{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:23:43Z","timestamp":1789424623070,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.pbb.2012.11.001","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T19:04:04Z","timestamp":1352747044000},"page":"643-651","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Adipocytokine signaling is altered in flinders sensitive line rats, and adiponectin correlates in humans with some symptoms of depression"],"prefix":"10.1016","volume":"103","author":[{"given":"Clare J.","family":"Wilhelm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongseok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Huckans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Manthe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Loftis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2012.11.001_bb0400","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.pbb.2012.11.001_bb0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-3956(98)00032-6","article-title":"Elevated nocturnal profiles of serum leptin in patients with depression","volume":"32","author":"Antonijevic","year":"1998","journal-title":"J Psychiatr Res"},{"issue":"2","key":"10.1016\/j.pbb.2012.11.001_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/0269881107069944","article-title":"Development and validation of the Generalized Anxiety Disorder Inventory (GADI)","volume":"21","author":"Argyropoulos","year":"2007","journal-title":"J Psychopharmacol"},{"issue":"3","key":"10.1016\/j.pbb.2012.11.001_bb0020","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of Beck Depression Inventories-IA and -II in psychiatric outpatients","volume":"67","author":"Beck","year":"1996","journal-title":"J Pers Assess"},{"key":"10.1016\/j.pbb.2012.11.001_bb0025","doi-asserted-by":"crossref","first-page":"e12596","DOI":"10.1371\/journal.pone.0012596","article-title":"Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours","volume":"5","author":"Blaveri","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.pbb.2012.11.001_bb0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1176\/ajp.157.1.115","article-title":"Hippocampal volume reduction in major depression","volume":"157","author":"Bremner","year":"2000","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0040","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1176\/appi.ajp.161.4.598","article-title":"Lower hippocampal volume in patients suffering from depression: a meta-analysis","volume":"161","author":"Campbell","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0045","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.pnpbp.2010.05.019","article-title":"Early-life stress and antidepressants modulate peripheral biomarkers in a gene\u2013environment rat model of depression","volume":"34","author":"Carboni","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"8","key":"10.1016\/j.pbb.2012.11.001_bb9000","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.4088\/JCP.09m05314blu","volume":"71","author":"Cizza","year":"2010","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: recent developments and future needs","volume":"23","author":"Cryan","year":"2002","journal-title":"Trends Pharmacol Sci"},{"issue":"12","key":"10.1016\/j.pbb.2012.11.001_bb9005","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1055\/s-2007-979885","article-title":"Plasma leptin in depressed patients and healthy controls","volume":"28","author":"Deuschle","year":"1996","journal-title":"Horm Metab Res"},{"issue":"8","key":"10.1016\/j.pbb.2012.11.001_bb9010","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jpsychires.2012.04.028","article-title":"Reduced serum levels of adiponectin in elderly patients with major depression","volume":"46","author":"Diniz","year":"2012","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.pbb.2012.11.001_bb0055","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neuroscience.2004.04.044","article-title":"Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats","volume":"126","author":"Drossopoulou","year":"2004","journal-title":"Neuroscience"},{"issue":"Suppl. 3","key":"10.1016\/j.pbb.2012.11.001_bb0060","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0924-9338(02)00654-5","article-title":"Pathophysiology of depression: the concept of synaptic plasticity","volume":"17","author":"Duman","year":"2002","journal-title":"Eur Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0065","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.mp.4001862","article-title":"Reduced brain leptin in patients with major depressive disorder and in suicide victims","volume":"11","author":"Eikelis","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0070","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00004714-199908000-00008","article-title":"Open study of the catechol-O-methyltransferase inhibitor tolcopane in major depressive disorder","volume":"19","author":"Fava","year":"1999","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0075","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1017\/S1461145710000957","article-title":"Efficacy of antidepressants: a re-analysis and re-interpretation of the Kirsch data","volume":"14","author":"Fountoulakis","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12031-007-9016-8","article-title":"VTA dopamine neuron bursting is altered in an animal model of depression and corrected by desipramine","volume":"34","author":"Friedman","year":"2008","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.pbb.2012.11.001_bb0410","unstructured":"Frodl T, O'Keane V. How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol Dis in press. PMID: 22426398 [Epub ahead of print PubMed]."},{"key":"10.1016\/j.pbb.2012.11.001_bb0090","doi-asserted-by":"crossref","first-page":"15533","DOI":"10.1073\/pnas.0507666102","article-title":"Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia","volume":"25","author":"Glatt","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2012.11.001_bb0095","first-page":"505","article-title":"Adipocytokines \u2014 novel link between inflammation and vascular function?","volume":"57","author":"Guzik","year":"2006","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0100","doi-asserted-by":"crossref","first-page":"R70","DOI":"10.1186\/gb-2003-4-10-r70","article-title":"Identifying biological themes within lists of genes with EASE","volume":"4","author":"Hosack","year":"2003","journal-title":"Genome Biol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0105","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.pbb.2012.11.001_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths towards the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pbb.2012.11.001_bb0115","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/sj.npp.1300178","article-title":"Topiramate normalizes hippocampal NPY-LI in Flinders sensitive line \u2018depressed\u2019 rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects","volume":"28","author":"Husum","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2012.11.001_bb0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ajmg.1320540412","article-title":"Is cholinergic sensitivity a genetic marker for the affective disorders?","volume":"54","author":"Janowsky","year":"1994","journal-title":"Am J Med Genet"},{"issue":"7","key":"10.1016\/j.pbb.2012.11.001_bb9100","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.psyneuen.2011.11.002","article-title":"Plasma adiponectin elevation in elderly individuals with subsyndromal depression","volume":"37","author":"Jeong","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pbb.2012.11.001_bb0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jad.2005.09.015","article-title":"Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia","volume":"90","author":"Jow","year":"2006","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pbb.2012.11.001_bb0135","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.pnpbp.2009.10.018","article-title":"Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus","volume":"34","author":"Kajiyama","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pbb.2012.11.001_bb0145","doi-asserted-by":"crossref","first-page":"D354","DOI":"10.1093\/nar\/gkj102","article-title":"From genomics to chemical genomics: new developments in KEGG","volume":"34","author":"Kanehisa","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pbb.2012.11.001_bb0140","doi-asserted-by":"crossref","first-page":"D355","DOI":"10.1093\/nar\/gkp896","article-title":"KEGG for representation and analysis of molecular networks involving diseases and drugs","volume":"38","author":"Kanehisa","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.pbb.2012.11.001_bb0155","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.clinpsy.3.022806.091444","article-title":"Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century","volume":"3","author":"Kessler","year":"2007","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0160","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000054641","article-title":"Low leptin levels but normal body mass indices in patients with depression or schizophrenia","volume":"73","author":"Kraus","year":"2002","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.pbb.2012.11.001_bb0165","first-page":"599","article-title":"Relationship between serum angiogenin, adiponectin and resistin levels with biochemical risk factors and the angiographic severity of three-vessel coronary disease","volume":"17","author":"Krecki","year":"2010","journal-title":"Cardiol J"},{"key":"10.1016\/j.pbb.2012.11.001_bb0170","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1586\/ern.09.53","article-title":"Strategies to enhance the therapeutic efficacy of antidepressants: targeting residual symptoms","volume":"9","author":"Kurian","year":"2009","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.pbb.2012.11.001_bb0175","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jad.2009.04.007","article-title":"Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers","volume":"120","author":"Lalovic","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pbb.2012.11.001_bb0180","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-6606-3-8","article-title":"Depression research: where are we now?","volume":"3","author":"Lee","year":"2010","journal-title":"Mol Brain"},{"issue":"2","key":"10.1016\/j.pbb.2012.11.001_bb0185","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","article-title":"Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression","volume":"36","author":"Leonard","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pbb.2012.11.001_bb0190","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biopsych.2008.07.014","article-title":"Vaccination as a novel approach for treating depressive behavior","volume":"65","author":"Lewitus","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0195","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00213-009-1684-3","article-title":"Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine","volume":"207","author":"Liu","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2012.11.001_bb0205","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00213-002-1209-9","article-title":"Cocaine treatment- and withdrawal-induced alterations in the expression and serine phosphorylation of the NR1 NMDA receptor subunit","volume":"164","author":"Loftis","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2012.11.001_bb0210","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.psyneuen.2006.07.006","article-title":"Administration of pegylated interferon-alpha-2a or -2b does not induce sickness behavior in Lewis rats","volume":"31","author":"Loftis","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pbb.2012.11.001_bb0200","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.nbd.2009.11.015","article-title":"Neuroimmune mechanisms of cytokine-induced depression: current theories and novel treatment strategies","volume":"37","author":"Loftis","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.pbb.2012.11.001_bb0215","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1073\/pnas.0508901103","article-title":"Leptin: a potential novel antidepressant","volume":"103","author":"Lu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2012.11.001_bb0220","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1073\/pnas.0337481100","article-title":"Course of illness, hippocampal function, and hippocampal volume in major depression","volume":"100","author":"Macqueen","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2012.11.001_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-1781(96)02915-0","article-title":"Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs","volume":"66","author":"Maes","year":"1997","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pbb.2012.11.001_bb0230","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus","volume":"20","author":"Malberg","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2012.11.001_bb0235","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2008.09.006","article-title":"SONU20176289, a compound comining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression","volume":"598","author":"Michael-Titus","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0240","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/YPG.0b013e328306c979","article-title":"Ghrelin gene polymorphism is associated with depression, but not panic disorder","volume":"18","author":"Nakashima","year":"2008","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.pbb.2012.11.001_bb0245","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pneurobio.2010.06.003","article-title":"Depression and the role of genes involved in dopamine metabolism and signaling","volume":"92","author":"Opmeer","year":"2010","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0250","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00041433-200312000-00003","article-title":"Obesity, adiponectin and vascular inflammatory disease","volume":"14","author":"Ouchi","year":"2003","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0260","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0006-3223(86)90007-7","article-title":"Selective breeding for increased cholinergic function: development of a new animal model of depression","volume":"21","author":"Overstreet","year":"1986","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0265","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0149-7634(05)80230-1","article-title":"The Flinders sensitive line rats: a genetic animal model of depression","volume":"17","author":"Overstreet","year":"1993","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pbb.2012.11.001_bb0255","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF00432254","article-title":"Selective breeding for diisopropyl fluorophosphates-sensitivity: behavioural effects of cholinergic agonists and antagonists","volume":"78","author":"Overstreet","year":"1982","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2012.11.001_bb0270","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neubiorev.2005.03.015","article-title":"The Flinders sensitive line rat: a selectively bred putative animal model of depression","volume":"29","author":"Overstreet","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.pbb.2012.11.001_bb0275","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jad.2007.07.024","article-title":"Leptin in depressed women: cross-sectional and longitudinal data from an epidemiologic study","volume":"107","author":"Pasco","year":"2008","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pbb.2012.11.001_bb0280","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.genhosppsych.2011.04.005","article-title":"Screening for depression in patients with hepatitis C using the Beck Depression Inventory-II: do somatic symptoms compromise validity?","volume":"33","author":"Patterson","year":"2011","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0285","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuroscience.2010.12.043","article-title":"Regulation of cytoskeleton machinery, neurogenesis and energy metabolism pathways in a rat gene\u2013environment model of depression revealed by proteomic analysis","volume":"176","author":"Piubelli","year":"2011","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.pbb.2012.11.001_bb0295","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/YCO.0b013e32834b9db6","article-title":"Inflammatory mechanisms in major depressive disorder","volume":"24","author":"Raedler","year":"2011","journal-title":"Curr Opin Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0300","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archpsyc.57.4.349","article-title":"Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: preliminary findings","volume":"57","author":"Rosoklija","year":"2000","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0305","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1460-9568.2009.06840.x","article-title":"Antidepressant treatment facilitates dopamine release and drug seeking behavior in a genetic animal model of depression","volume":"30","author":"Roth-Deri","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pbb.2012.11.001_bb0310","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0165-1781(02)00263-9","article-title":"Sexual diergism of baseline plasma leptin and leptin suppression by arginine vasopressin in major depressives and matched controls","volume":"113","author":"Rubin","year":"2002","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.pbb.2012.11.001_bb0315","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.pbb.2012.11.001_bb0320","unstructured":"Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent Teague T, Drevets WC. Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun in press, http:\/\/dx.doi.org\/10.1016\/j.bbi.2012.10.007. pii: S0889-1591(12)00469-2. PubMed PMID: 23064081. [Electronic publication ahead of print]."},{"issue":"Suppl. 20","key":"10.1016\/j.pbb.2012.11.001_bb0415","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0330","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.93.9.3908","article-title":"Hippocampal atrophy in recurrent major depression","volume":"93","author":"Sheline","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2012.11.001_bb0335","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/mp.2010.52","article-title":"Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression","volume":"16","author":"Shelton","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"4","key":"10.1016\/j.pbb.2012.11.001_bb0340","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10608-011-9363-1","article-title":"Responding to anxiety with rumination and hopelessness: mechanism of anxiety\u2013depression symptom co-occurrence?","volume":"36","author":"Starr","year":"2012","journal-title":"Cogn Ther Res"},{"key":"10.1016\/j.pbb.2012.11.001_bb0350","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000117529","article-title":"A linkage study of depression spectrum disease: the use of the sib-pair method","volume":"2","author":"Tanna","year":"1976","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.pbb.2012.11.001_bb0360","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1601-183X.2008.00402.x","article-title":"Gene expression patterns in brain cortex of three different animal models of depression","volume":"7","author":"Uriquen","year":"2008","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.pbb.2012.11.001_bb0365","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0306-4522(98)00289-9","article-title":"Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures","volume":"89","author":"Vaidya","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2012.11.001_bb0370","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1176\/appi.ajp.161.11.1957","article-title":"Hippocampal volume and depression: a meta-analysis of MRI studies","volume":"161","author":"Videbach","year":"2004","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.pbb.2012.11.001_bb0375","first-page":"1","article-title":"Neuropeptide S alters anxiety, but not depression-like behavior in Flinders sensitive line rats: a genetic animal model of depression","volume":"9","author":"Wegener","year":"2011","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.pbb.2012.11.001_bb0380","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuropharm.2011.07.040","article-title":"Corticotropin releasing factor-1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1\u03b2 administration","volume":"62","author":"Wilhelm","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2012.11.001_bb0390","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1210\/en.2011-0004","article-title":"Impaired CNS leptin action is implicated in depression associated with obesity","volume":"152","author":"Yamada","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.pbb.2012.11.001_bb0395","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/00048670601057759","article-title":"Levels of serum interleukin (IL)-6, IL-1beta, tumour necrosis factor-alpha and leptin and their correlation in depression","volume":"41","author":"Yang","year":"2007","journal-title":"Aust N Z J Psychiatry"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305712003127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305712003127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:31:44Z","timestamp":1758774704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305712003127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0091305712003127"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2012.11.001","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipocytokine signaling is altered in flinders sensitive line rats, and adiponectin correlates in humans with some symptoms of depression","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2012.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}