{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:47:25Z","timestamp":1781714845756,"version":"3.54.5"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004975","name":"Fundaci\u00f3 Bancaixa-UJI","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004975","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Plan Nacional de Drogas"},{"name":"Red de Trastornos Adictivos"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.pbb.2011.10.002","type":"journal-article","created":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T15:19:18Z","timestamp":1318691958000},"page":"404-412","source":"Crossref","is-referenced-by-count":22,"title":["Anxiogenic and stress-inducing effects of peripherally administered acetaldehyde in mice: Similarities with the disulfiram\u2013ethanol reaction"],"prefix":"10.1016","volume":"100","author":[{"given":"Miguel A.","family":"Escrig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Aragon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2011.10.002_bb0005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0376-8716(01)00125-9","article-title":"The pharmacologic and expectancy effects of alcohol on social anxiety in individuals with social phobia","volume":"64","author":"Abrams","year":"2001","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.pbb.2011.10.002_bb0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-2952(92)90042-H","article-title":"Ethanol metabolism in rat brain homogenates by a catalase\u2013H2O2 system","volume":"44","author":"Aragon","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-4328(03)00158-X","article-title":"Behavioral effects of intraventricular injections of low doses of ethanol, acetaldehyde, and acetate in rats: studies with low and high rate operant schedules","volume":"147","author":"Arizzi","year":"2003","journal-title":"Behav Brain Res"},{"issue":"9","key":"10.1016\/j.pbb.2011.10.002_bb0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/187152710790966678","article-title":"Disulfiram: an old therapeutic with new applications","volume":"1","author":"Barth","year":"2010","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.pbb.2011.10.002_bb0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00213-002-1000-y","article-title":"Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis","volume":"161","author":"Boehm","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2011.10.002_bb0030","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.pbb.2011.10.002_bb0035","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1038\/sj.npp.1301327","article-title":"Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats","volume":"32","author":"Cao","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2011.10.002_bb0040","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-3565(25)20542-0","article-title":"Central nervous system effects of acetate: contribution to the central effects of ethanol","volume":"259","author":"Carmichael","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2011.10.002_bb0045","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1530-0277.1995.tb01477.x","article-title":"Alcohol and the mystique of flushing","volume":"19","author":"Chao","year":"1995","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0050","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1530-0277.1982.tb04963.x","article-title":"Mechanism of ethanol-induced adrenal stimulation","volume":"6","author":"Cobb","year":"1982","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0055","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0026-0495(81)90127-X","article-title":"Effects of ethanol and acetaldehyde on the rat adrenal","volume":"30","author":"Cobb","year":"1981","journal-title":"Metabolism"},{"key":"10.1016\/j.pbb.2011.10.002_bb0060","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.brainresbull.2003.09.013","article-title":"Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate","volume":"62","author":"Correa","year":"2003","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.pbb.2011.10.002_bb0065","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00213-008-1219-3","article-title":"Reduction in the anxiolytic effects of ethanol by centrally formed acetaldehyde: the role of catalase inhibitors and acetaldehyde-sequestering agents","volume":"200","author":"Correa","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2011.10.002_bb0070","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/FPC.0b013e328324e726","article-title":"Ethanol intake and ethanol-induced locomotion and locomotor sensitization in Cyp2e1 knockout mice","volume":"19","author":"Correa","year":"2009","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.pbb.2011.10.002_bb0075","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1172\/JCI113875","article-title":"Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity: the inactive ALDH2 allele is dominant","volume":"83","author":"Crabb","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pbb.2011.10.002_bb0345","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/0006-2952(73)90009-9","article-title":"Ethanol and acetaldehyde metabolism in rat strains genetically selected for their ethanol preference","volume":"22","author":"Eriksson","year":"1973","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0335","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1111\/j.1530-0277.2001.tb02369.x","article-title":"The role of acetaldehyde in the actions of alcohol (update 2000)","volume":"25","author":"Eriksson","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0085","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/01.ALC.0000171945.30494.AF","article-title":"Prevention of ethanol-induced behavioral stimulation by d-penicillamine: a sequestration agent for acetaldehyde","volume":"29","author":"Font","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0090","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00213-002-1291-z","article-title":"The consequences of beer consumption in rats: acute anxiolytic and ataxic effects and withdrawal-induced anxiety","volume":"166","author":"Gallate","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2011.10.002_bb0095","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/alcalc\/35.5.435","article-title":"Paradigm to test a drug-induced aversion to ethanol","volume":"35","author":"Garver","year":"2000","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0741-8329(96)00006-7","article-title":"The regulation of alcohol consumption in rats: the role of alcohol-metabolizing enzymes-catalase and aldehyde dehydrogenase","volume":"13","author":"Gill","year":"1996","journal-title":"Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0105","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0140-6736(82)92722-2","article-title":"Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan","volume":"2","author":"Harada","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.pbb.2011.10.002_bb0110","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1360-0443.1997.tb03370.x","article-title":"The efficacy of disulfiram: a review of outcome studies","volume":"92","author":"Hughes","year":"1997","journal-title":"Addiction"},{"key":"10.1016\/j.pbb.2011.10.002_bb0115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0741-8329(95)02026-8","article-title":"Role of acetaldehyde in the actions of ethanol on the brain \u2014 a review","volume":"13","author":"Hunt","year":"1996","journal-title":"Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0130","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1530-0277.1994.tb00894.x","article-title":"Acetate-mediated effects of ethanol","volume":"18","author":"Israel","year":"1994","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0125","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00008571-200211000-00006","article-title":"Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity","volume":"12","author":"Isse","year":"2002","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.pbb.2011.10.002_bb0120","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1097\/01.alc.0000187161.07820.21","article-title":"Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages","volume":"29","author":"Isse","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0773.1992.tb00423.x","article-title":"Clinical responses in relation to blood acetaldehyde levels","volume":"70","author":"Johnsen","year":"1992","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/alcalc\/36.1.59","article-title":"Acetaldehyde, a metabolite of ethanol, activates the hypothalamic\u2013pituitary\u2013adrenal axis in the rat","volume":"36","author":"Kinoshita","year":"2001","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0145","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0091-3057(93)90107-5","article-title":"Mitochondrial aldehyde dehydrogenase (ALDH2) polymorphism in AA and ANA rats: lack of genotype and phenotype line differences","volume":"45","author":"Koivisto","year":"1993","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.10.002_bb0150","first-page":"411","article-title":"Pharmacotherapy treatment of PTSD and comorbid disorders","volume":"21","author":"Kozari\u0107-Kovaci\u0107","year":"2009","journal-title":"Psychiatr Danub"},{"key":"10.1016\/j.pbb.2011.10.002_bb0155","first-page":"775","article-title":"How to get the best out of Antabuse","volume":"30","author":"Kristenson","year":"1995","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0165","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1097\/01.ALC.0000086065.06203.DD","article-title":"Long-term influence of an initial exposure to alcohol on the rat hypothalamic\u2013pituitary axis","volume":"27","author":"Lee","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0160","doi-asserted-by":"crossref","first-page":"74","DOI":"10.15288\/jsa.2002.63.74","article-title":"Genetic risk for alcoholism relates to level of response to alcohol in Asian-American men and women","volume":"63","author":"Luczak","year":"2002","journal-title":"J Stud Alcohol"},{"issue":"9","key":"10.1016\/j.pbb.2011.10.002_bb0340","first-page":"55","article-title":"Ethanol metabolism and production of free acetate in the human liver","volume":"41","author":"Lundquist","year":"1962","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pbb.2011.10.002_bb0170","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1086\/504113","article-title":"Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence","volume":"78","author":"Luo","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.pbb.2011.10.002_bb0175","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-0773.1978.tb02258.x","article-title":"A comparative study on the effects of disulfiram, cyanamide and 1-aminocyclopropanol on the acetaldehyde metabolism in rats","volume":"43","author":"Marchner","year":"1978","journal-title":"Acta Pharmacol Toxicol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0180","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0091-3057(83)90159-4","article-title":"Alcohol sensitivity related to polymorphism of alcohol-metabolizing enzymes in Japanese","volume":"18","author":"Mizoi","year":"1983","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.10.002_bb0185","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00439-003-0971-z","article-title":"Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population","volume":"113","author":"Mulligan","year":"2003","journal-title":"Hum Genet"},{"key":"10.1016\/j.pbb.2011.10.002_bb0190","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/alcalc\/agg011","article-title":"Comparison of cyanamide and placebo in the treatment of alcohol dependence of adolescents","volume":"38","author":"Niederhofer","year":"2003","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0195","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/alcalc\/37.1.9","article-title":"Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference an low alcohol preference rat model system","volume":"37","author":"Nishiguchi","year":"2002","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0200","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1566-0702(02)00206-0","article-title":"Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects","volume":"102","author":"Nishimura","year":"2002","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.pbb.2011.10.002_bb0205","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1152\/ajplegacy.1973.224.6.1450","article-title":"Carrier-mediated blood\u2013brain transport of short-chain monocarboxylic organic acids","volume":"224","author":"Oldendorf","year":"1973","journal-title":"Am J Physiol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0210","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1097\/01.ALC.0000148107.64739.76","article-title":"Brain catalase activity inhibition as well as opioid receptor antagonism increases ethanol-induced HPA axis activation","volume":"28","author":"Pastor","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0215","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1073\/pnas.0710181105","article-title":"Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism","volume":"105","author":"Pastor","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2011.10.002_bb0220","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1530-0277.1983.tb05435.x","article-title":"A placebo-controlled double-blind comparative clinical study of the disulfiram- and calcium carbimide-acetaldehyde mediated ethanol reactions in social drinkers","volume":"7","author":"Peachey","year":"1983","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0225","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/FPC.0b013e3282609e67","article-title":"Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele","volume":"17","author":"Peng","year":"2007","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.pbb.2011.10.002_bb0230","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s00213-004-1911-x","article-title":"Behavioral characterization of acetaldehyde in C57BL\/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects","volume":"177","author":"Quertemont","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2011.10.002_bb0235","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1096\/fj.04-2172com","article-title":"Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats","volume":"19","author":"Quintanilla","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.pbb.2011.10.002_bb0240","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1152\/ajpendo.00187.2007","article-title":"Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective","volume":"293","author":"Quintanilla","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.pbb.2011.10.002_bb0245","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1111\/j.1460-9568.2008.06455.x","article-title":"Alcohol self-administration acutely stimulates the hypothalamic\u2013pituitary\u2013adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state","volume":"28","author":"Richardson","year":"2008","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pbb.2011.10.002_bb0250","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1096\/fj.09-132563","article-title":"Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model","volume":"24","author":"Rivera-Meza","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.pbb.2011.10.002_bb0255","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1530-0277.2001.tb02133.x","article-title":"Effect of repeated exposure to alcohol on the response of the hypothalamic\u2013pituitary\u2013adrenal axis of the rat: II. Role of the length and regimen of alcohol treatment","volume":"25","author":"Rivier","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0260","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00008571-200308000-00009","article-title":"Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats","volume":"13","author":"Sapag","year":"2003","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.pbb.2011.10.002_bb0265","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1530-0277.1986.tb05092.x","article-title":"Mandatory supervised antabuse therapy in an outpatient alcoholism program: a pilot study","volume":"10","author":"Sereny","year":"1986","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0270","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF00288263","article-title":"Genotype of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and nonflushers","volume":"82","author":"Shibuya","year":"1989","journal-title":"Hum Genet"},{"key":"10.1016\/j.pbb.2011.10.002_bb0275","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.euroneuro.2005.04.014","article-title":"Dissociation between the locomotor and anxiolytic effects of acetaldehyde in the elevated plus-maze: evidence that acetaldehyde is not involved in the anxiolytic effects of ethanol in mice","volume":"15","author":"Tambour","year":"2005","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0280","doi-asserted-by":"crossref","first-page":"257","DOI":"10.15288\/jsa.2002.63.257","article-title":"Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats","volume":"63","author":"Tampier","year":"2002","journal-title":"J Stud Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0285","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1530-0277.2008.00658.x","article-title":"Tolerance to disulfiram induced by chronic alcohol intake in the rat","volume":"32","author":"Tampier","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0290","first-page":"344","article-title":"Cyanamide and its calcium form: do they differ with respect to their action on the liver cell? Experimental study in the rat","volume":"7","author":"Val\u00e9rdiz","year":"1989","journal-title":"Appl Pathol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0295","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0165-1110(87)90007-8","article-title":"Acute aldehyde syndrome and chronic aldehydism","volume":"186","author":"Von Wartburg","year":"1987","journal-title":"Mutat Res"},{"key":"10.1016\/j.pbb.2011.10.002_bb0300","doi-asserted-by":"crossref","first-page":"207","DOI":"10.15288\/jsa.1994.55.207","article-title":"Cortisol responses following placebo and alcohol in Asians with different ALDH2 genotypes","volume":"55","author":"Wall","year":"1994","journal-title":"J Stud Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2001.tb03556.x","article-title":"Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors","volume":"937","author":"Weiss","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pbb.2011.10.002_bb0310","article-title":"Effects of ethanol administration on corticosterone levels in adolescent and adult rats","author":"Willey","year":"2011","journal-title":"Alcohol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0315","doi-asserted-by":"crossref","first-page":"943","DOI":"10.7326\/0003-4819-111-11-943","article-title":"Disulfiram treatment of alcoholism. American College of Physicians Position Paper","volume":"111","author":"Wright","year":"1989","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pbb.2011.10.002_bb0320","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0006-2952(89)90380-8","article-title":"Comparative aspects of disulfiram and its metabolites in the disulfiram\u2013ethanol reaction in the rat","volume":"38","author":"Yourick","year":"1989","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0325","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/13556219772444","article-title":"Ethanol metabolism in the brain","volume":"2","author":"Zimatkin","year":"1997","journal-title":"Addict Biol"},{"key":"10.1016\/j.pbb.2011.10.002_bb0330","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1530-0277.2006.00181.x","article-title":"Enzymatic mechanisms of ethanol oxidation in the brain","volume":"30","author":"Zimatkin","year":"2006","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711003248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305711003248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T23:14:21Z","timestamp":1741821261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305711003248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0091305711003248"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2011.10.002","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}