","author":"Bresalier","year":"1987","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0045","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1440-1746.2007.04923.x","article-title":"Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology","volume":"23","author":"Nawa","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0050","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1158\/1055-9965.EPI-11-1020","article-title":"Trends in colorectal cancer incidence rates in the United States by tumor location and stage, 1992\u20132008","volume":"21","author":"Siegel","year":"2012","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0055","doi-asserted-by":"crossref","first-page":"779","DOI":"10.7326\/0003-4819-113-10-779","article-title":"Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location","volume":"113","author":"Bufill","year":"1990","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0060","first-page":"10","article-title":"Two colons\u2013two cancers\u2013proximal or distal adenocarcinoma: arguments for a different carcinogenesis","volume":"82","author":"Pocard","year":"1995","journal-title":"Bull. Cancer (Paris)"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0065","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000171605","article-title":"Are right- and left-sided colon neoplasms distinct tumors?","volume":"15","author":"Distler","year":"1997","journal-title":"Dig. Dis. (Basel, Switzerland)"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0070","first-page":"755","article-title":"Distinguishing right from left colon by the pattern of gene expression","volume":"12","author":"Glebov","year":"2003","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0075","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/gut.2003.036848","article-title":"Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid","volume":"54","author":"Birkenkamp-Demtroder","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0080","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1245\/s10434-008-0015-y","article-title":"Is there a difference in survival between right- versus left-sided colon cancers?","volume":"15","author":"Meguid","year":"2008","journal-title":"Ann. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.pathophys.2018.02.002_bib0085","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cellimm.2008.08.007","article-title":"Relationship between CD107a expression and cytotoxic activity","volume":"254","author":"Aktas","year":"2009","journal-title":"Cell. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.pathophys.2018.02.002_bib0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jim.2004.08.008","article-title":"CD107a as a functional marker for the identification of natural killer cell activity","volume":"294","author":"Alter","year":"2004","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0095","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1590\/S0102-86502012000600001","article-title":"A novel model of distal colon cancer in athymic mice","volume":"27","author":"Priolli","year":"2012","journal-title":"Acta Cir. Bras."},{"issue":"12","key":"10.1016\/j.pathophys.2018.02.002_bib0100","doi-asserted-by":"crossref","first-page":"6244","DOI":"10.4049\/jimmunol.164.12.6244","article-title":"IL-2 activation of NK cells: involvement of MKK1\/2\/ERK but not p38 kinase pathway","volume":"164","author":"Yu","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0105","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3389\/fimmu.2014.00439","article-title":"Natural killer cells for cancer immunotherapy: pluripotent stem cells-derived NK cells as an immunotherapeutic perspective","volume":"5","author":"Eguizabal","year":"2014","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.pathophys.2018.02.002_bib0110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nri3174","article-title":"Targeting natural killer cells and natural killer T cells in cancer","volume":"12","author":"Vivier","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00384-008-0569-y","article-title":"A simple colostomy implantation model for evaluating colon cancer","volume":"24","author":"Jin","year":"2009","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0120","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jss.2008.05.028","article-title":"Novel murine model for colon cancer: non-operative trans-anal rectal injection","volume":"154","author":"Donigan","year":"2009","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0125","doi-asserted-by":"crossref","first-page":"e28858","DOI":"10.1371\/journal.pone.0028858","article-title":"Utilization of murine colonoscopy for orthotopic implantation of colorectal cancer","volume":"6","author":"Zigmond","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0130","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/carcin\/15.8.1571","article-title":"Colonoscopic colostomy model in rats for colon tumorigenesis studies","volume":"15","author":"Zhang","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0135","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ijc.21185","article-title":"A novel mouse model for segmental orthotopic colon cancer","volume":"117","author":"Alencar","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0140","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.3390\/cancers3011274","article-title":"The prognostic impact of p53 expression on sporadic colorectal cancer is dependent on p21 status","volume":"3","author":"Kruschewski","year":"2011","journal-title":"Cancers"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0145","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/sj.bjc.6690660","article-title":"Expression of high p53 levels in colorectal cancer: a favourable prognostic factor","volume":"81","author":"Adrover","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0150","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1572-0241.1998.00292.x","article-title":"P53 protein immunohistochemical expression in colonic adenomas with and without associated carcinoma","volume":"93","author":"Saleh","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0155","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1126\/science.278.5340.1041","article-title":"Cancer Models: systems for identifying new drugs are often faulty","volume":"278","author":"Gura","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0160","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1054\/bjoc.2001.1796","article-title":"Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials","volume":"84","author":"Johnson","year":"2001","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0165","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.ejca.2003.11.021","article-title":"Orthotopic models of cancer for preclinical drug evaluation: advantages and disadvantages","volume":"40","author":"Bibby","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0170","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ejca.2004.01.003","article-title":"Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development","volume":"40","author":"Peterson","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.pathophys.2018.02.002_bib0175","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nrd1635","article-title":"Opinion: what\u2019s wrong with our cancer models?","volume":"4","author":"Kamb","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pathophys.2018.02.002_bib0180","volume":"vol. 3","author":"Bosman","year":"2010"}],"container-title":["Pathophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928468017301529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928468017301529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T09:41:56Z","timestamp":1529142116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928468017301529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0928468017301529"],"URL":"https:\/\/doi.org\/10.1016\/j.pathophys.2018.02.002","relation":{},"ISSN":["0928-4680"],"issn-type":[{"value":"0928-4680","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revisiting colorectal cancer animal model \u2013 An improved metastatic model for distal rectosigmoid colon carcinoma","name":"articletitle","label":"Article Title"},{"value":"Pathophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pathophys.2018.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}