{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:58:30Z","timestamp":1772121510266,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.pbb.2014.03.018","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T10:47:26Z","timestamp":1396262846000},"page":"82-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["3-Methoxynaltrexone is not a selective antagonist for the acute psychomotor stimulating effects of heroin and 6-monoacetylmorphine in mice"],"prefix":"10.1016","volume":"122","author":[{"given":"Guro S\u00f8e","family":"Eriksen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jannike M\u00f8rch","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Boix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rg","family":"M\u00f8rland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2014.03.018_bb0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1124\/jpet.109.152462","article-title":"Increased locomotor activity induced by heroin in mice: pharmacokinetic demonstration of heroin acting as a pro-drug for the mediator, 6-monoacetylmorphine, in vivo","volume":"331","author":"Andersen","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0010","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1124\/jpet.302.1.264","article-title":"Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys","volume":"302","author":"Bowen","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0015","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0022-3565(24)36961-7","article-title":"3H-morphine-6beta-glucuronide binding in brain membranes and an MOR-1-transfected cell line","volume":"282","author":"Brown","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-5793(97)00710-2","article-title":"3-Methoxynaltrexone, a selective heroin\/morphine-6[beta]-glucuronide antagonist","volume":"412","author":"Brown","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pbb.2014.03.018_bb0025","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejphar.2004.03.050","article-title":"Pharmacological characterization of dihydromorphine, 6-acetyldihydromorphine and dihydroheroin analgesia and their differentiation from morphine","volume":"492","author":"Gilbert","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2014.03.018_bb0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vascn.2012.04.009","article-title":"Simultaneous measurement of heroin and its metabolites in brain extracellular fluid by microdialysis and ultra performance liquid chromatography tandem mass spectrometry","volume":"66","author":"Gottas","year":"2012","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.pbb.2014.03.018_bb0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0773.1998.tb01390.x","article-title":"Morphine-6-glucuronide-induced locomotor stimulation in mice: role of opioid receptors","volume":"82","author":"Grung","year":"1998","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.pbb.2014.03.018_bb0040","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0091-3057(02)00925-5","article-title":"Pharmacokinetic differences of morphine and morphine-glucuronides are reflected in locomotor activity","volume":"73","author":"Handal","year":"2002","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.pbb.2014.03.018_bb0045","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0022-3565(25)11333-5","article-title":"Heroin, 6-acetylmorphine and morphine effects on threshold for rewarding and aversive brain stimulation","volume":"260","author":"Hubner","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0050","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/jat\/33.7.345","article-title":"Determination of heroin and its main metabolites in small sample volumes of whole blood and brain tissue by reversed-phase liquid chromatography\u2013tandem mass spectrometry","volume":"33","author":"Karinen","year":"2009","journal-title":"J Anal Toxicol"},{"key":"10.1016\/j.pbb.2014.03.018_bb0055","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0014-2999(02)02821-2","article-title":"14-Methoxymetopon, a very potent mu-opioid receptor-selective analgesic with an unusual pharmacological profile","volume":"459","author":"King","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2014.03.018_bb0060","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10571-006-9101-5","article-title":"Codeine and 6-acetylcodeine analgesia in mice","volume":"26","author":"Milo","year":"2006","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.pbb.2014.03.018_bb0065","doi-asserted-by":"crossref","first-page":"PL163","DOI":"10.1016\/0024-3205(94)00493-5","article-title":"Morphine-6-glucoronide: a potent stimulator of locomotor activity in mice","volume":"55","author":"Morland","year":"1994","journal-title":"Life Sci"},{"key":"10.1016\/j.pbb.2014.03.018_bb0070","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1073\/pnas.0811586106","article-title":"Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions","volume":"106","author":"Pan","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2014.03.018_bb0075","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.neuropharm.2013.03.039","article-title":"Opioids and their receptors: are we there yet?","volume":"76","author":"Pasternak","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2014.03.018_bb0080","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1124\/jpet.103.060962","article-title":"Opioid partial agonist effects of3-O-methylnaltrexone in rhesus monkeys","volume":"308","author":"Platt","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0085","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1124\/jpet.104.082966","article-title":"In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice","volume":"313","author":"Raehal","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1360-0443.2001.9611038.x","article-title":"Incentive-sensitization and addiction","volume":"96","author":"Robinson","year":"2001","journal-title":"Addiction"},{"key":"10.1016\/j.pbb.2014.03.018_bb0095","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/157488406775268219","article-title":"Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature","volume":"1","author":"Rook","year":"2006","journal-title":"Curr Clin Pharmacol"},{"key":"10.1016\/j.pbb.2014.03.018_bb0105","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0014-5793(95)00757-Z","article-title":"Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor","volume":"369","author":"Rossi","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pbb.2014.03.018_bb0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0304-3940(95)11977-5","article-title":"Differential blockade of morphine and morphine-6[beta]-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein [alpha] subunits in rats","volume":"198","author":"Rossi","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2014.03.018_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(96)12976-1","article-title":"Novel receptor mechanisms for heroin and morphine-6 beta-glucuronide analgesia","volume":"216","author":"Rossi","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pbb.2014.03.018_bb0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0022-3565(24)36555-3","article-title":"Antisense mapping of MOR-1 in rats: distinguishing between morphine and morphine-6beta-glucuronide antinociception","volume":"281","author":"Rossi","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/5706","article-title":"Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1","volume":"2","author":"Schuller","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pbb.2014.03.018_bb0125","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0022-3565(25)32685-6","article-title":"Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice","volume":"218","author":"Umans","year":"1981","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(99)00633-0","article-title":"Antagonism of heroin and morphine self-administration in rats by the morphine-6beta-glucuronide antagonist 3-O-methylnaltrexone","volume":"383","author":"Walker","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2014.03.018_bb0135","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1124\/jpet.103.054049","article-title":"Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence","volume":"308","author":"Wang","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pbb.2014.03.018_bb0140","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1037\/0033-295X.94.4.469","article-title":"A psychomotor stimulant theory of addiction","volume":"94","author":"Wise","year":"1987","journal-title":"Psychol Rev"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305714000884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305714000884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T02:26:10Z","timestamp":1746152770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305714000884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":28,"alternative-id":["S0091305714000884"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2014.03.018","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718339462.793493343","asserted-by":"object"}]},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"3-Methoxynaltrexone is not a selective antagonist for the acute psychomotor stimulating effects of heroin and 6-monoacetylmorphine in mice","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2014.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}