{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:46:58Z","timestamp":1777574818484,"version":"3.51.4"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02846"],"award-info":[{"award-number":["21H02846"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2109"],"award-info":[{"award-number":["JPMJSP2109"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.pbb.2024.173906","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T16:45:20Z","timestamp":1731689120000},"page":"173906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Splenic \u03b3\u03b4 T cells mediate antidepressant and prophylactic actions of arketamine in lipopolysaccharide-induced depression in mice"],"prefix":"10.1016","volume":"245","author":[{"given":"Guilin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akemi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiayun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Anzai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.pbb.2024.173906_bb0005","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The bidirectional relationship of depression and inflammation: double trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.pbb.2024.173906_bb0010","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.cpr.2007.02.005","article-title":"Risk for recurrence in depression","volume":"27","author":"Burcusa","year":"2007","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.pbb.2024.173906_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pbb.2019.04.008","article-title":"Comparison of antidepressant and side effects in mice after intranasal administration of (R,S)-ketamine, (R)-ketamine, and (S)-ketamine","volume":"181","author":"Chang","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pbb.2024.173906_bb0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainresbull.2022.02.004","article-title":"Brain-gut-microbiota axis in depression: a historical overview and future directions","volume":"182","author":"Chang","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.pbb.2024.173906_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106573","article-title":"Role of oxidative phosphorylation in the antidepressant effects of arketamine via the vagus nerve-dependent spleen-brain axis","volume":"199","author":"Chang","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.pbb.2024.173906_bb0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","article-title":"\u03b3\u03b4 T cells: first line of defense and beyond","volume":"32","author":"Chien","year":"2014","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0035","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.pbb.2024.173906_bb0040","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/s41380-022-01919-7","article-title":"Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis","volume":"28","author":"Foley","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0045","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1186\/s12889-016-3638-0","article-title":"The role of socio-economic status in depression: results from the COURAGE (aging survey in Europe)","volume":"16","author":"Freeman","year":"2016","journal-title":"BMC Public Health"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/jpet.116.239228","article-title":"Antidepressant potential of (R)-ketamine in rodent models: comparison with (S)-ketamine","volume":"361","author":"Fukumoto","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.pbb.2024.173906_bb0055","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.3390\/ijms16047796","article-title":"Inflammatory biomarkers as differential predictors of antidepressant response","volume":"16","author":"Hashimoto","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.pbb.2024.173906_bb0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/pcn.12902","article-title":"Rapid-acting antidepressant ketamine, its metabolites and other candidates: a historical overview and future perspective","volume":"73","author":"Hashimoto","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.pbb.2024.173906_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113935","article-title":"Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine","volume":"177","author":"Hashimoto","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pbb.2024.173906_bb0070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/bs.pbr.2023.01.003","article-title":"Neuroinflammation through the vagus nerve-dependent gut-microbiota-brain axis in treatment-resistant depression","volume":"278","author":"Hashimoto","year":"2023","journal-title":"Prog. Brain Res."},{"issue":"9","key":"10.1016\/j.pbb.2024.173906_bb0075","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1038\/s41380-023-02287-6","article-title":"Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions","volume":"28","author":"Hashimoto","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"12","key":"10.1016\/j.pbb.2024.173906_bb0080","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1038\/s41380-023-02161-5","article-title":"Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: the role of Epstein-Barr virus and the gut-brain axis","volume":"28","author":"Hashimoto","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"7","key":"10.1016\/j.pbb.2024.173906_bb0085","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s00406-023-01570-5","article-title":"Arketamine for cognitive impairment in psychiatric disorders","volume":"273","author":"Hashimoto","year":"2023","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.pbb.2024.173906_bb0090","doi-asserted-by":"crossref","DOI":"10.1007\/s00406-024-01770-7","article-title":"Are \u201cmystical experiences\u201d essential for antidepressant actions of ketamine and the classic psychedelics?","author":"Hashimoto","year":"2024","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"3","key":"10.1016\/j.pbb.2024.173906_bb0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jatmed.2024.07.001","article-title":"Ketamine and its two enantiomers in anesthesiology and psychiatry: a historical review and future directions","volume":"3","author":"Hashimoto","year":"2024","journal-title":"J. Anes. Transl. Med."},{"key":"10.1016\/j.pbb.2024.173906_bb0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jad.2022.06.018","article-title":"Socioeconomic differences in major depressive disorder onset among adults are partially explained by lifestyle factors: a longitudinal analysis of the Lifelines Cohort Study","volume":"314","author":"Hoveling","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0105","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41392-023-01653-8","article-title":"\u03b3\u03b4 T cells: origin and fate, subsets, diseases and immunotherapy","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"33","key":"10.1016\/j.pbb.2024.173906_bb0110","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci. Immuno."},{"key":"10.1016\/j.pbb.2024.173906_bb0115","doi-asserted-by":"crossref","first-page":"1206299","DOI":"10.3389\/fimmu.2023.1206299","article-title":"The intestinal \u03b3\u03b4 T cells: functions in the gut and in the distant organs","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.pbb.2024.173906_bb0120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12974-019-1475-7","article-title":"Role of inflammation in depression relapse","volume":"16","author":"Liu","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.pbb.2024.173906_bb0125","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41380-019-0474-5","article-title":"Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pbb.2024.173906_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2023.173659","article-title":"Prophylactic effects of arketamine, but not hallucinogenic psychedelic DOI nor non-hallucinogenic psychedelic analog lisuride, in lipopolysaccharide-treated mice and mice exposed to chronic restrain stress","volume":"233","author":"Liu","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pbb.2024.173906_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104527","article-title":"Gut microbiota and its metabolites in depression: from pathogenesis to treatment","volume":"90","author":"Liu","year":"2023","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0140","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jad.2013.01.014","article-title":"A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise","volume":"148","author":"Lopresti","year":"2013","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41398-022-01803-6","article-title":"Nuclear factor of activated T cells 4 in the prefrontal cortex is required for prophylactic actions of (R)-ketamine","volume":"12","author":"Ma","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pbb.2024.173906_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109250","article-title":"A role of microRNA-149 in the prefrontal cortex for prophylactic actions of (R)-ketamine in inflammation model","volume":"219","author":"Ma","year":"2022","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0155","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41398-022-02192-6","article-title":"A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice","volume":"12","author":"Ma","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pbb.2024.173906_bb0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jad.2022.08.087","article-title":"Effects of spleen nerve denervation on depression-like phenotype, systemic inflammation, and abnormal composition of gut microbiota in mice after administration of lipopolysaccharide: a role of brain-spleen axis","volume":"317","author":"Ma","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0165","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41398-023-02564-6","article-title":"A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice","volume":"13","author":"Ma","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pbb.2024.173906_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2024.173736","article-title":"A role of gut-brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress","volume":"238","author":"Ma","year":"2024","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"7","key":"10.1016\/j.pbb.2024.173906_bb0175","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1038\/s41380-020-00867-4","article-title":"The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression","volume":"26","author":"Mac Giollabhui","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pbb.2024.173906_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.100800","article-title":"Inflammation and the dimensions of depression","volume":"56","author":"Majd","year":"2020","journal-title":"Front. Neuroendocrinol."},{"issue":"8","key":"10.1016\/j.pbb.2024.173906_bb0185","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.pbb.2024.173906_bb0190","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1038\/s41380-021-01188-w","article-title":"Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts","volume":"26","author":"Milaneschi","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0195","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.pbb.2024.173906_bb0200","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3390\/ijms25031747","article-title":"Interplay between microbiota and \u03b3\u03b4 T cells: insights into immune homeostasis and neuro-immune interactions","volume":"25","author":"Mohamed","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0205","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12865-022-00479-3","article-title":"A novel 4 immune-related genes as diagnostic markers and correlated with immune infiltrates in major depressive disorder","volume":"23","author":"Ning","year":"2022","journal-title":"BMC Immunol."},{"issue":"4","key":"10.1016\/j.pbb.2024.173906_bb0210","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.pbb.2012.12.003","article-title":"Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration","volume":"103","author":"Ohgi","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pbb.2024.173906_bb0215","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2020.02.010","article-title":"Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls","volume":"87","author":"Osimo","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/j.pbb.2024.173906_bb0220","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41564-021-00948-2","article-title":"Crosstalk between \u03b3\u03b4 T cells and the microbiota","volume":"6","author":"Papotto","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.pbb.2024.173906_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173500","article-title":"Rapid antidepressant-like effect of non-hallucinogenic psychedelic analog lisuride, but not hallucinogenic psychedelic DOI, in lipopolysaccharide-treated mice","volume":"222","author":"Qu","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.pbb.2024.173906_bb0230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41577-020-00452-4","article-title":"\u03b3\u03b4 T cells in tissue physiology and surveillance","volume":"21","author":"Ribot","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.pbb.2024.173906_bb0235","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jad.2022.04.038","article-title":"Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio in depression: a meta-analysis","volume":"308","author":"Su","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.pbb.2024.173906_bb0240","article-title":"Impact of broad-spectrum antibiotics on the gut\u2013microbiota\u2013spleen\u2013brain axis","volume":"27","author":"Wan","year":"2022","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.pbb.2024.173906_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172870","article-title":"A historical review of antidepressant effects of ketamine and its enantiomers","volume":"190","author":"Wei","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pbb.2024.173906_bb0250","article-title":"Abnormalities of the composition of the gut microbiota and short-chain fatty acids in mice after splenectomy","volume":"11","author":"Wei","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0255","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41380-021-01121-1","article-title":"Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor","volume":"27","author":"Wei","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pbb.2024.173906_bb0260","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainresbull.2022.02.008","article-title":"Brain-spleen axis in health and disease: a review and future perspective","volume":"182","author":"Wei","year":"2022","journal-title":"Brain Res. Bull."},{"issue":"8","key":"10.1016\/j.pbb.2024.173906_bb0265","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1177\/0271678X231167946","article-title":"Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal \u03b3\u03b4 T-cell migration into the brain and lung","volume":"43","author":"Xie","year":"2023","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0270","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1038\/s41467-024-51209-9","article-title":"Gut-derived memory \u03b3\u03b4 T17 cells exacerbate sepsis-induced acute lung injury in mice","volume":"15","author":"Xie","year":"2024","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.pbb.2024.173906_bb0275","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1038\/s41386-018-0084-y","article-title":"(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice","volume":"43","author":"Yamaguchi","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"9","key":"10.1016\/j.pbb.2024.173906_bb0280","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.136","article-title":"R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects. R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects","volume":"5","author":"Yang","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.pbb.2024.173906_bb0285","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/j.biopsych.2016.12.020","article-title":"(R)-ketamine shows greater potency and longer lasting antidepressant effects than its metabolite (2R,6R)-hydroxynorketamine","volume":"82","author":"Yang","year":"2017","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0290","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biopsych.2017.05.016","article-title":"Mechanistic target of rapamycin-independent antidepressant effects of (R)-ketamine in a social defeat stress model","volume":"83","author":"Yang","year":"2018","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0295","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41398-019-0624-1","article-title":"Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites","volume":"9","author":"Yang","year":"2019","journal-title":"Transl. Psychiatry"},{"issue":"7","key":"10.1016\/j.pbb.2024.173906_bb0300","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3109\/08820131003753026","article-title":"Isolation of murine small intestinal intraepithelial \u03b3\u03b4t cells","volume":"39","author":"Ye","year":"2010","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.pbb.2024.173906_bb0305","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pbb.2013.11.033","article-title":"R(\u2212)-ketamine shows greater potency and longer lasting antidepressant effects than S(+)-ketamine","volume":"116","author":"Zhang","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"7","key":"10.1016\/j.pbb.2024.173906_bb0310","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/1570159X14666160119094646","article-title":"Brain-derived Neurotrophic Factor (BDNF)-trkB signaling in inflammation-related depression and potential therapeutic targets","volume":"14","author":"Zhang","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"7807","key":"10.1016\/j.pbb.2024.173906_bb0315","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41586-020-2235-7","article-title":"Brain control of humoral immune responses amenable to behavioural modulation","volume":"581","author":"Zhang","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0320","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41398-020-0733-x","article-title":"Essential role of microglial transforming growth factor-\u03b21 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-\u03b21","volume":"10","author":"Zhang","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.pbb.2024.173906_bb0325","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jad.2020.03.128","article-title":"Abnormal expression of colony stimulating factor 1 receptor (CSF1R) and transcription factor PU.1 (SPI1) in the spleen from patients with major psychiatric disorders: a role of brain-spleen axis","volume":"272","author":"Zhang","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.pbb.2024.173906_bb0330","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41398-020-00878-3","article-title":"A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration","volume":"10","author":"Zhang","year":"2020","journal-title":"Transl. Psychiatry"},{"issue":"10","key":"10.1016\/j.pbb.2024.173906_bb0335","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1007\/s00213-021-05889-6","article-title":"(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation","volume":"238","author":"Zhang","year":"2021","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"10.1016\/j.pbb.2024.173906_bb0340","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00406-019-01092-z","article-title":"Splenic NKG2D confers resilience versus susceptibility in mice after chronic social defeat stress: beneficial effects of (R)-ketamine","volume":"271","author":"Zhang","year":"2021","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.pbb.2024.173906_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109219","article-title":"Arketamine, a new rapid-acting antidepressant: a historical review and future directions","volume":"218","author":"Zhang","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2024.173906_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109305","article-title":"Ketamine and its metabolites: potential as novel treatments for depression","volume":"222","author":"Zhang","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pbb.2024.173906_bb0355","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbi.2023.09.026","article-title":"The role of CD38 in inflammation-induced depression-like behavior and the antidepressant effect of (R)-ketamine","volume":"115","author":"Zhang","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.pbb.2024.173906_bb0360","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41590-023-01447-8","article-title":"Dectin-1 signaling on colonic \u03b3\u03b4 T cells promotes psychosocial stress responses","volume":"24","author":"Zhu","year":"2023","journal-title":"Nat. Immunol."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305724002004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305724002004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T13:52:57Z","timestamp":1733233977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305724002004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":72,"alternative-id":["S0091305724002004"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2024.173906","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Splenic \u03b3\u03b4 T cells mediate antidepressant and prophylactic actions of arketamine in lipopolysaccharide-induced depression in mice","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2024.173906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"173906"}}