{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:57:38Z","timestamp":1780509458748,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.pbb.2007.02.013","type":"journal-article","created":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T11:36:49Z","timestamp":1172230609000},"page":"678-685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sedative\u2013hypnotic profile of novel isatin ketals"],"prefix":"10.1016","volume":"86","author":[{"given":"Gisele","family":"Zapata-Sudo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana B.","family":"Pontes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaiana C.F.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00fabia M.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo C.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete M.","family":"Trachez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto T.","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2007.02.013_bib1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0031-9384(94)00365-C","article-title":"Behavioral effects of isatin on open field activity and immobility in the forced swim test in rats","volume":"57","author":"Abel","year":"1995","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2007.02.013_bib3","first-page":"453","article-title":"Further investigations on the anxiogenic effects of isatin","volume":"9","author":"Bhattacharya","year":"1993","journal-title":"Biog Amines"},{"key":"10.1016\/j.pbb.2007.02.013_bib5","first-page":"118","article-title":"Dose-related proconvulsant and anticonvulsant activity of isatin, a putative biological factor, in rats","volume":"36","author":"Bhattacharya","year":"1998","journal-title":"Indian J Exp Biol"},{"key":"10.1016\/j.pbb.2007.02.013_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0304-3940(91)90429-W","article-title":"Effect of aromatic amino acids, pentylenetetrazole and yohimbine on isatin and tribulin activity in rat brain","volume":"132","author":"Bhattacharya","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2007.02.013_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0893-133X(95)00204-Q","article-title":"Anxiolytic activity of intraventricularly administered atrial natriuretic peptide in the rat","volume":"15","author":"Bhattacharya","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2007.02.013_bib6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/bbrc.2000.3477","article-title":"The endogenous oxindoles 5-hydroxyoxindole and isatin are antiproliferative and proapoptotic","volume":"276","author":"Cane","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pbb.2007.02.013_bib7","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1016\/S0960-894X(03)00756-X","article-title":"Synthesis and evaluations of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain","volume":"13","author":"Chiyanzu","year":"2003","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.pbb.2007.02.013_bib8","first-page":"495","article-title":"Effect of isatin (2,3-dioxoindoline) on audiogenic seizures in rats and its relationship to electrographic and behavioural phenomena","volume":"28","author":"Chocholova","year":"1979","journal-title":"Physiol Bohemoslov"},{"key":"10.1016\/j.pbb.2007.02.013_bib9","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1471-4159.2003.01564.x","article-title":"In situ imaging of specific binding of [3H]isatin in rat brain","volume":"84","author":"Crumeyrolle-Arias","year":"2003","journal-title":"J Neurochem"},{"key":"10.1016\/j.pbb.2007.02.013_bib10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.bcp.2003.10.021","article-title":"Inhibition of brain mitochondrial monoamine oxidases by the endogenous compound 5-hydroxyoxindole","volume":"67","author":"Crumeyrolle-Arias","year":"2004","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1021\/jm960644a","article-title":"Substituted indole-2-carboxylates as in vivo potent antagonists acting at the strychnine-insensitive glycine binding site","volume":"40","author":"Di Fabio","year":"1997","journal-title":"J Med Chem"},{"key":"10.1016\/j.pbb.2007.02.013_bib12","unstructured":"Evanno Y, Dubois L, Sevrin M, Marguet F, Proissant J, Bartsch R, Gille C. 4-Oxo-3,5-dihydro-4H-pyridazano-4,5-b-indole-1-acetamide Derivatives, Their Preparation and their Application in Therapy as GABA Agonists, Fr. PAT. 9,906,406, 11 Feb 1999. Chemical Abstracts 130 168385f. 1999."},{"key":"10.1016\/j.pbb.2007.02.013_bib13","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1016\/j.bmc.2004.09.016","article-title":"Design, synthesis, computational and biological evaluation of new anxiolytics","volume":"12","author":"Geronikaki","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.pbb.2007.02.013_bib14","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1471-4159.1988.tb01089.x","article-title":"Isatin: identity with the purified endogenous monoamine oxidase inhibitor tribulin","volume":"5","author":"Glover","year":"1988","journal-title":"J Neurochem"},{"key":"10.1016\/j.pbb.2007.02.013_bib15","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/0024-3205(95)02189-P","article-title":"Isatin is a potent endogenous antagonist of guanylate cyclase-coupled atrial natriuretic peptide receptors","volume":"57","author":"Glover","year":"1995","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2007.02.013_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-4347(91)80585-Z","article-title":"Isatin (indole-2,3-dione) in urine and tissues. Detection and determination by gas chromatography\u2013mass spectrometry","volume":"562","author":"Halket","year":"1991","journal-title":"J Chromatogr"},{"key":"10.1016\/j.pbb.2007.02.013_bib18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1248\/yakushi1947.120.4_352","article-title":"Pharmacological role of isatin, an endogenous MAO inhibitor","volume":"120","author":"Hamaue","year":"2000","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.pbb.2007.02.013_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0306-3623(97)00274-7","article-title":"Determination of isatin, an endogenous monoamine oxidase inhibitor, in urine and tissues of rats by HPLC","volume":"30","author":"Hamaue","year":"1998","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0161-813X(03)00100-1","article-title":"Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus","volume":"25","author":"Hamaue","year":"2004","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.pbb.2007.02.013_bib20","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.physbeh.2003.11.005","article-title":"Effect of acute stress and gender on isatin in rat tissues and serum","volume":"80","author":"Igosheva","year":"2004","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2007.02.013_bib21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.2165\/00003495-198835040-00002","article-title":"Propofol: a review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anaesthesia","volume":"35","author":"Langley","year":"1998","journal-title":"Drugs"},{"key":"10.1016\/j.pbb.2007.02.013_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0161-813X(03)00098-6","article-title":"Tribulin and endogenous MAO-inhibitory regulation in vivo","volume":"25","author":"Medvedev","year":"2004","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.pbb.2007.02.013_bib22","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0006-2952(92)90454-Q","article-title":"Inhibitory potency of some isatin analogues on human monoamine oxidase A and B","volume":"44","author":"Medvedev","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0006-2952(96)00206-7","article-title":"Isatin: a link between natriuretic peptides and monoamines?","volume":"52","author":"Medvedev","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib24","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0006-2952(98)00371-2","article-title":"Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclase","volume":"57","author":"Medvedev","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0006-2952(01)00809-7","article-title":"Effect of isatin on nitric oxide-stimulated soluble guanylate cyclase from human platelets","volume":"63","author":"Medvedev","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jep.2004.10.028","article-title":"Central nervous system activity of the hydroalcoholic extract of Casimiroa edulis in rats and mice","volume":"97","author":"Mora","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-2999(96)00162-8","article-title":"Isatin inhibits food intake in mice","volume":"305","author":"Morley","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/00000542-199704000-00021","article-title":"Multiple mechanisms of ketamine blockade on N-methyl-d-aspartate receptors","volume":"86","author":"Orser","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pbb.2007.02.013_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0928-0987(99)00038-X","article-title":"Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(49-chlorophenyl)thiazol-2-yl] thiosemicarbazide","volume":"9","author":"Pandeya","year":"1999","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.pbb.2007.02.013_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/1521-4184(200204)335:4<129::AID-ARDP129>3.0.CO;2-W","article-title":"Anticonvulsant and sedative\u2013hypnotic activities of N-substituted isatin semicarbazones","volume":"335","author":"Pandeya","year":"2002","journal-title":"Arch Pharm"},{"key":"10.1016\/j.pbb.2007.02.013_bib32","first-page":"27","article-title":"Biological activities of isatin and its derivatives","volume":"55","author":"Pandeya","year":"2005","journal-title":"Acta Pharm"},{"key":"10.1016\/j.pbb.2007.02.013_bib33","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0196-9781(00)00149-2","article-title":"Isatin (indole-2,3-dione) inhibits natriuretic peptide-induced hyperthermia in rats","volume":"21","author":"Pataki","year":"2000","journal-title":"Peptides"},{"key":"10.1016\/j.pbb.2007.02.013_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2202-3-2","article-title":"The effects of isatin (indole-2,3-dione) on pituitary adenylate cyclase-activating polypeptide-induced hyperthermia in rats","volume":"3","author":"Pataki","year":"2002","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.pbb.2007.02.013_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib36","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1021\/jm00400a018","article-title":"Potential anticonvulsants. synthesis and anticonvulsant activity of spiro[1,3-dioxolane-2,3\u2032-indolin]-2\u2032ones and structural analogues","volume":"31","author":"Rajopadhye","year":"1988","journal-title":"J Med Chem"},{"key":"10.1016\/j.pbb.2007.02.013_bib37","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1248\/bpb.24.1149","article-title":"Synthesis and pharmacological activities of hydrazones, Schiff and Mannich bases of isatin derivatives","volume":"24","author":"Sridhar","year":"2001","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.pbb.2007.02.013_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0928-0987(02)00077-5","article-title":"Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives","volume":"16","author":"Sridhar","year":"2002","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.pbb.2007.02.013_bib39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0361-9230(00)00359-2","article-title":"The action of isatin (2,3-dioxoindole) an endogenous indole on brain natriuretic and C-type natriuretic peptide-induced facilitation of memory consolidation in passive-avoidance learning in rats","volume":"53","author":"Telegdy","year":"2000","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pbb.2007.02.013_bib40","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0006-2952(98)00199-3","article-title":"Stress-induced increase in urinary isatin excretion in rats. Reversal by both dexamethasone and \u03b1-methyl-P-tyrosine","volume":"56","author":"Tozawa","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2007.02.013_bib41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1053\/smrv.2000.0126","article-title":"Non-benzodiazepines for the treatment of insomnia","volume":"4","author":"Wagner","year":"2000","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.pbb.2007.02.013_bib42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0197-0186(90)90154-L","article-title":"Isatin, regional distribution in rat brain and tissues","volume":"17","author":"Watkins","year":"1990","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pbb.2007.02.013_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.theochem.2006.05.052","article-title":"Substituent effect of halogen (F, Cl and Br) on uracil tetrad: a theoretical study","volume":"770","author":"Zhao","year":"2006","journal-title":"Theochem"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305707000846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305707000846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:28:26Z","timestamp":1758774506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305707000846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0091305707000846"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2007.02.013","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sedative\u2013hypnotic profile of novel isatin ketals","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2007.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}