{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T07:10:34Z","timestamp":1741849834558,"version":"3.38.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIAAA14032"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.pbb.2011.10.013","type":"journal-article","created":{"date-parts":[[2011,10,24]],"date-time":"2011-10-24T14:33:13Z","timestamp":1319466793000},"page":"545-553","source":"Crossref","is-referenced-by-count":9,"title":["Behavioral deficits and cellular damage following developmental ethanol exposure in rats are attenuated by CP-101,606, an NMDAR antagonist with unique NR2B specificity"],"prefix":"10.1016","volume":"100","author":[{"given":"B.","family":"Lewis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.A.","family":"Wellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.H.","family":"Kehrberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Barron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2011.10.013_bb0005","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/dev.420060406","article-title":"Statistical procedure in developmental studies on species with multiple offspring","volume":"6","author":"Abbey","year":"1973","journal-title":"Dev Psychobiol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0376-8716(84)90012-7","article-title":"Prenatal effects of alcohol","volume":"14","author":"Abel","year":"1984","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.pbb.2011.10.013_bb0015","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0197-0186(02)00046-3","article-title":"Ethanol sensitivity of NMDA receptors","volume":"41","author":"Allgaier","year":"2002","journal-title":"Neurochem Int."},{"key":"10.1016\/j.pbb.2011.10.013_bb0020","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00006205-199510000-00002","article-title":"Fetal alcohol syndrome: diagnosis, management, and prevention","volume":"20","author":"Appelbaum","year":"1995","journal-title":"Nurse Pract."},{"key":"10.1016\/j.pbb.2011.10.013_bb0025","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1530-0277.2008.00649.x","article-title":"Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures","volume":"32","author":"Barron","year":"2008","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0030","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0014-2999(95)00846-2","article-title":"The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia","volume":"299","author":"Bath","year":"1996","journal-title":"Eur J Pharmacol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0035","first-page":"83","article-title":"Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat","volume":"14","author":"Bayer","year":"1993","journal-title":"Neurotoxicology."},{"key":"10.1016\/j.pbb.2011.10.013_bb0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<94::AID-HIPO11>3.0.CO;2-T","article-title":"Effects of prenatal alcohol exposure on the hippocampus: spatial behavior, electrophysiology, and neuroanatomy","volume":"10","author":"Berman","year":"2000","journal-title":"Hippocampus."},{"key":"10.1016\/j.pbb.2011.10.013_bb0045","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/hbm.21052","article-title":"The role of puberty in the developing adolescent brain","volume":"31","author":"Blakemore","year":"2010","journal-title":"Hum Brain Mapp."},{"key":"10.1016\/j.pbb.2011.10.013_bb0050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0892-0362(87)90010-9","article-title":"Deficits on a spatial navigation task following prenatal exposure to ethanol","volume":"9","author":"Blanchard","year":"1987","journal-title":"Neurotoxicol Teratol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0055","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neuroscience.2009.10.018","article-title":"Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-d-asparate-type glutamate receptors","volume":"165","author":"Butler","year":"2010","journal-title":"Neuroscience."},{"key":"10.1016\/j.pbb.2011.10.013_bb0060","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1530-0277.1999.tb04123.x","article-title":"Chronic ethanol upregulates NMDA and AMPA, but not kainate receptor subunit proteins in rat primary cortical cultures","volume":"23","author":"Chandler","year":"1999","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0065","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1523\/JNEUROSCI.23-07-03001.2003","article-title":"Switching memory systems during learning: changes in patterns of brain acetylcholine release in the hippocampus and striatum in rats","volume":"23","author":"Chang","year":"2003","journal-title":"J Neurosci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0070","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0028-3908(01)00191-5","article-title":"Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists","volume":"42","author":"Chazot","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2011.10.013_bb0075","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1021\/jm00016a017","article-title":"(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-d-aspartate responses","volume":"38","author":"Chenard","year":"1995","journal-title":"J Med Chem."},{"key":"10.1016\/j.pbb.2011.10.013_bb0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/09595230601146686","article-title":"Alcohol and injuries: a review of international emergency room studies since 1995","volume":"26","author":"Cherpitel","year":"2007","journal-title":"Drug Alcohol Rev."},{"key":"10.1016\/j.pbb.2011.10.013_bb0085","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1037\/0735-7044.115.1.138","article-title":"Critical periods for the effects of alcohol exposure on learning in rats","volume":"115","author":"Cronise","year":"2001","journal-title":"Behav Neurosci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0090","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0959-4388(00)00215-4","article-title":"NMDA receptor subunits: diversity, development and disease","volume":"11","author":"Cull-Candy","year":"2001","journal-title":"Curr Opin Neurobiol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0095","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1111\/j.1530-0277.1999.tb04063.x","article-title":"Effect of repeated ethanol withdrawal on glutamate microdialysate in the hippocampus","volume":"23","author":"Dahchour","year":"1999","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0301-0082(99)00031-3","article-title":"Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate","volume":"60","author":"Dahchour","year":"2000","journal-title":"Prog Neurobiol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0105","first-page":"2","article-title":"Pregnancy and alcohol","volume":"4","author":"Danis","year":"1981","journal-title":"Curr Probl Obstet Gynecol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-8993(94)01440-S","article-title":"Increased NMDA-induced excitability during ethanol withdrawal: a behavioural and histological study","volume":"674","author":"Davidson","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0115","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum Dev."},{"key":"10.1016\/j.pbb.2011.10.013_bb0120","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3171\/jns.1997.87.6.0921","article-title":"Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia","volume":"87","author":"Dogan","year":"1997","journal-title":"J Neurosurg."},{"key":"10.1016\/j.pbb.2011.10.013_bb0125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.pbb.2006.09.001","article-title":"Effects of prenatal exposure to alcohol on activity, anxiety, motor coordination, and memory in young adult Wistar rats","volume":"85","author":"Dursun","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2011.10.013_bb0130","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/j.1530-0277.2007.00443.x","article-title":"Prenatal alcohol exposure affects frontal-striatal BOLD response during inhibitory control","volume":"31","author":"Fryer","year":"2007","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0135","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/01.ALC.0000075824.10502.DD","article-title":"Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor","volume":"27","author":"Gibson","year":"2003","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0140","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1530-0277.2000.tb04611.x","article-title":"Early postnatal ethanol exposure has long-term effects on the performance of male rats in a delayed matching-to-place task in the Morris water maze","volume":"24","author":"Girard","year":"2000","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0150","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0892-0362(97)00062-7","article-title":"Neonatal binge ethanol exposure using intubation: timing and dose effects on place learning","volume":"19","author":"Goodlett","year":"1997","journal-title":"Neurotoxicol Teratol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/nlme.1995.0009","article-title":"Sex differences in vulnerability to developmental spatial learning deficits induced by limited binge alcohol exposure in neonatal rats","volume":"64","author":"Goodlett","year":"1995","journal-title":"Neurobiol Learn Mem."},{"key":"10.1016\/j.pbb.2011.10.013_bb0145","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/15353702-0323006-07","article-title":"Alcohol teratogenesis: mechanisms of damage and strategies for intervention","volume":"230","author":"Goodlett","year":"2005","journal-title":"Exp Biol Med (Maywood)."},{"key":"10.1016\/j.pbb.2011.10.013_bb0160","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0006-8993(98)01101-9","article-title":"Synaptic reorganization in explanted cultures of rat hippocampus","volume":"815","author":"Gutierrez","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0165","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0166-4328(03)00028-7","article-title":"Children with Fetal Alcohol Syndrome are impaired at place learning but not cued-navigation in a virtual Morris water task","volume":"143","author":"Hamilton","year":"2003","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0170","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/siny.2000.0027","article-title":"Alcohol in pregnancy and neonatal outcome","volume":"5","author":"Hannigan","year":"2000","journal-title":"Semin Neonatol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0175","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1097\/01.ALC.0000093601.33119.E3","article-title":"The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-d-aspartate receptors","volume":"27","author":"Harris","year":"2003","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0180","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF01991784","article-title":"Glutamate receptors in alcohol withdrawal-induced neurotoxicity","volume":"10","author":"Hoffman","year":"1995","journal-title":"Metab Brain Dis."},{"key":"10.1016\/j.pbb.2011.10.013_bb0190","first-page":"61","article-title":"The role of the NMDA receptor in ethanol withdrawal","volume":"71","author":"Hoffman","year":"1994","journal-title":"EXS."},{"key":"10.1016\/j.pbb.2011.10.013_bb0195","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0169-328X(95)00019-O","article-title":"Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons","volume":"30","author":"Hu","year":"1995","journal-title":"Mol Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0200","first-page":"209","article-title":"Glutamate-induced neurotoxicity is increased in cerebellar granule cells exposed chronically to ethanol","volume":"248","author":"Iorio","year":"1993","journal-title":"Eur J Pharmacol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0205","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0166-4328(03)00246-8","article-title":"Chronic prenatal ethanol exposure alters hippocampal GABA(A) receptors and impairs spatial learning in the guinea pig","volume":"150","author":"Iqbal","year":"2004","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0215","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1530-0277.2002.tb02435.x","article-title":"Selective and enduring deficits in spatial learning after limited neonatal binge alcohol exposure in male rats","volume":"26","author":"Johnson","year":"2002","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0210","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/dmd.31.1.76","article-title":"Metabolism, pharmacokinetics, and excretion of a highly selective N-methyl-d-aspartate receptor antagonist, traxoprodil, in human cytochrome P450 2D6 extensive and poor metabolizers","volume":"31","author":"Johnson","year":"2003","journal-title":"Drug Metab Dispos."},{"key":"10.1016\/j.pbb.2011.10.013_bb0220","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0169-328X(98)00112-0","article-title":"Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment","volume":"58","author":"Kalluri","year":"1998","journal-title":"Mol Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0225","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1037\/0735-7044.111.5.985","article-title":"Object-recognition and spatial learning and memory in rats prenatally exposed to ethanol","volume":"111","author":"Kim","year":"1997","journal-title":"Behav Neurosci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0230","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/089771504772695977","article-title":"The NMDA NR2B subunit-selective receptor antagonist, CP-101,606, enhances the functional recovery the NMDA NR2B subunit-selective receptor and reduces brain damage after cortical compression-induced brain ischemia","volume":"21","author":"Kundrotiene","year":"2004","journal-title":"J Neurotrauma."},{"key":"10.1016\/j.pbb.2011.10.013_bb0235","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00001756-199312000-00029","article-title":"Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes","volume":"5","author":"Kuner","year":"1993","journal-title":"Neuroreport."},{"key":"10.1016\/j.pbb.2011.10.013_bb0240","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00425-008-0772-7","article-title":"Polyamines: essential factors for growth and survival","volume":"228","author":"Kusano","year":"2008","journal-title":"Planta."},{"key":"10.1016\/j.pbb.2011.10.013_bb0245","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1651-2227.1985.tb10915.x","article-title":"Children of alcoholic mothers. Growth and motor performance compared to matched controls","volume":"74","author":"Kyllerman","year":"1985","journal-title":"Acta Paediatr Scand."},{"key":"10.1016\/j.pbb.2011.10.013_bb0250","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pbb.2007.07.012","article-title":"Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure","volume":"88","author":"Lewis","year":"2007","journal-title":"Pharmacol Biochem Behav."},{"key":"10.1016\/j.pbb.2011.10.013_bb0255","doi-asserted-by":"crossref","first-page":"132S","DOI":"10.1111\/j.1530-0277.2001.tb02387.x","article-title":"Role of polyamines and NMDA receptors in ethanol dependence and withdrawal","volume":"25","author":"Littleton","year":"2001","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0260","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.2467382","article-title":"Ethanol inhibits NMDA-activated ion current in hippocampal neurons","volume":"243","author":"Lovinger","year":"1989","journal-title":"Science."},{"key":"10.1016\/j.pbb.2011.10.013_bb0265","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ijdevneu.2004.04.005","article-title":"Vitamin E protects against alcohol-induced cell loss and oxidative stress in the neonatal rat hippocampus","volume":"22","author":"Marino","year":"2004","journal-title":"Int J Dev Neurosci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0270","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0026-895X(25)09931-6","article-title":"Differential ethanol sensitivity of recombinant N-methyl-d-aspartate receptor subunits","volume":"45","author":"Masood","year":"1994","journal-title":"Mol Pharmacol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0275","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1530-0277.2000.tb04595.x","article-title":"Parent ratings of behavior in children with heavy prenatal alcohol exposure and IQ-matched controls","volume":"24","author":"Mattson","year":"2000","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0280","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1530-0277.1996.tb05256.x","article-title":"Verbal learning and memory in children with fetal alcohol syndrome","volume":"20","author":"Mattson","year":"1996","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0285","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0022-3476(97)70099-4","article-title":"Heavy prenatal alcohol exposure with or without physical features of fetal alcohol syndrome leads to IQ deficits","volume":"131","author":"Mattson","year":"1997","journal-title":"J Pediatr."},{"key":"10.1016\/j.pbb.2011.10.013_bb0290","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1530-0277.2002.tb02587.x","article-title":"Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat","volume":"26","author":"Mayer","year":"2002","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0295","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1111\/j.1530-0277.2002.tb02445.x","article-title":"Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus","volume":"26","author":"Mayer","year":"2002","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0300","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1152\/physrev.1994.74.3.723","article-title":"N-methyl-d-aspartic acid receptor structure and function","volume":"74","author":"McBain","year":"1994","journal-title":"Physiol Rev."},{"key":"10.1016\/j.pbb.2011.10.013_bb0305","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-2999(97)10092-9","article-title":"CP-101,606, a potent neuroprotectant selective for forebrain neurons","volume":"331","author":"Menniti","year":"1997","journal-title":"Eur J Pharmacol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0310","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1749-6632.1999.tb07979.x","article-title":"A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury","volume":"890","author":"Merchant","year":"1999","journal-title":"Ann N Y Acad Sci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0315","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4684-3632-7_4","article-title":"Chronic ethanol intake and synaptosomal glutamate binding activity","volume":"126","author":"Michaelis","year":"1980","journal-title":"Adv Exp Med Biol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0320","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0028-3908(94)00155-L","article-title":"Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg(2+)-insensitive mutants","volume":"34","author":"Mirshahi","year":"1995","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2011.10.013_bb0325","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0079-6123(08)60437-9","article-title":"Molecular determinants of NMDA receptor pharmacological diversity","volume":"116","author":"Monaghan","year":"1998","journal-title":"Prog Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0330","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J Neurosci Methods."},{"key":"10.1016\/j.pbb.2011.10.013_bb0335","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/1568007043337409","article-title":"The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence","volume":"3","author":"Nagy","year":"2004","journal-title":"Curr Drug Targets CNS Neurol Disord."},{"key":"10.1016\/j.pbb.2011.10.013_bb0340","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/neu.1997.14.211","article-title":"Effects of the novel NMDA antagonists CP-98,113, CP-101,581 and CP-101,606 on cognitive function and regional cerebral edema following experimental brain injury in the rat","volume":"14","author":"Okiyama","year":"1997","journal-title":"J Neurotrauma."},{"key":"10.1016\/j.pbb.2011.10.013_bb0345","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/nlme.1996.0007","article-title":"Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning","volume":"65","author":"Packard","year":"1996","journal-title":"Neurobiol Learn Mem."},{"key":"10.1016\/j.pbb.2011.10.013_bb0350","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0031-9384(95)00120-8","article-title":"Spatial learning ability of rats following acute exposure to alcohol during early postnatal life","volume":"58","author":"Pauli","year":"1995","journal-title":"Physiol Behav."},{"key":"10.1016\/j.pbb.2011.10.013_bb0355","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pedn.2004.12.011","article-title":"Puberty-timing is everything!","volume":"20","author":"Pinyerd","year":"2005","journal-title":"J Pediatr Nurs"},{"key":"10.1016\/j.pbb.2011.10.013_bb0360","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1111\/j.1530-0277.2000.tb01990.x","article-title":"In vitro effects of ethanol withdrawal and spermidine on viability of hippocampus from male and female rat","volume":"24","author":"Prendergast","year":"2000","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0365","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.neuroscience.2003.12.013","article-title":"Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-d-aspartate receptors","volume":"124","author":"Prendergast","year":"2004","journal-title":"Neuroscience."},{"key":"10.1016\/j.pbb.2011.10.013_bb0370","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/S0006-8993(97)01280-8","article-title":"Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic\/ischemic damage","volume":"782","author":"Reyes","year":"1998","journal-title":"Brain Res."},{"issue":"Suppl 3","key":"10.1016\/j.pbb.2011.10.013_bb0375","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/ehp.00108s3511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ Health Perspect."},{"key":"10.1016\/j.pbb.2011.10.013_bb0380","doi-asserted-by":"crossref","first-page":"110S","DOI":"10.1111\/j.1530-0277.2001.tb02384.x","article-title":"Fetal alcohol effects: mechanisms and treatment","volume":"25","author":"Riley","year":"2001","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0385","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1530-0277.1999.tb04227.x","article-title":"Behavioral and psychosocial profiles of alcohol-exposed children","volume":"23","author":"Roebuck","year":"1999","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0390","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1037\/0033-2909.84.6.1098","article-title":"On the construct validity of open-field measures","volume":"84","author":"Royce","year":"1977","journal-title":"Psychology Bulletin."},{"key":"10.1016\/j.pbb.2011.10.013_bb0395","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.pbb.2008.10.008","article-title":"Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats","volume":"92","author":"Rubin","year":"2009","journal-title":"Pharmacol Biochem Behav."},{"key":"10.1016\/j.pbb.2011.10.013_bb0400","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1096-9926(199711)56:5<317::AID-TERA5>3.0.CO;2-U","article-title":"Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder","volume":"56","author":"Sampson","year":"1997","journal-title":"Teratology."},{"key":"10.1016\/j.pbb.2011.10.013_bb0405","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1111\/j.1530-0277.2010.01266.x","article-title":"Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits","volume":"34","author":"Savage","year":"2010","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0410","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1096\/fasebj.8.10.8050674","article-title":"Modulation of NMDA receptor function: implications for vertebrate neural development","volume":"8","author":"Scheetz","year":"1994","journal-title":"FASEB J."},{"key":"10.1016\/j.pbb.2011.10.013_bb0415","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1523\/JNEUROSCI.23-04-01151.2003","article-title":"Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits","volume":"23","author":"Schorge","year":"2003","journal-title":"J Neurosci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0420","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0022-3565(25)24680-8","article-title":"Ethanol inhibits NMDA-evoked electrophysiological activity in vivo","volume":"257","author":"Simson","year":"1991","journal-title":"J Pharmacol Exp Ther."},{"key":"10.1016\/j.pbb.2011.10.013_bb0425","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0361-9230(86)90236-4","article-title":"Role of ornithine decarboxylase and the polyamines in nervous system development: a review","volume":"17","author":"Slotkin","year":"1986","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.pbb.2011.10.013_bb0430","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-0270(91)90128-M","article-title":"A simple method for organotypic cultures of nervous tissue","volume":"37","author":"Stoppini","year":"1991","journal-title":"J Neurosci Methods."},{"key":"10.1016\/j.pbb.2011.10.013_bb0435","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.6992275","article-title":"Teratogenic effects of alcohol in humans and laboratory animals","volume":"209","author":"Streissguth","year":"1980","journal-title":"Science."},{"key":"10.1016\/j.pbb.2011.10.013_bb0440","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0165-6147(96)80008-3","article-title":"NMDA receptors: from genes to channels","volume":"17","author":"Sucher","year":"1996","journal-title":"Trends Pharmacol Sci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0445","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0022-3565(25)38158-9","article-title":"Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-d-aspartate receptors in cultured cortical neurons","volume":"265","author":"Tamura","year":"1993","journal-title":"J Pharmacol Exp Ther."},{"key":"10.1016\/j.pbb.2011.10.013_bb0450","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1530-0277.2001.tb02277.x","article-title":"MK-801 can exacerbate or attenuate behavioral alterations associated with neonatal alcohol exposure in the rat, depending on the timing of administration","volume":"25","author":"Thomas","year":"2001","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0455","first-page":"1307","article-title":"Administration of low doses of MK-801 during ethanol withdrawal in the developing rat pup attenuates alcohol's teratogenic effects","volume":"26","author":"Thomas","year":"2002","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0460","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00213-004-1806-x","article-title":"Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits","volume":"175","author":"Thomas","year":"2004","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.pbb.2011.10.013_bb0465","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-9384(97)00424-1","article-title":"Spatial learning ability of rats following differing levels of exposure to alcohol during early postnatal life","volume":"63","author":"Tomlinson","year":"1998","journal-title":"Physiol Behav."},{"key":"10.1016\/j.pbb.2011.10.013_bb0470","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.ajog.2005.12.023","article-title":"Learning enhancement with neuropeptides","volume":"194","author":"Toso","year":"2006","journal-title":"Am J Obstet Gynecol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0475","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0006-8993(93)90267-Q","article-title":"Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18h) therapeutic window","volume":"620","author":"Toulmond","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0480","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0024-3205(81)90752-9","article-title":"Blood ethanol levels in sober alcohol users seen in an emergency room","volume":"28","author":"Urso","year":"1981","journal-title":"Life Sci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0485","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbr.2005.07.016","article-title":"Profound but transient deficits in learning and memory after global ischemia using a novel water maze test","volume":"166","author":"von Euler","year":"2006","journal-title":"Behav Brain Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0490","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/00001756-199309150-00015","article-title":"Preferential co-assembly of recombinant NMDA receptors composed of three different subunits","volume":"4","author":"Wafford","year":"1993","journal-title":"Neuroreport."},{"key":"10.1016\/j.pbb.2011.10.013_bb1000","unstructured":"Wellmann KA, Lewis B, Carter ML, Barron S. Neonatal ethanol exposure alters ultrasonic vocalizations in neonatal and periadolescent rats and agmatine reduces these deficits. Accepted pending revisions. Dev Psychobiol. in press."},{"key":"10.1016\/j.pbb.2011.10.013_bb0500","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0741-8329(84)90101-0","article-title":"Delay in brain growth induced by alcohol in artificially reared rat pups","volume":"1","author":"West","year":"1984","journal-title":"Alcohol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0495","first-page":"347","article-title":"Manipulating peak blood alcohol concentrations in neonatal rats: review of an animal model for alcohol-related developmental effects","volume":"10","author":"West","year":"1989","journal-title":"Neurotoxicology."},{"key":"10.1016\/j.pbb.2011.10.013_bb0505","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1111\/j.1530-0277.2006.00210.x","article-title":"Potential value of changes in cell markers in organotypic hippocampal cultures associated with chronic EtOH exposure and withdrawal: comparison with NMDA-induced changes","volume":"30","author":"Wilkins","year":"2006","journal-title":"Alcohol Clin Exp Res."},{"key":"10.1016\/j.pbb.2011.10.013_bb0510","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0024-3205(91)90463-L","article-title":"Modulation of the NMDA receptor by polyamines","volume":"48","author":"Williams","year":"1991","journal-title":"Life Sci."},{"key":"10.1016\/j.pbb.2011.10.013_bb0515","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0026-895X(25)10190-9","article-title":"Sensitivity of the N-methyl-d-aspartate receptor to polyamines is controlled by NR2 subunits","volume":"45","author":"Williams","year":"1994","journal-title":"Mol Pharmacol."},{"key":"10.1016\/j.pbb.2011.10.013_bb0520","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3171\/jns.2003.98.2.0397","article-title":"Reduced brain infarct volume and improved neurological outcome by inhibition of the NR2B subunit of NMDA receptors by using CP101,606-27 alone and in combination with rt-PA in a thromboembolic stroke model in rats","volume":"98","author":"Yang","year":"2003","journal-title":"J Neurosurg."},{"key":"10.1016\/j.pbb.2011.10.013_bb0525","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s007260070029","article-title":"Excitatory amino acid neurotoxicity and modulation of glutamate receptor expression in organotypic brain slice cultures","volume":"19","author":"Zimmer","year":"2000","journal-title":"Amino Acids."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130571100342X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130571100342X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T06:48:47Z","timestamp":1741848527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009130571100342X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":105,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S009130571100342X"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2011.10.013","relation":{},"ISSN":["0091-3057"],"issn-type":[{"type":"print","value":"0091-3057"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}