{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:32:57Z","timestamp":1784539977036,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NCET Foundation"},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["30725045"],"award-info":[{"award-number":["30725045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"crossref","award":["81072627"],"award-info":[{"award-number":["81072627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Global Research Network for Medicinal Plants (GRNMP)"},{"name":"King Saud University, Shanghai Leading Academic Discipline Project"},{"name":"FP7-PEOPLE-IRSES-2008","award":["230232"],"award-info":[{"award-number":["230232"]}]},{"name":"Key laboratory of drug research for special environments"},{"name":"PLA"},{"name":"Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products","award":["10DZ2251300"],"award-info":[{"award-number":["10DZ2251300"]}]},{"name":"Scientific Foundation of Shanghai China","award":["09DZ1975700"],"award-info":[{"award-number":["09DZ1975700"]}]},{"name":"Scientific Foundation of Shanghai China","award":["09DZ1971500"],"award-info":[{"award-number":["09DZ1971500"]}]},{"name":"Scientific Foundation of Shanghai China","award":["10DZ1971700"],"award-info":[{"award-number":["10DZ1971700"]}]},{"name":"National Major Project of China","award":["2011ZX09307-002-03"],"award-info":[{"award-number":["2011ZX09307-002-03"]}]},{"name":"National Key Technology R&D Program of China","award":["2012BAI29B06"],"award-info":[{"award-number":["2012BAI29B06"]}]},{"name":"Pujiang talent project of Shanghai"},{"DOI":"10.13039\/501100013314","name":"111 Project","doi-asserted-by":"crossref","award":["B07023"],"award-info":[{"award-number":["B07023"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012599","name":"Shanghai Key Laboratory of New Drug Design","doi-asserted-by":"crossref","award":["11DZ2260600"],"award-info":[{"award-number":["11DZ2260600"]}],"id":[{"id":"10.13039\/501100012599","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.pbb.2013.07.007","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T17:30:23Z","timestamp":1373995823000},"page":"224-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system"],"prefix":"10.1016","volume":"110","author":[{"given":"Xiaojun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongcai","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoude","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2013.07.007_bb0005","first-page":"1085","article-title":"The effect of chlorpromazine and Li2CO3 on the superoxide dismutase and glutathione peroxidase activities of rat brain, liver and erythrocytes","volume":"34","author":"Abdalla","year":"1994","journal-title":"Biochem Mol Biol Int"},{"key":"10.1016\/j.pbb.2013.07.007_bb0010","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1073\/pnas.85.13.4934","article-title":"cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties","volume":"85","author":"Bach","year":"1988","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.pbb.2013.07.007_bb0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pbb.2008.10.007","article-title":"Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes","volume":"92","author":"Bhutani","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2013.07.007_bb0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0165-0327(00)00199-3","article-title":"Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments","volume":"64","author":"Bilici","year":"2001","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pbb.2013.07.007_bb0025","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.addr.2008.06.002","article-title":"Monoamine oxidase inactivation: from pathophysiology to therapeutics","volume":"60","author":"Bortolato","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.pbb.2013.07.007_bb0030","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0924-977X(02)00057-3","article-title":"The role of noradrenaline and selective noradrenaline reuptake inhibition in depression","volume":"12","author":"Brunello","year":"2002","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pbb.2013.07.007_bb0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00004714-198706000-00002","article-title":"5-hydroxytryptophan: a review of its antidepressant efficacy and adverse effects","volume":"7","author":"Byerley","year":"1987","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.pbb.2013.07.007_bb0040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0160-5402(78)90018-9","article-title":"A new model for the detection of antidepressant drugs: olfactory bulbectomy in the rat compared with existing models","volume":"1","author":"Cairncross","year":"1978","journal-title":"J Pharmacol Methods"},{"key":"10.1016\/j.pbb.2013.07.007_bb0045","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","article-title":"Purification and characterization of the flavoenzyme glutathione reductase from rat liver","volume":"250","author":"Carlberg","year":"1975","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2013.07.007_bb0050","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0031-9422(01)00275-8","article-title":"Bacopaside I and II: two pseudojujubogenin glycosides from Bacopa monniera","volume":"58","author":"Chakravarty","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.pbb.2013.07.007_bb0055","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1476-5381.1963.tb01302.x","article-title":"A method for assessing the effects of drugs on the central actions of 5-hydroxytryptamine","volume":"20","author":"Corne","year":"1963","journal-title":"Br J Pharmacol Chemother"},{"key":"10.1016\/j.pbb.2013.07.007_bb0060","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.7901908","article-title":"Oxidative stress, glutamate, and neurodegenerative disorders","volume":"262","author":"Coyle","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.pbb.2013.07.007_bb0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0895-3988(08)60002-1","article-title":"In vitro safety evaluation and anticlastogenic effect of BacoMindTM on human lymphocytes","volume":"21","author":"Deb","year":"2008","journal-title":"Biomed Environ Sci"},{"key":"10.1016\/j.pbb.2013.07.007_bb0070","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s11064-007-9289-x","article-title":"Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain","volume":"32","author":"Eren","year":"2007","journal-title":"Neurochem Res"},{"key":"10.1016\/j.pbb.2013.07.007_bb0075","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1124\/jpet.102.045716","article-title":"Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin2C (5-HT2C) receptors in rat prefrontal cortex","volume":"306","author":"Filip","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2013.07.007_bb0080","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.arcmed.2006.10.005","article-title":"Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment","volume":"38","author":"Herken","year":"2007","journal-title":"Arch Med Res"},{"key":"10.1016\/j.pbb.2013.07.007_bb0085","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/mp.2011.50","article-title":"Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice","volume":"17","author":"Jacobsen","year":"2011","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.pbb.2013.07.007_bb0090","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1179\/135100003225003393","article-title":"Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors","volume":"8","author":"Khanzode","year":"2003","journal-title":"Redox Rep"},{"key":"10.1016\/j.pbb.2013.07.007_bb0095","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pbb.2013.07.007_bb0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pbb.2013.07.007_bb0105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01250331","article-title":"Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs","volume":"46","author":"\u00d6gren","year":"1979","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pbb.2013.07.007_bb0120","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.pbb.2013.07.007_bb0115","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(78)90414-4","article-title":"Behavioural despair in rats and mice: strain differences and the effects of imipramine","volume":"51","author":"Porsolt","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2013.07.007_bb0125","series-title":"Animal models in psychopharmacology, advances in pharmacological science","first-page":"137","article-title":"Pharmacological models of depression","author":"Porsolt","year":"1991"},{"key":"10.1016\/j.pbb.2013.07.007_bb0110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF00433508","article-title":"Antagonism of hypothermia and behavioral response to apomorphine: a simple, rapid and discriminating test for screening antidepressants and neuroleptics","volume":"75","author":"Puech","year":"1981","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2013.07.007_bb0130","series-title":"Bioactive molecules and medicinal plants","first-page":"175","article-title":"Bacopa monnieri, a nootropic drug","author":"Rajani","year":"2008"},{"key":"10.1016\/j.pbb.2013.07.007_bb0135","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0024-3205(01)01498-9","article-title":"Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus","volume":"70","author":"Rodrigues","year":"2002","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2013.07.007_bb0140","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1600-0773.1993.tb01345.x","article-title":"Increased striatal lipid peroxidation after intracerebroventricular MPP+administration to mice","volume":"72","author":"Rojas","year":"1993","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.pbb.2013.07.007_bb0145","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuint.2011.05.007","article-title":"Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress","volume":"59","author":"Rojas","year":"2011","journal-title":"Neurochem Int"},{"key":"10.1016\/j.pbb.2013.07.007_bb0150","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.phymed.2003.12.008","article-title":"Bacopa monniera, a reputed nootropic plant: an overview","volume":"12","author":"Russo","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.pbb.2013.07.007_bb0155","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.neuro.22.1.197","article-title":"Monoamine oxidase: from genes to behavior","volume":"22","author":"Shih","year":"1999","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.pbb.2013.07.007_bb0160","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/1523-1747.ep12371744","article-title":"Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin","volume":"102","author":"Shindo","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.pbb.2013.07.007_bb0165","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.clinthera.2009.07.002","volume":"31","author":"Skaer","year":"2009","journal-title":"Clin Ther"},{"key":"10.1016\/j.pbb.2013.07.007_bb0170","series-title":"Neurotransmitter alterations in PTSD: catecholamines and serotonin","first-page":"242","volume":"4","author":"Southwick","year":"1999"},{"key":"10.1016\/j.pbb.2013.07.007_bb0180","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1365\/s10337-004-0302-0","article-title":"A rapid densitometric method for the quantification of luteolin in medicinal plants using HPTLC","volume":"60","author":"Srinivasa","year":"2004","journal-title":"Chromatographia"},{"key":"10.1016\/j.pbb.2013.07.007_bb0175","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2013.07.007_bb0185","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-8993(75)90276-0","article-title":"Inhibition of both noradrenergic and serotonergic neurons in brain by the \u03b1-adrenergic agonist clonidine","volume":"92","author":"Svensson","year":"1975","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2013.07.007_bb0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jad.2006.06.021","article-title":"The evidence base of complementary and alternative therapies in depression","volume":"97","author":"Thachil","year":"2007","journal-title":"J Affect Disord"},{"key":"10.1016\/j.pbb.2013.07.007_bb0195","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1192\/bjp.178.3.234","article-title":"Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors","volume":"178","author":"Thasa","year":"2001","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.pbb.2013.07.007_bb9000","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/35072566","article-title":"Research and treatment approaches to depression","volume":"2","author":"Wong","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pbb.2013.07.007_bb0200","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pbb.2005.08.009","article-title":"Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats","volume":"82","author":"Xu","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2013.07.007_bb0205","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejphar.2005.06.002","article-title":"The effects of curcumin on depressive-like behaviors in mice","volume":"518","author":"Xu","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2013.07.007_bb0210","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.euroneuro.2010.02.013","article-title":"Antidepressant-like effect of trans-resveratrol: involvement of serotonin and noradrenaline system","volume":"20","author":"Xu","year":"2010","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.pbb.2013.07.007_bb0215","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/sj.bjp.0704240","article-title":"Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice","volume":"134","author":"Yacoubi","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2013.07.007_bb0220","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0028-3908(80)90047-7","article-title":"Analgesia and ptosis caused by caerulein and cholecystokinin octapeptide (CCK-8)","volume":"19","author":"Zetler","year":"1980","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2013.07.007_bb0225","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1021\/np060470s","article-title":"Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models","volume":"70","author":"Zhou","year":"2007","journal-title":"J Nat Prod"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305713001755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305713001755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T10:25:35Z","timestamp":1646130335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305713001755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":46,"alternative-id":["S0091305713001755"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2013.07.007","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antidepressant-like effect of bacopaside I: Possible involvement of the oxidative stress system and the noradrenergic system","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2013.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}