{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T13:17:56Z","timestamp":1771247876947,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Espa\u00f1ola de Patolog\u00eda"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.patol.2026.100856","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:33:46Z","timestamp":1769200426000},"page":"100856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pure non-gestational ovarian choriocarcinoma in a postmenopausal woman coexisting with a clear cell adenofibroma and endometriosis foci: A case report and review of the literature"],"prefix":"10.1016","volume":"59","author":[{"given":"Ainhoa","family":"Ordo\u00f1ez Arrillaga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6488-1641","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Resano Abarzuza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rezola Bajineta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Aguiar Losada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yessica P.","family":"Rodr\u00edguez-Velandia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Moreno Valladares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iraide","family":"Bernal Sim\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibon","family":"Jaunarena Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irune","family":"Ruiz D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.patol.2026.100856_bib0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/20363613211052506","article-title":"Pure primary non-gestational choriocarcinoma originating in the ovary: a case report and literature review","volume":"13","author":"Yu","year":"2021","journal-title":"Rare Tumors."},{"key":"10.1016\/j.patol.2026.100856_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13048-014-0091-5","article-title":"Malignant mixed germ cell tumour of ovary \u2013 an unusual combination and review of literature","volume":"7","author":"Goyal","year":"2014","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.patol.2026.100856_bib0155","doi-asserted-by":"crossref","first-page":"547","DOI":"10.12659\/PJR.902578","article-title":"Extremely rare case of bilateral pure primary non-gestational ovarian choriocarcinoma","volume":"82","author":"Syed","year":"2017","journal-title":"Polish J Radiol"},{"key":"10.1016\/j.patol.2026.100856_bib0160","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/PGP.0000000000000913","article-title":"Molecular evidence for epithelial origin of mixed ovarian epithelial-germ cell neoplasms: report of 2 cases and review of literature","volume":"42","author":"Hall","year":"2022","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.patol.2026.100856_bib0165","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00404-020-05502-9","article-title":"Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma","volume":"301","author":"Liu","year":"2020","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.patol.2026.100856_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/diagnostics12030560","article-title":"Non-gestational ovarian choriocarcinoma: a rare ovarian cancer subtype","volume":"12","author":"Cronin","year":"2022","journal-title":"Diagnostics"},{"key":"10.1016\/j.patol.2026.100856_bib0175","first-page":"1","article-title":"Pure nongestational ovarian choriocarcinoma: a scoping review","volume":"4","author":"Garrett","year":"2017","journal-title":"Integr Cancer Sci Ther"},{"key":"10.1016\/j.patol.2026.100856_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ol.2015.2985","article-title":"Primary non-gestational pure choriocarcinoma arising in the ovary: a case report and literature review","volume":"9","author":"Hayashi","year":"2015","journal-title":"Oncol Lett"},{"key":"10.1016\/j.patol.2026.100856_bib0185","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.3892\/ol.2016.4257","article-title":"Clinicopathological analysis of non-gestational ovarian choriocarcinoma: report of two cases and review of the literature","volume":"11","author":"Wang","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1016\/j.patol.2026.100856_bib0290","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/pin.12445","article-title":"Ovarian nongestational choriocarcinoma and associated adenocarcinoma with the same germ cell origin determined by a molecular genetic approach: a case report","volume":"66","author":"Koyanagi","year":"2016","journal-title":"Pathol Int."},{"key":"10.1016\/j.patol.2026.100856_bib0195","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3802\/jgo.2009.20.3.192","article-title":"A case of non-gestational choriocarcinoma arising in the ovary of a postmenopausal woman","volume":"20","author":"Park","year":"2009","journal-title":"J Gynecol Oncol"},{"key":"10.1016\/j.patol.2026.100856_bib0200","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/PGP.0b013e318241d556","article-title":"Molecular genetic analysis of nongestational choriocarcinoma in a postmenopausal woman: a case report and literature review","volume":"31","author":"Hirata","year":"2012","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.patol.2026.100856_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7819-11-7","article-title":"Pure nongestational choriocarcinoma of the ovary: a case report","volume":"11","author":"Choi","year":"2013","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.patol.2026.100856_bib0210","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000098425","article-title":"Benign clear cell adenofibroma of the ovary. A case report with literature review","volume":"64","author":"Pa\u015fao\u011flu","year":"2007","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.patol.2026.100856_bib0215","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4132\/jptm.2015.08.07","article-title":"Clear cell adenocarcinoma arising from adenofibroma in a patient with endometriosis of the ovary","volume":"50","author":"Lim","year":"2016","journal-title":"J Pathol Transl Med"},{"key":"10.1016\/j.patol.2026.100856_bib0220","unstructured":"WHO Classification of Tumours Editorial Board. WHO Classification of Tumours. Female Genital Tumours. 5th ed. Lyon; 2020. 62 p."},{"key":"10.1016\/j.patol.2026.100856_bib0225","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/01.pgp.0000215301.39900.07","article-title":"Primary malignant melanoma of the ovary: a report of 9 definite or probable cases with emphasis on their morphologic diversity and mimicry of other primary and secondary ovarian neoplasms","volume":"25","author":"Mccluggage","year":"2006","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.patol.2026.100856_bib0230","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-18-4278","article-title":"Lineage-specific alterations in gynecologic neoplasms with choriocarcinomatous differentiation: implications for origin and therapeutics","volume":"25","author":"Xing","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.patol.2026.100856_bib0235","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ygyno.2006.01.001","article-title":"Ovarian nongestational choriocarcinoma mixed with various epithelial malignancies in association with endometriosis","volume":"102","author":"Hirabayashi","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.patol.2026.100856_bib0295","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1440-1827.2006.02016.x","article-title":"Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis","volume":"56","author":"Koo","year":"2006","journal-title":"Pathol Int."},{"key":"10.1016\/j.patol.2026.100856_bib0245","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/IGC.0b013e3181cc2526","article-title":"Clinical analysis of 21 cases of nongestational ovarian choriocarcinoma","volume":"20","author":"Jiao","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.patol.2026.100856_bib0250","first-page":"7049","article-title":"A pilot study comparing the genetic molecular biology of gestational and non-gestational choriocarcinoma","volume":"11","author":"Lazare","year":"2019","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.patol.2026.100856_bib0255","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/1097-0142(19920201)69:3<839::AID-CNCR2820690336>3.0.CO;2-E","article-title":"Gestational and nongestational trophoblastic tumors distinguished by DNA analysis","volume":"69","author":"Fisher","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.patol.2026.100856_bib0260","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1525-1438.2006.00764.x","article-title":"A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature","volume":"17","author":"Yamamoto","year":"2007","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.patol.2026.100856_bib0265","doi-asserted-by":"crossref","first-page":"94","DOI":"10.7150\/jca.2.94","article-title":"Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development","volume":"2","author":"Zhao","year":"2011","journal-title":"J Cancer"},{"key":"10.1016\/j.patol.2026.100856_bib0300","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ijgo.13585","article-title":"Endometriosis and malignancy: the intriguing relationship","volume":"1","author":"Dahiya","year":"2021","journal-title":"Int J Gynaecol Obstet."},{"key":"10.1016\/j.patol.2026.100856_bib0275","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5005\/jp-journals-10006-1851","article-title":"Ovarian collision tumors","volume":"12","author":"Sujithra","year":"2020","journal-title":"J South Asian Feder Obst Gynaecol"},{"key":"10.1016\/j.patol.2026.100856_bib0280","first-page":"FD14","volume":"Vol 8","author":"Singh","year":"2014"}],"container-title":["Revista Espa\u00f1ola de Patolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1699885526000012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1699885526000012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:33:34Z","timestamp":1771245214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1699885526000012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1699885526000012"],"URL":"https:\/\/doi.org\/10.1016\/j.patol.2026.100856","relation":{},"ISSN":["1699-8855"],"issn-type":[{"value":"1699-8855","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pure non-gestational ovarian choriocarcinoma in a postmenopausal woman coexisting with a clear cell adenofibroma and endometriosis foci: A case report and review of the literature","name":"articletitle","label":"Article Title"},{"value":"Revista Espa\u00f1ola de Patolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.patol.2026.100856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Sociedad Espa\u00f1ola de Anatom\u00eda Patol\u00f3gica. Published by Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"100856"}}