{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:51:03Z","timestamp":1790401863195,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.pbb.2004.07.011","type":"journal-article","created":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T14:24:21Z","timestamp":1095776661000},"page":"243-251","source":"Crossref","is-referenced-by-count":49,"title":["Bone cancer pain model in mice: evaluation of pain behavior, bone destruction and morphine sensitivity"],"prefix":"10.1016","volume":"79","author":[{"given":"Hilde","family":"Vermeirsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony M.","family":"Nuydens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo F.","family":"Meert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2004.07.011_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0149-7634(80)90028-7","article-title":"Stress-induced analgesia: neural and hormonal determinants","volume":"4","author":"Bodnar","year":"1980","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pbb.2004.07.011_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1526-4637.2001.002001015.x","article-title":"Functional interactions between tumor and peripheral nerve in a model of cancer pain in the mouse","volume":"2","author":"Cain","year":"2001","journal-title":"Pain Med."},{"issue":"3 Suppl.","key":"10.1016\/j.pbb.2004.07.011_bib3","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/cncr.11144","article-title":"Bone cancer pain","volume":"97","author":"Clohisy","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.pbb.2004.07.011_bib4","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/jor.1100130613","article-title":"Tumor osteolysis in osteopetrotic mice","volume":"13","author":"Clohisy","year":"1995","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.pbb.2004.07.011_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jor.1100140103","article-title":"Localized, tumor-associated osteolysis involves the recruitment and activation of osteoclasts","volume":"14","author":"Clohisy","year":"1996","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.pbb.2004.07.011_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0304-3959(00)00455-3","article-title":"The Amsterdam Pain Management Index compared to eight frequently used outcome measures to evaluate the adequacy of pain treatment in cancer patients with chronic pain","volume":"91","author":"de Wit","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2004.07.011_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1526-4637.2000.00047.x","article-title":"Bone cancer pain: from mechanism to model to therapy","volume":"1","author":"Honore","year":"2000","journal-title":"Pain Med."},{"key":"10.1016\/j.pbb.2004.07.011_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/74999","article-title":"Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord","volume":"6","author":"Honore","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.pbb.2004.07.011_bib9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0306-4522(00)00110-X","article-title":"Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons","volume":"98","author":"Honore","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2004.07.011_bib10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0079-6123(00)29030-4","article-title":"Cellular and neurochemical remodeling of the spinal cord in bone cancer pain","volume":"129","author":"Honore","year":"2000","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.pbb.2004.07.011_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/ijc.1425","article-title":"Involvement of parathyroid hormone-related protein in experimental cachexia induced by a human lung cancer-derived cell line established from a bone metastasis specimen","volume":"94","author":"Iguchi","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.pbb.2004.07.011_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1023\/A:1006689719505","article-title":"A novel orthotopic model of breast cancer metastasis to bone","volume":"17","author":"Lelekakis","year":"1999","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.pbb.2004.07.011_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1179\/his.2001.24.2.81","article-title":"Osteolytic bone lesions in the 5T2 multiple myeloma model: radiographic, scanning electron microscopic and microtomographic studies","volume":"24","author":"Libouban","year":"2001","journal-title":"J. Histotechnol."},{"key":"10.1016\/j.pbb.2004.07.011_bib14","first-page":"4038","article-title":"Osteoprotegerin diminishes advanced bone cancer pain","volume":"61","author":"Luger","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.pbb.2004.07.011_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0304-3959(02)00102-1","article-title":"Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs. inflammatory pain","volume":"99","author":"Luger","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2004.07.011_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4522(02)00165-3","article-title":"Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur","volume":"113","author":"Mach","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2004.07.011_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc747","article-title":"Molecular mechanisms of cancer pain","volume":"2","author":"Mantyh","year":"2002","journal-title":"Nat. Rev., Cancer"},{"key":"10.1016\/j.pbb.2004.07.011_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0304-3959(01)00437-7","article-title":"A rat model of bone cancer pain","volume":"96","author":"Medhurst","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2004.07.011_bib19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0305-7372(98)90005-6","article-title":"Breakthrough pain in cancer patients: pathophysiology and treatment","volume":"24","author":"Mercadante","year":"1998","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.pbb.2004.07.011_bib20","series-title":"Methods in pain research","first-page":"11","article-title":"Assessing nociception in murine subjects","author":"Mogil","year":"2001"},{"key":"10.1016\/j.pbb.2004.07.011_bib21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","article-title":"Metastasis to bone: causes, consequences and therapeutic opportunities","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat. Rev., Cancer"},{"key":"10.1016\/j.pbb.2004.07.011_bib22","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0140-6736(99)01310-0","article-title":"Management of cancer pain","volume":"353","author":"Portenoy","year":"1999","journal-title":"Lancet"},{"issue":"Suppl. 3","key":"10.1016\/j.pbb.2004.07.011_bib23","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/cncr.11150","article-title":"Animal models of bone metastasis","volume":"97","author":"Rosol","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.pbb.2004.07.011_bib24","doi-asserted-by":"crossref","first-page":"10886","DOI":"10.1523\/JNEUROSCI.19-24-10886.1999","article-title":"Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain","volume":"19","author":"Schwei","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pbb.2004.07.011_bib25","first-page":"287","article-title":"Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma","volume":"63","author":"Vanderkerken","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.pbb.2004.07.011_bib26","doi-asserted-by":"crossref","first-page":"9355","DOI":"10.1523\/JNEUROSCI.21-23-09355.2001","article-title":"Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain","volume":"21","author":"Wacnik","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pbb.2004.07.011_bib27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0304-3959(02)00040-4","article-title":"Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain","volume":"100","author":"Walker","year":"2002","journal-title":"Pain"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130570400259X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130570400259X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T14:24:01Z","timestamp":1549203841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009130570400259X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S009130570400259X"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2004.07.011","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}