{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:03:09Z","timestamp":1792206189681,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31121061"],"award-info":[{"award-number":["31121061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171010"],"award-info":[{"award-number":["31171010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171049"],"award-info":[{"award-number":["31171049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271164"],"award-info":[{"award-number":["31271164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81420108015"],"award-info":[{"award-number":["81420108015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["J1210041"],"award-info":[{"award-number":["J1210041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["10FX041"],"award-info":[{"award-number":["10FX041"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20110071110033"],"award-info":[{"award-number":["20110071110033"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["ZDSYS14005"],"award-info":[{"award-number":["ZDSYS14005"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["13140903100"],"award-info":[{"award-number":["13140903100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["13dz2260700"],"award-info":[{"award-number":["13dz2260700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["14JC1400900"],"award-info":[{"award-number":["14JC1400900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012150","name":"Shanghai Leading Academic Discipline Project","doi-asserted-by":"publisher","award":["B119"],"award-info":[{"award-number":["B119"]}],"id":[{"id":"10.13039\/501100012150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2009ZX09303-006"],"award-info":[{"award-number":["2009ZX09303-006"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2011CB711000"],"award-info":[{"award-number":["2011CB711000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2015CB856401"],"award-info":[{"award-number":["2015CB856401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.pbb.2014.12.002","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T15:00:22Z","timestamp":1418310022000},"page":"56-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Doxepin and diphenhydramine increased non-rapid eye movement sleep through blockade of histamine H1 receptors"],"prefix":"10.1016","volume":"129","author":[{"given":"Yi-Qun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohko","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Urade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Min","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2014.12.002_bb0005","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0306-4522(88)90167-4","article-title":"A detailed mapping of histamine H1-receptors in guinea-pig central nervous system established by autoradiography with [125I]iodobolpyramine","volume":"26","author":"Bouthenet","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2014.12.002_bb0010","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0006-2952(95)02123-X","article-title":"Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells","volume":"51","author":"Burde","year":"1996","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0015","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neures.2004.05.001","article-title":"Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats","volume":"49","author":"Chu","year":"2004","journal-title":"Neurosci Res"},{"key":"10.1016\/j.pbb.2014.12.002_bb0020","series-title":"The mouse brain in stereotaxic coordinates","author":"Franklin","year":"1997"},{"key":"10.1016\/j.pbb.2014.12.002_bb0025","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1517\/14656560903005587","article-title":"Low-dose doxepin for the treatment of insomnia: emerging data","volume":"10","author":"Goforth","year":"2009","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.pbb.2014.12.002_bb0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2008.06.099","article-title":"MDMA treatment 6months earlier attenuates the effects of CP-94,253, a 5-HT1B receptor agonist, on motor control but not sleep inhibition","volume":"1231","author":"Gyongyosi","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2014.12.002_bb0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrn1034","article-title":"The role of histamine and the tuberomamillary nucleus in the nervous system","volume":"4","author":"Haas","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.pbb.2014.12.002_bb0040","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4088\/JCP.v62n0609","article-title":"Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study","volume":"62","author":"Hajak","year":"2001","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.pbb.2014.12.002_bb0055","doi-asserted-by":"crossref","first-page":"9965","DOI":"10.1073\/pnas.181330998","article-title":"Arousal effect of orexin A depends on activation of the histaminergic system","volume":"98","author":"Huang","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2014.12.002_bb0060","doi-asserted-by":"crossref","first-page":"5975","DOI":"10.1523\/JNEUROSCI.23-14-05975.2003","article-title":"Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats","volume":"23","author":"Huang","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2014.12.002_bb0050","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nn1491","article-title":"Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine","volume":"8","author":"Huang","year":"2005","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.pbb.2014.12.002_bb0045","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1073\/pnas.0600451103","article-title":"Altered sleep\u2013wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice","volume":"103","author":"Huang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2014.12.002_bb0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1476-5381.2011.01547.x","article-title":"Induction of prolonged, continuous slow-wave sleep by blocking cerebral H(1) histamine receptors in rats","volume":"165","author":"Ikeda-Sagara","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0070","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/cne.902730302","article-title":"Organization of histaminergic fibers in the rat brain","volume":"273","author":"Inagaki","year":"1988","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0075","doi-asserted-by":"crossref","first-page":"13316","DOI":"10.1073\/pnas.93.23.13316","article-title":"Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors","volume":"93","author":"Inoue","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pbb.2014.12.002_bb0080","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.smrv.2008.08.001","article-title":"A compendium of placebo-controlled trials of the risks\/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice","volume":"13","author":"Krystal","year":"2009","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.pbb.2014.12.002_bb0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.smrv.2012.08.001","article-title":"Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications","volume":"17","author":"Krystal","year":"2013","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.pbb.2014.12.002_bb0090","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0021-5198(19)43508-7","article-title":"Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay","volume":"43","author":"Kubo","year":"1987","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0095","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/j.1552-4604.1990.tb03592.x","article-title":"Clinical evaluation of diphenhydramine hydrochloride for the treatment of insomnia in psychiatric patients: a double-blind study","volume":"30","author":"Kudo","year":"1990","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0028-3908(88)90159-1","article-title":"Evidence for histaminergic arousal mechanisms in the hypothalamus of cat","volume":"27","author":"Lin","year":"1988","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2014.12.002_bb0105","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(90)91508-E","article-title":"Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat","volume":"523","author":"Lin","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2014.12.002_bb0110","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1755-5949.2012.00334.x","article-title":"Safranal enhances non-rapid eye movement sleep in pentobarbital-treated mice","volume":"18","author":"Liu","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.pbb.2014.12.002_bb0115","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0006-8993(90)91240-H","article-title":"Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates","volume":"526","author":"Martinez-Mir","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2014.12.002_bb0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1358\/dot.2010.46.3.1437247","article-title":"Serotonin 5-HT(2A) receptor antagonists in the treatment of insomnia: present status and future prospects","volume":"46","author":"Monti","year":"2010","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.pbb.2014.12.002_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01262953","article-title":"Effects of H1- and H2-histamine receptor agonists and antagonists on sleep and wakefulness in the rat","volume":"66","author":"Monti","year":"1986","journal-title":"J Neural Transm"},{"key":"10.1016\/j.pbb.2014.12.002_bb0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejphar.2004.11.006","article-title":"Comparative anticholinergic activities of 10 histamine H1 receptor antagonists in two functional models","volume":"506","author":"Orzechowski","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0306-4522(81)90240-2","article-title":"The distribution of histamine H1-receptors in the rat brain: an autoradiographic study","volume":"6","author":"Palacios","year":"1981","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2014.12.002_bb0145","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00167449","article-title":"Modulation by dopamine receptors of the histamine release in the rat hypothalamus","volume":"347","author":"Prast","year":"1993","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0140","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF00169363","article-title":"In vivo modulation of histamine release by autoreceptors and muscarinic acetylcholine receptors in the rat anterior hypothalamus","volume":"350","author":"Prast","year":"1994","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0150","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1523\/JNEUROSCI.4936-09.2010","article-title":"Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice","volume":"30","author":"Qu","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.pbb.2014.12.002_bb0155","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1476-5381.2012.02010.x","article-title":"Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice","volume":"167","author":"Qu","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0160","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1476-5381.1948.tb00371.x","article-title":"Comparisons of various histamine antagonists","volume":"3","author":"Reuse","year":"1948","journal-title":"Br J Pharmacol Chemother"},{"key":"10.1016\/j.pbb.2014.12.002_bb0165","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/j.1552-4604.1983.tb02730.x","article-title":"Diphenhydramine in insomniac family practice patients: a double-blind study","volume":"23","author":"Rickels","year":"1983","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0170","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00213-003-1565-0","article-title":"The sleep-improving effects of doxepin are paralleled by a normalized plasma cortisol secretion in primary insomnia","volume":"170","author":"Rodenbeck","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2014.12.002_bb0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainres.2005.07.040","article-title":"Histamine H1 antagonists block M-currents in dissociated rat cortical neurons","volume":"1057","author":"Sato","year":"2005","journal-title":"Brain Res"},{"key":"10.1016\/j.pbb.2014.12.002_bb0180","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5664\/jcsm.27286","article-title":"Clinical guideline for the evaluation and management of chronic insomnia in adults","volume":"4","author":"Schutte-Rodin","year":"2008","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.pbb.2014.12.002_bb0185","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejphar.2004.05.010","article-title":"Effects of second-generation histamine H1 receptor antagonists on the sleep\u2013wakefulness cycle in rats","volume":"494","author":"Shigemoto","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0190","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1017\/S1092852900017089","article-title":"Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines","volume":"13","author":"Stahl","year":"2008","journal-title":"CNS Spectr"},{"key":"10.1016\/j.pbb.2014.12.002_bb0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0165-6147(99)01437-6","article-title":"Cardiotoxic potential and CNS effects of first-generation antihistamines","volume":"21","author":"Taglialatela","year":"2000","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pbb.2014.12.002_bb0200","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.smrv.2010.06.004","article-title":"Histamine in the regulation of wakefulness","volume":"15","author":"Thakkar","year":"2011","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.pbb.2014.12.002_bb0205","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1254\/jphs.FP0061173","article-title":"Effects of some H1-antagonists on the sleep\u2013wake cycle in sleep-disturbed rats","volume":"103","author":"Tokunaga","year":"2007","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.pbb.2014.12.002_bb0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1248\/bpb.32.51","article-title":"Effects of histamine H1-antagonists on sleep\u2013awake state in rats placed on a grid suspended over water or on sawdust","volume":"32","author":"Tokunaga","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.pbb.2014.12.002_bb0215","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ejphar.2012.03.017","article-title":"First and second generation H(1) histamine receptor antagonists produce different sleep-inducing profiles in rats","volume":"683","author":"Unno","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pbb.2014.12.002_bb0220","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0166-4328(03)00091-3","article-title":"Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats","volume":"144","author":"Vanni-Mercier","year":"2003","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.pbb.2014.12.002_bb0225","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrd2464","article-title":"Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time","volume":"7","author":"Wafford","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.pbb.2014.12.002_bb0230","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1471-4159.2011.07558.x","article-title":"Acute administration of fluoxetine normalizes rapid eye movement sleep abnormality, but not depressive behaviors in olfactory bulbectomized rats","volume":"120","author":"Wang","year":"2012","journal-title":"J Neurochem"},{"key":"10.1016\/j.pbb.2014.12.002_bb0235","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2165\/11200810-000000000-00000","article-title":"Low-dose doxepin: in the treatment of insomnia","volume":"24","author":"Weber","year":"2010","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pbb.2014.12.002_bb0240","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0006-291X(91)90673-U","article-title":"Biochemical characterization of histamine H1 receptors in bovine adrenal medulla","volume":"177","author":"Yamashita","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pbb.2014.12.002_bb0245","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1479-8425.2010.00484.x","article-title":"Selection of optimal epoch duration in assessment of rodent sleep\u2013wake profiles","volume":"9","author":"Yan","year":"2011","journal-title":"Sleep Biol Rhythms"},{"key":"10.1016\/j.pbb.2014.12.002_bb0250","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0304-3940(92)90390-S","article-title":"Histamine H1 receptors in human brain visualized in vivo by [11C]doxepin and positron emission tomography","volume":"137","author":"Yanai","year":"1992","journal-title":"Neurosci Lett"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305714003402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305714003402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:32:50Z","timestamp":1758774770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305714003402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":50,"alternative-id":["S0091305714003402"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2014.12.002","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doxepin and diphenhydramine increased non-rapid eye movement sleep through blockade of histamine H1 receptors","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2014.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}