{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:50:50Z","timestamp":1778403050000,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"\u201cMolecular and Cell Biology\u201d Program of RAS","award":["6.9"],"award-info":[{"award-number":["6.9"]}]},{"DOI":"10.13039\/501100003182","name":"SB RAS","doi-asserted-by":"crossref","award":["18"],"award-info":[{"award-number":["18"]}],"id":[{"id":"10.13039\/501100003182","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.pbb.2011.06.020","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T22:05:50Z","timestamp":1309471550000},"page":"683-687","source":"Crossref","is-referenced-by-count":19,"title":["Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice"],"prefix":"10.1016","volume":"99","author":[{"given":"Alexander V.","family":"Kulikov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Tikhonova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria V.","family":"Osipova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor A.","family":"Kulikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina K.","family":"Popova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2011.06.020_bb0005","doi-asserted-by":"crossref","first-page":"10333","DOI":"10.1073\/pnas.0810793106","article-title":"Growth retardation and altered autonomic control in mice lacking brain serotonin","volume":"106","author":"Alenina","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.pbb.2011.06.020_bb0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0924-977X(02)00173-6","article-title":"The pharmacology of putative early-onset antidepressant strategies","volume":"13","author":"Blier","year":"2003","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0015","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0149-7634(94)00050-B","article-title":"Role of the serotonergic system in the forced swimming test","volume":"19","author":"Borsini","year":"1995","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pbb.2011.06.020_bb0020","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00176837","article-title":"Is the forced swimming test a suitable model for revealing antidepressant activity?","volume":"94","author":"Borsini","year":"1988","journal-title":"Psychopharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0025","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1471-4159.2007.04806.x","article-title":"Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity","volume":"103","author":"Calcagno","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.pbb.2011.06.020_bb0030","doi-asserted-by":"crossref","first-page":"8165","DOI":"10.1523\/JNEUROSCI.1816-05.2005","article-title":"Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression","volume":"25","author":"Cervo","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2011.06.020_bb0045","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.mp.4001457","article-title":"In search of a depressive mouse: utility of models for studying depression-related behavior in genetically modified mice","volume":"9","author":"Cryan","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pbb.2011.06.020_bb0050","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pbb.2011.06.020_bb0055","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jneumeth.2005.06.008","article-title":"Specificity and efficacy of noradrenaline, serotonin depletion in discrete brain areas of Swiss mice by neurotoxins","volume":"150","author":"Dailly","year":"2006","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.pbb.2011.06.020_bb0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00213-002-1335-4","article-title":"Antidepressant-like effects in various mice strains in the forced swimming test","volume":"166","author":"David","year":"2003","journal-title":"Psychopharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0065","first-page":"1","article-title":"Treatment of depression: clinical aspects","volume":"55","author":"Dudek","year":"2003","journal-title":"Polish J Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0070","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0006-3223(03)00231-2","article-title":"Diagnosis and definition of treatment-resistant depression","volume":"53","author":"Fava","year":"2003","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pbb.2011.06.020_bb0075","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00702-008-0096-6","article-title":"Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice","volume":"115","author":"Gutknecht","year":"2008","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pbb.2011.06.020_bb0080","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejphar.2008.07.031","article-title":"Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin","volume":"594","author":"Guzzetti","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0085","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/jnr.21330","article-title":"Role of TPH-2 in brain function: news from behavioral and pharmacologic studies","volume":"85","author":"Invernizzi","year":"2007","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.pbb.2011.06.020_bb0090","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00213-010-2140-0","article-title":"Antidepressant response to chronic citalopram treatment in eight inbred mouse strains","volume":"213","author":"Jiao","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.06.020_bb0095","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0022-3565(25)27497-3","article-title":"p-chlorophenylalanine: a specific depletor of brain serotonin","volume":"154","author":"Koe","year":"1966","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1016\/j.pbb.2011.06.020_bb0100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2005.09.013","article-title":"Central serotonin depletion affects rat brain areas differently: a qualitative and quantitative comparison between different treatment schemes","volume":"392","author":"Kornum","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2011.06.020_bb0105","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1601-183X.2005.00145.x","article-title":"Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains","volume":"4","author":"Kulikov","year":"2005","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pbb.2011.06.020_bb0110","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1134\/S1022795407120101","article-title":"The C1473G polymorphism in gene tph2 is the main factor mediating the genetically defined variability of tryptophan hydroxylase-2 activity in the mouse brain","volume":"43","author":"Kulikov","year":"2007","journal-title":"Russ J Genet"},{"key":"10.1016\/j.pbb.2011.06.020_bb0115","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jneumeth.2010.06.002","article-title":"Automated analysis of antidepressant's effect in the forced swim test","volume":"191","author":"Kulikov","year":"2010","journal-title":"J Neurosci Meth"},{"key":"10.1016\/j.pbb.2011.06.020_bb0120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swim test as a model for core component behavioral effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0125","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s002130100694","article-title":"Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice","volume":"155","author":"Lucki","year":"2001","journal-title":"Psychopharmacol (Berl)"},{"key":"10.1016\/j.pbb.2011.06.020_bb0130","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejphar.2008.11.010","article-title":"Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains","volume":"602","author":"Mason","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0166-4328(03)00094-9","article-title":"Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice","volume":"145","author":"Mehta","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2011.06.020_bb0140","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00213-007-0728-9","article-title":"Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test","volume":"192","author":"O'Leary","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.06.020_bb0145","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/jnr.21928","article-title":"C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test","volume":"87","author":"Osipova","year":"2009","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.pbb.2011.06.020_bb0150","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.mp.4001502","article-title":"Investigation of serotonin-related genes in antidepressant response","volume":"9","author":"Peters","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pbb.2011.06.020_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/FPC.0b013e3283163ecd","article-title":"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response","volume":"19","author":"Peters","year":"2009","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.pbb.2011.06.020_bb0160","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swim test in mice: a review of antidepressant activity","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2011.06.020_bb0165","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioral despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0170","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.pbb.2011.06.020_bb0175","first-page":"1253","article-title":"Diagnosis and management of depression in primary care: a clinical update and review","volume":"167","author":"Remick","year":"2002","journal-title":"JAMC"},{"key":"10.1016\/j.pbb.2011.06.020_bb0185","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1471-4159.2005.03604.x","article-title":"Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function","volume":"96","author":"Sakowski","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.pbb.2011.06.020_bb0190","doi-asserted-by":"crossref","first-page":"e3301","DOI":"10.1371\/journal.pone.0003301","article-title":"Genetic disruption of both tryptophan hydroxylase genes dramatically reduced serotonin and affect behavior in models sensitive to antidepressants","volume":"3","author":"Savelieva","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.pbb.2011.06.020_bb0195","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/YIC.0b013e3283306a2f","article-title":"The role of pharmacogenetics in the treatment of depression and anxiety disorders","volume":"24","author":"Schosser","year":"2009","journal-title":"Int Clin Psychopharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0200","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2010.06.035","article-title":"Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl\/6J and BALB\/cJ congenic mice","volume":"481","author":"Siesser","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2011.06.020_bb0205","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1176\/appi.ajp.160.4.646","article-title":"The genes and brains of mice and men","volume":"160","author":"Tecott","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pbb.2011.06.020_bb0210","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.pnpbp.2009.02.020","article-title":"Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response","volume":"33","author":"Tsai","year":"2009","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pbb.2011.06.020_bb0215","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/FPC.0b013e3282fb02cb","article-title":"Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment","volume":"18","author":"Tzvetkov","year":"2008","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.pbb.2011.06.020_bb0220","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0006-2952(03)00556-2","article-title":"A unique central tryptophan hydroxylase isoform","volume":"66","author":"Walther","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0225","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second thryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.pbb.2011.06.020_bb0230","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0163-7258(90)90076-E","article-title":"Animal models of depression: an overview","volume":"45","author":"Willner","year":"1990","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.pbb.2011.06.020_bb0235","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00008877-200205000-00001","article-title":"The validity of animal models of predisposition to depression","volume":"13","author":"Willner","year":"2002","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0240","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coph.2006.11.002","article-title":"Genetic rodent models of depression","volume":"7","author":"Yacoubi","year":"2007","journal-title":"Curr Opinion Pharmacol"},{"key":"10.1016\/j.pbb.2011.06.020_bb0245","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1097540","article-title":"Tryptophan hydroxylase-2 controls brain serotonin synthesis","volume":"305","author":"Zhang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.pbb.2011.06.020_bb0250","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2004.12.014","article-title":"Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression","volume":"45","author":"Zhang","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.pbb.2011.06.020_bb0255","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00018-005-5417-4","article-title":"Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2","volume":"63","author":"Zhang","year":"2006","journal-title":"Cell Mol Life Sci"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130571100219X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130571100219X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T21:11:44Z","timestamp":1741295504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009130571100219X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S009130571100219X"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2011.06.020","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}