{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:46:55Z","timestamp":1777052815976,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.pbb.2010.06.011","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T08:37:55Z","timestamp":1277973475000},"page":"395-401","source":"Crossref","is-referenced-by-count":37,"title":["Alcohol-induced depressive-like behavior is associated with cortical norepinephrine reduction"],"prefix":"10.1016","volume":"96","author":[{"given":"Bruk","family":"Getachew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheketha R.","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Tizabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2010.06.011_bb0005","series-title":"Goodman and Gillman's the pharmacologic basis of therapeutics","first-page":"429","article-title":"Drug therapy for depression and anxiety disorders","author":"Baldessarini","year":"2006"},{"key":"10.1016\/j.pbb.2010.06.011_bb0010","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1001\/archpsyc.1979.01780020114013","article-title":"Alcohol and central serotonin metabolism in man","volume":"36","author":"Ballenger","year":"1979","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0006-3223(01)01336-1","article-title":"Reduced volume of orbitofrontal cortex in major depression","volume":"51","author":"Bremner","year":"2002","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0020","doi-asserted-by":"crossref","first-page":"412","DOI":"10.15288\/jsa.1988.49.412","article-title":"Changes in depression among abstinent alcoholics","volume":"49","author":"Brown","year":"1988","journal-title":"J Stud Alcohol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/syn.890090404","article-title":"Clinical and biochemical aspects of depressive disorders: II. Transmitter\/receptor theories","volume":"9","author":"Caldecott-Hazard","year":"1991","journal-title":"Synapse"},{"key":"10.1016\/j.pbb.2010.06.011_bb0030","first-page":"15","article-title":"The relevance of dopamine agonists in the treatment of depression","volume":"23","author":"Clausius","year":"2009","journal-title":"Neuropsychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1530-0277.1986.tb05615.x","article-title":"Dexamethasone suppression test testing of depressed alcoholics","volume":"10","author":"Dackis","year":"1986","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2010.06.011_bb0045","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2010.06.011_bb0050","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1176\/appi.ajp.157.5.751","article-title":"Prospective study of depression and the risk of heavy alcohol use in women","volume":"157","author":"Dixit","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0055","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/386824a0","article-title":"Subgenual prefrontal cortex abnormalities in mood disorders","volume":"386","author":"Drevets","year":"1997","journal-title":"Lett Nat"},{"key":"10.1016\/j.pbb.2010.06.011_bb0060","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pbb.2008.06.016","article-title":"Desipramine blocks alcohol-induced anxiety- and depressive-like behaviors in two rat strains","volume":"91","author":"Getachew","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2010.06.011_bb0065","article-title":"Substance use and the treatment of resistant depression in adolescents","author":"Goldstein","year":"2010","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0070","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/BF02245224","article-title":"Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents","volume":"113","author":"Griebel","year":"1994","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2010.06.011_bb0075","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/archpsyc.1996.01830120061011","article-title":"Psychopathological and behavioral correlates of dopaminergic sensitivity in alcohol-dependent patients","volume":"53","author":"Heinz","year":"1996","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0080","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1037\/0022-006X.63.3.400","article-title":"Prospective and retrospective reports of mood states before relapse to substance use","volume":"63","author":"Hodgins","year":"1995","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.drugalcdep.2008.08.010","article-title":"Concurrent anxiety and substance use disorders among outpatients with major depression: clinical features and effect on treatment outcome","volume":"99","author":"Howland","year":"2009","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.pbb.2010.06.011_bb0090","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.pnpbp.2005.06.017","article-title":"Antidepressant drug induced alteration to central dopamine transporter sites in the Wistar Kyoto rat strain","volume":"30","author":"Jiao","year":"2006","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0031-6997(25)00022-5","article-title":"The pharmacology of cocaine related to its abuse","volume":"41","author":"Johanson","year":"1989","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pbb.2010.06.011_bb0110","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1017\/S0033291797005588","article-title":"Childhood adversity and adult psychiatric disorder in the U.S. National Co-morbidity Survey","volume":"27","author":"Kessler","year":"1997","journal-title":"Psychol Med"},{"key":"10.1016\/j.pbb.2010.06.011_bb0115","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1097\/01.ALC.0000131976.40428.8F","article-title":"Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalation","volume":"28","author":"Kliethermes","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2010.06.011_bb0120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(97)01276-4","article-title":"Are Wistar\u2013Kyoto rats a genetic animal model of depression resistant to antidepressants?","volume":"337","author":"Lahmame","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.mp.4000514","article-title":"Dopamine transporters increase in human brain after alcohol withdrawal","volume":"4","author":"Laine","year":"1999","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1530-0277.2000.tb04560.x","article-title":"Prolonged exposure to intermittent alcohol vapors blunts hypothalamic responsiveness to immune and non-immune signals","volume":"24","author":"Lee","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2010.06.011_bb0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0893-133X(99)00100-1","article-title":"Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test","volume":"22","author":"Lopez-Rubalcava","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2010.06.011_bb0140","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0145","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.euroneuro.2004.05.009","article-title":"Antidepressants attenuate both the enhanced ethanol intake and ethanol-induced anxiolytic effects in diazepam withdrawn rats","volume":"15","author":"Martijena","year":"2005","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0150","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3109\/07853899009147921","article-title":"Alcohol and drug interactions","volume":"22","author":"Mattila","year":"1990","journal-title":"Ann Med"},{"key":"10.1016\/j.pbb.2010.06.011_bb0155","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1176\/jnp.6.4.428","article-title":"Frontal lobe dysfunction in secondary depression","volume":"6","author":"Mayberg","year":"1994","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.pbb.2010.06.011_bb0160","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0193-953X(18)30339-3","article-title":"Comorbidity for alcoholism and depression","volume":"13","author":"Merikangas","year":"1990","journal-title":"Psychiatry Clin North Am"},{"key":"10.1016\/j.pbb.2010.06.011_bb0165","series-title":"Psychiatric genetics","author":"Nurnberger","year":"1998"},{"key":"10.1016\/j.pbb.2010.06.011_bb0170","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0031-9384(92)90444-7","article-title":"Maudsley reactive and nonreactive rats differ only in some tasks reflecting emotionality","volume":"52","author":"Overstreet","year":"1992","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2010.06.011_bb0175","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neubiorev.2005.03.015","article-title":"The Flinders Sensitive Line rat: a selectively bred putative animal model of depression","volume":"29","author":"Overstreet","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pbb.2010.06.011_bb0180","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1007\/s11064-008-9791-9","article-title":"Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism","volume":"33","author":"Overstreet","year":"2008","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pbb.2010.06.011_bb0185","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0022-3565(24)37161-7","article-title":"Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites","volume":"283","author":"Owens","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2010.06.011_bb0190","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0031-9384(99)00054-2","article-title":"Negative affect and voluntary alcohol consumption in Wistar\u2013Kyoto (WKY) and Sprague\u2013Dawley rats","volume":"67","author":"Par\u00e9","year":"1999","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2010.06.011_bb0195","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.pbb.2010.06.011_bb0200","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0079-6123(00)26026-3","article-title":"Histopathology of the prefrontal cortex in major depression: what does it tell us about dysfunctional monoaminergic circuits?","volume":"126","author":"Rajkowska","year":"2000","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.pbb.2010.06.011_bb0205","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/alcalc\/37.6.522","article-title":"Neurochemical markers of alcoholism vulnerability in humans","volume":"37","author":"Ratsma","year":"2002","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00041444-200203000-00001","article-title":"The Fawn-Hooded (FH\/Wjd) rat: a genetic animal model of comorbid depression and alcoholism","volume":"12","author":"Rezvani","year":"2002","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.pbb.2010.06.011_bb0215","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/YPG.0b013e328012d7c3","article-title":"Further genetic characterization of the Fawn-Hooded (FH\/Wjd) rat, an animal model of co-morbid depression and alcoholism","volume":"17","author":"Rezvani","year":"2007","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.pbb.2010.06.011_bb0220","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1017\/S0033291799001865","article-title":"No-linear relationships in associations of depression and anxiety with alcohol use","volume":"30","author":"Rodgers","year":"2000","journal-title":"Psychol Med"},{"key":"10.1016\/j.pbb.2010.06.011_bb0225","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1517\/13543770902932934","article-title":"Improving antidepressant drugs: update on recently patented compounds","volume":"19","author":"Rozas","year":"2009","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.pbb.2010.06.011_bb0230","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1472-8206.1990.tb01021.x","article-title":"The pharmacokinetics of the antidepressant tianeptine and its main metabolite in healthy humans\u2014influence of alcohol co-administration","volume":"4","author":"Salvadori","year":"1990","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0235","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/FBP.0b013e3282ee2aa8","article-title":"The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior","volume":"18","author":"Schmidt","year":"2007","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0240","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1176\/ajp.154.7.948","article-title":"Comparison of induced and independent major depressive disorders in 2, 945 alcoholics","volume":"154","author":"Schuckit","year":"1997","journal-title":"Am J Psychol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0245","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1073\/pnas.92.13.5880","article-title":"Decreased brain reward produced by ethanol withdrawal","volume":"92","author":"Schulteis","year":"1995","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.pbb.2010.06.011_bb0250","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.93.9.3908","article-title":"Hippocampal atrophy in recurrent major depression","volume":"93","author":"Sheline","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pbb.2010.06.011_bb0255","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1034\/j.1600-0447.2000.102001044.x","article-title":"Alcoholism and depression in a Swedish female population: co-morbidity and risk factors","volume":"102","author":"Spak","year":"2000","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.pbb.2010.06.011_bb0260","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbr.2003.09.015","article-title":"What the rodent prefrontal cortex can teach us about attention-deficit\/hyperactivity disorder: the critical role of early developmental events on prefrontal function","volume":"146","author":"Sullivan","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2010.06.011_bb0265","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0278-5846(02)00308-1","article-title":"Strain-dependent modification of behavior following antidepressant treatment","volume":"27","author":"Tejani-Butt","year":"2003","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0270","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s002130050879","article-title":"Antidepressant effects of nicotine in an animal model of depression","volume":"142","author":"Tizabi","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2010.06.011_bb0275","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/alcalc\/36.4.318","article-title":"Alcohol preference: association with reduced striatal nicotinic receptors","volume":"36","author":"Tizabi","year":"2001","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pbb.2010.06.011_bb0280","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.pnpbp.2004.06.022","article-title":"Dopamine and alcoholism: neurobiological basis of ethanol abuse","volume":"28","author":"Tupala","year":"2004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pbb.2010.06.011_bb0285","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00004850-199707003-00002","article-title":"The mesolimbic DA system as a target for rapid antidepressant action","volume":"12","author":"Willner","year":"1997","journal-title":"Int Clin Psychopharmacol"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130571000198X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130571000198X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T12:42:20Z","timestamp":1740228140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009130571000198X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S009130571000198X"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2010.06.011","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}