{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:59:09Z","timestamp":1760853549871,"version":"3.44.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":660,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.pbb.2011.07.003","type":"journal-article","created":{"date-parts":[[2011,7,10]],"date-time":"2011-07-10T13:26:05Z","timestamp":1310304365000},"page":"782-788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models"],"prefix":"10.1016","volume":"99","author":[{"given":"Adriana M.","family":"Godin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wallace C.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Tadeu S.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Gabriel T.","family":"Seniuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Luiz L.","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo A.","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Elias B.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro F.S.","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio M.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2011.07.003_bb0005","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1469-7793.1998.743bj.x","article-title":"Na+-activated K+ channels in small dorsal root ganglion neurones of rat","volume":"510","author":"Bischoff","year":"1998","journal-title":"J Physiol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1021\/jp0765547","article-title":"Molecular structure, vibrational spectra, quantum chemical calculations and photochemistry of picolinamide and isonicotinamide isolated in cryogenic inert matrixes and in the neat low-temperature solid phases","volume":"112","author":"Borba","year":"2008","journal-title":"J Phys Chem A"},{"key":"10.1016\/j.pbb.2011.07.003_bb0015","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.pbb.2011.07.003_bb0020","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/18906","article-title":"A capsaicin-receptor homologue with a high threshold for noxious heat","volume":"398","author":"Caterina","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.pbb.2011.07.003_bb0025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0014-2999(94)90789-7","article-title":"Anti-tumor necrosis factor properties of non-peptide drugs in acute-phase responses","volume":"271","author":"Chen","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0030","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/sj.cdd.4400658","article-title":"The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate","volume":"7","author":"Crowley","year":"2000","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.pbb.2011.07.003_bb0035","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/sj.bjp.0703434","article-title":"Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist","volume":"130","author":"Cunha","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0040","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0024-3205(99)00325-2","article-title":"Protective effects of poly (ADP-ribose) synthase inhibitors in zymosan-activated plasma induced paw edema","volume":"65","author":"Cuzzocrea","year":"1999","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2011.07.003_bb0045","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S0024-3205(99)00365-3","article-title":"Regulation of prostaglandin production by inhibition of poly (ADP-ribose) synthase in carrageenan-induced pleurisy","volume":"65","author":"Cuzzocrea","year":"1999","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2011.07.003_bb0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejphar.2003.10.056","article-title":"Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation","volume":"483","author":"Cuzzocrea","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0055","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1085\/jgp.200910316","article-title":"Activation of Slo2.1 channels by niflumic acid","volume":"135","author":"Dai","year":"2010","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0060","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00213-008-1130-y","article-title":"Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL\/6 mice: comparison with (\u2212)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)","volume":"198","author":"Fischer","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2011.07.003_bb0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0165-2478(97)00088-6","article-title":"Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-alpha","volume":"59","author":"Fukuzawa","year":"1997","journal-title":"Immunol Lett"},{"key":"10.1016\/j.pbb.2011.07.003_bb0070","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bcp.2010.12.010","article-title":"Sirtuins and inflammation: friends or foes?","volume":"81","author":"Gall\u00ed","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0075","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.applanim.2008.10.002","article-title":"Some like it hot: mouse temperature preferences in laboratory housing","volume":"116","author":"Gaskill","year":"2009","journal-title":"Appl Anim Behav Sci"},{"key":"10.1016\/j.pbb.2011.07.003_bb0080","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.bcp.2010.04.022","article-title":"PARP inhibitors: new tools to protect from inflammation","volume":"80","author":"Giansanti","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0085","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0031-9384(90)90025-Y","article-title":"Thermal biology of the laboratory rat","volume":"47","author":"Gordon","year":"1990","journal-title":"Physiol Behav"},{"key":"10.1016\/j.pbb.2011.07.003_bb0090","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jdermsci.2009.08.001","article-title":"Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kB and MAPK pathways","volume":"56","author":"Grange","year":"2009","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.pbb.2011.07.003_bb0095","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0300-9084(96)88154-5","article-title":"The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy","volume":"77","author":"Griffin","year":"1995","journal-title":"Biochimie"},{"key":"10.1016\/j.pbb.2011.07.003_bb0100","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/sj.bjp.0701735","article-title":"A comparison of the effects of L-NAME, 7-NI and L-NIL on carrageenan-induced hindpaw oedema and NOS activity","volume":"123","author":"Handy","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0105","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1007\/s00018-002-8527-2","article-title":"The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders","volume":"59","author":"Hassa","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.pbb.2011.07.003_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-4632.2004.01959.x","article-title":"Pellagra: dermatitis, dementia, and diarrhea","volume":"43","author":"Hegyi","year":"2004","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0115","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1089\/089771503770802871","article-title":"Treatment with vitamin B3 improves functional recovery and reduces GFAP expression following traumatic brain injury in the rat","volume":"20","author":"Hoane","year":"2003","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.pbb.2011.07.003_bb0120","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1089\/neu.2006.23.1535","article-title":"Nicotinamide treatment reduces behavioral impairments and provides cortical protection after fluid percussion injury in the rat","volume":"23","author":"Hoane","year":"2006","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.pbb.2011.07.003_bb0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neulet.2006.07.011","article-title":"Nicotinamide reduces acute cortical neuronal death and edema in the traumatically injured brain","volume":"408","author":"Hoane","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2011.07.003_bb0130","first-page":"235","article-title":"Treatment of arthritis by nicotinic acid and nicotinamide","volume":"81","author":"Hoffer","year":"1959","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.pbb.2011.07.003_bb0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0033-3182(67)72029-0","article-title":"Biochemistry of nicotinic acid and nicotinamide","volume":"8","author":"Hoffer","year":"1967","journal-title":"Psychosomatics"},{"key":"10.1016\/j.pbb.2011.07.003_bb0140","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s001250051113","article-title":"Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis","volume":"42","author":"Hoorens","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.pbb.2011.07.003_bb0145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","article-title":"The formalin test in mice: dissociation between inflammatory and non-inflammatory pain","volume":"30","author":"Hunskaar","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2011.07.003_bb0150","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1016\/S0021-9258(18)99829-7","article-title":"Studies on the biosynthesis of nicotinamide adenine dinucleotide. 3. Comparative in vivo studies on nicotinic acid, nicotinamide, and quinolinic acid as precursors of nicotinamide adenine dinucleotide","volume":"241","author":"Ijichi","year":"1966","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2011.07.003_bb0155","doi-asserted-by":"crossref","first-page":"15464","DOI":"10.1016\/S0021-9258(17)42572-5","volume":"259","author":"Itoh","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2011.07.003_bb0160","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1874467210801030255","article-title":"TRPV1: on the road to pain relief","volume":"1","author":"Jara-Oseguera","year":"2008","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0165","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1172\/JCI106180","article-title":"Diabetogenic action of streptozotocin: relationship of dose to metabolic response","volume":"48","author":"Junod","year":"1969","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pbb.2011.07.003_bb0170","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/FJC.0b013e3180cbd18a","article-title":"Niacinamide abrogates the organ dysfunction and acute lung injury caused by endotoxin","volume":"50","author":"Kao","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0175","doi-asserted-by":"crossref","first-page":"6812","DOI":"10.1016\/j.bmcl.2010.08.121","article-title":"Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives","volume":"20","author":"Kort","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.pbb.2011.07.003_bb0180","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0091-3057(81)90117-9","article-title":"Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures","volume":"14","author":"Lapin","year":"1981","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.07.003_bb0185","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.tox.2010.03.011","article-title":"Formaldehyde induces apoptosis through decreased Prx 2 via p38 MAPK in lung epithelial cells","volume":"271","author":"Lim","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.pbb.2011.07.003_bb0190","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/j.2042-7158.2010.01131.x","article-title":"Ion channels as novel therapeutic targets in the treatment of pain","volume":"62","author":"Mathie","year":"2010","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0195","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","volume":"104","author":"McNamara","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2011.07.003_bb0200","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF01534394","article-title":"Modulation of inflammatory arthritis by inhibition of poly(ADP-ribose) polymerase","volume":"19","author":"Miesel","year":"1995","journal-title":"Inflammation"},{"key":"10.1016\/j.pbb.2011.07.003_bb0205","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1476-5381.1996.tb15205.x","article-title":"Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia","volume":"117","author":"Nakamura","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0210","doi-asserted-by":"crossref","first-page":"14165","DOI":"10.1523\/JNEUROSCI.3150-10.2010","article-title":"PKA-induced internalization of slack KNa channels produces dorsal root ganglion neuron hyperexcitability","volume":"30","author":"Nuwer","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2011.07.003_bb0215","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1093\/emboj\/18.16.4446","article-title":"Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly(ADP-ribose) polymerase-1 deficient mice","volume":"18","author":"Oliver","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.pbb.2011.07.003_bb0220","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1006932714982","article-title":"Newly discovered anti-inflammatory properties of the benzamides and nicotinamides","volume":"193","author":"Pero","year":"1999","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.pbb.2011.07.003_bb0225","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1016\/S0021-9258(18)96630-5","article-title":"On the relative efficacy of nicotinamide and nicotinic acid as precursors of nicotinamide adenine dinucleotide","volume":"241","author":"Petrack","year":"1966","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2011.07.003_bb0230","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0304-3959(96)03048-5","article-title":"Individual differences in the hotplate test and effects of habituation on sensitivity to morphine","volume":"66","author":"Plone","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2011.07.003_bb0235","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1006\/bbrc.1994.1368","article-title":"Nitric oxide toxicity in islet cells involves poly(ADP-ribose)polymerase activation and concomitant NAD+ depletion","volume":"199","author":"Radons","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pbb.2011.07.003_bb0240","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.pbb.2011.07.003_bb0245","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/bjc.1993.490","article-title":"Pharmacokinetics of varying doses of nicotinamide and tumour radiosensitisation with carbogen and nicotinamide: clinical considerations","volume":"68","author":"Rojas","year":"1993","journal-title":"Br J Cancer"},{"key":"10.1016\/j.pbb.2011.07.003_bb0250","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1476-5381.1996.tb15475.x","article-title":"Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation","volume":"118","author":"Salvemini","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0255","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.molcel.2004.12.032","article-title":"Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition","volume":"17","author":"Sauve","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.pbb.2011.07.003_bb0260","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/mrc.2133","article-title":"14N NQR study of nicotinamide and related compounds","volume":"46","author":"Seliger","year":"2008","journal-title":"Magn Reson Chem"},{"key":"10.1016\/j.pbb.2011.07.003_bb0265","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.bjp.0704434","article-title":"In vivo evidence for a role of protein kinase C in peripheral nociceptive processing","volume":"135","author":"Souza","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0270","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1124\/jpet.106.109702","article-title":"Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats","volume":"320","author":"Stevens","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2011.07.003_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(98)00249-0","article-title":"Role of poly(ADP-ribose)synthetase in inflammation","volume":"350","author":"Szabo","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0280","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1523\/JNEUROSCI.0859-09.2009","article-title":"NAD+ activates KNa channels in dorsal root ganglion neurons","volume":"29","author":"Tamsett","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2011.07.003_bb0285","first-page":"404","article-title":"Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde","volume":"61","author":"Tian","year":"2009","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.pbb.2011.07.003_bb0290","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","article-title":"The formalin test: an evaluation of the method","volume":"51","author":"Tjolsen","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2011.07.003_bb0295","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0014-2999(94)90398-0","article-title":"Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization","volume":"251","author":"Tonussi","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0300","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(20)65108-0","article-title":"Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis","volume":"257","author":"Uchigata","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2011.07.003_bb0305","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.1365-2249.2003.02031.x","article-title":"Nicotinamide is a potent inhibitor of proinflammatory cytokines","volume":"131","author":"Ungerstedt","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0310","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.bcp.2008.11.015","article-title":"The peripheral pro-nociceptive state induced by repetitive inflammatory stimuli involves continuous activation of protein kinase A and protein kinase C epsilon and its Na(V)1.8 sodium channel functional regulation in the primary sensory neuron","volume":"77","author":"Villarreal","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2011.07.003_bb0315","first-page":"118","article-title":"Pathway to carrageenan-induced inflammation in the hind limb of the rat","volume":"46","author":"Vinegar","year":"1987","journal-title":"Fed Proc"},{"key":"10.1016\/j.pbb.2011.07.003_bb0320","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1124\/pr.54.3.375","article-title":"The therapeutic potential of poly(ADP-ribose) polymerase inhibitors","volume":"54","author":"Vir\u00e1g","year":"2002","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pbb.2011.07.003_bb0325","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1016\/j.bmcl.2008.08.105","article-title":"Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1","volume":"18","author":"Westaway","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.pbb.2011.07.003_bb0330","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0022-3565(24)37166-6","article-title":"Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production","volume":"283","author":"Zhang","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2011.07.003_bb0335","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711002395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711002395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:31:46Z","timestamp":1758774706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305711002395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0091305711002395"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2011.07.003","relation":{},"ISSN":["0091-3057"],"issn-type":[{"type":"print","value":"0091-3057"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antinociceptive and anti-inflammatory activities of nicotinamide and its isomers in different experimental models","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2011.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}