{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:04:54Z","timestamp":1758845094841,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.pbb.2020.172977","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T20:42:28Z","timestamp":1593463348000},"page":"172977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Striatal and cortical metabotropic glutamate 5 receptor expression and behavioral effects of the positive allosteric modulator CDPPB in a model of DYT1 dystonia"],"prefix":"10.1016","volume":"196","author":[{"given":"Stefanie","family":"Perl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2020.172977_bb0005","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/mds.25475","article-title":"Phenomenology and classification of dystonia: a consensus update","volume":"28","author":"Albanese","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.pbb.2020.172977_bb0010","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.neuropharm.2009.01.002","article-title":"Metabotropic glutamate receptor-dependent long-term potentiation","volume":"56","author":"Anwyl","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2020.172977_bb0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.expneurol.2016.10.013","article-title":"Altered postnatal maturation of striatal GABAergic interneurons in a phenotypic animal model of dystonia","volume":"287","author":"Bode","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pbb.2020.172977_bb0020","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pharmthera.2005.01.008","article-title":"Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis","volume":"111","author":"Dhami","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.pbb.2020.172977_bb0025","doi-asserted-by":"crossref","first-page":"e271","DOI":"10.1038\/tp.2013.46","article-title":"mRNA and protein expression for novel GABAA receptors theta and rho2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway","volume":"3","author":"Fatemi","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pbb.2020.172977_bb0030","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1124\/pr.109.001735","article-title":"Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms","volume":"61","author":"Gladding","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.pbb.2020.172977_bb0035","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.neuron.2005.11.010","article-title":"Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope","volume":"48","author":"Goodchild","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.pbb.2020.172977_bb0040","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuroscience.2017.05.051","article-title":"Alterations of M1 and M4 acetylcholine receptors in the genetically dystonic (dt(sz)) hamster and moderate antidystonic efficacy of M1 and M4 anticholinergics","volume":"357","author":"Hamann","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2020.172977_bb0045","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.neuroscience.2010.06.023","article-title":"Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus","volume":"169","author":"Iyo","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2020.172977_bb0050","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1124\/jpet.104.079244","article-title":"A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models","volume":"313","author":"Kinney","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pbb.2020.172977_bb0055","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.nbd.2004.01.012","article-title":"Increased excitability in cortico-striatal synaptic pathway in a model of paroxysmal dystonia","volume":"16","author":"K\u00f6hling","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pbb.2020.172977_bb0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nbd.2004.07.005","article-title":"Transcriptome analysis in arat model of L-DOPA-induced dyskinesia","volume":"17","author":"Konradi","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pbb.2020.172977_bb0065","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbr.2015.12.029","article-title":"Effects of the metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on rats tested with the paired associates learning task in touchscreen-equipped operant conditioning chambers","volume":"301","author":"Lins","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2020.172977_bb0070","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuropharm.2016.03.036","article-title":"Metabotropic glutamate receptors as therapeutic targets in Parkinson\u2019s disease: an update from the last 5 years of research","volume":"115","author":"Litim","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2020.172977_bb0075","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.33331","article-title":"Early structural and functional plasticity alterations in a susceptibility period of DYT1 dystonia mouse striatum","volume":"7","author":"Maltese","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.pbb.2020.172977_bb0080","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/brain\/awp194","article-title":"Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine","volume":"132","author":"Martella","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.pbb.2020.172977_bb0085","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","article-title":"Metabotropic glutamate receptors: physiology, pharmacology, and disease","volume":"50","author":"Niswender","year":"2010","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.pbb.2020.172977_bb0090","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.neurobiolaging.2009.07.014","article-title":"Metabotropic glutamate receptor type 5 in levodopa-induced motor complications","volume":"32","author":"Ouattara","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.pbb.2020.172977_bb0095","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.neuropharm.2010.11.013","article-title":"Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration","volume":"62","author":"Parmentier-Batteur","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2020.172977_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172527","article-title":"Expression of metabotropic glutamate 5 receptors in the striatum and cortex and effects of modulators on the severity of dystonia in the phenotypic dt(sz) model","volume":"859","author":"Perl","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.pbb.2020.172977_bb0105","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.nbd.2009.12.003","article-title":"Convergent evidence for abnormal striatal synaptic plasticity in dystonia","volume":"37","author":"Peterson","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pbb.2020.172977_bb0110","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.parkreldis.2014.05.003","article-title":"Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias","volume":"20","author":"Rascol","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.pbb.2020.172977_bb0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pneurobio.2014.07.002","article-title":"Genetic animal models of dystonia: common features and diversities","volume":"121","author":"Richter","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.pbb.2020.172977_bb0120","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bbr.2016.10.028","article-title":"Sensorimotor tests unmask a phenotype in the DYT1 knock-in mouse model of dystonia","volume":"317","author":"Richter","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2020.172977_bb0125","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ebiom.2019.02.042","article-title":"Optogenetic augmentation of the hypercholinergic endophenotype in DYT1 knock-in mice induced erratic hyperactive movements but not dystonia","volume":"41","author":"Richter","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.pbb.2020.172977_bb0130","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.nbd.2010.05.001","article-title":"A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys","volume":"39","author":"Rylander","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pbb.2020.172977_bb0135","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.neuropharm.2014.06.013","article-title":"Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia","volume":"85","author":"Sciamanna","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2020.172977_bb0140","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1523\/JNEUROSCI.22-10-03910.2002","article-title":"Receptor activation and homer differentially control the lateral mobility of metabotropic glutamate receptor 5 in the neuronal membrane","volume":"22","author":"Serge","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pbb.2020.172977_bb0145","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1074\/jbc.M116.757724","article-title":"Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization","volume":"292","author":"Sergin","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pbb.2020.172977_bb0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2019.04.052","article-title":"Effects of exercise on mGluR-mediated glutamatergic transmission in the striatum of hemiparkinsonian rats","volume":"705","author":"Shi","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pbb.2020.172977_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.irn.2018.09.007","article-title":"Neuroimaging applications in dystonia","volume":"143","author":"Simonyan","year":"2018","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.pbb.2020.172977_bb0160","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0006-8993(97)01141-4","article-title":"Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons","volume":"780","author":"Tallaksen-Greene","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2020.172977_bb0165","doi-asserted-by":"crossref","unstructured":"Testa CM, Standaert DG, Young AB, Penney JB, Jr. Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat. J. Neurosci. 1994; 14:3005\u20133018.","DOI":"10.1523\/JNEUROSCI.14-05-03005.1994"},{"key":"10.1016\/j.pbb.2020.172977_bb0170","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuropharm.2009.07.022","article-title":"Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus","volume":"57","author":"Uslaner","year":"2009","journal-title":"Neuropharmacology"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305720302070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305720302070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:37:48Z","timestamp":1758775068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305720302070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"alternative-id":["S0091305720302070"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2020.172977","relation":{},"ISSN":["0091-3057"],"issn-type":[{"type":"print","value":"0091-3057"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Striatal and cortical metabotropic glutamate 5 receptor expression and behavioral effects of the positive allosteric modulator CDPPB in a model of DYT1 dystonia","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2020.172977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"172977"}}