{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:48:51Z","timestamp":1770504531547,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20100001110048"],"award-info":[{"award-number":["20100001110048"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2009ZX09103-124"],"award-info":[{"award-number":["2009ZX09103-124"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30640070"],"award-info":[{"award-number":["30640070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30772556"],"award-info":[{"award-number":["30772556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.pbb.2011.06.001","type":"journal-article","created":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T10:47:44Z","timestamp":1308912464000},"page":"566-572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A\/2C receptors: Role for dorsal raphe nucleus"],"prefix":"10.1016","volume":"99","author":[{"given":"Su-Ying","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Fu","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Qiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-He","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2011.06.001_bb0005","doi-asserted-by":"crossref","first-page":"C452","DOI":"10.1152\/ajpcell.1990.258.3.C452","article-title":"Augmentation of GABA-induced current in frog sensory neurons by pentobarbital","volume":"258","author":"Akaike","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pbb.2011.06.001_bb0010","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0006-8993(97)00758-0","article-title":"Sleep\/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats","volume":"770","author":"Bjorvatn","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.06.001_bb0015","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/sleep\/23.4.9","article-title":"On the functional significance of c-fos induction during the sleep-waking cycle","volume":"23","author":"Cirelli","year":"2000","journal-title":"Sleep"},{"key":"10.1016\/j.pbb.2011.06.001_bb0020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1113\/jphysiol.1984.sp015482","article-title":"Inhibitory post-synaptic currents in rat hippocampal CA1 neurones","volume":"356","author":"Collingridge","year":"1984","journal-title":"J Physiol"},{"key":"10.1016\/j.pbb.2011.06.001_bb0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2869.1992.tb00032.x","article-title":"Functional activity of 5-HT2 receptors in the modulation of the sleep\/wakefulness states","volume":"1","author":"Dugovic","year":"1992","journal-title":"J Sleep Res"},{"key":"10.1016\/j.pbb.2011.06.001_bb0030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0014-2999(87)90196-8","article-title":"5-HT2 receptors could be primarily involved in the regulation of slow-wave sleep in the rat","volume":"137","author":"Dugovic","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.001_bb0035","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/BF00439544","article-title":"Functional role of 5-HT2 receptors in the regulation of sleep and wakefulness in the rat","volume":"97","author":"Dugovic","year":"1989","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.06.001_bb0040","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0028-3908(92)90140-K","article-title":"5-HT1-like receptor agonists enhance wakefulness","volume":"31","author":"Dzoljic","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2011.06.001_bb0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/BF00179315","article-title":"The 5-HT 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo","volume":"338","author":"Hjorth","year":"1988","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.001_bb0050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/frne.1993.1006","article-title":"C-Fos and related immediate early gene products as markers of activity in neuroendocrine system","volume":"14","author":"Hoffman","year":"1993","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.pbb.2011.06.001_bb0055","first-page":"24S","article-title":"Sleep and serotonin: an unfinished story","volume":"21","author":"Jouvet","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2011.06.001_bb0060","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1111\/j.1471-4159.1993.tb03320.x","article-title":"Molecular determinants of general anesthetic action: role of GABAA receptor structure","volume":"60","author":"Lin","year":"1993","journal-title":"J Neurochem"},{"key":"10.1016\/j.pbb.2011.06.001_bb0065","series-title":"Serotonin and sleep: molecular, functional and clinical aspects","first-page":"25","article-title":"Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus","author":"Lowry","year":"2008"},{"key":"10.1016\/j.pbb.2011.06.001_bb0070","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/cne.21685","article-title":"Role of endogenous sleep\u2013wake and analgesic systems in anesthesia","volume":"508","author":"Lu","year":"2008","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pbb.2011.06.001_bb0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.smrv.2009.10.003","article-title":"The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep","volume":"14","author":"Monti","year":"2010","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.pbb.2011.06.001_bb0080","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2869.1992.tb00033.x","article-title":"Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat","volume":"1","author":"Monti","year":"1992","journal-title":"J Sleep Res"},{"key":"10.1016\/j.pbb.2011.06.001_bb0085","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0028-3908(94)90176-7","article-title":"Stereoselective antagonism by the pindolol enantiomers of 8-OH-DPAT-induced changes of sleep and wakefulness","volume":"33","author":"Monti","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2011.06.001_bb0090","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nn913","article-title":"The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway","volume":"5","author":"Nelson","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pbb.2011.06.001_bb0095","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0304-3940(78)90142-8","article-title":"Occurrence of dopamine-containing neurons in the midbrain raphe nuclei of the rat","volume":"8","author":"Ochi","year":"1978","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2011.06.001_bb0100","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.pbb.2011.06.001_bb0105","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1523\/JNEUROSCI.16-08-02820.1996","article-title":"Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving rat","volume":"16","author":"Portas","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2011.06.001_bb0110","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0166-2236(00)02002-6","article-title":"The sleep switch: hypothalamic control of sleep and wakefulness","volume":"24","author":"Saper","year":"2001","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pbb.2011.06.001_bb0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00213-003-1727-0","article-title":"Effects of three hypnotics on the sleep-wakefulness cycle in sleep-disturbed rats","volume":"173","author":"Shinomiya","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.06.001_bb0120","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0091-3057(92)90091-S","article-title":"Study of the 5-HT2 antagonist ritanserin on sleep-walking cycle in the rat","volume":"41","author":"Silhol","year":"1992","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.06.001_bb0125","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0006-8993(01)02101-1","article-title":"Sleep and waking following microdialysis perfusion of the selective 5-HT1A receptor antagonist p-MPPI into the dorsal raphe nucleus in the freely moving rat","volume":"897","author":"Sorensen","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2011.06.001_bb0130","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0306-4522(81)90146-9","article-title":"Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals","volume":"6","author":"Steinbusch","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2011.06.001_bb0135","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0924-977X(98)00051-0","article-title":"Different effects of L-type and T-type calcium channel blockers on the hypnotic potency of triazolam and zolpidem in rats","volume":"9","author":"Takahashi","year":"1999","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pbb.2011.06.001_bb0140","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/00000542-199304000-00020","article-title":"The role of the GABAA receptor\/chloride channel complex in anesthesia","volume":"78","author":"Tanelian","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1016\/j.pbb.2011.06.001_bb0145","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.smrv.2004.01.003","article-title":"Anesthesia and sleep","volume":"8","author":"Tung","year":"2004","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.pbb.2011.06.001_bb0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1053\/smrv.2001.0174","article-title":"Serotonin and sleep","volume":"6","author":"Ursin","year":"2002","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.pbb.2011.06.001_bb0155","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/syn.10008","article-title":"Immunoelectron microscopic study of beta-endorphinergic synaptic innervation of GABAergic neurons in the dorsal raphe nucleus","volume":"42","author":"Wang","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.pbb.2011.06.001_bb0160","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.phymed.2010.01.014","article-title":"Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1A) receptors","volume":"17","author":"Wang","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.pbb.2011.06.001_bb0165","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2004.10.046","article-title":"Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system","volume":"506","author":"Zhao","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.001_bb0170","doi-asserted-by":"crossref","first-page":"1395-02","DOI":"10.1007\/s00702-005-0422-1","article-title":"Potentiating effects of L-type Ca(2+) channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system","volume":"113","author":"Zhao","year":"2006","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pbb.2011.06.001_bb0175","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuropharm.2009.01.017","article-title":"Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: the TMN and VLPO as key elements in the pathway","volume":"56","author":"Zhao","year":"2009","journal-title":"Neuropharmacology"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711001936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711001936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:30:14Z","timestamp":1758774614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305711001936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0091305711001936"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2011.06.001","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diltiazem potentiates pentobarbital-induced hypnosis via 5-HT1A and 5-HT2A\/2C receptors: Role for dorsal raphe nucleus","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2011.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}