{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:40:55Z","timestamp":1778658055974,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":470,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.pbb.2012.11.006","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T01:16:24Z","timestamp":1353460584000},"page":"678-683","source":"Crossref","is-referenced-by-count":20,"title":["The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice"],"prefix":"10.1016","volume":"103","author":[{"given":"Cristiane Flora","family":"Villarreal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mani Indiana","family":"Funez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando de Queiroz","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Am\u00edlcar","family":"Parada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio Henrique","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2012.11.006_bb0010","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1523\/JNEUROSCI.20-12-04680.2000","article-title":"Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the e isozyme of protein kinase C","volume":"20","author":"Aley","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2012.11.006_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.pbb.2012.11.006_bb0020","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/jn.1969.32.6.1025","article-title":"Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli","volume":"32","author":"Bessou","year":"1969","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0165-6147(98)01185-7","article-title":"The role of IP prostanoid receptors in inflammatory pain","volume":"19","author":"Bley","year":"1998","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pbb.2012.11.006_bb0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0304-3959(84)90122-2","article-title":"Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests","volume":"18","author":"Coderre","year":"1984","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2012.11.006_bb0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-6997(25)06784-5","article-title":"International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes","volume":"46","author":"Coleman","year":"1994","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.pbb.2012.11.006_bb0045","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/sj.bjp.0702601","article-title":"Pharmacological modulation of secondary mediator systems-cyclic AMP and cyclic GMP-on inflammatory hyperalgesia","volume":"127","author":"Cunha","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0050","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1073\/pnas.0409225102","article-title":"A cascade of cytokines mediates mechanical inflammatory hypernociception in mice","volume":"102","author":"Cunha","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2012.11.006_bb0055","first-page":"171","article-title":"A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse","volume":"13","author":"Dawson","year":"1991","journal-title":"Int J Tissue React"},{"key":"10.1016\/j.pbb.2012.11.006_bb0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.2042-7158.1972.tb08940.x","article-title":"Biological properties of carrageenan","volume":"24","author":"Di Rosa","year":"1972","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0065","first-page":"341","article-title":"Participation of the sympathetic system in acetic acid-induced writhing in mice","volume":"21","author":"Duarte","year":"1988","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.pbb.2012.11.006_bb0070","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/newbio240200a0","article-title":"Prostaglandin, aspirin-like drugs and analgesia","volume":"240","author":"Ferreira","year":"1972","journal-title":"Nat New Biol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0090-6980(79)90103-5","article-title":"I \u2014 prostaglandin hyperalgesia, a cAMP\/Ca2+ dependent process","volume":"18","author":"Ferreira","year":"1979","journal-title":"Prostaglandins"},{"key":"10.1016\/j.pbb.2012.11.006_bb0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-2999(78)90265-0","article-title":"Central and peripheral antialgesic action of aspirin-like drugs","volume":"53","author":"Ferreira","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0085","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0304-3959(90)91149-D","article-title":"Induction, blockade and restoration of a persistent hypersensitive state","volume":"42","author":"Ferreira","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2012.11.006_bb0095","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.2235","article-title":"Nociceptor sensitization in pain pathogenesis","volume":"16","author":"Gold","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.pbb.2012.11.006_bb0100","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1073\/pnas.93.3.1108","article-title":"Hyperalgesic agents increase a tetrodotoxin-resistant Na1 current in nociceptors","volume":"93","author":"Gold","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2012.11.006_bb0105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0304-3959(92)90259-E","article-title":"Painful neuropathy: altered central processing maintained dynamically by peripheral input","volume":"51","author":"Gracely","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2012.11.006_bb0130","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1515\/jom-1989-890813","article-title":"Shoulder pain and repetition strain injury to the supraspinatus muscle: etiology and manipulative treatment","volume":"89","author":"Jacobson","year":"1989","journal-title":"J Am Osteopath Assoc"},{"key":"10.1016\/j.pbb.2012.11.006_bb0140","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1152\/jn.1999.81.3.1104","article-title":"Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors","volume":"81","author":"Khasar","year":"1999","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0145","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1213\/ANE.0b013e3181cde882","article-title":"The development of new analgesics over the past 50years: a lack of real breakthrough drugs","volume":"110","author":"Kissin","year":"2010","journal-title":"Anesth Analg"},{"key":"10.1016\/j.pbb.2012.11.006_bb0150","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/nm.2231","article-title":"Central mechanisms of pathological pain","volume":"16","author":"Kuner","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.pbb.2012.11.006_bb0160","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1124\/jpet.106.105569","article-title":"Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity","volume":"319","author":"Lin","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2012.11.006_bb0165","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2165\/00007256-199520010-00003","article-title":"Delayed muscle soreness. The inflammatory response to muscle injury and its clinical implications","volume":"20","author":"MacIntyre","year":"1995","journal-title":"Sports Med"},{"key":"10.1016\/j.pbb.2012.11.006_bb0170","series-title":"Wall and Melzack's textbook of pain","first-page":"49","article-title":"Inflammatory mediators and modulators of pain","author":"McMahon","year":"2008"},{"key":"10.1016\/j.pbb.2012.11.006_bb0175","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00003086-199806000-00015","article-title":"Cumulative trauma disorders and repetitive strain injuries. The future","volume":"351","author":"Melhorn","year":"1998","journal-title":"Clin Orthop"},{"key":"10.1016\/j.pbb.2012.11.006_bb0180","first-page":"19","article-title":"Pharmacology and biochemistry of dopamine receptors in the central nervous system and peripheral tissue","volume":"22","author":"Memo","year":"1986","journal-title":"J Neural Transm Suppl"},{"key":"10.1016\/j.pbb.2012.11.006_bb0190","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","article-title":"Dopamine receptors: from structure to function","volume":"78","author":"Missale","year":"1998","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pbb.2012.11.006_bb0195","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1073\/pnas.87.17.6723","article-title":"Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation","volume":"87","author":"Monsma","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2012.11.006_bb0200","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0014-2999(87)90606-6","article-title":"A peripheral sympathetic component in inflammatory hyperalgesia","volume":"135","author":"Nakamura","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0205","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1124\/jpet.107.122010","article-title":"CJ-023,423, a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties","volume":"322","author":"Nakao","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2012.11.006_bb0210","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0306-4522(94)00397-N","article-title":"Multiple second messenger systems act sequentially to mediate rolipram-induced prolongation of prostaglandin E2-induced mechanical hyperalgesia in the rat","volume":"64","author":"Ouseph","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2012.11.006_bb0225","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jpain.2005.12.011","article-title":"Peripheral and central contributions to hyperalgesia in irritable bowel syndrome","volume":"7","author":"Price","year":"2006","journal-title":"J Pain"},{"key":"10.1016\/j.pbb.2012.11.006_bb0220","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.neuroimage.2009.04.028","article-title":"Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo\/nocebo factors: evidence from human psychophysics, animal models, and neuroimaging","volume":"47","author":"Price","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.pbb.2012.11.006_bb0245","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S0028-3908(02)00028-X","article-title":"The role of the sympathetic efferents in endotoxin-induced localized inflammatory hyperalgesia and cytokine upregulation","volume":"42","author":"Safieh-Garabedian","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2012.11.006_bb0255","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pain.2009.05.020","article-title":"Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study","volume":"145","author":"Staud","year":"2009","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2012.11.006_bb0260","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1074\/jbc.R600038200","article-title":"Prostaglandin and receptors","volume":"282","author":"Sugimoto","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2012.11.006_bb0270","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0306-4522(91)90255-M","article-title":"Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia","volume":"44","author":"Taiwo","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2012.11.006_bb0265","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0306-4522(89)90280-7","article-title":"Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system","volume":"32","author":"Taiwo","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2012.11.006_bb0275","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1037\/0022-006X.56.2.233","article-title":"Toward an empirically derived taxonomy of chronic pain patients: integration of psychological assessment data","volume":"56","author":"Turk","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0280","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0304-3959(03)00210-0","article-title":"Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients","volume":"105","author":"Verne","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.pbb.2012.11.006_bb0285","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.lfs.2009.10.018","article-title":"Acute and persistent nociceptive paw sensitisation in mice: the involvement of distinct signalling pathways","volume":"85","author":"Villarreal","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2012.11.006_bb0290","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1076\/ceyr.18.1.3.5395","article-title":"Ocular inflammation models by topical application: croton-oil induced uveitis","volume":"18","author":"Villena","year":"1999","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.pbb.2012.11.006_bb0295","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/0014-4886(74)90197-6","article-title":"Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma","volume":"43","author":"Wall","year":"1974","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pbb.2012.11.006_bb0300","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305712003176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305712003176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T08:12:42Z","timestamp":1745223162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305712003176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0091305712003176"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2012.11.006","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}