{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:52:30Z","timestamp":1787161950605,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"am","delay-in-days":293,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["HU00012020014"],"award-info":[{"award-number":["HU00012020014"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US Government National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["HU00012020014"],"award-info":[{"award-number":["HU00012020014"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.pbb.2024.173847","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T02:39:32Z","timestamp":1723603172000},"page":"173847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Kappa opioid receptor mediated operant performance in male and female rats"],"prefix":"10.1016","volume":"244","author":[{"given":"Amanda B.","family":"Namchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mumeko C.","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin","family":"Lucki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A.","family":"Browne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.pbb.2024.173847_bb0005","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1038\/s41386-021-01168-2","article-title":"Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition","volume":"46","author":"Abraham","year":"2021","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.pbb.2024.173847_bb0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002130050812","article-title":"Withdrawal following repeated exposure to d-amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement","volume":"141","author":"Barr","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2024.173847_bb0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pharmthera.2019.04.009","article-title":"Targeting opioid dysregulation in depression for the development of novel therapeutics","volume":"201","author":"Browne","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.pbb.2024.173847_bb0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/164_2020_432","article-title":"Kappa opioid receptors in the pathology and treatment of major depressive disorder","volume":"271","author":"Browne","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"issue":"1","key":"10.1016\/j.pbb.2024.173847_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.119.256354","article-title":"Impact of pharmacological manipulation of the \u03ba-opioid receptor system on self-grooming and anhedonic-like behaviors in male mice","volume":"370","author":"Butelman","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.pbb.2024.173847_bb0030","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1124\/jpet.105.092304","article-title":"Depressive-like effects of the kappa-opioid receptor agonist salvinorin a on behavior and neurochemistry in rats","volume":"316","author":"Carlezon","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pbb.2024.173847_bb0035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuropharm.2018.12.002","article-title":"Females are less sensitive than males to the motivational- and dopamine-suppressing effects of kappa opioid receptor activation","volume":"146","author":"Conway","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2024.173847_bb8000","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.psychres.2019.01.073","article-title":"Deconstructing Avolition: Initiation vs persistence of reward-directed effort","volume":"273","author":"DeRosse","year":"2019","journal-title":"Psychiatry Res."},{"issue":"2","key":"10.1016\/j.pbb.2024.173847_bb0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00213-010-1836-5","article-title":"Depressive-like effects of the kappa opioid receptor agonist salvinorin a are associated with decreased phasic dopamine release in the nucleus accumbens","volume":"210","author":"Ebner","year":"2010","journal-title":"Psychopharmacology"},{"issue":"9","key":"10.1016\/j.pbb.2024.173847_bb0045","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1007\/s00213-018-4969-6","article-title":"Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats","volume":"235","author":"Hailwood","year":"2018","journal-title":"Psychopharmacology"},{"issue":"3483","key":"10.1016\/j.pbb.2024.173847_bb0050","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.134.3483.943","article-title":"Progressive ratio as a measure of reward strength","volume":"134","author":"Hodos","year":"1961","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.pbb.2024.173847_bb0055","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(91)91319-V","article-title":"Ventral pallidal microinjections of receptor-selective opioid agonists produce differential effects on circling and locomotor activity in rats","volume":"550","author":"Hoffman","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.pbb.2024.173847_bb0060","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev-pharmtox-010919-023317","article-title":"Kappa opioid receptor antagonists as potential therapeutics for stress-related disorders","volume":"60","author":"Jacobson","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.pbb.2024.173847_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108254","article-title":"Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling","volume":"177","author":"Jacobson","year":"2020","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.pbb.2024.173847_bb0070","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41591-020-0806-7","article-title":"A randomized proof-of-mechanism trial applying the \u2018fast-fail\u2019 approach to evaluating kappa-opioid antagonism as a treatment for anhedonia","volume":"26","author":"Krystal","year":"2020","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.pbb.2024.173847_bb0075","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0022-3565(25)24372-5","article-title":"Human psychopharmacology of ketocyclazocine as compared with cyclazocine, morphine and placebo","volume":"238","author":"Kumor","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pbb.2024.173847_bb0080","first-page":"170","article-title":"The kappa opioid receptor: from addiction to depression, and back","volume":"5","author":"Lalanne","year":"2014","journal-title":"Front. Psychol."},{"issue":"2","key":"10.1016\/j.pbb.2024.173847_bb9000","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1523\/JNEUROSCI.4458-07.2008","article-title":"The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system","volume":"28","author":"Land","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pbb.2024.173847_bb0085","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2016.11.018","article-title":"Association of OPRK1 and OPRM1 methylation with mild cognitive impairment in Xinjiang Han and Uygur populations","volume":"636","author":"Liu","year":"2017","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.pbb.2024.173847_bb0090","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00213-012-2912-9","article-title":"Dose-related effects of salvinorin A in humans: dissociative, hallucinogenic, and memory effects","volume":"226","author":"MacLean","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2024.173847_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104504","article-title":"Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion","volume":"129","author":"Margolis","year":"2019","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.pbb.2024.173847_bb0100","doi-asserted-by":"crossref","first-page":"E81","DOI":"10.1152\/ajpendo.00308.2017","article-title":"Intragastric nutrient infusion reduces motivation for food in male and female rats","volume":"315","author":"Maske","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.pbb.2024.173847_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2019.02.029","article-title":"Pain-induced negative affect is mediated via recruitment of the nucleus accumbens kappa opioid system","volume":"102","author":"Massaly","year":"2019","journal-title":"Neuron"},{"issue":"1\u20132","key":"10.1016\/j.pbb.2024.173847_bb0110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0006-8993(00)03302-3","article-title":"Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer\u2019s disease patients","volume":"893","author":"Mathieu-Kia","year":"2001","journal-title":"Brain Res."},{"issue":"13","key":"10.1016\/j.pbb.2024.173847_bb0115","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1523\/JNEUROSCI.23-13-05674.2003","article-title":"Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses","volume":"23","author":"McLaughlin","year":"2003","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.pbb.2024.173847_bb0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s002130000486","article-title":"Comparison of the effects of clozapine, haloperidol, chlorpromazine and d-amphetamine on performance on a time-constrained progressive ratio schedule and on locomotor behaviour in the rat","volume":"152","author":"Mobini","year":"2000","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.pbb.2024.173847_bb0125","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF00432213","article-title":"Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning","volume":"86","author":"Mucha","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2024.173847_bb0130","article-title":"Resistance of food-maintained operant responding to mechanical punishment in rats: further evidence for weak \u201caffective\/motivational pain\u201d in rat models of inflammatory and neuropathic pain","volume":"11","author":"Negus","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.pbb.2024.173847_bb0135","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00213-010-1834-7","article-title":"Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats","volume":"210","author":"Nemeth","year":"2010","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/j.pbb.2024.173847_bb0140","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.biopsych.2006.11.017","article-title":"Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats","volume":"62","author":"Paine","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"4765","key":"10.1016\/j.pbb.2024.173847_bb0145","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1126\/science.3016896","article-title":"Psychotomimesis mediated by kappa opiate receptors","volume":"233","author":"Pfeiffer","year":"1986","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.pbb.2024.173847_bb0150","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/s41386-020-0738-4","article-title":"Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)","volume":"45","author":"Pizzagalli","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.pbb.2024.173847_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0270(95)00153-0","article-title":"Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy","volume":"66","author":"Richardson","year":"1996","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.pbb.2024.173847_bb0160","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.eurpsy.2018.09.008","article-title":"Measurement of negative and depressive symptoms: discriminatory relevance of affect and expression","volume":"55","author":"Richter","year":"2019","journal-title":"Eur. Psychiatry"},{"issue":"3","key":"10.1016\/j.pbb.2024.173847_bb0165","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00192549","article-title":"The cardiovascular and central nervous system effects in the human of U-62066E. A selective opioid receptor agonist","volume":"46","author":"Rimoy","year":"1994","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.pbb.2024.173847_bb0170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbr.2014.01.003","article-title":"Effects of kappa opioid receptors on conditioned place aversion and social interaction in males and females","volume":"262","author":"Robles","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.pbb.2024.173847_bb0175","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/BF00169546","article-title":"Increased dopamine receptor sensitivity in the rat following acute administration of sufentanil, U50,488H and D-Ala2-D-Leu5-enkephalin","volume":"343","author":"Rooney","year":"1991","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.pbb.2024.173847_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-psych-020223-012208","article-title":"The neurobiology of activational aspects of motivation: exertion of effort, effort-based decision making, and the role of dopamine","volume":"75","author":"Salamone","year":"2024","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.pbb.2024.173847_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.appet.2024.107504","article-title":"Control of motivation for sucrose in the paraventricular hypothalamic nucleus by dynorphin peptides and the kappa opioid receptor","volume":"200","author":"Sandoval-Caballero","year":"2024","journal-title":"Appetite"},{"issue":"8","key":"10.1016\/j.pbb.2024.173847_bb0190","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.neuropharm.2007.09.002","article-title":"Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats","volume":"53","author":"Shannon","year":"2007","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.pbb.2024.173847_bb9005","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1471-4159.2004.02589.x","article-title":"Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects","volume":"90","author":"Shirayama","year":"2004","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.pbb.2024.173847_bb0195","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s002130050702","article-title":"Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review","volume":"139","author":"Stafford","year":"1998","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2024.173847_bb0200","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2018.09.023","article-title":"Dynorphin\/kappa-opioid receptor control of dopamine dynamics: implications for negative affective states and psychiatric disorders","volume":"1713","author":"Tejeda","year":"2019","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.pbb.2024.173847_bb0205","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00018-011-0844-x","article-title":"The dynorphin\/kappa-opioid receptor system and its role in psychiatric disorders","volume":"69","author":"Tejeda","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.pbb.2024.173847_bb0210","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/164_2021_440","article-title":"Dynorphin\/kappa-opioid receptor system modulation of cortical circuitry","volume":"271","author":"Tejeda","year":"2021","journal-title":"Handb. Exp."},{"key":"10.1016\/j.pbb.2024.173847_bb0215","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/164_2021_440","article-title":"Dynorphin\/kappa-opioid receptor system modulation of cortical circuitry","volume":"271","author":"Tejeda","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"issue":"4","key":"10.1016\/j.pbb.2024.173847_bb0220","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00213-003-1680-y","article-title":"Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats","volume":"172","author":"Todtenkopf","year":"2004","journal-title":"Psychopharmacology"},{"issue":"5","key":"10.1016\/j.pbb.2024.173847_bb0225","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/sj.bjp.0700971","article-title":"The effects of spiradoline (U-62066E), a kappa-opioid receptor agonist, on neuroendocrine function in man","volume":"120","author":"Ur","year":"1997","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.pbb.2024.173847_bb0230","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00213-013-3195-5","article-title":"Role of kappa-opioid receptors in stress and anxiety-related behavior","volume":"229","author":"Van't Veer","year":"2013","journal-title":"Psychopharmacology"},{"issue":"2&3","key":"10.1016\/j.pbb.2024.173847_bb0235","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/FBP.0000000000000559","article-title":"Opioid system modulation of cognitive affective bias: implications for the treatment of mood disorders","volume":"31","author":"Varastehmoradi","year":"2020","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.pbb.2024.173847_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2022.100493","article-title":"Kappa opioid receptor antagonism protects working memory performance from mild stress exposure in Rhesus macaques","volume":"21","author":"Wallace","year":"2022","journal-title":"Neurobiol Stress"},{"issue":"2","key":"10.1016\/j.pbb.2024.173847_bb0245","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s002130100788","article-title":"Enadoline, a selective kappa opioid agonist: comparison with butorphanol and hydromorphone in humans","volume":"157","author":"Walsh","year":"2001","journal-title":"Psychopharmacology"},{"issue":"1\u20132","key":"10.1016\/j.pbb.2024.173847_bb0250","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00213-004-1936-1","article-title":"Progressive ratio performance following challenge with antipsychotics, amphetamine, or NMDA antagonists in adult rats treated perinatally with phencyclidine","volume":"177","author":"Wiley","year":"2004","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.pbb.2024.173847_bb9010","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0166-4328(94)00150-E","article-title":"Stress-induced behavioral responses and multiple opioid systems in the brain","volume":"67","author":"Yamada","year":"1995","journal-title":"Behav. Brain Res."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305724001412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305724001412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:44:21Z","timestamp":1762231461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305724001412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":54,"alternative-id":["S0091305724001412"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2024.173847","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kappa opioid receptor mediated operant performance in male and female rats","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2024.173847","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"173847"}}