{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:37:56Z","timestamp":1786995476338,"version":"build-2736575974"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.pbb.2012.03.021","type":"journal-article","created":{"date-parts":[[2012,3,31]],"date-time":"2012-03-31T03:24:56Z","timestamp":1333164296000},"page":"95-100","source":"Crossref","is-referenced-by-count":80,"title":["Rolapitant (SCH 619734): A potent, selective and orally active neurokinin NK1 receptor antagonist with centrally-mediated antiemetic effects in ferrets"],"prefix":"10.1016","volume":"102","author":[{"given":"Ruth A.","family":"Duffy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Naylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey B.","family":"Varty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean E.","family":"Lachowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2012.03.021_bb0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-2999(01)00724-5","article-title":"Inhibition of shock-induced foot tapping behaviour in the gerbil by a tachykinin NK1 receptor antagonist","volume":"412","author":"Ballard","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0010","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1111\/j.1476-5381.1995.tb15117.x","article-title":"The pharmacology of GR203040, a novel, potent and selective non-peptide tachykinin NK1 receptor antagonist","volume":"116","author":"Beattie","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0015","doi-asserted-by":"crossref","first-page":"R3","DOI":"10.1016\/0014-2999(93)90673-6","article-title":"Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets","volume":"249","author":"Bountra","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0014-2999(94)90198-8","article-title":"Chromodacryorrhea and repetitive hind paw tapping: models of peripheral and central tachykinin NK1 receptor activation in gerbils","volume":"253","author":"Bristow","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0025","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.2165\/11203680-000000000-00000","article-title":"Aprepitant: a review of its use in the prevention of nausea and vomiting","volume":"69","author":"Curran","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.pbb.2012.03.021_bb0030","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2165\/00003495-200060030-00002","article-title":"Potential of substance P antagonists as antiemetics","volume":"60","author":"Diemunsch","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.pbb.2012.03.021_bb0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/bja\/aep125","article-title":"Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting","volume":"103","author":"Diemunsch","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.pbb.2012.03.021_bb0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1517\/14728214.9.1.9","article-title":"Potential therapeutic targets for Neurokinin 1 (NK1) receptor antagonists","volume":"9","author":"Duffy","year":"2004","journal-title":"Expert Opin Emerg Drugs"},{"key":"10.1016\/j.pbb.2012.03.021_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.301.2.536","article-title":"Correlation of neurokinin NK1 receptor occupancy in gerbil striatum with the behavioral effects of NK1 antagonists","volume":"301","author":"Duffy","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2012.03.021_bb0050","doi-asserted-by":"crossref","first-page":"25668","DOI":"10.1016\/S0021-9258(18)35658-8","article-title":"Molecular basis for the species selectivity of the neurokin-1 receptor antagonist CP-96345","volume":"267","author":"Fong","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2012.03.021_bb0055","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1213\/ANE.0b013e31820886c3","article-title":"Rolapitant for the prevention of postoperative nausea and vomiting: a prospective, double-blinded, placebo-controlled randomized trial","volume":"112","author":"Gan","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1016\/j.pbb.2012.03.021_bb0060","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1111\/j.1476-5381.1995.tb15118.x","article-title":"The broad spectrum anti-emetic activity of the novel non-peptide tachykinin NK1 receptor antagonisr GR203040","volume":"116","author":"Gardner","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0167-0115(96)00071-7","article-title":"GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity","volume":"65","author":"Gardner","year":"1996","journal-title":"Regul Pept"},{"key":"10.1016\/j.pbb.2012.03.021_bb0070","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1037\/a0015733","article-title":"Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting","volume":"123","author":"Ray","year":"2009","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.pbb.2012.03.021_bb0075","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1476-5381.1996.tb15761.x","article-title":"The action of the NK1 tachykinin receptor antagonist, CP-99,994, in antagonizing the acute and delayed emesis induced by cisplatin in the ferret","volume":"119","author":"Rudd","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0080","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0014-2999(98)00920-0","article-title":"Inhibition of emesis by tachykinin NK1 receptor antagonists in Suncus murinus (house musk shrew)","volume":"366","author":"Rudd","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0085","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0165-6147(99)01396-6","article-title":"Discovery of the anti-depressant and anti-emetic efficacy of substance P receptor (NK1) antagonists","volume":"20","author":"Rupniak","year":"1999","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pbb.2012.03.021_bb0090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0014-2999(94)90430-8","article-title":"Differential inhibition of foot tapping and chromodacryorrhoea in gerbils by CNS penetrant and non-penetrant tachykinin NK1 receptor antagonists","volume":"265","author":"Rupniak","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0095","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-2999(99)00259-9","article-title":"The tachykinin NK1 receptor in the brain: pharmacology and putative functions","volume":"375","author":"Saria","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0100","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-2999(96)00950-8","article-title":"The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced emesis in the ferret","volume":"321","author":"Singh","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0105","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1016\/0014-2999(93)90649-3","article-title":"The tachykinin NK1 receptor antagonist CP-99994 attenuates cisplatin-induced emesis in the ferret","volume":"250","author":"Tattersall","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.03.021_bb0110","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0028-3908(94)90018-3","article-title":"Enantiomeric inhibition of apomorphine-induced emesis in the ferret by the neurokinin1 receptor antagonist CP-99,994","volume":"33","author":"Tattersall","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2012.03.021_bb0115","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0028-3908(96)00020-2","article-title":"Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets","volume":"35","author":"Tattersall","year":"1996","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2012.03.021_bb0120","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0028-3908(99)00172-0","article-title":"The novel NK1 receptor antagonist MK0869 (L-754,030) and its water soluble phosphoryl prodrug, L-754-298, inhibit acute and delated cisplatin-induced emesis in ferrets","volume":"39","author":"Tattersall","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2012.03.021_bb0125","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1476-5381.1995.tb16324.x","article-title":"The anti-emetic effects of CP-99,994 in the ferret and the dog: role of the NK1 receptor","volume":"115","author":"Watson","year":"1995","journal-title":"Br J Pharmacol"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305712000925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305712000925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T14:21:16Z","timestamp":1641738076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305712000925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0091305712000925"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2012.03.021","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}