{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:24:51Z","timestamp":1791404691821,"version":"4.3.3"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.pbb.2021.173273","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T21:18:04Z","timestamp":1631740684000},"page":"173273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":128,"special_numbering":"C","title":["Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: A reflection based on the literature and experience"],"prefix":"10.1016","volume":"210","author":[{"given":"L\u00edlian Juliana","family":"Lissner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista Min\u00e9ia","family":"Wartchow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Toniazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos-Alberto","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2021.173273_bb0005","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000093129","article-title":"Analysis of the stress response in rats trained in the water-maze: differential expression of corticotropin-releasing hormone, CRH-R1, glucocorticoid receptors and brain-derived neurotrophic factor in limbic regions","volume":"82","author":"Aguilar-Valles","year":"2005","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.pbb.2021.173273_bb0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neubiorev.2015.03.013","article-title":"Moving beyond standard procedures to assess spontaneous recognition memory","volume":"53","author":"Ameen-Ali","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pbb.2021.173273_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2021.107439","article-title":"Perirhinal cortex and the recognition of relative familiarity","volume":"182","author":"Ameen-Ali","year":"2021","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.pbb.2021.173273_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"key":"10.1016\/j.pbb.2021.173273_bb0025","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbr.2015.06.012","article-title":"The recognition of a novel-object in a novel context leads to hippocampal and parahippocampal c-Fos involvement","volume":"292","author":"Arias","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0030","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.yhbeh.2008.04.001","article-title":"Effects of gonadectomy and hormone replacement on a spontaneous novel object recognition task in adult male rats","volume":"54","author":"Aubele","year":"2008","journal-title":"Horm. Behav."},{"key":"10.1016\/j.pbb.2021.173273_bb0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1101\/lm.46102","article-title":"Effects of stress and hippocampal NMDA receptor antagonism on recognition memory in rats","volume":"9","author":"Baker","year":"2002","journal-title":"Learn. Mem. Cold Spring Harb. N"},{"key":"10.1016\/j.pbb.2021.173273_bb0040","doi-asserted-by":"crossref","first-page":"10721","DOI":"10.1523\/JNEUROSCI.6413-10.2011","article-title":"When is the hippocampus involved in recognition memory?","volume":"31","author":"Barker","year":"2011","journal-title":"J. Neurosci."},{"issue":"25","key":"10.1016\/j.pbb.2021.173273_bb0045","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/cercor\/bht245","article-title":"Object-in-place associative recognition memory depends on glutamate receptor neurotransmission within two defined hippocampal-cortical circuits: a critical role for AMPA and NMDA receptors in the hippocampus, perirhinal, and prefrontal cortices","volume":"1991","author":"Barker","year":"2015","journal-title":"Cereb. Cortex N. Y. N"},{"key":"10.1016\/j.pbb.2021.173273_bb0050","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1523\/JNEUROSCI.1802-17.2017","article-title":"A critical role for the nucleus reuniens in long-term, but not short-term associative recognition memory formation","volume":"38","author":"Barker","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pbb.2021.173273_bb0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbr.2012.08.039","article-title":"Green tea (-)epigallocatechin-3-gallate reverses oxidative stress and reduces acetylcholinesterase activity in a streptozotocin-induced model of dementia","volume":"236","author":"Biasibetti","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0060","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbr.2016.08.057","article-title":"Hippocampal changes in STZ-model of Alzheimer's disease are dependent on sex","volume":"316","author":"Biasibetti","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbr.2016.08.057","article-title":"Hippocampal changes in STZ-model of Alzheimer's disease are dependent on sex","volume":"316","author":"Biasibetti","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1101\/lm.1650110","article-title":"Object recognition memory and the rodent hippocampus","volume":"17","author":"Broadbent","year":"2010","journal-title":"Learn. Mem. Cold Spring Harb. N"},{"key":"10.1016\/j.pbb.2021.173273_bb0075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nn.3304","article-title":"Memory, navigation and theta rhythm in the hippocampal-entorhinal system","volume":"16","author":"Buzs\u00e1ki","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.pbb.2021.173273_bb0080","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.expneurol.2013.01.003","article-title":"The interaction between the dopaminergic forebrain projections and the medial prefrontal cortex is critical for memory of objects: implications for Parkinson's disease","volume":"247","author":"Chao","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pbb.2021.173273_bb0085","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neubiorev.2020.04.007","article-title":"The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: behavioral, anatomical and neurochemical properties","volume":"113","author":"Chao","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pbb.2021.173273_bb0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0376-6357(99)00034-0","article-title":"Sex-related differences in spatial learning during the early postnatal development of the rat","volume":"46","author":"Cimadevilla","year":"1999","journal-title":"Behav. Process."},{"key":"10.1016\/j.pbb.2021.173273_bb0095","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2014.08.002","article-title":"Assessing rodent hippocampal involvement in the novel object recognition task.\u00a0A review","volume":"285","author":"Cohen","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2014.08.002","article-title":"Assessing rodent hippocampal involvement in the novel object recognition task.\u00a0A review","volume":"285","author":"Cohen","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0105","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.cub.2013.07.002","article-title":"The rodent hippocampus is essential for nonspatial object memory","volume":"23","author":"Cohen","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.pbb.2021.173273_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.beproc.2020.104180","article-title":"A Go\/No-go delayed nonmatching-to-sample procedure to measure object-recognition memory in rats","volume":"178","author":"Cole","year":"2020","journal-title":"Behav. Process."},{"key":"10.1016\/j.pbb.2021.173273_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112013","article-title":"The expression of allocentric object-place recognition memory during development","volume":"372","author":"Contreras","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0120","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.bbr.2011.09.035","article-title":"Neuroglial alterations in rats submitted to the okadaic acid-induced model of dementia","volume":"226","author":"Costa","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112360","article-title":"Neuroinflammation induced by lipopolysaccharide leads to memory impairment and alterations in hippocampal leptin signaling","volume":"379","author":"Da R\u00e9","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0130","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.neubiorev.2007.01.005","article-title":"The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents","volume":"31","author":"Dere","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pbb.2021.173273_bb0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0166-4328(98)00079-5","article-title":"Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition","volume":"99","author":"Dix","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0140","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3233\/JAD-170211","article-title":"Early and persistent O-GlcNAc protein modification in the streptozotocin model of Alzheimer's disease","volume":"61","author":"Dos Santos","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.pbb.2021.173273_bb0145","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbr.2013.09.014","article-title":"Single prolonged stress impairs social and object novelty recognition in rats","volume":"256","author":"Eagle","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0150","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbr.2009.12.036","article-title":"One-trial object recognition in rats and mice: methodological and theoretical issues","volume":"215","author":"Ennaceur","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0165","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/PL00005603","article-title":"Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix","volume":"113","author":"Ennaceur","year":"1997","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nlm.2015.02.005","article-title":"Two waves of proteasome-dependent protein degradation in the hippocampus are required for recognition memory consolidation","volume":"120","author":"Figueiredo","year":"2015","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.pbb.2021.173273_bb0175","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/hipo.20059","article-title":"Hippocampal lesions that abolish spatial maze performance spare object recognition memory at delays of up to 48 hours","volume":"15","author":"Forwood","year":"2005","journal-title":"Hippocampus"},{"key":"10.1016\/j.pbb.2021.173273_bb0180","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1037\/0735-7044.117.6.1283","article-title":"Sex differences in the behavioral response to spatial and object novelty in adult C57BL\/6 mice","volume":"117","author":"Frick","year":"2003","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.pbb.2021.173273_bb0185","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbr.2014.10.025","article-title":"Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents","volume":"285","author":"Grayson","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0190","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/hipo.22021","article-title":"Dissociable anterograde amnesic effects of retrosplenial cortex and hippocampal lesions on spontaneous object recognition memory in rats","volume":"22","author":"Haijima","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.pbb.2021.173273_bb0195","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.physbeh.2016.05.046","article-title":"Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain","volume":"164","author":"Hansen","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.pbb.2021.173273_bb0200","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbr.2008.10.015","article-title":"Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks","volume":"198","author":"Harrison","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0205","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.nlm.2005.10.002","article-title":"Wistar rats show episodic-like memory for unique experiences","volume":"85","author":"Kart-Teke","year":"2006","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.pbb.2021.173273_bb0210","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1523\/JNEUROSCI.4623-04.2005","article-title":"Amygdalar inactivation blocks stress-induced impairments in hippocampal long-term potentiation and spatial memory","volume":"25","author":"Kim","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pbb.2021.173273_bb0215","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/hipo.20714","article-title":"Associative recognition and the hippocampus: differential effects of hippocampal lesions on object-place, object-context and object-place-context memory","volume":"20","author":"Langston","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.pbb.2021.173273_bb0220","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.pbb.2021.173273_bb0225","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neulet.2006.06.044","article-title":"Temporary inactivation reveals an essential role of the dorsal hippocampus in consolidation of object recognition memory","volume":"405","author":"de Lima","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pbb.2021.173273_bb0230","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11064-020-03154-4","article-title":"Short-term alterations in behavior and astroglial function after intracerebroventricular infusion of methylglyoxal in rats","volume":"46","author":"Lissner","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0235","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/npp.2015.180","article-title":"Stress and fear extinction","volume":"41","author":"Maren","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2021.173273_bb0240","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.neuroscience.2015.01.011","article-title":"The effect of chronic corticosterone on fear learning and memory depends on dose and the testing protocol","volume":"289","author":"Marks","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2021.173273_bb0245","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.1098180","article-title":"Sites of neocortical reorganization critical for remote spatial memory","volume":"305","author":"Maviel","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.pbb.2021.173273_bb0250","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbr.2019.02.003","article-title":"Impact of early exposure to a cafeteria diet on prefrontal cortex monoamines and novel object recognition in adolescent rats","volume":"363","author":"Moreton","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0255","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0023-9690(81)90020-5","article-title":"Spatial localization does not require the presence of local cues","volume":"12","author":"Morris","year":"1981","journal-title":"Learn. Motiv."},{"key":"10.1016\/j.pbb.2021.173273_bb0260","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.pbb.2021.173273_bb0265","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.pbb.2021.173273_bb0270","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.neuro.31.061307.090723","article-title":"Place cells, grid cells, and the brain's spatial representation system","volume":"31","author":"Moser","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.pbb.2021.173273_bb0275","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1101\/lm.41302","article-title":"Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts","volume":"9","author":"Mumby","year":"2002","journal-title":"Learn. Mem. Cold Spring Harb. N"},{"key":"10.1016\/j.pbb.2021.173273_bb0280","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/hipo.20122","article-title":"Hippocampal damage and anterograde object-recognition in rats after long retention intervals","volume":"15","author":"Mumby","year":"2005","journal-title":"Hippocampus"},{"key":"10.1016\/j.pbb.2021.173273_bb0285","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1073\/pnas.0307803100","article-title":"Glucocorticoid effects on object recognition memory require training-associated emotional arousal","volume":"101","author":"Okuda","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pbb.2021.173273_bb0290","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1101\/lm.1625310","article-title":"Post-training reversible inactivation of the hippocampus enhances novel object recognition memory","volume":"17","author":"Oliveira","year":"2010","journal-title":"Learn. Mem. Cold Spring Harb. N"},{"key":"10.1016\/j.pbb.2021.173273_bb0295","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/29542","article-title":"Stress and glucocorticoids impair retrieval of long-term spatial memory","volume":"394","author":"de Quervain","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.pbb.2021.173273_bb0300","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00213-018-5116-0","article-title":"Glucocorticoid-induced enhancement of extinction-from animal models to clinical trials","volume":"236","author":"de Quervain","year":"2019","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2021.173273_bb0305","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/dev.21432","article-title":"Determinants of object-in-context and object-place-context recognition in the developing rat","volume":"58","author":"Ramsaran","year":"2016","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.pbb.2021.173273_bb0310","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2015.04.026","article-title":"Lesions of the hippocampus or dorsolateral striatum disrupt distinct aspects of spatial navigation strategies based on proximal and distal information in a cued variant of the Morris water task","volume":"289","author":"Rice","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0315","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/JAD-2009-1034","article-title":"Hippocampal alterations in rats submitted to streptozotocin-induced dementia model are prevented by aminoguanidine","volume":"17","author":"Rodrigues","year":"2009","journal-title":"J. Alzheimers Dis."},{"issue":"117","key":"10.1016\/j.pbb.2021.173273_bb0320","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00702-010-0501-9","article-title":"Treadmill training restores spatial cognitive deficits and neurochemical alterations in the hippocampus of rats submitted to an intracerebroventricular administration of streptozotocin","volume":"1996","author":"Rodrigues","year":"2010","journal-title":"J. Neural Transm. Vienna Austria"},{"key":"10.1016\/j.pbb.2021.173273_bb0325","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1006\/nlme.2002.4080","article-title":"Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval","volume":"78","author":"Roozendaal","year":"2002","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.pbb.2021.173273_bb0330","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.pnpbp.2003.09.015","article-title":"Systems mediating acute glucocorticoid effects on memory consolidation and retrieval","volume":"27","author":"Roozendaal","year":"2003","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.pbb.2021.173273_bb0335","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0006-8993(95)01305-9","article-title":"The memory-modulatory effects of glucocorticoids depend on an intact stria terminalis","volume":"709","author":"Roozendaal","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0340","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1073\/pnas.0601874103","article-title":"Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala","volume":"103","author":"Roozendaal","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.pbb.2021.173273_bb0345","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1101\/lm.422607","article-title":"On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory","volume":"14","author":"Rossato","year":"2007","journal-title":"Learn. Mem. Cold Spring Harb. N"},{"key":"10.1016\/j.pbb.2021.173273_bb0350","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.lfs.2010.09.004","article-title":"Assessment of spatial memory in mice","volume":"87","author":"Sharma","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.pbb.2021.173273_bb0355","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jneumeth.2007.06.032","article-title":"Automation of the novel object recognition task for use in adolescent rats","volume":"166","author":"Silvers","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.pbb.2021.173273_bb0360","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1038\/s41598-018-30030-7","article-title":"The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias","volume":"8","author":"Sivakumaran","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pbb.2021.173273_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111944","article-title":"Altered entrainment to the day\/night cycle attenuates the daily rise in circulating corticosterone in the mouse","volume":"9","author":"Sollars","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.pbb.2021.173273_bb0370","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrn2154","article-title":"Recognition memory and the medial temporal lobe: a new perspective","volume":"8","author":"Squire","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.pbb.2021.173273_bb0375","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.nlm.2016.06.016","article-title":"Temporary inactivation reveals that the CA1 region of the mouse dorsal hippocampus plays an equivalent role in the retrieval of long-term object memory and spatial memory","volume":"133","author":"Stackman","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.pbb.2021.173273_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113039","article-title":"Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity","volume":"321","author":"Tang","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.pbb.2021.173273_bb0385","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainresbull.2017.05.017","article-title":"Brain networks activated to form object recognition memory","volume":"141","author":"Tanimizu","year":"2018","journal-title":"Brain Res. Bull."},{"issue":"118","key":"10.1016\/j.pbb.2021.173273_bb0390","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00702-011-0680-z","article-title":"The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer\u2019s disease in rats","volume":"1996","author":"Tramontina","year":"2011","journal-title":"J. Neural Transm. Vienna Austria"},{"key":"10.1016\/j.pbb.2021.173273_bb0395","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.brainres.2008.11.032","article-title":"Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat","volume":"1251","author":"Vicente","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0400","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.pbb.2021.173273_bb0405","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ntt.2014.07.003","article-title":"Value of water mazes for assessing spatial and egocentric learning and memory in rodent basic research and regulatory studies","volume":"45","author":"Vorhees","year":"2014","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.pbb.2021.173273_bb0410","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbr.2014.09.050","article-title":"Neural circuitry for rat recognition memory","volume":"285","author":"Warburton","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117587","article-title":"Insulin-producing cells from mesenchymal stromal cells: protection against cognitive impairment in diabetic rats depends upon implant site","volume":"251","author":"Wartchow","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.pbb.2021.173273_bb0420","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1037\/bne0000145","article-title":"A role for puberty in water maze performance in male and female rats","volume":"130","author":"Willing","year":"2016","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.pbb.2021.173273_bb0425","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1523\/JNEUROSCI.1346-04.2004","article-title":"Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe","volume":"24","author":"Winters","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pbb.2021.173273_bb0430","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.brainres.2009.04.013","article-title":"Stress and memory in humans: twelve years of progress?","volume":"1293","author":"Wolf","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2021.173273_bb0435","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1007\/s12035-016-9798-1","article-title":"Exendin-4 reverses biochemical and functional alterations in the blood-brain and blood-CSF barriers in diabetic rats","volume":"54","author":"Zanotto","year":"2017","journal-title":"Mol. Neurobiol."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305721001726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305721001726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:41:41Z","timestamp":1758775301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305721001726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":87,"alternative-id":["S0091305721001726"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2021.173273","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Object recognition and Morris water maze to detect cognitive impairment from mild hippocampal damage in rats: A reflection based on the literature and experience","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2021.173273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"173273"}}