{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:30:31Z","timestamp":1791145831114,"version":"4.1.0"},"reference-count":110,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Science Foundation","award":["03\u201316083"],"award-info":[{"award-number":["03\u201316083"]}]},{"name":"National Science Foundation","award":["IOS-0957148"],"award-info":[{"award-number":["IOS-0957148"]}]},{"name":"National Institute of Health","award":["MH0676980"],"award-info":[{"award-number":["MH0676980"]}]},{"name":"National Institute of Health","award":["RMH067698B"],"award-info":[{"award-number":["RMH067698B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.pbb.2011.05.024","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T04:31:10Z","timestamp":1307939470000},"page":"525-531","source":"Crossref","is-referenced-by-count":27,"title":["Progesterone attenuates depressive behavior of younger and older adult C57\/BL6, wildtype, and progesterone receptor knockout mice"],"prefix":"10.1016","volume":"99","author":[{"given":"Cheryl A.","family":"Frye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2011.05.024_bb0005","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.pnpbp.2006.12.006","article-title":"Gender differences of acute and chronic administration of dehydroepiandrosterone in rats submitted to the forced swimming test","volume":"31","author":"Andrade","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pbb.2011.05.024_bb0010","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0149-7634(98)00029-3","article-title":"Ethopharmacology of imipramine in the forced-swimming test: gender differences","volume":"23","author":"Barros","year":"1998","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pbb.2011.05.024_bb0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0166-4328(89)80112-3","article-title":"Estrous cycle-dependent variation in amphetamine-induced behaviors and striatal dopamine release assessed with microdialysis","volume":"35","author":"Becker","year":"1989","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s00213-005-0179-0","article-title":"Animal model of menopausal depressive-like state in female mice: prolongation of immobility time in the forced swimming test following ovariectomy","volume":"183","author":"Bekku","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0025","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00213-006-0395-2","article-title":"Factors producing a menopausal depressive-like in mice following ovariectomy","volume":"187","author":"Bekku","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0030","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0149-7634(05)80041-7","article-title":"Anticonvulsant steroids and the GABA\/benzodiazepine receptor chloride ionophore complex","volume":"14","author":"Belelli","year":"1990","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pbb.2011.05.024_bb0035","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0031-9384(89)90238-2","article-title":"Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression","volume":"45","author":"Bernardi","year":"1989","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-8993(91)90761-J","article-title":"Anxiolytic effects of 3\u03b1-hydroxy-5\u03b1[\u03b2]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor","volume":"561","author":"Bitran","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0045","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00176837","article-title":"Is the forced swimming test a suitable model for revealing antidepressant activity?","volume":"94","author":"Borsini","year":"1988","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0050","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(03)03175-5","article-title":"The influence of ovariectomy with or without estrogen replacement on responses of rat gracile nucleus neurons to stimulation of hindquarter skin and pelvic viscera","volume":"986","author":"Bradshaw","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3959(99)00049-4","article-title":"Estrous variations in behavioral responses to vaginal and uterine distention in the rat","volume":"82","author":"Bradshaw","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2011.05.024_bb0060","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neuropharm.2003.10.001","article-title":"Chronic intermittent ethanol (CIE) administration in rats decreases levels of neurosteroids in hippocampus, accompanied by altered behavioral responses to neurosteroids and memory function","volume":"46","author":"Cagetti","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0065","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.physbeh.2009.03.016","article-title":"Effects of long-term ovariectomy on anxiety and behavioral despair in rats","volume":"97","author":"Chaves","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0039-128X(75)90006-9","article-title":"Properties and subcellular distribution of delta4-steroid (progesterone) 5\u03b1-reductase in rat anterior pituitary","volume":"26","author":"Cheng","year":"1975","journal-title":"Steroids"},{"key":"10.1016\/j.pbb.2011.05.024_bb0075","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/00000542-200607000-00021","article-title":"Different brain activation patterns to pain and pain-related unpleasantness during the menstrual cycle","volume":"105","author":"Choi","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0080","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.physbeh.2007.10.020","article-title":"Sex differences in the effects of two stress paradigms on dopaminergic neurotransmission","volume":"93","author":"Dalla","year":"2008","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-4328(00)00351-X","article-title":"Are there gender differences in the temperature profile of mice after acute antidepressant administration and exposure to two animal models of depression?","volume":"119","author":"David","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0090","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0022-3565(25)20630-9","article-title":"Sensitization of \u03b3-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal","volume":"278","author":"Devaud","year":"1996","journal-title":"J Pharmacol Exp"},{"key":"10.1016\/j.pbb.2011.05.024_bb0095","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuroscience.2003.09.023","article-title":"Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex","volume":"123","author":"Djebaili","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2011.05.024_bb0100","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1073\/pnas.051628598","article-title":"Brain 5\u03b1-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation","volume":"98","author":"Dong","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2011.05.024_bb0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00213-003-1707-4","article-title":"Interaction between estrogens and antidepressants in the forced swimming test in rats","volume":"173","author":"Estrada-Camarena","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0110","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0091-3057(98)00011-2","article-title":"Comparison of behavioral effects of moclobemide and deprenyl during forced swimming","volume":"60","author":"Ferigolo","year":"1998","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0120","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0022-3565(25)22739-2","article-title":"The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid","volume":"271","author":"Finn","year":"1994","journal-title":"J Pharmacol Exp"},{"key":"10.1016\/j.pbb.2011.05.024_bb0125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pharmthera.2003.10.006","article-title":"The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches","volume":"102","author":"Finn","year":"2004","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pbb.2011.05.024_bb0130","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pbb.2004.04.016","article-title":"Interaction of chronic ethanol exposure and finasteride: sex and strain differences","volume":"78","author":"Finn","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0135","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1601-183X.2005.00137.x","article-title":"Selected line difference in sensitivity to a GABAergic neurosteroid during ethanol withdrawal","volume":"5","author":"Finn","year":"2006","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0140","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/00004714-200210000-00013","article-title":"Allopregnanolone levels and symptom improvement in severe premenstrual syndrome","volume":"22","author":"Freeman","year":"2002","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0145","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0006-8993(01)02560-4","article-title":"3\u03b1,5\u03b1-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures","volume":"911","author":"Frye","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0150","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0306-4530(02)00049-5","article-title":"Olanzapine's effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats","volume":"28","author":"Frye","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0155","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1037\/0735-7044.115.5.1118","article-title":"Progesterone and 3\u03b1,5\u03b1-THP enhance sexual receptivity in mice","volume":"115","author":"Frye","year":"2001","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pbb.2011.05.024_bb0160","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1006\/hbeh.2002.1763","article-title":"Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats","volume":"41","author":"Frye","year":"2002","journal-title":"Horm Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0165","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.pbb.2004.03.024","article-title":"Hippocampal 3\u03b1,5\u03b1-THP may alter depressive behavior of pregnant and lactating rats","volume":"78","author":"Frye","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0170","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0018-506X(03)00159-4","article-title":"Effect of prenatal stress and gonadal hormone condition on depressive behaviors of female and male rats","volume":"44","author":"Frye","year":"2003","journal-title":"Horm Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0175","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0006-8993(00)02897-3","article-title":"Infusion of 3\u03b1,5\u03b1-THP to the pontine reticular formation attenuates PTZ-induced seizures","volume":"881","author":"Frye","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0180","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0091-3057(00)00392-0","article-title":"Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3\u03b1,5\u03b1-THP","volume":"67","author":"Frye","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1046\/j.1528-1157.43.s.5.19.x","article-title":"Progesterone reduces pentylenetetrazol-induced ictal activity of wild-type mice but not those deficient in type I 5\u03b1-reductase","volume":"5","author":"Frye","year":"2002","journal-title":"Epilepsia"},{"key":"10.1016\/j.pbb.2011.05.024_bb0190","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2004.01.020","article-title":"Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 \u03b1-reductase","volume":"1004","author":"Frye","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0195","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00213-006-0309-3","article-title":"Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors","volume":"186","author":"Frye","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0200","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00213-005-0300-4","article-title":"Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3\u03b1,5\u03b1-THP-facilitated lordosis","volume":"185","author":"Frye","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(01)00170-X","article-title":"Estradiol alleviates depressive-like symptoms in a novel animal model of post-partum depression","volume":"122","author":"Galea","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0210","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.fertnstert.2003.08.022","article-title":"Conjugated equine estrogens reverse the effects of aging on central and peripheral allopregnanolone and beta-endorphin levels in female rats","volume":"81","author":"Genazzani","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.pbb.2011.05.024_bb0215","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/09513590500361747","article-title":"3\u03b1-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period","volume":"21","author":"Gilbert Evans","year":"2005","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0220","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0006-3223(00)01044-1","article-title":"Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder","volume":"49","author":"Girdler","year":"2001","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pbb.2011.05.024_bb0225","doi-asserted-by":"crossref","first-page":"13512","DOI":"10.1073\/pnas.96.23.13512","article-title":"Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes","volume":"96","author":"Griffin","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.pbb.2011.05.024_bb0230","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001756-200301200-00008","article-title":"Progesterone withdrawal increases the anxiolytic actions of gaboxadol: role of alpha4betadelta GABAA receptors","volume":"14","author":"Gulinello","year":"2003","journal-title":"Neuroreport"},{"key":"10.1016\/j.pbb.2011.05.024_bb0235","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2165\/00023210-200115100-00005","article-title":"Role of estrogen in the aetiology and treatment of mood disorders","volume":"15","author":"Halbreich","year":"2001","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pbb.2011.05.024_bb0240","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0028-3908(02)00330-1","article-title":"Behavioral action of ethanol in Porsolt's forced swim test: modulation by 3\u03b1-hydroxy-5\u03b1-pregnan-20-one","volume":"43","author":"Hirani","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0245","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1152\/jn.00195.2002","article-title":"Progesterone withdrawal produces paired-pulse inhibition in rat hippocampus: dependence on GABAA receptor \u03b14 subunit upregulation","volume":"89","author":"Hsu","year":"2003","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0250","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0039-128X(86)90088-7","article-title":"Binding of 5\u03b1-dihydroprogesterone and other progestins to female rat anterior pituitary nuclear extracts","volume":"47","author":"Iswari","year":"1986","journal-title":"Steroids"},{"key":"10.1016\/j.pbb.2011.05.024_bb0255","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0006-3223(03)00319-6","article-title":"Depressed new neurons?\u2013Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression","volume":"54","author":"Kempermann","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pbb.2011.05.024_bb0260","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0006-8993(00)02373-8","article-title":"Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3\u03b1-hydroxy-5\u03b1-pregnan-20-one in mice","volume":"86","author":"Khisti","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.05.024_bb0265","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0091-3057(00)00300-2","article-title":"Antidepressant-like effect of the neurosteroid 3\u03b1-hydroxy-5\u03b1-pregnan-20-one in mice forced swim test","volume":"67","author":"Khisti","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0270","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0022-3565(25)22531-9","article-title":"Anticonvulsant activity of neurosteroids: correlation with \u03b3-aminobutyric acid-evoked chloride current potentiation","volume":"270","author":"Kokate","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2011.05.024_bb0275","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0028-3908(96)00021-4","article-title":"Neuroactive steroids protect against pilocarpineand kainic acid-induced limbic seizures and status epilepticus in mice","volume":"35","author":"Kokate","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0280","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0165-6147(00)89058-6","article-title":"Neurosteroids and GABAA receptor function","volume":"16","author":"Lambert","year":"1995","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pbb.2011.05.024_bb0285","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.yhbeh.2006.03.002","article-title":"Progesterone withdrawal effects in the open field test can be predicted by elevated plus maze performance","volume":"50","author":"L\u00f6fgren","year":"2006","journal-title":"Horm Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0290","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yfrne.2007.05.002","article-title":"Regulation of anxiety during the postpartum period","volume":"28","author":"Lonstein","year":"2007","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0295","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1210\/edrv-12-4-372","article-title":"Recurrent secretion of progesterone in large amounts: an endocrine\/metabolic disorder unique to young women?","volume":"12","author":"MacDonald","year":"1991","journal-title":"Endocr Rev"},{"key":"10.1016\/j.pbb.2011.05.024_bb0300","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0301-0082(92)90025-A","article-title":"Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance","volume":"38","author":"Majewska","year":"1992","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0305","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.2422758","article-title":"Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor","volume":"232","author":"Majewska","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.pbb.2011.05.024_bb0310","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.tips.2005.10.005","article-title":"Antidepressant action: to the nucleus and beyond","volume":"26","author":"Malberg","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pbb.2011.05.024_bb0315","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.pbb.2004.05.016","article-title":"Testosterone-dependent antidepressant-like effect of noradrenergic but not of serotonergic drugs","volume":"78","author":"Martinez-Mota","year":"2004","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.npp.1300015","article-title":"Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents","volume":"28","author":"Marx","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0330","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0028-3908(99)00018-0","article-title":"Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss","volume":"38","author":"Matsumoto","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0335","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/10253890500159022","article-title":"Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis","volume":"8","author":"Matsumoto","year":"2005","journal-title":"Stress: Int J Biol Stress"},{"key":"10.1016\/j.pbb.2011.05.024_bb0340","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/10253890701200997","article-title":"GABA(A) receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders","volume":"10","author":"Matsumoto","year":"2007","journal-title":"Stress"},{"key":"10.1016\/j.pbb.2011.05.024_bb0345","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s002130000496","article-title":"Antidepressant-like effects of pregnancy and progesterone in Wistar rats as measured in the differential reinforcement of the low-rate 72s task","volume":"151","author":"Molina-Hern\u00e1ndez","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0350","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0014-2999(87)90094-X","article-title":"Steroid hormone metabolites potentiate GABA receptor mediated chloride ion flux with nanomolar potency","volume":"142","author":"Morrow","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0355","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0029-7844(00)01112-1","article-title":"Serum allopregnanolone in women with postpartum \u201cblues\u201d","volume":"97","author":"Nappi","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0360","first-page":"805","article-title":"Differential contributions of ovarian and extraovarian factors to age-related reductions in plasma estradiol and progesterone during the estrous cycle of C57BL\/6J mice","volume":"130","author":"Nelson","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0365","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1385\/ENDO:28:3:235","article-title":"Estrogen action in mood and neurodegenerative disorders: estrogenic compounds with selective properties\u2014the next generation of therapeutics","volume":"28","author":"Osterlund","year":"2005","journal-title":"Endocrine"},{"key":"10.1016\/j.pbb.2011.05.024_bb0370","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1210\/jcem.86.2.7179","article-title":"Evidence that cyproterone acetate improves psychological 26 symptoms and enhances the activity of the dopaminergic system in postmenopause","volume":"86","author":"Paoletti","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pbb.2011.05.024_bb0375","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/0031-9384(93)90345-G","article-title":"Sex differences and stress response of WKY rats","volume":"54","author":"Par\u00e9","year":"1993","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0380","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1096\/fasebj.6.6.1347506","article-title":"Neuroactive steroids","volume":"6","author":"Paul","year":"1992","journal-title":"FASEB J"},{"key":"10.1016\/j.pbb.2011.05.024_bb0385","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0306-4522(98)00131-6","article-title":"Spatial learning and hippocampal volume in male deer mice: relations to age, testosterone and adrenal gland weight","volume":"86","author":"Perrot-Sinal","year":"1998","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2011.05.024_bb0390","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swimming test in mice: a review of antidepressant activity","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0400","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/FBP.0b013e32833d8ba0","article-title":"In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis","volume":"21","author":"Pinna","year":"2010","journal-title":"Behav Pharmacol"},{"issue":"100","key":"10.1016\/j.pbb.2011.05.024_bb0405","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1073\/pnas.0337642100","article-title":"In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine","volume":"18","author":"Pinna","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2011.05.024_bb0410","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00213-005-0213-2","article-title":"Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake","volume":"186","author":"Pinna","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0415","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.coph.2008.12.006","article-title":"SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake","volume":"9","author":"Pinna","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0420","first-page":"77","article-title":"Psychosexual problems in menopause","volume":"50","author":"Pisani","year":"1998","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0425","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.pbb.2011.05.024_bb0430","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0435","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11920-002-0069-7","article-title":"The clinical nature and formal diagnosis of premenstrual, postpartum, and perimenopausal affective disorders","volume":"4","author":"Rapkin","year":"2002","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.pbb.2011.05.024_bb0440","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1017\/S1092852900023166","article-title":"Perimenopausal mental disorders: epidemiology and phenomenology","volume":"10","author":"Rasgon","year":"2005","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pbb.2011.05.024_bb0445","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.biopsych.2006.03.026","article-title":"Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder","volume":"60","author":"Rasmusson","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pbb.2011.05.024_bb0450","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2165\/00023210-200115030-00002","article-title":"Psychotic and mood disorders associated with the perimenopausal period: epidemiology, aetiology and management","volume":"15","author":"Robinson","year":"2001","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pbb.2011.05.024_bb0455","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1177\/0269881106064203","article-title":"Allopregnanolone reduces immobility in the forced swimming test and increases the firing rate of lateral septal neurons through actions on the GABAA receptor in the rat","volume":"21","author":"Rodr\u00edguez-Landa","year":"2007","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0460","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0960-0760(95)00233-2","article-title":"Neurosteroids: molecular mechanisms of action and psychopharmacological significance","volume":"56","author":"Rupprecht","year":"1996","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0465","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pbb.2005.12.016","article-title":"Differential progesterone effects on defensive burying and forced swimming tests depending upon a gradual decrease or an abrupt suppression schedules","volume":"83","author":"Saavedra","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0470","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.psyneuen.2006.06.002","article-title":"Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone\/CRH test results in depressed patients","volume":"31","author":"Sch\u00fcle","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0475","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1046\/j.1471-4159.2000.0750732.x","article-title":"Social isolation-induced decreases in both the abundance of neuroactive steroids and GABAA receptor function in rat brain","volume":"75","author":"Serra","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.pbb.2011.05.024_bb0480","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euroneuro.2006.03.004","article-title":"Social isolation stress and neuroactive steroids","volume":"17","author":"Serra","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"issue":"12 Suppl 12","key":"10.1016\/j.pbb.2011.05.024_bb0485","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1017\/S1092852900026365","article-title":"Factors impacting the selection of antidepressant treatment in patients with major depressive disorder at risk for nonadherence","volume":"14","author":"Shelton","year":"2009","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pbb.2011.05.024_bb0490","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nn1868","article-title":"Reversal of neurosteroid effects at alpha4beta2delta GABA(A) receptors triggers anxiety at puberty","volume":"10","author":"Shen","year":"2007","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pbb.2011.05.024_bb0495","doi-asserted-by":"crossref","first-page":"5924","DOI":"10.1016\/S0021-9258(20)79907-2","article-title":"Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus","volume":"249","author":"Smith","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2011.05.024_bb0500","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0741-8329(04)00079-5","article-title":"Effects of a low dose of ethanol in an animal model of premenstrual anxiety","volume":"33","author":"Smith","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/j.pbb.2011.05.024_bb0505","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00213-005-0168-3","article-title":"Steroid withdrawal in the mouse results in anxiogenic effects of 3\u03b1,5\u03b2-THP: a possible model of premenstrual dysphoric disorder","volume":"186","author":"Smith","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.05.024_bb0510","doi-asserted-by":"crossref","first-page":"468","DOI":"10.4088\/JCP.v58n1101","article-title":"Sex therapy in psychiatric treatment has a new partner: reproductive hormones","volume":"58","author":"Stahl","year":"1997","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pbb.2011.05.024_bb0515","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0165-0327(02)00432-9","article-title":"Hormones and mood: from menarche to menopause and beyond","volume":"74","author":"Steiner","year":"2003","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pbb.2011.05.024_bb0520","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.physbeh.2004.08.033","article-title":"Ovarian hormone withdrawal-induced \u201cdepression\u201d in female rats","volume":"83","author":"Stoffel","year":"2004","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0525","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0022-3565(24)29502-1","article-title":"The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test","volume":"298","author":"Urani","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2011.05.024_bb0530","doi-asserted-by":"crossref","first-page":"12599","DOI":"10.1073\/pnas.93.22.12599","article-title":"Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography","volume":"93","author":"Uzunov","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2011.05.024_bb0535","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1073\/pnas.95.6.3239","article-title":"Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine","volume":"95","author":"Uzunova","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2011.05.024_bb0540","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0022-3565(24)36770-9","article-title":"Ultrasonic vocalizations in rat pups: modulation at the gamma-aminobutyric acid A receptor complex and the neurosteroid recognition site","volume":"282","author":"Vivian","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2011.05.024_bb0545","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0091-3057(99)00140-9","article-title":"Progesterone in conjunction with estradiol has neuroprotective effects in an animal model of neurodegeneration","volume":"64","author":"Vongher","year":"1999","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.05.024_bb0550","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.pbb.2011.05.024_bb0555","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s00213-005-0100-x","article-title":"Inhibiting 5\u03b1-reductase in the amygdala attenuates antianxiety and antidepressive behavior of naturally receptive and hormone-primed ovariectomized rats","volume":"186","author":"Walf","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2011.05.024_bb0560","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.pnpbp.2007.01.007","article-title":"Sex differences in antidepressant-like effect of chronic repetitive transcranial magnetic stimulation in rats","volume":"31","author":"Yang","year":"2007","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pbb.2011.05.024_bb0565","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1017\/S1092852900010312","article-title":"The neurobiology of postpartum depression","volume":"10","author":"Zonana","year":"2005","journal-title":"CNS Spectr"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711001687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711001687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T04:06:14Z","timestamp":1741233974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305711001687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":110,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0091305711001687"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2011.05.024","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}