{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:08:13Z","timestamp":1784804893650,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.pbb.2016.02.010","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T03:09:04Z","timestamp":1456369744000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Baclofen blocks yohimbine-induced increases in ethanol-reinforced responding in rats"],"prefix":"10.1016","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-0491","authenticated-orcid":false,"given":"Keith L.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa M.","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Bielak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2016.02.010_bb0005","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.2174\/138161210791516440","article-title":"Safety and efficacy of baclofen in the treatment of alcohol-dependent patients","volume":"16","author":"Addolorato","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.pbb.2016.02.010_bb0010","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1530-0277.2003.tb04414.x","article-title":"Effect of baclofen on alcohol and sucrose self-administration in rats","volume":"27","author":"Anstrom","year":"2003","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2016.02.010_bb0015","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1007\/s00213-014-3605-3","article-title":"Wistar rats acquire and maintain self-administration of 20% ethanol without water deprivation, saccharin\/sucrose fading, or extended access training","volume":"231","author":"Augier","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.coph.2008.12.014","article-title":"Dissecting components of reward: \u2018liking\u2019, \u2018wanting\u2019, and learning","volume":"9","author":"Berridge","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.pbb.2016.02.010_bb0025","first-page":"99","article-title":"Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review","volume":"5","author":"Brennan","year":"2013","journal-title":"Clin. Pharmacol."},{"key":"10.1016\/j.pbb.2016.02.010_bb0030","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1111\/j.1530-0277.2006.00155.x","article-title":"Standardization of alcohol calculations in research","volume":"30","author":"Brick","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2016.02.010_bb0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuropharm.2015.02.005","article-title":"Pharmacological stress is required for the anti-alcohol effect of the alpha3beta4* nAChR partial agonist AT-1001","volume":"93","author":"Cippitelli","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0040","first-page":"58","article-title":"Ability of baclofen in reducing alcohol intake and withdrawal severity: I\u2013preclinical evidence","volume":"24","author":"Colombo","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2016.02.010_bb0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0376-8716(02)00333-2","article-title":"Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats","volume":"70","author":"Colombo","year":"2003","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.pbb.2016.02.010_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00213-003-1397-y","article-title":"Baclofen suppresses motivation to consume alcohol in rats","volume":"167","author":"Colombo","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0055","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0741-8329(87)90087-5","article-title":"GABA transmission, but not benzodiazepine receptor stimulation, modulates ethanol intake by rats","volume":"4","author":"Daoust","year":"1987","journal-title":"Alcohol"},{"key":"10.1016\/j.pbb.2016.02.010_bb0060","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.physbeh.2014.02.019","article-title":"Effect of recurrent yohimbine on immediate and post-hoc behaviors, stress hormones, and energy homeostatic parameters","volume":"129","author":"Figlewicz","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.pbb.2016.02.010_bb0065","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1038\/sj.npp.1300964","article-title":"The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors","volume":"31","author":"Ghitza","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0070","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/08897077.2012.663326","article-title":"Is baclofen a revolutionary medication in alcohol addiction management? Review and recent updates","volume":"33","author":"Gorsane","year":"2012","journal-title":"Subst. abus."},{"key":"10.1016\/j.pbb.2016.02.010_bb0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0165-1781(97)00041-3","article-title":"Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls","volume":"71","author":"Gurguis","year":"1997","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.pbb.2016.02.010_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0741-8329(03)00068-5","article-title":"Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose","volume":"30","author":"Janak","year":"2003","journal-title":"Alcohol"},{"key":"10.1016\/j.pbb.2016.02.010_bb0085","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s002130050285","article-title":"Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-chlorophenylpiperazine (mCPP)","volume":"131","author":"Krystal","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0090","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.pbb.2008.08.026","article-title":"Effects of repeated yohimbine on the extinction and reinstatement of cocaine seeking","volume":"91","author":"Kupferschmidt","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pbb.2016.02.010_bb0095","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s00213-004-2036-y","article-title":"Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats","volume":"179","author":"Le","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fpsyt.2013.00148","article-title":"Increased ethanol consumption following chronic psychosocial stress: Do Oxytocin and baclofen hold any therapeutic promise?","volume":"4","author":"Lee","year":"2013","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.pbb.2016.02.010_bb0105","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00213-014-3838-1","article-title":"Enhanced motivation for food reward induced by stress and attenuation by corticotrophin-releasing factor receptor antagonism in rats: Implications for overeating and obesity","volume":"232","author":"Liu","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0110","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.neuropharm.2011.07.007","article-title":"Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder","volume":"62","author":"Logrip","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0115","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuroscience.2014.06.053","article-title":"Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction","volume":"277","author":"Lu","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2016.02.010_bb0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.alcohol.2005.08.003","article-title":"Baclofen-induced reduction of alcohol reinforcement in alcohol-preferring rats","volume":"36","author":"Maccioni","year":"2005","journal-title":"Alcohol"},{"key":"10.1016\/j.pbb.2016.02.010_bb0125","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.drugalcdep.2008.02.006","article-title":"Baclofen attenuates cue-induced reinstatement of alcohol-seeking behavior in Sardinian alcohol-preferring (sP) rats","volume":"95","author":"Maccioni","year":"2008","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.pbb.2016.02.010_bb0130","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1111\/j.1530-0277.2012.01782.x","article-title":"Comparison of the effect of the GABABeta receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats","volume":"36","author":"Maccioni","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2016.02.010_bb0135","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00213-014-3815-8","article-title":"Inhibition of alcohol self-administration by positive allosteric modulators of the GABAB receptor in rats: lack of tolerance and potentiation of baclofen","volume":"232","author":"Maccioni","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF02244907","article-title":"Animal models of drug craving","volume":"112","author":"Markou","year":"1993","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0145","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/HRP.0000000000000058","article-title":"Treatment of co-occurring anxiety disorders and substance use disorders","volume":"23","author":"McHugh","year":"2015","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.pbb.2016.02.010_bb0150","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/alcalc\/agu062","article-title":"Baclofen for the treatment of alcohol dependence and possible role of comorbid anxiety","volume":"49","author":"Morley","year":"2014","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.pbb.2016.02.010_bb0155","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.euroneuro.2015.04.002","article-title":"High-dose baclofen for the treatment of alcohol dependence (BACLAD study): a randomized, placebo-controlled trial","volume":"25","author":"Muller","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.pbb.2016.02.010_bb0160","series-title":"Guide for the care and use of laboratory animals","author":"National Research Council","year":"2011"},{"key":"10.1016\/j.pbb.2016.02.010_bb0165","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jsat.2014.11.007","article-title":"Baclofen as add-on to standard psychosocial treatment for alcohol dependence: a randomized, double-blind, placebo-controlled trial with 1year follow-up","volume":"52","author":"Ponizovsky","year":"2015","journal-title":"J. Subst. abus. Treat."},{"key":"10.1016\/j.pbb.2016.02.010_bb0170","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1007\/s00213-014-3529-y","article-title":"Impaired flexibility in decision making in rats after administration of the pharmacological stressor yohimbine","volume":"231","author":"Schwager","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0175","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.biopsych.2004.02.032","article-title":"The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse","volume":"55","author":"Shepard","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pbb.2016.02.010_bb0180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00213-011-2451-9","article-title":"Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in long-Evans rats by the alpha-2 adrenoreceptor antagonist yohimbine","volume":"218","author":"Simms","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0185","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00213-013-3292-5","article-title":"Vendor differences in alcohol consumption and the contribution of dopamine receptors to Pavlovian-conditioned alcohol-seeking in long-Evans rats","volume":"231","author":"Sparks","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2016.02.010_bb0190","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.physbeh.2015.01.027","article-title":"Adolescent alcohol exposure: are there separable vulnerable periods within adolescence?","volume":"148","author":"Spear","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.pbb.2016.02.010_bb0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2014.04.012","article-title":"Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: a mini-review","volume":"45","author":"Spear","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pbb.2016.02.010_bb0200","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0006-3223(01)01292-6","article-title":"Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients","volume":"51","author":"Stine","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pbb.2016.02.010_bb0205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1530-0277.2006.00259.x","article-title":"The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats","volume":"31","author":"Walker","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2016.02.010_bb0210","series-title":"Actions of Alcohol: I. Biochemical, Physiological, and Psychological Aspects","author":"Wallgren","year":"1970"},{"key":"10.1016\/j.pbb.2016.02.010_bb0215","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neulet.2015.09.008","article-title":"Yohimbine is a 5-HT1A agonist in rats in doses exceeding 1mg\/kg","volume":"606","author":"Zaretsky","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pbb.2016.02.010_bb0220","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.yfrne.2014.01.001","article-title":"Corticotropin releasing factor: a key role in the neurobiology of addiction","volume":"35","author":"Zorrilla","year":"2014","journal-title":"Front. Neuroendocrinol."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305716300223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305716300223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T19:57:16Z","timestamp":1567627036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305716300223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":44,"alternative-id":["S0091305716300223"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2016.02.010","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baclofen blocks yohimbine-induced increases in ethanol-reinforced responding in rats","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2016.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}