{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:03:10Z","timestamp":1782961390977,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research Special Fund for Public Welfare Industry of Health","award":["200802041"],"award-info":[{"award-number":["200802041"]}]},{"name":"National Significant Projects of New Drugs Creation","award":["2009ZM09501-021"],"award-info":[{"award-number":["2009ZM09501-021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.pbb.2011.01.011","type":"journal-article","created":{"date-parts":[[2011,1,23]],"date-time":"2011-01-23T04:19:07Z","timestamp":1295756347000},"page":"286-291","source":"Crossref","is-referenced-by-count":80,"title":["Baicalein protects the brain against neuron impairments induced by MPTP in C57BL\/6 mice"],"prefix":"10.1016","volume":"98","author":[{"given":"Xin","family":"Mu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Rong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Xiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Hua","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2011.01.011_bb0005","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/bies.10067","article-title":"Animal models of Parkinson's disease","volume":"24","author":"Betarbet","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.pbb.2011.01.011_bb0010","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/bjp.2008.345","article-title":"Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury","volume":"155","author":"Chen","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2011.01.011_bb0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2008.05.116","article-title":"Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile","volume":"441","author":"Cheng","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2011.01.011_bb0020","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0891-5849(92)90151-6","article-title":"Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation through dopamine autooxidation in the caudate nucleus: effects of MPP+","volume":"13","author":"Chiueh","year":"1992","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.pbb.2011.01.011_bb0025","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.pbb.2010.07.007","article-title":"Baicalein is neuroprotective in rat MCAO model: role of 12\/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2","volume":"96","author":"Cui","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.01.011_bb0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0278-5846(88)90034-6","article-title":"Prevention of progression of Parkinson's disease with antioxidative therapy","volume":"12","author":"Grimes","year":"1988","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pbb.2011.01.011_bb0035","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.6610213","article-title":"Dopaminergic neurotoxicity of 1-methyl-4- phenyl-1, 2, 5, 6-tetrahydropyridine in mice","volume":"224","author":"Heikkila","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.pbb.2011.01.011_bb0040","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1254\/jphs.SC0050014","article-title":"Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice","volume":"98","author":"Im","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.pbb.2011.01.011_bb0045","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/ana.10483","article-title":"Oxidative stress in Parkinson's disease","volume":"53","author":"Jenner","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.pbb.2011.01.011_bb0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00702-004-0213-0","article-title":"Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons","volume":"112","author":"Li","year":"2005","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pbb.2011.01.011_bb0055","doi-asserted-by":"crossref","first-page":"38581","DOI":"10.1074\/jbc.M005385200","article-title":"The parkinsonism-inducing drug 1-methyl-4- phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity","volume":"275","author":"Lotharius","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2011.01.011_bb0060","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.freeradbiomed.2004.04.012","article-title":"Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases","volume":"37","author":"Mandel","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.pbb.2011.01.011_bb0065","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.parkreldis.2008.04.012","article-title":"Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol","volume":"14","author":"Meredith","year":"2008","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.pbb.2011.01.011_bb0070","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.pbb.2009.03.008","article-title":"Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro","volume":"92","author":"Mu","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.01.011_bb0075","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S1471-1931(00)00028-8","article-title":"Pathophysiology of the basal ganglia in Parkinson's disease","volume":"23","author":"Obeso","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pbb.2011.01.011_bb0080","first-page":"S1","article-title":"An algorithm (decision tree) for the management of Parkinson's disease: treatment guidelines","volume":"50","author":"Olanow","year":"1998","journal-title":"American Academy of Neurology. Neurology"},{"key":"10.1016\/j.pbb.2011.01.011_bb0085","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1749-6632.2003.tb07476.x","article-title":"The 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease","volume":"991","author":"Przedborski","year":"2003","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.pbb.2011.01.011_bb0090","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s007020100004","article-title":"Neurochemical findings in the MPTP model of Parkinson's disease","volume":"108","author":"Schmidt","year":"2001","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pbb.2011.01.011_bb0095","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00441-004-0938-y","article-title":"Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP","volume":"318","author":"Schober","year":"2004","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.pbb.2011.01.011_bb0100","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(90)91656-2","article-title":"Chronic neurochemical and behavioral changes in MPTP-lesioned C57BL\/6 mice: a model for Parkinson's disease","volume":"528","author":"Sundstrom","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.01.011_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1142\/S0192415X01000083","article-title":"Anti-HIV activity of medicinal herbs: usage and potential development","volume":"29","author":"Wu","year":"2001","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.pbb.2011.01.011_bb0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12264-007-0018-x","article-title":"Pathogenesis of Parkinson's disease: oxidative stress, environmental impact factors and inflammatory processes","volume":"23","author":"Yuan","year":"2007","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.pbb.2011.01.011_bb0115","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s11064-008-9900-9","article-title":"Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease","volume":"34","author":"Zhao","year":"2009","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pbb.2011.01.011_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(08)60277-9","article-title":"Animal models of parkinsonism using selective neurotoxins: clinical and basic implications","volume":"31","author":"Zigmond","year":"1989","journal-title":"Int Rev Neurobiol"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711000256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711000256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T05:23:23Z","timestamp":1543987403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305711000256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0091305711000256"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2011.01.011","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}