{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:21:56Z","timestamp":1784258516579,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.pbb.2008.08.006","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T20:45:39Z","timestamp":1218660339000},"page":"351-357","source":"Crossref","is-referenced-by-count":26,"title":["Repeated heroin in rats produces locomotor sensitization and enhances appetitive Pavlovian and instrumental learning involving food reward"],"prefix":"10.1016","volume":"91","author":[{"given":"Robert","family":"Ranaldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Fein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Delamater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2008.08.006_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0091-3057(98)00112-9","article-title":"Effects of dopamine antagonists and accumbens dopamine depletions on time-constrained progressive-ratio performance","volume":"61","author":"Aberman","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2008.08.006_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuropharm.2004.06.020","article-title":"Brain substrates for increased drug seeking during protracted withdrawal","volume":"47","author":"Aston-Jones","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1476-5381.1972.tb06866.x","article-title":"Time\u2013dose relationships for locomotor activity effects of morphine after acute or repeated treatment","volume":"46","author":"Babbini","year":"1972","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2008.08.006_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0165-0173(98)00019-8","article-title":"What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience","volume":"28","author":"Berridge","year":"1998","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.pbb.2008.08.006_bib5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0024-3205(81)90148-X","article-title":"Intracranial self-administration of morphine into the ventral tegmental area in rats","volume":"28","author":"Bozarth","year":"1981","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2008.08.006_bib6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0166-2236(02)02289-0","article-title":"Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse","volume":"25","author":"Carlezon","year":"2002","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pbb.2008.08.006_bib7","doi-asserted-by":"crossref","first-page":"6729","DOI":"10.1523\/JNEUROSCI.1498-05.2005","article-title":"Extended habit training reduces dopamine mediation of appetitive response expression","volume":"25","author":"Choi","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2008.08.006_bib8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/cercor\/bhj120","article-title":"Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific","volume":"17","author":"Clarke","year":"2007","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.pbb.2008.08.006_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0006-8993(75)90834-3","article-title":"The pharmacological and anatomical substrates of the amphetamine response in the rat","volume":"83","author":"Creese","year":"1975","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2008.08.006_bib10","doi-asserted-by":"crossref","first-page":"9471","DOI":"10.1523\/JNEUROSCI.21-23-09471.2001","article-title":"Differential involvement of NMDA, AMPA\/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of Pavlovian approach behavior","volume":"21","author":"Di Ciano","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2008.08.006_bib11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00213-007-1051-1","article-title":"Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans","volume":"197","author":"Ersche","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1523\/JNEUROSCI.16-01-00274.1996","article-title":"Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents","volume":"16","author":"Fitzgerald","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2008.08.006_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00008877-199807000-00001","article-title":"Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine","volume":"9","author":"Harmer","year":"1998","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pbb.2008.08.006_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1523\/JNEUROSCI.12-02-00483.1992","article-title":"Opioids excite dopamine neurons by hyperpolarization of local interneurons","volume":"12","author":"Johnson","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2008.08.006_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0304-3940(79)96149-4","article-title":"The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat","volume":"14","author":"Joyce","year":"1979","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2008.08.006_bib16","first-page":"204","article-title":"Sensitization to repeated morphine injection in the rat: possible involvement of A10 dopamine neurons","volume":"241","author":"Kalivas","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2008.08.006_bib17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1037\/h0024169","article-title":"Reversal learning as a function of the size of the reward during acquisition and reversal","volume":"73","author":"Kendler","year":"1967","journal-title":"J Exp Psychol"},{"key":"10.1016\/j.pbb.2008.08.006_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-4328(99)00109-6","article-title":"Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule","volume":"107","author":"Lorrain","year":"2000","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2008.08.006_bib19","series-title":"The Psychology of Animal Learning","author":"Mackintosh","year":"1974"},{"key":"10.1016\/j.pbb.2008.08.006_bib20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s002130050530","article-title":"Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule","volume":"135","author":"Mendrek","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2008.08.006_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00213-004-1992-6","article-title":"Binge self-administration and deprivation produces sensitization to the reinforcing effects of cocaine in rats","volume":"178","author":"Morgan","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2008.08.006_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s002130050373","article-title":"Ethanol, like psychostimulants and morphine, causes long-lasting hyperreactivity of dopamine and acetylcholine neurons of rat nucleus accumbens: possible role in behavioural sensitization","volume":"133","author":"Nestby","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0166-4328(02)00291-7","article-title":"Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function","volume":"137","author":"Parkinson","year":"2002","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2008.08.006_bib24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0014-2999(97)01195-3","article-title":"Functional correlates of heroin sensitization in the rat brain","volume":"335","author":"Pontieri","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2008.08.006_bib25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/sj.npp.1301555","article-title":"Neural mechanisms of extinction learning and retrieval","volume":"33","author":"Quirk","year":"2008","journal-title":"Neuropsychopharmacol Rev"},{"key":"10.1016\/j.pbb.2008.08.006_bib26","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s002130000480","article-title":"Morphine and amphetamine sensitization demonstrated under moderate- and high-dose NMDA receptor blockade with MK-801 (dizocilpine)","volume":"151","author":"Ranaldi","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.brainres.2004.11.041","article-title":"Microinjections of SCH 23390 in the ventral tegmental area reduce operant responding under a progressive ratio schedule of food reinforcement in rats","volume":"1033","author":"Sharf","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2008.08.006_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/syn.890140307","article-title":"Long lasting changes in morphine-induced mesolimbic dopamine release after chronic morphine exposure","volume":"14","author":"Spanagel","year":"1993","journal-title":"Synapse"},{"key":"10.1016\/j.pbb.2008.08.006_bib29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1196\/annals.1401.014","article-title":"Neural correlates of inflexible behavior in the orbitofrontal\u2013amygdalar circuit after cocaine exposure","volume":"1121","author":"Stalnaker","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pbb.2008.08.006_bib30","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nn1931","article-title":"Cocaine-induced decision-making deficits are mediated by miscoding in basolateral amygdala","volume":"10","author":"Stalnaker","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pbb.2008.08.006_bib31","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0893-133X(02)00379-2","article-title":"Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in a D1 dopamine receptor dependent manner","volume":"27","author":"Suto","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib32","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/sj.npp.1300075","article-title":"Previous exposure to VTA amphetamine enhances cocaine self-administration under a progressive ratio schedule in an NMDA, AMPA\/kainate, and metabotropic glutamate receptor-dependent manner","volume":"28","author":"Suto","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s002130050859","article-title":"Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization","volume":"142","author":"Taylor","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0006-3223(01)01106-4","article-title":"Repeated intermittent administration of psychomotor stimulant drugs alters the acquisition of Pavlovian approach behavior in rats: differential effects of cocaine, d-amphetamine and 3,4-methylenedioxymethamphetamine (\u201cEcstasy\u201d)","volume":"50","author":"Taylor","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pbb.2008.08.006_bib35","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/BF00179197","article-title":"6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine","volume":"90","author":"Taylor","year":"1986","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002130000493","article-title":"Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies","volume":"151","author":"Vanderschuren","year":"2000","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib37","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00213-005-0288-9","article-title":"Discrete-trials heroin self-administration produces sensitization to the reinforcing effects of cocaine in rats","volume":"185","author":"Ward","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2008.08.006_bib38","series-title":"Statistical Principles in Experimental Design","author":"Winer","year":"1971"},{"key":"10.1016\/j.pbb.2008.08.006_bib39","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1098\/rstb.2006.1854","article-title":"Role of brain dopamine in food reward and reinforcement","volume":"361","author":"Wise","year":"2006","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.pbb.2008.08.006_bib40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.ps.40.020189.001203","article-title":"Brain dopamine and reward","volume":"40","author":"Wise","year":"1989","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.pbb.2008.08.006_bib41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF02251293","article-title":"Relative roles of ventral striatal D1 and D2 dopamine receptors in responding with conditioned reinforcement","volume":"110","author":"Wolterink","year":"1993","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2008.08.006_bib42","doi-asserted-by":"crossref","first-page":"8122","DOI":"10.1523\/JNEUROSCI.20-21-08122.2000","article-title":"Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward \u201cwanting\u201d without enhanced \u201cliking\u201d or response reinforcement","volume":"20","author":"Wyvell","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2008.08.006_bib43","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.1523\/JNEUROSCI.21-19-07831.2001","article-title":"Incentive sensitization by previous amphetamine exposure: increased cue-triggered \u201cwanting\u201d for sucrose reward","volume":"21","author":"Wyvell","year":"2001","journal-title":"J Neurosci"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305708002803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305708002803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T09:39:28Z","timestamp":1557740368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305708002803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0091305708002803"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2008.08.006","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}