{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:45:01Z","timestamp":1790336701485,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.pbb.2014.06.007","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T11:34:02Z","timestamp":1403091242000},"page":"269-277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Cyclic ovarian hormone modulation of supraspinal \u03949-tetrahydrocannabinol-induced antinociception and cannabinoid receptor binding in the female rat"],"prefix":"10.1016","volume":"124","author":[{"given":"Alexa A.","family":"Wakley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha A.","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda K.","family":"Vaughn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4768-2160","authenticated-orcid":false,"given":"Rebecca M.","family":"Craft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.pbb.2014.06.007_bb0005","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s10571-010-9570-4","article-title":"Estradiol inhibits depolarization-evoked exocytosis in PC12 cells via N-type voltage-gated calcium channels","volume":"30","author":"Adams","year":"2010","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"10.1016\/j.pbb.2014.06.007_bb0010","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/hbeh.2002.1835","article-title":"Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats","volume":"42","author":"Asarian","year":"2002","journal-title":"Horm Behav"},{"issue":"4","key":"10.1016\/j.pbb.2014.06.007_bb0015","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1210\/en.2004-1142","article-title":"Strategies and methods for research on sex differences in brain and behavior","volume":"146","author":"Becker","year":"2005","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.pbb.2014.06.007_bb0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/1044-7431(92)90028-Z","article-title":"Estrogenic modulation of delta(9)-tetrahydrocannabinol effects on nigrostriatal dopaminergic activity in the female rat brain","volume":"3","author":"Bonnin","year":"1992","journal-title":"Mol Cell Neurosci"},{"issue":"2\u20133","key":"10.1016\/j.pbb.2014.06.007_bb0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01244868","article-title":"Delta 9-tetrahydrocannabinol affects mesolimbic dopaminergic activity in the female rat brain: interactions with estrogens","volume":"92","author":"Bonnin","year":"1993","journal-title":"J Neural Transm Gen Sect"},{"issue":"2","key":"10.1016\/j.pbb.2014.06.007_bb0030","doi-asserted-by":"crossref","first-page":"R349","DOI":"10.1152\/ajpregu.00933.2005","article-title":"Sex and hormonal cycle differences in rat brain levels of pain-related cannabimimetic lipid mediators","volume":"291","author":"Bradshaw","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.pbb.2014.06.007_bb0035","first-page":"149","article-title":"Cannabinoid receptor binding to membrane homogenates and cannabinoid-stimulated [35S]GTPgammaS binding to membrane homogenates or intact cultured cells","volume":"123","author":"Breivogel","year":"2006","journal-title":"Methods Mol Med"},{"issue":"5\u20136","key":"10.1016\/j.pbb.2014.06.007_bb0040","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/FBP.0b013e3282ee7b7e","article-title":"Sex differences in the effects of delta(9)-tetrahydrocannabinol on spatial learning in adolescent and adult rats","volume":"18","author":"Cha","year":"2007","journal-title":"Behav Pharmacol"},{"issue":"1","key":"10.1016\/j.pbb.2014.06.007_bb0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2007.09.004","article-title":"Gonadal hormone modulation of the behavioral effects of delta(9)-tetrahydrocannabinol in male and female rats","volume":"578","author":"Craft","year":"2008","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.pbb.2014.06.007_bb0050","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1124\/jpet.111.188540","article-title":"4. Sex differences in CB1 vs. CB2 receptor-selective antagonism of antinociception produced by delta-9-THC and CP55,490 in the rat","volume":"340","author":"Craft","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"10.1016\/j.pbb.2014.06.007_bb0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0006-8993(00)02103-X","article-title":"Cerebellar CB(1) receptor mediation of delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse","volume":"864","author":"Dar","year":"2000","journal-title":"Brain Res"},{"issue":"5","key":"10.1016\/j.pbb.2014.06.007_bb0060","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.bjp.0707465","article-title":"Cannabinoid self-administration in rats: sex differences and the influence of ovarian function","volume":"152","author":"Fattore","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2014.06.007_bb0065","series-title":"Neuroendocrinology of Reproduction","first-page":"279","article-title":"Estrous cyclicity in mammals","author":"Feder","year":"1981"},{"key":"10.1016\/j.pbb.2014.06.007_bb0070","series-title":"The Physiology of Reproduction","first-page":"1893","article-title":"The ovarian cycle of the rat","author":"Freeman","year":"1988"},{"issue":"1","key":"10.1016\/j.pbb.2014.06.007_bb0075","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/bbrc.2000.2406","article-title":"Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland","volume":"270","author":"Gonz\u00e1lez","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.pbb.2014.06.007_bb0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00426547","article-title":"Delta9-tetrahydrocannabinol and the extrapyramidal system","volume":"54","author":"Gough","year":"1977","journal-title":"Psychopharmacologia"},{"issue":"10","key":"10.1016\/j.pbb.2014.06.007_bb0085","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/BF03348201","article-title":"Serum levels of sex hormones and corticosterone throughout 4- and 5-day estrous cycles in Fischer 344 rats and their simulation in ovariectomized females","volume":"26","author":"Haim","year":"2003","journal-title":"J Endocrinol Invest"},{"issue":"1\u20133","key":"10.1016\/j.pbb.2014.06.007_bb0090","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejphar.2008.02.055","article-title":"Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice","volume":"586","author":"Kalbasi Anaraki","year":"2008","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"10.1016\/j.pbb.2014.06.007_bb0095","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1046\/j.1471-4159.1999.0722379.x","article-title":"Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP\/GTP exchange","volume":"72","author":"Kearn","year":"1999","journal-title":"J Neurochem"},{"issue":"6","key":"10.1016\/j.pbb.2014.06.007_bb0100","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0091-3057(77)90250-7","article-title":"GABA stimulation and blockade in the hypothalamus and midbrain: effects on feeding and locomotor activity","volume":"7","author":"Kelly","year":"1977","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"10.1016\/j.pbb.2014.06.007_bb0105","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00008877-200605000-00007","article-title":"Role of ventral tegmental area, periaqueductal gray and parabrachial nucleus in the discriminative stimulus effects of morphine in the rat","volume":"17","author":"Krivsky","year":"2006","journal-title":"Behav Pharmacol"},{"issue":"17","key":"10.1016\/j.pbb.2014.06.007_bb0110","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0024-3205(01)01534-X","article-title":"17Beta-estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism","volume":"70","author":"Lee","year":"2002","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.pbb.2014.06.007_bb0115","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0022-3565(25)12310-0","article-title":"Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement","volume":"276","author":"Lichtman","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"issue":"23\u201324","key":"10.1016\/j.pbb.2014.06.007_bb0125","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/0024-3205(95)00195-C","article-title":"An examination of the central sites of action of cannabinoid-induced antinociception in the rat","volume":"56","author":"Martin","year":"1995","journal-title":"Life Sci"},{"issue":"1\u20132","key":"10.1016\/j.pbb.2014.06.007_bb0120","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0006-8993(98)01368-7","article-title":"Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections","volume":"822","author":"Martin","year":"1999","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.pbb.2014.06.007_bb0130","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0006-8993(00)01998-3","article-title":"Acute and long-term effects of 17beta-estradiol on G(i\/o) coupled neurotransmitter receptor function in the female rat brain as assessed by agonist-stimulated [35S]GTPgammaS binding","volume":"859","author":"Mize","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2014.06.007_bb0135","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011"},{"issue":"2","key":"10.1016\/j.pbb.2014.06.007_bb0140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000096996","article-title":"Estrogen differentially modulates the cannabinoid-induced presynaptic inhibition of amino acid neurotransmission in proopiomelanocortin neurons of the arcuate nucleus","volume":"84","author":"Nguyen","year":"2006","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.pbb.2014.06.007_bb0145","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"issue":"8","key":"10.1016\/j.pbb.2014.06.007_bb0150","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.psyneuen.2010.02.008","article-title":"Estrogenic regulation of limbic cannabinoid receptor binding","volume":"35","author":"Riebe","year":"2010","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"10.1016\/j.pbb.2014.06.007_bb0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0024-3205(94)00585-0","article-title":"Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement","volume":"54","author":"Rodriguez De Fonseca","year":"1994","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.pbb.2014.06.007_bb0160","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-3806(02)00306-1","article-title":"Antinociceptive, behavioural and neuroendocrine effects of CP 55,940 in young rats","volume":"136","author":"Romero","year":"2002","journal-title":"Brain Res Dev Brain Res"},{"issue":"1","key":"10.1016\/j.pbb.2014.06.007_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/syn.20088","article-title":"Dose and behavioral context dependent inhibition of movement and basal ganglia neural activity by delta-9-tetrahydrocannabinol during spontaneous and treadmill locomotion tasks in rats","volume":"55","author":"Shi","year":"2005","journal-title":"Synapse"},{"issue":"1\u20132","key":"10.1016\/j.pbb.2014.06.007_bb0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0006-8993(92)90222-U","article-title":"Spinal mechanisms of delta 9-tetrahydrocannabinol-induced analgesia","volume":"578","author":"Smith","year":"1992","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.pbb.2014.06.007_bb0170","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1210\/endo-96-1-219","article-title":"The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy","volume":"96","author":"Smith","year":"1975","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.pbb.2014.06.007_bb0180","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/s0304-3959(02)00457-8","article-title":"Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats","volume":"103","author":"Stoffel","year":"2003","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.pbb.2014.06.007_bb0185","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0014-2999(01)01267-5","article-title":"Sex differences in antinociceptive and motoric effects of cannabinoids","volume":"430","author":"Tseng","year":"2001","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.pbb.2014.06.007_bb0190","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0026-895X(24)23200-4","article-title":"Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro","volume":"57","author":"Vaughan","year":"2000","journal-title":"Mol Pharmacol"},{"issue":"1","key":"10.1016\/j.pbb.2014.06.007_bb0195","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbr.2010.07.037","article-title":"Antinociception and sedation following intracerebroventricular administration of \u03949-tetrahydrocannabinol in female vs. male rats","volume":"216","author":"Wakley","year":"2011","journal-title":"Behav Brain Res"},{"issue":"7","key":"10.1016\/j.pbb.2014.06.007_bb0200","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.neuropharm.2008.07.026","article-title":"Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats","volume":"55","author":"Wiley","year":"2008","journal-title":"Neuropharmacology"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305714001774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305714001774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T11:10:06Z","timestamp":1746270606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305714001774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":40,"alternative-id":["S0091305714001774"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2014.06.007","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclic ovarian hormone modulation of supraspinal \u03949-tetrahydrocannabinol-induced antinociception and cannabinoid receptor binding in the female rat","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2014.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}