{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:42:13Z","timestamp":1766065333618},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.pbb.2024.173842","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T10:30:40Z","timestamp":1721989840000},"page":"173842","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Prospecting for para-endogenous anxiolytics in the human microbiome: Some promising pathways"],"prefix":"10.1016","volume":"244","author":[{"given":"Stephen","family":"Skolnick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2024.173842_bb0005","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/hep.31496","article-title":"A randomized clinical trial of fecal microbiota transplant for alcohol use disorder","volume":"73","author":"Bajaj","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.pbb.2024.173842_bb0010","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/0016-5085(89)90647-1","article-title":"Effects of the benzodiazepine receptor antagonist flumazenil in hepatic encephalopathy in humans","volume":"97","author":"Bansky","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pbb.2024.173842_bb0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.chom.2023.01.018","article-title":"Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites","volume":"31","author":"Bogaert","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pbb.2024.173842_bb0020","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1039\/C8OB03063D","article-title":"The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases","volume":"17","author":"Borgman","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.pbb.2024.173842_bb0025","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/1570159X13666141210215423","article-title":"GHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome","volume":"13","author":"Busard\u00f2","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.pbb.2024.173842_bb0030","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pharmthera.2008.10.003","article-title":"Behavioral analyses of GHB: receptor mechanisms","volume":"121","author":"Carter","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.pbb.2024.173842_bb0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1084\/jem.122.1.67","article-title":"Indigenous, normal, and autochthonous flora of the gastrointestinal tract","volume":"122","author":"Dubos","year":"1965","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.pbb.2024.173842_bb0040","doi-asserted-by":"crossref","first-page":"36246","DOI":"10.1038\/srep36246","article-title":"Acrolein contributes strongly to antimicrobial and heterocyclic amine transformation activities of reuterin","volume":"6","author":"Engels","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.pbb.2024.173842_bb0045","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1042\/bj0340392","article-title":"The production of amines by bacteria","volume":"34","author":"Gale","year":"1940","journal-title":"Biochem. J."},{"key":"10.1016\/j.pbb.2024.173842_bb0050","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1528-1157.1988.tb03732.x","article-title":"\u03b3-Hydroxybutyrate model of generalized absence seizures: further characterization and comparison with other absence models","volume":"29","author":"Iii","year":"1988","journal-title":"Epilepsia"},{"key":"10.1016\/j.pbb.2024.173842_bb0055","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.chom.2020.05.013","article-title":"Cholesterol metabolism by uncultured human gut Bacteria influences host cholesterol level","volume":"28","author":"Kenny","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.pbb.2024.173842_bb0060","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1074\/jbc.M411114200","article-title":"A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12","volume":"280","author":"Kurihara","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pbb.2024.173842_bb0065","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0028-3908(71)90013-X","article-title":"Blood-brain barrier to H3-\u03b3-aminobutyric acid in normal and amino oxyacetic acid-treated animals","volume":"10","author":"Kuriyama","year":"1971","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2024.173842_bb0070","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/jat\/26.6.340","article-title":"Intra- and Interindividuai variations in urinary concentrations of endogenous gamma-Hydroxybutyrate","volume":"26","author":"LeBeau","year":"2002","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.pbb.2024.173842_bb0075","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/jat\/30.2.98","article-title":"A comprehensive study on the variations in urinary concentrations of endogenous gamma-Hydroxybutyrate (GHB)*","volume":"30","author":"LeBeau","year":"2006","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.pbb.2024.173842_bb0080","doi-asserted-by":"crossref","DOI":"10.1177\/2470547018818555","article-title":"Overview of the molecular steps in steroidogenesis of the GABAergic Neurosteroids Allopregnanolone and Pregnanolone","volume":"2","author":"Liang","year":"2018","journal-title":"Chronic Stress"},{"key":"10.1016\/j.pbb.2024.173842_bb0085","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jflm.2008.08.014","article-title":"What constitutes a normal ante-mortem urine GHB concentration?","volume":"16","author":"Mari","year":"2009","journal-title":"J. Forensic Leg. Med."},{"key":"10.1016\/j.pbb.2024.173842_bb0090","article-title":"Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas","volume":"0","author":"McCurry","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.pbb.2024.173842_bb0095","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1699-0463.1990.tb05004.x","article-title":"Intestinal microbial conversion of cholesterol to coprostanol in man","volume":"98","author":"Midtvedt","year":"1990","journal-title":"APMIS"},{"key":"10.1016\/j.pbb.2024.173842_bb0100","first-page":"183","article-title":"Eubacterium desmolans sp. nov., a steroid Desmolase-producing species from cat fecal Flora","volume":"36","author":"Morris","year":"1986","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.pbb.2024.173842_bb0105","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1046\/j.0022-3042.2002.00780.x","article-title":"Evidence for a \u03b3-hydroxybutyrate (GHB) uptake by rat brain synaptic vesicles","volume":"80","author":"Muller","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.pbb.2024.173842_bb0110","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0925-4439(02)00220-X","article-title":"Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation","volume":"1637","author":"Nguyen","year":"2003","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.pbb.2024.173842_bb0115","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.cell.2018.04.027","article-title":"The gut microbiota mediates the anti-seizure effects of the ketogenic diet","volume":"173","author":"Olson","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.pbb.2024.173842_bb0120","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.psyneuen.2017.02.012","article-title":"Lower allopregnanolone during pregnancy predicts postpartum depression: an exploratory study","volume":"79","author":"Osborne","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.pbb.2024.173842_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-021-01689-y","article-title":"Components of a Neanderthal gut microbiome recovered from fecal sediments from El salt","volume":"4","author":"Rampelli","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.pbb.2024.173842_bb0130","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0016-5085(19)33641-8","article-title":"A controlled clinical trial of lactulose in hepatic encephalopathy","volume":"59","author":"Simmons","year":"1970","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pbb.2024.173842_bb0135","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1016\/0006-2952(82)90310-0","article-title":"Studies on the relation of \u03b3-hydroxybutyric acid (GHB) to \u03b3-aminobutyric acid (GABA): evidence that GABA is not the sole source for GHB in rat brain","volume":"31","author":"Snead","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pbb.2024.173842_bb0140","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41564-018-0307-3","article-title":"GABA-modulating bacteria of the human gut microbiota","volume":"4","author":"Strandwitz","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pbb.2024.173842_bb0145","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1517\/14728214.2015.1115480","article-title":"Emerging drugs for common conditions of sleepiness: obstructive sleep apnea and narcolepsy","volume":"20","author":"Sullivan","year":"2015","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.pbb.2024.173842_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.03092","article-title":"Production of the neurotoxin Salsolinol by a gut-associated bacterium and its modulation by alcohol","volume":"9","author":"Villageli\u00fa","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.pbb.2024.173842_bb0155","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0022-4731(78)90604-0","article-title":"21-dehydroxylation of corticoids by anaerobic bacteria isolated from human fecal flora","volume":"9","author":"Winter","year":"1978","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.pbb.2024.173842_bb0160","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/0022-4731(87)90201-9","article-title":"Bacterial metabolism of natural and synthetic sex hormones undergoing enterohepatic circulation","volume":"27","author":"Winter","year":"1987","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.pbb.2024.173842_bb0165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0006-8993(95)00241-H","article-title":"Gut bacteria provide precursors of benzodiazepine receptor ligands in a rat model of hepatic encephalopathy","volume":"679","author":"Yurdaydin","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2024.173842_bb0170","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1848158","article-title":"Gut Bacteroides species in health and disease","volume":"13","author":"Zafar","year":"2021","journal-title":"Gut Microbes"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305724001369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305724001369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T18:54:32Z","timestamp":1726772072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305724001369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":34,"alternative-id":["S0091305724001369"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2024.173842","relation":{},"ISSN":["0091-3057"],"issn-type":[{"type":"print","value":"0091-3057"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prospecting for para-endogenous anxiolytics in the human microbiome: Some promising pathways","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2024.173842","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"173842"}}