{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:59:28Z","timestamp":1791223168726,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.pbb.2006.05.010","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T04:46:45Z","timestamp":1153889205000},"page":"1-7","source":"Crossref","is-referenced-by-count":56,"title":["Effect of MK-801 and ketamine on hydroxyl radical generation in the posterior cingulate and retrosplenial cortex of free-moving mice, as determined by in vivo microdialysis"],"prefix":"10.1016","volume":"86","author":[{"given":"Dai-Ying","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Liang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xue","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Fu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2006.05.010_bib1","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0022-3565(24)35047-5","article-title":"Characterization of MK-801-induced behavior as a putative rat model of psychosis","volume":"290","author":"Andine","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2006.05.010_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0091-3057(98)00149-X","article-title":"Parallel recovery of MK-801-induced spatial learning impairment and neuronal injury in male mice","volume":"62","author":"Brosnan-Watters","year":"1999","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2006.05.010_bib3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.7901908","article-title":"Oxidative stress, glutamate, and neurodegenerative disorders","volume":"262","author":"Coyle","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.pbb.2006.05.010_bib4","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1046\/j.1460-9568.2000.00229.x","article-title":"Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo","volume":"12","author":"Do","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pbb.2006.05.010_bib5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0165-0173(99)00002-8","article-title":"An integrated view of pathophysiological models of schizophrenia","volume":"29","author":"Duncan","year":"1999","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.pbb.2006.05.010_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0165-0173(94)00014-G","article-title":"The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias","volume":"20","author":"Ellison","year":"1995","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.pbb.2006.05.010_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.mp.4000912","article-title":"Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity","volume":"7","author":"Farber","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pbb.2006.05.010_bib8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0306-4522(88)90040-1","article-title":"MK-801 is neuroprotective in gerbil when administered in the post-ischemic period","volume":"25","author":"Gill","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2006.05.010_bib9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1749-6632.2000.tb06182.x","article-title":"Free radicals and antioxidants in the year 2000. A historical look to the future","volume":"899","author":"Gutteridge","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pbb.2006.05.010_bib10","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/S0024-3205(97)00924-7","article-title":"Amphetamine induces hydroxyl radical formation in the striatum of rats","volume":"61","author":"Huang","year":"1997","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2006.05.010_bib11","first-page":"969","article-title":"MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys","volume":"245","author":"Koek","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2006.05.010_bib12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/archpsyc.1994.03950030035004","article-title":"Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses","volume":"51","author":"Krystal","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pbb.2006.05.010_bib13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0006-8993(89)91074-3","article-title":"Effects of NMDA antagonists, MK-801 and CPP, upon local cerebral glucose use","volume":"496","author":"Kurumaji","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2006.05.010_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0893-133X(94)00131-I","article-title":"Subanesthetic doses of ketamine stimulate psychosis in schizophrenia","volume":"13","author":"Lahti","year":"1995","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2006.05.010_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0304-3940(00)01259-3","article-title":"The novel non-competitive N-methyl-d-aspartate antagonist gacyclidine blocks the glutamate-induced release of hydroxyl radicals in the striatum under conditions in which dizocilpine does not. A microdialysis study in rats","volume":"289","author":"Laplanche","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2006.05.010_bib16","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1523\/JNEUROSCI.22-08-03070.2002","article-title":"NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity","volume":"22","author":"Li","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2006.05.010_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0920-9964(95)00049-6","article-title":"Free radical pathology and antioxidant defense in schizophrenia: a review","volume":"19","author":"Mahadik","year":"1996","journal-title":"Schizophr Res"},{"key":"10.1016\/j.pbb.2006.05.010_bib18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/BF00965838","article-title":"Autoradiographic assessment of the effects of N-methyl-d-aspartate (NMDA) receptor antagonists in vivo","volume":"16","author":"McCulloch","year":"1991","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pbb.2006.05.010_bib19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0028-3908(88)90176-1","article-title":"Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models","volume":"27","author":"McNamara","year":"1988","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2006.05.010_bib20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.281.5381.1349","article-title":"Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats","volume":"281","author":"Moghaddam","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.pbb.2006.05.010_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1196\/annals.1300.065","article-title":"Glutamatergic animal models of schizophrenia","volume":"1003","author":"Moghaddam","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pbb.2006.05.010_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1097-4547(19960701)45:1<13::AID-JNR2>3.0.CO;2-K","article-title":"Effects of phencyclidine on immediate early gene expression in the brain","volume":"45","author":"Nakki","year":"1996","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.pbb.2006.05.010_bib23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0006-8993(99)02426-9","article-title":"The effect of ketamine isomers on both mice behavioral responses and c-Fos expression in the posterior cingulate and retrosplenial cortices","volume":"857","author":"Nishizawa","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2006.05.010_bib24","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/0024-3205(95)00150-5","article-title":"Hydroxyl radical formation in diabetic rats induced by streptozotocin","volume":"56","author":"Ohkuwa","year":"1995","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2006.05.010_bib25","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1001\/archpsyc.1995.03950240016004","article-title":"Glutamate receptor dysfunction and schizophrenia","volume":"52","author":"Olney","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pbb.2006.05.010_bib26","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1126\/science.2660263","article-title":"Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs","volume":"244","author":"Olney","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.pbb.2006.05.010_bib27","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1126\/science.1835799","article-title":"NMDA antagonist neurotoxicity: mechanism and prevention","volume":"254","author":"Olney","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.pbb.2006.05.010_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0022-3956(99)00029-1","article-title":"NMDA receptor hypofunction model of schizophrenia","volume":"33","author":"Olney","year":"1999","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pbb.2006.05.010_bib29","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1046\/j.1460-9568.1998.00392.x","article-title":"Acute phencyclidine neurotoxicity in rat forebrain : induction of haem oxygenase-1 and attenuation by the antioxidant dimethylthiourea","volume":"10","author":"Rajdev","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pbb.2006.05.010_bib31","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1046\/j.1432-1327.2000.01595.x","article-title":"Glutathione, oxidative stress and neurodegeneration","volume":"267","author":"Schulz","year":"2000","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.pbb.2006.05.010_bib30","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ana.410300609","article-title":"MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex","volume":"30","author":"Sharp","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pbb.2006.05.010_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neulet.2004.07.024","article-title":"Evidence for a dysfunctional retrosplenial cortex in patients with schizophrenia: a functional magnetic resonance imaging study with a semantic-perceptual contrast","volume":"369","author":"Tendolkar","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2006.05.010_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.pharmtox.42.082701.160735","article-title":"Glutamatergic mechanisms in schizophrenia","volume":"42","author":"Tsai","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.pbb.2006.05.010_bib34","doi-asserted-by":"crossref","first-page":"9141","DOI":"10.1523\/JNEUROSCI.19-20-09141.1999","article-title":"Methamphetamine-induced neurotoxicity alters locomotor activity, stereotypic behavior, and stimulated dopamine release in the rat","volume":"19","author":"Wallace","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2006.05.010_bib35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0197-4580(88)80081-2","article-title":"Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis","volume":"9","author":"Wu","year":"1988","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pbb.2006.05.010_bib36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0891-5849(95)00042-V","article-title":"Elevated extracellular glutamate levels increased the formation of hydroxyl radical in the striatum of anesthetized rat","volume":"19","author":"Yang","year":"1995","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pbb.2006.05.010_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2165\/00023210-200115040-00004","article-title":"Oxidative damage and schizophrenia: an overview of the evidence and its therapeutic implications","volume":"15","author":"Yao","year":"2001","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pbb.2006.05.010_bib38","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.lfs.2005.09.022","article-title":"Effect of acute and chronic MK-801 administration on extracellular glutamate and ascorbic acid release in the prefrontal cortex of freely moving mice on line with open-field behavior","volume":"78","author":"Zuo","year":"2006","journal-title":"Life Sci"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305706001432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305706001432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T02:26:06Z","timestamp":1736475966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305706001432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0091305706001432"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2006.05.010","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}