{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:25:57Z","timestamp":1790623557921,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Avanir Pharmaceuticals, Inc."},{"DOI":"10.13039\/100009455","name":"West Virginia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009455","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.pbb.2017.09.005","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T11:48:23Z","timestamp":1505216903000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Deuterated (d6)-dextromethorphan elicits antidepressant-like effects in mice"],"prefix":"10.1016","volume":"161","author":[{"given":"Linda","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Scandinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-1268","authenticated-orcid":false,"given":"Rae R.","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.pbb.2017.09.005_bb0005","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.biopsych.2012.05.003","article-title":"Ketamine for depression: where do we go from here?","volume":"72","author":"Aan Het Rot","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pbb.2017.09.005_bb0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev-med-053013-062946","article-title":"Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics","volume":"66","author":"Abdallah","year":"2015","journal-title":"Ann Rev Med"},{"key":"10.1016\/j.pbb.2017.09.005_bb0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.brainres.2015.01.001","article-title":"Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action","volume":"1601","author":"Andreasen","year":"2015","journal-title":"Brain Res."},{"issue":"7354","key":"10.1016\/j.pbb.2017.09.005_bb0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.pbb.2017.09.005_bb0025","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/sj.bjp.0704294","article-title":"Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands","volume":"134","author":"Bermack","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.pbb.2017.09.005_bb0030","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","article-title":"Antidepressant effects of ketamine in depressed patients","volume":"47","author":"Berman","year":"2000","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.pbb.2017.09.005_bb0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrn1846","article-title":"New approaches to antidepressant drug discovery: beyond monoamines","volume":"7","author":"Berton","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.pbb.2017.09.005_bb0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/187152707780363258","article-title":"AMPA receptors in the therapeutic management of depression","volume":"6","author":"Bleakman","year":"2007","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"1\u20133","key":"10.1016\/j.pbb.2017.09.005_bb0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejphar.2006.09.038","article-title":"Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors","volume":"553","author":"Brammer","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.pbb.2017.09.005_bb0050","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1001\/archpedi.160.12.1217","article-title":"Dextromethorphan abuse in adolescence: an increasing trend: 1999-2004","volume":"160","author":"Bryner","year":"2006","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.pbb.2017.09.005_bb0055","first-page":"75","article-title":"Antitussives and substance abuse","volume":"4","author":"Burns","year":"2013","journal-title":"Subst. Abuse Rehabil."},{"key":"10.1016\/j.pbb.2017.09.005_bb0060","first-page":"e3769","article-title":"The tail suspension test","volume":"59","author":"Can","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.pbb.2017.09.005_bb0510","first-page":"5","article-title":"Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice","author":"Castagn\u00e9","year":"2010","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.pbb.2017.09.005_bb0065","author":"ClinicalTrials.gov [Internet]"},{"issue":"3","key":"10.1016\/j.pbb.2017.09.005_bb0070","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0022-3565(25)10630-7","article-title":"Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception","volume":"274","author":"Codd","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"9","key":"10.1016\/j.pbb.2017.09.005_bb0075","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd1825","article-title":"The ascent of mouse: advances in modelling human depression and anxiety","volume":"4","author":"Cryan","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4\u20135","key":"10.1016\/j.pbb.2017.09.005_bb0080","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.pbb.2017.09.005_bb0085","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0090-9556(25)08371-0","article-title":"Pharmacokinetics of the neuroprotective glutamate antagonist NBQX (6-nitro-7-sulfamoyl-benzo(f)quinoxaline-2,3,-dione) in mice, rats, and dogs. Interactions with probenecid","volume":"22","author":"Dalgaard","year":"1994","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.pbb.2017.09.005_bb0090","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0022-3565(25)26687-3","article-title":"Species differences in the metabolism of imipramine and desmethylimipramine (DMI)","volume":"143","author":"Dingell","year":"1964","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"9","key":"10.1016\/j.pbb.2017.09.005_bb0095","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1017\/S1461145709991076","article-title":"Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm","volume":"13","author":"Farley","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"3","key":"10.1016\/j.pbb.2017.09.005_bb0100","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.pharmthera.2010.04.003","article-title":"Sigma receptors: potential targets for a new class of antidepressant drug","volume":"127","author":"Fishback","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"18","key":"10.1016\/j.pbb.2017.09.005_bb0105","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1007\/s00213-014-3664-5","article-title":"Ketamine administration in depressive disorders: a systematic review and meta-analysis","volume":"231","author":"Fond","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2017.09.005_bb0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neubiorev.2015.03.005","article-title":"The role of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in depression: central mediators of pathophysiology and antidepressant activity?","volume":"52","author":"Freudenberg","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.pbb.2017.09.005_bb0115","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/npp.2015.233","article-title":"The antidepressant effects of an mGlu2\/3 receptor antagonist and ketamine require AMPA receptor stimulation in the mPFC and subsequent activation of the 5-HT neurons in the DRN","volume":"41","author":"Fukumoto","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"10.1016\/j.pbb.2017.09.005_bb0120","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1021\/jm4007998","article-title":"Using deuterium in drug discovery: leaving the label in the drug","volume":"57","author":"Gant","year":"2014","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.pbb.2017.09.005_bb0125","first-page":"371","article-title":"Serotonin release in nucleus of the solitary tract and its modulation by antitussive drugs","volume":"76","author":"Kamei","year":"1992","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"10.1016\/j.pbb.2017.09.005_bb0130","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jad.2014.05.050","article-title":"The utility of the combination of dextromethorphan and quinidine in the treatment of bipolar II and bipolar NOS","volume":"167","author":"Kelly","year":"2014","journal-title":"J. Affect. Disord."},{"issue":"16","key":"10.1016\/j.pbb.2017.09.005_bb0135","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/S0024-3205(02)02505-5","article-title":"New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice","volume":"72","author":"Kim","year":"2003","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.pbb.2017.09.005_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0014-2999(02)01338-9","article-title":"Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model","volume":"440","author":"Knapp","year":"2002","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.pbb.2017.09.005_bb0145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbr.2011.05.035","article-title":"Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression","volume":"224","author":"Koike","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.pbb.2017.09.005_bb0150","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.mehy.2012.02.012","article-title":"An extension of hypotheses regarding rapid-acting, treatment-refractory, and conventional antidepressant activity of dextromethorphan and dextrorphan","volume":"78","author":"Lauterbach","year":"2012","journal-title":"Med. Hypotheses"},{"issue":"2","key":"10.1016\/j.pbb.2017.09.005_bb0155","first-page":"53","article-title":"Treatment resistant depression with loss of antidepressant response: rapid-acting antidepressant action of dextromethorphan, a possible treatment bridging molecule","volume":"46","author":"Lauterbach","year":"2016","journal-title":"Psychopharmacol. Bull."},{"issue":"8","key":"10.1016\/j.pbb.2017.09.005_bb0160","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0028-3908(00)00194-5","article-title":"Antidepressant-like actions of an AMPA receptor potentiator (LY392098)","volume":"40","author":"Li","year":"2001","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.pbb.2017.09.005_bb0165","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1017\/S1461145708008547","article-title":"Further evidence for an antidepressant potential of the selective sigma1 agonist SA 4503: electrophysiological, morphological and behavioural studies","volume":"11","author":"Lucas","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.pbb.2017.09.005_bb0170","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biopsych.2007.05.028","article-title":"Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors","volume":"63","author":"Maeng","year":"2008","journal-title":"Biol. Psychiatry"},{"issue":"2\u20133","key":"10.1016\/j.pbb.2017.09.005_bb0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0014-2999(01)00968-2","article-title":"Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice","volume":"419","author":"Matsumoto","year":"2001","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.pbb.2017.09.005_bb0180","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.pbb.2006.06.005","article-title":"Animal models of depression in drug discovery: a historical perspective","volume":"84","author":"McArthur","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"3","key":"10.1016\/j.pbb.2017.09.005_bb0185","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-2999(99)00113-2","article-title":"Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity","volume":"370","author":"McCracken","year":"1999","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.pbb.2017.09.005_bb0190","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1017\/S0033291714001603","article-title":"A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes","volume":"45","author":"McGirr","year":"2015","journal-title":"Psychol. Med."},{"issue":"1","key":"10.1016\/j.pbb.2017.09.005_bb0195","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hup.1164","article-title":"Dextromethorphan to dextrorphan: a pathway towards abuse liability","volume":"26","author":"Miller","year":"2011","journal-title":"Hum. Psychopharmacol."},{"issue":"1","key":"10.1016\/j.pbb.2017.09.005_bb0500","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0193-953X(05)70275-6","article-title":"Recovery, chronicity, and levels of psychopathology in major depression","volume":"19","author":"Mueller","year":"1996","journal-title":"Psychiatr. Clin. North. Am."},{"key":"10.1016\/j.pbb.2017.09.005_bb0200","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jad.2017.04.072","article-title":"Dextromethorphan\/quinidine pharmacotherapy in patients with treatment resistant depression: a proof of concept clinical trial","volume":"218","author":"Murrough","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"6","key":"10.1016\/j.pbb.2017.09.005_bb0205","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0006-3223(02)01405-1","article-title":"Preclinical models: status of basic research in depression","volume":"52","author":"Nestler","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pbb.2017.09.005_bb0210","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbr.2015.03.024","article-title":"Involvement of AMPA receptors in the antidepressant-like effects of dextromethorphan in mice","volume":"295","author":"Nguyen","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.pbb.2017.09.005_bb0215","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.neuropharm.2005.04.016","article-title":"Involvement of sigma (s) receptors in the acute actions of methamphetamine: receptor binding and behavioral studies","volume":"49","author":"Nguyen","year":"2005","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.pbb.2017.09.005_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089985","article-title":"Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan","volume":"9","author":"Nguyen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pbb.2017.09.005_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2016.01.016","article-title":"Dextromethorphan: an update on its utility for neurological and neuropsychiatric disorders","volume":"159","author":"Nguyen","year":"2016","journal-title":"Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.pbb.2017.09.005_bb0230","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00702-013-1130-x","article-title":"Glutamate and its receptors in the pathophysiology and treatment of major depressive disorder","volume":"121","author":"Niciu","year":"2013","journal-title":"J. Neural Transm."},{"issue":"5604","key":"10.1016\/j.pbb.2017.09.005_bb0505","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature."},{"issue":"5","key":"10.1016\/j.pbb.2017.09.005_bb0235","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/0269881111431748","article-title":"The hidden third: improving outcome in treatment-resistant depression","volume":"26","author":"Schlaepfer","year":"2012","journal-title":"J. Psychopharmacol."},{"issue":"6","key":"10.1016\/j.pbb.2017.09.005_bb0240","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/clpt.1985.235","article-title":"Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation","volume":"38","author":"Schmid","year":"1985","journal-title":"Clin. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.pbb.2017.09.005_bb0245","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/11599870-000000000-00000","article-title":"Randomized open-label drug-drug interaction trial of dextromethorphan\/quinidine and paroxetine in healthy volunteers","volume":"32","author":"Schoedel","year":"2012","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.pbb.2017.09.005_bb0250","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2147\/NDT.S30713","article-title":"Evaluating the safety and efficacy of dextromethorphan\/quinidine in the treatment of pseudobulbar affect","volume":"10","author":"Schoedel","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"2","key":"10.1016\/j.pbb.2017.09.005_bb0255","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1254\/jphs.11R02CR","article-title":"Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs","volume":"116","author":"Shin","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.pbb.2017.09.005_bb0260","series-title":"Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Application","author":"Stahl","year":"2013"},{"issue":"3","key":"10.1016\/j.pbb.2017.09.005_bb0515","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2017.09.005_bb0265","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pharmthera.2016.04.010","article-title":"Pharmacology of dextromethorphan: relevance to dextromethorphan\/quinidine (Nuedexta\u00ae) clinical use","volume":"164","author":"Taylor","year":"2016","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.pbb.2017.09.005_bb0270","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-134-5-200103060-00007","article-title":"The cost-utility of screening for depression in primary care","volume":"134","author":"Valenstein","year":"2001","journal-title":"Ann. Intern. Med."},{"issue":"10","key":"10.1016\/j.pbb.2017.09.005_bb0275","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.biopsych.2013.04.025","article-title":"Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses","volume":"74","author":"Voleti","year":"2013","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.pbb.2017.09.005_bb0280","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/YIC.0b013e328339fbcf","article-title":"A review of the costs associated with depression and treatment noncompliance: the potential benefits of online support","volume":"25","author":"Wade","year":"2010","journal-title":"Int. Clin. Psychopharmacol."},{"issue":"2","key":"10.1016\/j.pbb.2017.09.005_bb0285","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.expneurol.2007.06.013","article-title":"A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder","volume":"207","author":"Werling","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pbb.2017.09.005_bb0290","series-title":"Depression and Other Common Mental Disorders: Global Health Estimates","author":"World Health Organization","year":"2017"},{"issue":"7604","key":"10.1016\/j.pbb.2017.09.005_bb0295","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites","volume":"533","author":"Zanos","year":"2016","journal-title":"Nature"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305717302824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305717302824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T18:11:47Z","timestamp":1750875107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305717302824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":63,"alternative-id":["S0091305717302824"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2017.09.005","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deuterated (d6)-dextromethorphan elicits antidepressant-like effects in mice","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.pbb.2017.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}