{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:44:55Z","timestamp":1772491495727,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"crossref","award":["2Z03550"],"award-info":[{"award-number":["2Z03550"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Business Promotion of the \u201cBaekdudaegan Greenmine\u201d Resources","award":["R0000474"],"award-info":[{"award-number":["R0000474"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.pbb.2013.01.017","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T14:31:19Z","timestamp":1359383479000},"page":"163-168","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Ropinirole protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice via anti-apoptotic mechanism"],"prefix":"10.1016","volume":"104","author":[{"given":"Gunhyuk","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Joon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ok","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Sook","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2013.01.017_bb0005","doi-asserted-by":"crossref","first-page":"21878","DOI":"10.1074\/jbc.272.35.21878","article-title":"Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis","volume":"272","author":"Adachi","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2013.01.017_bb0010","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1353-8020(00)00061-4","article-title":"Neuroprotective effects of D3 dopamine receptor agonists","volume":"7","author":"Carvey","year":"2001","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.pbb.2013.01.017_bb0020","first-page":"829","article-title":"Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons","volume":"23","author":"Chen","year":"2002","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.pbb.2013.01.017_bb0015","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.febslet.2008.01.028","article-title":"D2\/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways","volume":"582","author":"Chen","year":"2008","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pbb.2013.01.017_bb0025","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1111\/j.1460-9568.2005.04438.x","article-title":"Dopamine D3 receptor\u2010preferring agonists induce neurotrophic effects on mesencephalic dopamine neurons","volume":"22","author":"Du","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pbb.2013.01.017_bb0030","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0091-3057(99)00240-3","article-title":"Effects of ropinirole on various parkinsonian models in mice, rats, and cynomolgus monkeys","volume":"65","author":"Fukuzaki","year":"2000","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2013.01.017_bb0035","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","article-title":"BCL-2 family members and the mitochondria in apoptosis","volume":"13","author":"Gross","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.pbb.2013.01.017_bb0040","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0006-8993(99)01688-1","article-title":"Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist","volume":"838","author":"Iida","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2013.01.017_bb0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0014-2999(84)90740-4","article-title":"Uptake of MPP+ by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP","volume":"106","author":"Javitch","year":"1984","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2013.01.017_bb0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.coph.2006.11.004","article-title":"Dopamine D3 receptor agonists for protection and repair in Parkinson's disease","volume":"7","author":"Joyce","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.pbb.2013.01.017_bb0055","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0014-4886(03)00353-4","article-title":"Neuroprotective effects of the novel D3\/D2 receptor agonist and antiparkinson agent, S32504, in vitro against 1-methyl-4-phenylpyridinium (MPP+) and in vivo against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a comparison to ropinirole","volume":"184","author":"Joyce","year":"2003","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pbb.2013.01.017_bb0060","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S0007114510000218","article-title":"Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models","volume":"104","author":"Kim","year":"2010","journal-title":"Br J Nutr"},{"key":"10.1016\/j.pbb.2013.01.017_bb0065","doi-asserted-by":"crossref","first-page":"15469","DOI":"10.1074\/jbc.M707238200","article-title":"Differential modulation of Akt\/glycogen synthase kinase-3\u03b2 pathway regulates apoptotic and cytoprotective signaling responses","volume":"283","author":"Nair","year":"2008","journal-title":"J Biol Chem"},{"issue":"283","key":"10.1016\/j.pbb.2013.01.017_bb0100","doi-asserted-by":"crossref","first-page":"15469","DOI":"10.1074\/jbc.M707238200","article-title":"Differential modulation of Akt\/GSK-3\u03b2 pathway regulates apoptotic and cytoprotective signaling responses","volume":"30","author":"Nair","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2013.01.017_bb0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.med.55.091902.104422","article-title":"The scientific basis for the current treatment of Parkinson's disease","volume":"55","author":"Olanow","year":"2004","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.pbb.2013.01.017_bb0080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4062\/biomolther.2010.18.3.235","article-title":"Reviews: mitochondria: the secret chamber of therapeutic targets for age-associated degenerative diseases","volume":"18","author":"Pak","year":"2010","journal-title":"Biomol Ther"},{"key":"10.1016\/j.pbb.2013.01.017_bb0075","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.bbabio.2010.02.001","article-title":"The dopamine-D2-receptor agonist ropinirole dose-dependently blocks the Ca2+-triggered permeability transition of mitochondria","volume":"1797","author":"Parvez","year":"2010","journal-title":"Biochim Biophys Acta Bioenerg"},{"key":"10.1016\/j.pbb.2013.01.017_bb0085","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.expneurol.2004.06.021","article-title":"Involvement of dopamine D2\/D3 receptors and BDNF in the neuroprotective effects of S32504 and pramipexole against 1-methyl-4-phenylpyridinium in terminally differentiated SH-SY5Y cells","volume":"190","author":"Presgraves","year":"2004","journal-title":"Exp Neurol"},{"key":"10.1016\/j.pbb.2013.01.017_bb0090","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0304-3940(87)90543-X","article-title":"Astrocytes convert the parkinsonism inducing neurotoxin, MPTP, to its active metabolite, MPP+","volume":"75","author":"Ransom","year":"1987","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2013.01.017_bb0095","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1056\/NEJM200005183422004","article-title":"A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa","volume":"342","author":"Rascol","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pbb.2013.01.017_bb0105","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1523\/JNEUROSCI.18-20-08145.1998","article-title":"1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2","volume":"18","author":"Yang","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2013.01.017_bb0110","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.neuropharm.2004.02.005","article-title":"Prevention of MPTP (N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax","volume":"46","author":"Youdim","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2013.01.017_bb0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0014-2999(86)90115-9","article-title":"1-Methyl-4-(2\u2032-methylphenyl)-1, 2, 3, 6-tetrahydropyridine (2\u2032-CH3-MPTP) is a more potent dopaminergic neurotoxin than MPTP in mice","volume":"122","author":"Youngster","year":"1986","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2013.01.017_bb0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neulet.2010.03.016","article-title":"Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo","volume":"474","author":"Zhang","year":"2010","journal-title":"Neurosci Lett"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130571300021X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130571300021X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T19:47:35Z","timestamp":1562615255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009130571300021X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":24,"alternative-id":["S009130571300021X"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2013.01.017","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}