{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:19:46Z","timestamp":1770135586343,"version":"3.49.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.pbb.2009.11.009","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T12:50:29Z","timestamp":1259153429000},"page":"543-552","source":"Crossref","is-referenced-by-count":31,"title":["Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP\/PSEN1 transgenic mice"],"prefix":"10.1016","volume":"94","author":[{"given":"F.E.","family":"Harrison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2009.11.009_bib1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jalz.2008.02.005","article-title":"Alzheimer's disease facts and figures","volume":"4","author":"Alzheimer's Association","year":"2008","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.pbb.2009.11.009_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.phrs.2003.10.004","article-title":"Effect of vitamins C and E on cognitive function in mouse","volume":"49","author":"Arzi","year":"2004","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.pbb.2009.11.009_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1601-183X.2006.00269.x","article-title":"Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice","volume":"6","author":"Bazalakova","year":"2007","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pbb.2009.11.009_bib4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuint.2004.11.007","article-title":"Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat","volume":"46","author":"Bemeur","year":"2005","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pbb.2009.11.009_bib5","article-title":"Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice","author":"Bernardo","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pbb.2009.11.009_bib6","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.neurobiolaging.2006.05.035","article-title":"Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet","volume":"28","author":"Bernardo","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pbb.2009.11.009_bib7","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1021\/ja00402a042","article-title":"Mechanisms of disproportionation of ascorbate radicals","volume":"103","author":"Bielski","year":"1981","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.pbb.2009.11.009_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3233\/JAD-2009-0923","article-title":"Ascorbic acid and rates of cognitive decline in Alzheimer's disease","volume":"16","author":"Bowman","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.pbb.2009.11.009_bib9","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S1471-4914(01)02173-6","article-title":"Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide","volume":"7","author":"Butterfield","year":"2001","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.pbb.2009.11.009_bib10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-079X.2008.00637.x","article-title":"Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice","volume":"46","author":"Caballero","year":"2009","journal-title":"J Pineal Res"},{"key":"10.1016\/j.pbb.2009.11.009_bib11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00401-006-0071-y","article-title":"Neuropathology of Alzheimer disease: pathognomonic but not pathogenic","volume":"111","author":"Castellani","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.pbb.2009.11.009_bib12","first-page":"99","article-title":"Lowered plasma vitamin C, but not vitamin E, concentrations in dementia patients","volume":"8","author":"Charlton","year":"2004","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.pbb.2009.11.009_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nn1372","article-title":"Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function","volume":"8","author":"Cleary","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pbb.2009.11.009_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/nlme.1995.1050","article-title":"The effects of ascorbic acid and oxiracetam on scopolamine-induced amnesia in a habituation test in aged mice","volume":"64","author":"de Angelis","year":"1995","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pbb.2009.11.009_bib15","first-page":"175","article-title":"Changes relevant to catecholamine metabolism in liver and brain of ascorbic acid deficient guinea-pigs. International journal for vitamin and nutrition research","volume":"45","author":"Deana","year":"1975","journal-title":"Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung"},{"key":"10.1016\/j.pbb.2009.11.009_bib16","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/ajcn\/54.4.712","article-title":"Ascorbic acid and dehydroascorbic acid measurements in human plasma and serum","volume":"54","author":"Dhariwal","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.pbb.2009.11.009_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/jmf.2006.9.281","article-title":"Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice","volume":"9","author":"Dhingra","year":"2006","journal-title":"J Med Food"},{"key":"10.1016\/j.pbb.2009.11.009_bib18","doi-asserted-by":"crossref","first-page":"11622","DOI":"10.1523\/JNEUROSCI.3153-08.2008","article-title":"Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model","volume":"28","author":"Ding","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2009.11.009_bib19","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0022-3565(24)29217-X","article-title":"M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL\/6J mouse","volume":"299","author":"Douglas","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2009.11.009_bib20","series-title":"Memory: a contribution to experimental psychology","author":"Ebbinghaus","year":"1885"},{"key":"10.1016\/j.pbb.2009.11.009_bib21","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1001\/jama.287.24.3223","article-title":"Dietary intake of antioxidants and risk of Alzheimer disease","volume":"287","author":"Engelhart","year":"2002","journal-title":"Jama"},{"key":"10.1016\/j.pbb.2009.11.009_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-079X.2004.00144.x","article-title":"Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease","volume":"37","author":"Feng","year":"2004","journal-title":"J Pineal Res"},{"key":"10.1016\/j.pbb.2009.11.009_bib23","first-page":"903","article-title":"Scopolamine-induced hypermotility in rats is mediated via a dopaminergic system","volume":"39","author":"Fink","year":"1980","journal-title":"Acta Biol Med Ger"},{"key":"10.1016\/j.pbb.2009.11.009_bib24","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1037\/0735-7044.107.4.618","article-title":"Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze","volume":"107","author":"Gallagher","year":"1993","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pbb.2009.11.009_bib25","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.nbd.2006.08.017","article-title":"Characterization of amyloid deposition in the APPswe\/PS1dE9 mouse model of Alzheimer disease","volume":"24","author":"Garcia-Alloza","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.pbb.2009.11.009_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/exnr.2001.7754","article-title":"Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse","volume":"173","author":"Gordon","year":"2002","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pbb.2009.11.009_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2008.01.030","article-title":"Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe\/PS1dE9 mouse model of Alzheimer's disease","volume":"583","author":"Goto","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2009.11.009_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1532-5415.2007.01531.x","article-title":"Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults","volume":"56","author":"Gray","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.pbb.2009.11.009_bib29","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2105\/AJPH.94.5.870","article-title":"Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994","volume":"94","author":"Hampl","year":"2004","journal-title":"Am J Public Health"},{"key":"10.1016\/j.pbb.2009.11.009_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2008.12.018","article-title":"Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2","author":"Harrison","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pbb.2009.11.009_bib31","first-page":"809","article-title":"Spatial and nonspatial escape strategies in the Barnes maze","volume":"vol. 13","author":"Harrison","year":"2006"},{"key":"10.1016\/j.pbb.2009.11.009_bib32","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/j.1471-4159.2008.05469.x","article-title":"Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid","volume":"106","author":"Harrison","year":"2008","journal-title":"J Neurochem"},{"issue":"2","key":"10.1016\/j.pbb.2009.11.009_bib33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bbr.2009.08.017","article-title":"Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze","volume":"205","author":"Harrison","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2009.11.009_bib34","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.pbb.2009.06.006","article-title":"Vitamin C reduces spatial learning deficits in middle-aged and very old APP\/PSEN1 transgenic and wild-type mice","volume":"93","author":"Harrison","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2009.11.009_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1179\/147683009X423364","article-title":"M., & McDonald, M. P. Antioxidants and cognitive training interact to affect oxidative stress and memory in APP\/PSEN1 mice","volume":"12","author":"Harrison","year":"2009","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.pbb.2009.11.009_bib36","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.nbd.2006.08.006","article-title":"Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease","volume":"24","author":"Hartman","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.pbb.2009.11.009_bib37","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/jn\/110.10.2085","article-title":"Effects of chronic ascorbic acid deficiency on guinea pig lysosomal hydrolase activities","volume":"110","author":"Hoehn","year":"1980","journal-title":"J Nutr"},{"key":"10.1016\/j.pbb.2009.11.009_bib38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1601-1848.2001.00005.x","article-title":"Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice","volume":"1","author":"Holmes","year":"2002","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pbb.2009.11.009_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/07448489809600224","article-title":"Vitamin C status of a campus population: college students get a C minus","volume":"46","author":"Johnston","year":"1998","journal-title":"J Am Coll Health"},{"key":"10.1016\/j.pbb.2009.11.009_bib40","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/07315724.1998.10718777","article-title":"Vitamin C status of an outpatient population","volume":"17","author":"Johnston","year":"1998","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.pbb.2009.11.009_bib41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0376-6357(86)90013-6","article-title":"Changes in social behavior and brain catecholamines during the development of ascorbate deficiency in guinea pigs","volume":"13","author":"Kaufmann","year":"1986","journal-title":"Behav Processes"},{"key":"10.1016\/j.pbb.2009.11.009_bib42","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1523\/JNEUROSCI.21-02-00372.2001","article-title":"Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease","volume":"21","author":"Kawarabayashi","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2009.11.009_bib43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neulet.2004.07.069","article-title":"Exploratory activity, anxiety, and motor coordination in bigenic APPswe+PS1\/DeltaE9 mice","volume":"369","author":"Lalonde","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2009.11.009_bib44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neulet.2005.08.028","article-title":"Exploratory activity and spatial learning in 12-month-old APP(695)SWE\/co+PS1\/DeltaE9 mice with amyloid plaques","volume":"390","author":"Lalonde","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2009.11.009_bib45","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/aje\/kwh124","article-title":"Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu\u2013Asia Aging study","volume":"159","author":"Laurin","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.pbb.2009.11.009_bib46","doi-asserted-by":"crossref","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","article-title":"The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse","volume":"21","author":"Lim","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2009.11.009_bib47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1001\/archneur.60.2.203","article-title":"Antioxidant vitamin intake and risk of Alzheimer disease","volume":"60","author":"Luchsinger","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1016\/j.pbb.2009.11.009_bib48","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neurobiolaging.2006.10.029","article-title":"Impairment of muscarinic transmission in transgenic APPswe\/PS1dE9 mice","volume":"29","author":"Machova","year":"2008","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pbb.2009.11.009_bib49","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.97.2.841","article-title":"Aortic wall damage in mice unable to synthesize ascorbic acid","volume":"97","author":"Maeda","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2009.11.009_bib50","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0361-9230(95)02034-X","article-title":"Beta-amyloid-induced toxicity in rat hippocampal cells: in vitro evidence for the involvement of free radicals","volume":"38","author":"Manelli","year":"1995","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pbb.2009.11.009_bib51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02755589","article-title":"Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease","volume":"12","author":"Mark","year":"1996","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.pbb.2009.11.009_bib52","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0006-8993(97)00928-1","article-title":"Locomotion and stereotypy induced by scopolamine: contributions of muscarinic receptors near the pedunculopontine tegmental nucleus","volume":"775","author":"Mathur","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2009.11.009_bib53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1749-6632.2000.tb05573.x","article-title":"Existing data suggest that Alzheimer's disease is preventable","volume":"924","author":"Mattson","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pbb.2009.11.009_bib54","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/abbi.1997.0473","article-title":"Protection and recycling of alpha-tocopherol in human erythrocytes by intracellular ascorbic acid","volume":"349","author":"May","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.pbb.2009.11.009_bib55","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0163-1047(05)80059-7","article-title":"Effects of an exogenous beta-amyloid peptide on retention for spatial learning","volume":"62","author":"McDonald","year":"1994","journal-title":"Behavioral Neural Biol"},{"key":"10.1016\/j.pbb.2009.11.009_bib56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/nlme.1996.0004","article-title":"Reversal of beta-amyloid-induced retention deficit after exposure to training and state cues","volume":"65","author":"McDonald","year":"1996","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pbb.2009.11.009_bib57","first-page":"289","article-title":"Hyperactivity and learning deficits in transgenic mice bearing a human mutant thyroid hormone beta1 receptor gene","volume":"vol. 5","author":"McDonald","year":"1998"},{"key":"10.1016\/j.pbb.2009.11.009_bib58","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1248\/bpb.29.2148","article-title":"Inhibition of dehydroascorbic acid transport across the rat blood\u2013retinal and \u2013brain barriers in experimental diabetes","volume":"29","author":"Minamizono","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.pbb.2009.11.009_bib59","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1523\/JNEUROSCI.21-14-05239.2001","article-title":"Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor","volume":"21","author":"Miyakawa","year":"2001","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2009.11.009_bib60","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/hipo.1092","article-title":"Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components","volume":"11","author":"Miyakawa","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/j.pbb.2009.11.009_bib61","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00002093-199809000-00001","article-title":"Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease","volume":"12","author":"Morris","year":"1998","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.pbb.2009.11.009_bib62","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1001\/jama.287.24.3230","article-title":"Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study","volume":"287","author":"Morris","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.pbb.2009.11.009_bib63","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2174\/187152707783399201","article-title":"Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases","volume":"6","author":"Nunomura","year":"2007","journal-title":"CNS & neurological disorders drug targets"},{"key":"10.1016\/j.pbb.2009.11.009_bib64","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0304-3940(85)90599-3","article-title":"Circadian changes in extracellular ascorbate in rat cortex, accumbens, striatum and hippocampus: correlations with motor activity","volume":"60","author":"O'Neill","year":"1985","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2009.11.009_bib65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0076-6879(79)62183-3","article-title":"Analysis of ascorbic acid by liquid chromatography with amperometric detection","volume":"62","author":"Pachla","year":"1979","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.pbb.2009.11.009_bib66","first-page":"871","article-title":"Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo","volume":"152","author":"Pappolla","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pbb.2009.11.009_bib67","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0404.1997.tb00245.x","article-title":"Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease","volume":"96","author":"Paraskevas","year":"1997","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.pbb.2009.11.009_bib68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1254\/jphs.93.129","article-title":"Ascorbic acid: a promising memory-enhancer in mice","volume":"93","author":"Parle","year":"2003","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.pbb.2009.11.009_bib69","first-page":"E1131","article-title":"Ascorbic acid-independent synthesis of collagen in mice","volume":"290","author":"Parsons","year":"2006","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pbb.2009.11.009_bib70","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jnr.20879","article-title":"In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress","volume":"84","author":"Perluigi","year":"2006","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.pbb.2009.11.009_bib71","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-2999(90)94161-P","article-title":"Stimulation of both D1 and D2 dopamine receptors increases behavioral activation and ascorbate release in the neostriatum of freely moving rats","volume":"191","author":"Pierce","year":"1990","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2009.11.009_bib72","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/BF00433739","article-title":"Habituation of exploratory activity in mice: a screening test for memory enhancing drugs","volume":"78","author":"Platel","year":"1982","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2009.11.009_bib73","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neurobiolaging.2005.12.014","article-title":"Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice","volume":"28","author":"Quinn","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.pbb.2009.11.009_bib74","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1601-183X.2006.00221.x","article-title":"Impaired spatial learning in the APPSwe+PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease","volume":"6","author":"Reiserer","year":"2007","journal-title":"Genes Brain Behav"},{"issue":"3","key":"10.1016\/j.pbb.2009.11.009_bib75","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neuroscience.2008.06.036","article-title":"Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death","volume":"155","author":"Resende","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2009.11.009_bib76","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/(SICI)1099-1166(1998110)13:11<749::AID-GPS860>3.0.CO;2-T","article-title":"Low plasma vitamin C in Alzheimer patients despite an adequate diet","volume":"13","author":"Riviere","year":"1998","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.pbb.2009.11.009_bib77","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.2042-7158.1975.tb10244.x","article-title":"Cerebral monoamine metabolism in guinea-pigs with ascorbic acid deficiency","volume":"27","author":"Saner","year":"1975","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.pbb.2009.11.009_bib78","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1601-183X.2005.00161.x","article-title":"Transgenic mice expressing a human mutant beta1 thyroid receptor are hyperactive, impulsive, and inattentive","volume":"5","author":"Siesser","year":"2006","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pbb.2009.11.009_bib79","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s002130051164","article-title":"Dose\u2013response curves and time-course effects of selected anticholinergics on locomotor activity in rats","volume":"147","author":"Sipos","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2009.11.009_bib80","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0014-4886(03)00399-6","article-title":"Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment","volume":"184","author":"Stackman","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pbb.2009.11.009_bib81","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1096\/fj.03-0961fje","article-title":"Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease","volume":"18","author":"Sung","year":"2004","journal-title":"Faseb J"},{"key":"10.1016\/j.pbb.2009.11.009_bib82","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/nlme.1997.3770","article-title":"Intrahippocampal injections of exogenous beta-amyloid induce postdelay errors in an eight-arm radial maze","volume":"68","author":"Sweeney","year":"1997","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.pbb.2009.11.009_bib83","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1471-4159.2007.05072.x","article-title":"Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein","volume":"104","author":"Tamagno","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.pbb.2009.11.009_bib84","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejphar.2007.05.009","article-title":"Pramipexole prevents neurotoxicity induced by oligomers of beta-amyloid","volume":"569","author":"Uberti","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2009.11.009_bib85","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12031-007-9033-7","article-title":"Coenzyme Q10 attenuates beta-amyloid pathology in the aged transgenic mice with Alzheimer presenilin 1 mutation","volume":"34","author":"Yang","year":"2008","journal-title":"J Mol Neurosci"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305709003207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305709003207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T12:05:14Z","timestamp":1739448314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305709003207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0091305709003207"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2009.11.009","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}