{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T10:32:35Z","timestamp":1774866755182,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"publisher","award":["2017-01322"],"award-info":[{"award-number":["2017-01322"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"publisher","award":["2015-02894"],"award-info":[{"award-number":["2015-02894"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bror Gardelius Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.pbb.2018.09.009","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T02:10:41Z","timestamp":1537927841000},"page":"101-107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Acamprosate's ethanol intake-reducing effect is associated with its ability to increase dopamine"],"prefix":"10.1016","volume":"175","author":[{"given":"PeiPei","family":"Chau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helga H.","family":"Lid\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"S\u00f6derpalm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Ericson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pbb.2018.09.009_bb0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1369-1600.2010.00206.x","article-title":"Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens","volume":"16","author":"Adermark","year":"2011","journal-title":"Addict. Biol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0010","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.coph.2008.12.014","article-title":"Dissecting components of reward: \u2018liking\u2019, \u2018wanting\u2019, and learning","volume":"9","author":"Berridge","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"issue":"6","key":"10.1016\/j.pbb.2018.09.009_bb0015","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1017\/S1461145708008584","article-title":"Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions","volume":"11","author":"Blednov","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-2999(93)90434-J","article-title":"The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine","volume":"249","author":"Blomqvist","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-2999(97)01220-X","article-title":"Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine","volume":"334","author":"Blomqvist","year":"1997","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0091-3057(84)80020-9","article-title":"A homotaurine derivative reduces the voluntary intake of ethanol by rats: are cerebral GABA receptors involved?","volume":"21","author":"Boismare","year":"1984","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.pbb.2018.09.009_bb0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00210-002-0674-3","article-title":"Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study","volume":"367","author":"Cano-Cebri\u00e1n","year":"2003","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1530-0277.2009.01062.x","article-title":"Glycine receptors involved in acamprosate's modulation of accumbal dopamine levels: an in vivo microdialysis study","volume":"34","author":"Chau","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2018.09.009_bb0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1530-0277.2009.01063.x","article-title":"Glycine receptors in the nucleus accumbens involved in the ethanol intake-reducing effect of acamprosate","volume":"34","author":"Chau","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2018.09.009_bb0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/13556210500223132","article-title":"The acute anti-craving effect of acamprosate in alcohol-preferring rats is associated with modulation of the mesolimbic dopamine system","volume":"10","author":"Cowen","year":"2005","journal-title":"Addict. Biol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0055","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1530-0277.2001.tb02220.x","article-title":"Effects of acamprosate on ethanol-seeking and self-administration in the rat","volume":"25","author":"Czachowski","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2018.09.009_bb0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0301-0082(99)00031-3","article-title":"Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate","volume":"60","author":"Dahchour","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0065","first-page":"485","article-title":"Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study","volume":"29","author":"Dahchour","year":"1994","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0006-8993(96)00537-9","article-title":"Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats","volume":"735","author":"Dahchour","year":"1996","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.pbb.2018.09.009_bb0075","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0091-3057(92)90210-7","article-title":"Acamprosate modulates synaptosomal GABA transmission in chronically alcoholised rats","volume":"41","author":"Daoust","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pbb.2018.09.009_bb0080","first-page":"229","article-title":"Acute and chronic alcohol injections increase taurine in the nucleus accumbens","volume":"2","author":"De Witte","year":"1994","journal-title":"Alcohol Alcohol. Suppl."},{"issue":"6","key":"10.1016\/j.pbb.2018.09.009_bb0085","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2165\/00023210-200519060-00004","article-title":"Neuroprotective and abstinence-promoting effects of acamprosate: elucidating the mechanism of action","volume":"19","author":"De Witte","year":"2005","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pbb.2018.09.009_bb0090","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-2999(03)01564-4","article-title":"Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors","volume":"467","author":"Ericson","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0095","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1111\/j.1460-9568.2006.04868.x","article-title":"Taurine elevates dopamine levels in the rat nucleus accumbens; antagonism by strychnine","volume":"23","author":"Ericson","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.pbb.2018.09.009_bb0100","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1369-1600.2010.00245.x","article-title":"Rising taurine and ethanol concentrations in nucleus accumbens interact to produce dopamine release after ethanol administration","volume":"16","author":"Ericson","year":"2011","journal-title":"Addict. Biol."},{"key":"10.1016\/j.pbb.2018.09.009_bb0105","series-title":"Alcohol Consumption in the Rat: Modulation by Adrenal Steroids and Mesotelencephalic Dopamine","author":"Fahlke","year":"1994"},{"key":"10.1016\/j.pbb.2018.09.009_bb0110","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1111\/j.1530-0277.2008.00787.x","article-title":"Acute effects of acamprosate and MPEP on ethanol drinking-in-the-dark in male C57BL\/6J mice","volume":"32","author":"Gupta","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2018.09.009_bb0115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00213-009-1515-6","article-title":"The effects of acamprosate on alcohol-cue reactivity and alcohol priming in dependent patients: a randomized controlled trial","volume":"205","author":"Hammarberg","year":"2009","journal-title":"Psychopharmacology"},{"issue":"19","key":"10.1016\/j.pbb.2018.09.009_bb0120","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.2174\/138161210791516341","article-title":"Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapy","volume":"16","author":"Kiefer","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.pbb.2018.09.009_bb0125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jsat.2010.06.002","article-title":"Effect of early and late compliance on the effectiveness of acamprosate in the treatment of alcohol dependence","volume":"39","author":"Koeter","year":"2010","journal-title":"J. Subst. Abus. Treat."},{"key":"10.1016\/j.pbb.2018.09.009_bb0130","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1176\/jnp.9.3.482","article-title":"The neurobiology of drug addiction","volume":"9","author":"Koob","year":"1997","journal-title":"J. Neuropsychiatr. Clin. Neurosci."},{"key":"10.1016\/j.pbb.2018.09.009_bb0135","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1471-4159.2008.05346.x","article-title":"High temporal resolution of amino acid levels in rat nucleus accumbens during operant ethanol self-administration: involvement of elevated glycine in anticipation","volume":"106","author":"Li","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pbb.2018.09.009_bb0140","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1530-0277.2009.00938.x","article-title":"The glycine reuptake inhibitor org 25935 interacts with basal and ethanol-induced dopamine release in rat nucleus accumbens","volume":"33","author":"Lid\u00f6","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"5","key":"10.1016\/j.pbb.2018.09.009_bb0145","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1369-1600.2011.00367.x","article-title":"The glycine reuptake inhibitor Org24598 and acamprosate reduce ethanol intake in the rat; tolerance development to acamprosate but not to Org24598","volume":"17","author":"Lid\u00f6","year":"2012","journal-title":"Addict. Biol."},{"issue":"9","key":"10.1016\/j.pbb.2018.09.009_bb0150","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1360-0443.1995.tb01088.x","article-title":"Acamprosate in alcohol dependence: how does it work?","volume":"90","author":"Littleton","year":"1995","journal-title":"Addiction"},{"key":"10.1016\/j.pbb.2018.09.009_bb0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/01.ALC.0000108656.81563.05","article-title":"The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis","volume":"28","author":"Mann","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.pbb.2018.09.009_bb0160","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.4088\/JCP.14com09632","article-title":"Acamprosate, alcoholism, and abstinence","volume":"76","author":"Mason","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.pbb.2018.09.009_bb0165","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.ALC.0000150012.09608.81","article-title":"Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system","volume":"29","author":"Molander","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2018.09.009_bb0170","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/alcalc\/agl085","article-title":"The glycine reuptake inhibitor org 25935 decreases ethanol intake and preference in male Wistar rats","volume":"42","author":"Molander","year":"2007","journal-title":"Alcohol Alcohol."},{"issue":"4","key":"10.1016\/j.pbb.2018.09.009_bb0175","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1530-0277.1998.tb03871.x","article-title":"Mechanism of action of acamprosate. Part I. characterization of spermidine-sensitive acamprosate binding site in rat brain","volume":"22","author":"Naassila","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2018.09.009_bb0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(02)01272-4","article-title":"Effects of acute acamprosate and homotaurine on ethanol intake and ethanol-stimulated mesolimbic dopamine release","volume":"437","author":"Olive","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pbb.2018.09.009_bb1000","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"issue":"4","key":"10.1016\/j.pbb.2018.09.009_bb0185","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1530-0277.1998.tb03872.x","article-title":"Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex","volume":"22","author":"al Qatari","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.pbb.2018.09.009_bb0190","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1530-0277.2007.00569.x","article-title":"Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes","volume":"32","author":"Reilly","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2018.09.009_bb0195","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1530-0277.2008.00753.x","article-title":"Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats","volume":"32","author":"Simms","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"11","key":"10.1016\/j.pbb.2018.09.009_bb0200","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/acer.13483","article-title":"The glycine receptor \u2013 a functionally important primary brain target of ethanol","volume":"41","author":"S\u00f6derpalm","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.pbb.2018.09.009_bb0205","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00013.2008","article-title":"Alcoholism: a systems approach from molecular physiology to addictive behavior","volume":"89","author":"Spanagel","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pbb.2018.09.009_bb0210","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0014-2999(96)00174-4","article-title":"Acamprosate and alcohol: I. effects on alcohol intake following alcohol deprivation in the rat","volume":"305","author":"Spanagel","year":"1996","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.pbb.2018.09.009_bb0215","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/npp.2013.264","article-title":"Acamprosate produces its anti-relapse effects via calcium","volume":"39","author":"Spanagel","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2018.09.009_bb0220","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.biopsych.2010.05.029","article-title":"Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats","volume":"68","author":"Vengeliene","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pbb.2018.09.009_bb0225","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrn1406","article-title":"Dopamine, learning and motivation","volume":"5","author":"Wise","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pbb.2018.09.009_bb0230","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.ps.40.020189.001203","article-title":"Brain dopamine and reward","volume":"40","author":"Wise","year":"1989","journal-title":"Annu. Rev. Psychol."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305718302703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305718302703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T19:29:59Z","timestamp":1720639799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305718302703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":47,"alternative-id":["S0091305718302703"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2018.09.009","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acamprosate's ethanol intake-reducing effect is associated with its ability to increase dopamine","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2018.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}