{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:20:42Z","timestamp":1761664842451,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Patolog\u00eda"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.patol.2023.06.003","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T16:43:55Z","timestamp":1695141835000},"page":"243-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["El enigma de la enfermedad de Enrique IV, rey de Castilla: \u00bfpadeci\u00f3 s\u00edndrome de McCune-Albright\/displasia fibrosa?"],"prefix":"10.1016","volume":"56","author":[{"given":"M. Teresa","family":"Tu\u00f1\u00f3n \u00c1lvarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Ruiz Calleja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiomar","family":"P\u00e9rez de Nanclares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.patol.2023.06.003_bib0165","article-title":"Medical diagnosis and Henry IV of Castile","volume":"183","author":"Irvine","year":"1984","journal-title":"An la Univ Alicant Hist Mediev"},{"key":"10.1016\/j.patol.2023.06.003_bib0170","unstructured":"Puyol y Alonso, J. Los cronistas de Enrique IV. En: Bolet\u00edn de la Real Academia de la Historia 399-415, 1921."},{"key":"10.1016\/j.patol.2023.06.003_bib0175","unstructured":"Serrano A. Enrique IV: La pol\u00edtica monetaria de un periodo convulso. We are numismatics 1-9, 2022 [consultado 28 Abr 2023] Disponible en: https:\/\/wearenumismatics.com\/enrique-iv-la-politica-monetaria-de-un-periodo-convulso\/"},{"key":"10.1016\/j.patol.2023.06.003_bib0180","unstructured":"Benito, M. Estudio antropol\u00f3gico y forense del cuerpo de san Isidro Labrador. Tecnolog\u00eda, Noticias de la Ciencia y la, 2022 [consultado 28 Abr 2023] Disponible en: https:\/\/noticiasdelaciencia.com\/art\/45540\/estudio-antropologico-y-forense-del-cuerpo-de-san-isidro-labrador"},{"key":"10.1016\/j.patol.2023.06.003_bib0185","unstructured":"Tu\u00f1on T, Bayo M, Ruiz-Calleja A. Un signo cl\u00ednico in\u00e9dito aportado por las acu\u00f1aciones de Enrique IV de Castilla. Desmontando la leyenda negra. We are numismatics, 2023 [consultado 28 Abr 2023] Disponible en: https:\/\/wearenumismatics.com\/signo-clinico-inedito-aportado-por-las-acunaciones-de-enrique-iv\/"},{"key":"10.1016\/j.patol.2023.06.003_bib0190","series-title":"Bolet\u00edn de la Real Academia de la Historia","first-page":"11","article-title":"Ensayo biol\u00f3gico sobre Enrique IV de Castilla \/Gregorio Mara\u00f1\u00f3n","author":"Mara\u00f1on","year":"2011"},{"key":"10.1016\/j.patol.2023.06.003_bib0195","first-page":"245","article-title":"Enrique IV de Castilla (1454-1474). Un singular enfermo urol\u00f3gico. Una endocrinopat\u00eda causa de los problemas uro-androl\u00f3gicos del Monarca. Infertilidad o esterilidad. Intentos de inseminaci\u00f3n artificial (IV)","volume":"56","author":"Maganto Pav\u00f3n","year":"2003","journal-title":"Arch Esp Urol"},{"key":"10.1016\/j.patol.2023.06.003_bib0200","series-title":"Bolet\u00edn de la Real Academia de la Historia","first-page":"41","article-title":"Los restos de Enrique IV de Castilla","author":"G\u00f3mez-Moreno Mart\u00ednez","year":"1947"},{"key":"10.1016\/j.patol.2023.06.003_bib0205","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnz011","article-title":"Fibrous Dysplasia\/McCune-Albright Syndrome: A Rare, Mosaic Disease of G\u03b1 s Activation","volume":"41","author":"Boyce","year":"2020","journal-title":"Endocr Rev"},{"key":"10.1016\/j.patol.2023.06.003_bib0210","unstructured":"Boyce A, Florenzano P, de Castro L, Collins, MT. Fibrous Dysplasia \/McCune-Albright Syndrome. En: GeneReviews\u00ae (ed. Adam MP, Mirzaa GM, Pagon RA, et al., editors) 2015."},{"key":"10.1016\/j.patol.2023.06.003_bib0215","unstructured":"Ruiz-Calleja A. Los reales de Enrique IV de La Coru\u00f1a. Ruiz Calleja 2020 [consultado 28 Abr 2023] Disponible en: https:\/\/blognumismatico.com\/2020\/11\/18\/los-reales-de-enrique-iv-de-la-coruna\/"},{"key":"10.1016\/j.patol.2023.06.003_bib0220","unstructured":"Ruiz-Calleja, A. Real de Enrique IV, busto con barba. Ruiz Calleja 2020 [consultado 28 Abr 2023] Disponible en: https:\/\/blognumismatico.com\/2020\/07\/23\/real-de-enrique-iv-busto-con-barba\/"},{"key":"10.1016\/j.patol.2023.06.003_bib0225","unstructured":"Roma Vald\u00e9s, A. Momeca 74.A7 Real, escudo de Girones (Enrique IV - moneda de plata entre 1454 y 1471). Moneda Medieval 2020 [consultado 28 Abr 2023] Disponible en: https:\/\/monedamedieval.es\/"},{"key":"10.1016\/j.patol.2023.06.003_bib0230","first-page":"955","article-title":"Precocious puberty: The clinical profile and the etiological classification of children presented at a tertiary care children's hospital","volume":"38","author":"Aftab","year":"2022","journal-title":"Pakistan J Med Sci"},{"key":"10.1016\/j.patol.2023.06.003_bib0235","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.medcli.2021.02.004","article-title":"Autoinmune polyendocrinopathy","volume":"157","author":"Fern\u00e1ndez Mir\u00f3","year":"2021","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.patol.2023.06.003_bib0240","first-page":"370","article-title":"Multiple endocrine neoplasia, the old and the new: A mini review","volume":"33","author":"Pasquali","year":"2012","journal-title":"G Chir"},{"key":"10.1016\/j.patol.2023.06.003_bib0245","article-title":"Kallmann Syndrome","author":"Sonne","year":"2023","journal-title":"StatPearls"},{"key":"10.1016\/j.patol.2023.06.003_bib0250","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11914-015-0268-x","article-title":"GNAS Spectrum of Disorders","volume":"13","author":"Turan","year":"2015","journal-title":"Curr Osteoporos Rep"},{"issue":"Suppl 1","key":"10.1016\/j.patol.2023.06.003_bib0255","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1750-1172-7-S1-S4","article-title":"McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia","volume":"7","author":"Collins","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.patol.2023.06.003_bib0260","first-page":"743","article-title":"Osteitis fibrosa cystica: The case of a nine year old girl who also exhibits precocious puberty, multiple pigmentation of the skin and hyperthyroidism","volume":"52","author":"McCune","year":"1936","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.patol.2023.06.003_bib0265","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJM193704292161701","article-title":"Syndrome Characterized by Osteitis Fibrosa Disseminata, Areas of Pigmentation and Endocrine Dysfunction, with Precocious Puberty in Females","volume":"216","author":"Albright","year":"1937","journal-title":"N Engl. J Med"},{"key":"10.1016\/j.patol.2023.06.003_bib0270","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41574-018-0042-0","article-title":"Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement","volume":"14","author":"Mantovani","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.patol.2023.06.003_bib0275","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000504802","article-title":"The Clinical Spectrum of McCune-Albright Syndrome and Its Management","volume":"92","author":"Spencer","year":"2019","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.patol.2023.06.003_bib0280","article-title":"Best practice management guidelines for fibrous dysplasia\/McCune-Albright syndrome: A consensus statement from the FD\/MAS international consortium","volume":"14","author":"Javaid","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.patol.2023.06.003_bib0285","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1750-1172-3-12","article-title":"McCune-Albright syndrome","volume":"3","author":"Dumitrescu","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.patol.2023.06.003_bib0290","article-title":"Hipertiroidismo. Nuevos aspectos etiopatog\u00e9nicos","volume":"46","author":"Salmer\u00f3n de Diego","year":"1999","journal-title":"Endocrinol y Nutr"},{"key":"10.1016\/j.patol.2023.06.003_bib0295","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00428-018-2396-z","article-title":"Head and neck manifestations of an undiagnosed McCune-Albright syndrome: clinicopathological description and literature review","volume":"473","author":"Lecumberri","year":"2018","journal-title":"Virchows Arch"},{"key":"10.1016\/j.patol.2023.06.003_bib0300","doi-asserted-by":"crossref","first-page":"47","DOI":"10.17925\/USE.2020.16.1.47","article-title":"Acromegaly Due to McCune-Albright Syndrome","volume":"16","author":"Rutkowski","year":"2020","journal-title":"US Endocrinol"},{"key":"10.1016\/j.patol.2023.06.003_bib0305","first-page":"E428","article-title":"Expression of an active G\u03b1 s mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance","volume":"115","author":"Zhao","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.patol.2023.06.003_bib0310","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1210\/jc.2018-01022","article-title":"Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome","volume":"103","author":"Robinson","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"article-title":"Endocrine and neuroendocrine tumours","year":"2022","series-title":"WHO classification of tumours series","key":"10.1016\/j.patol.2023.06.003_bib0315"},{"key":"10.1016\/j.patol.2023.06.003_bib0320","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jpeds.2008.02.045","article-title":"Platelet dysfunction and increased bleeding tendency in McCune-Albright syndrome","volume":"153","author":"Bajpai","year":"2008","journal-title":"J Pediatr"}],"container-title":["Revista Espa\u00f1ola de Patolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S169988552300048X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S169988552300048X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:07:40Z","timestamp":1761664060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S169988552300048X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S169988552300048X"],"URL":"https:\/\/doi.org\/10.1016\/j.patol.2023.06.003","relation":{},"ISSN":["1699-8855"],"issn-type":[{"type":"print","value":"1699-8855"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"El enigma de la enfermedad de Enrique IV, rey de Castilla: \u00bfpadeci\u00f3 s\u00edndrome de McCune-Albright\/displasia fibrosa?","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Patolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.patol.2023.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Sociedad Espa\u00f1ola de Anatom\u00eda Patol\u00f3gica. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}