{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:20:41Z","timestamp":1756992041115,"version":"3.37.3"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"am","delay-in-days":320,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["AA025590","F32AA027962","AA013852","AA030061"],"award-info":[{"award-number":["AA025590","F32AA027962","AA013852","AA030061"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA030061","AA013852","AA025590"],"award-info":[{"award-number":["AA030061","AA013852","AA025590"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.pbb.2025.173958","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T16:04:30Z","timestamp":1736611470000},"page":"173958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex"],"prefix":"10.1016","volume":"248","author":[{"given":"Jonna M.","family":"Leyrer-Jackson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Kufahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Foster","family":"Olive","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.pbb.2025.173958_bb0005","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1476-5381.2009.00562.x","article-title":"Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors","volume":"159","author":"Adams","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.pbb.2025.173958_bb0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41398-017-0066-6","article-title":"Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder","volume":"8","author":"Akkus","year":"2018","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.pbb.2025.173958_bb0015","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/01.ALC.0000122101.13164.21","article-title":"Ionotropic glutamate receptor antagonists modulate cue-induced reinstatement of ethanol-seeking behavior","volume":"28","author":"Backstrom","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2025.173958_bb0020","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/sj.npp.1300381","article-title":"mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior","volume":"29","author":"Backstrom","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2025.173958_bb0025","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.physbeh.2017.10.025","article-title":"Gonadal hormones affect alcohol drinking, but not cue+yohimbine-induced alcohol seeking, in male and female rats","volume":"203","author":"Bertholomey","year":"2019","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.pbb.2025.173958_bb0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1530-0277.2007.00570.x","article-title":"Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats","volume":"32","author":"Besheer","year":"2008","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"9","key":"10.1016\/j.pbb.2025.173958_bb0035","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopsych.2009.09.016","article-title":"Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake","volume":"67","author":"Besheer","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.pbb.2025.173958_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149086","article-title":"Involvement of prelimbic cortex-nucleus accumbens projections in context-induced alcohol seeking","volume":"1841","author":"Bianchi","year":"2024","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.pbb.2025.173958_bb0045","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1017\/S1461145708008584","article-title":"Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions","volume":"11","author":"Blednov","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"7","key":"10.1016\/j.pbb.2025.173958_bb0050","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.steroids.2008.11.013","article-title":"Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology","volume":"74","author":"Boulware","year":"2009","journal-title":"Steroids"},{"issue":"5","key":"10.1016\/j.pbb.2025.173958_bb0055","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0296-19.2019","article-title":"Differential effects of dorsal and ventral medial prefrontal cortex inactivation during natural reward seeking, extinction, and cue-induced reinstatement","volume":"6","author":"Caballero","year":"2019","journal-title":"eNeuro"},{"issue":"16","key":"10.1016\/j.pbb.2025.173958_bb0060","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1523\/JNEUROSCI.2873-16.2017","article-title":"Prefrontal cortex KCa2 channels regulate mGlu5-dependent plasticity and extinction of alcohol-seeking behavior","volume":"37","author":"Cannady","year":"2017","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.pbb.2025.173958_bb0065","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2967\/jnumed.119.228825","article-title":"Recovery of decreased metabotropic glutamate receptor 5 availability in abstinent alcohol-dependent patients","volume":"61","author":"Ceccarini","year":"2020","journal-title":"J. Nucl. Med."},{"issue":"1\u20132","key":"10.1016\/j.pbb.2025.173958_bb0070","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00213-002-1380-z","article-title":"Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone","volume":"168","author":"Ciccocioppo","year":"2003","journal-title":"Psychopharmacology (Berl)"},{"issue":"9","key":"10.1016\/j.pbb.2025.173958_bb0075","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1111\/j.1530-0277.2012.01776.x","article-title":"Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures","volume":"36","author":"Cozzoli","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.pbb.2025.173958_bb0080","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/acer.12292","article-title":"The effect of mGluR5 antagonism during binge drinking on subsequent ethanol intake in C57BL\/6J mice: sex- and age-induced differences","volume":"38","author":"Cozzoli","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"11","key":"10.1016\/j.pbb.2025.173958_bb0085","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1038\/s41386-021-01050-1","article-title":"Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice","volume":"46","author":"Dao","year":"2021","journal-title":"Neuropsychopharmacology"},{"issue":"12","key":"10.1016\/j.pbb.2025.173958_bb0090","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/s41386-024-01889-0","article-title":"Parvalbumin interneuron mGlu5 receptors govern sex differences in prefrontal cortex physiology and binge drinking","volume":"49","author":"Fabian","year":"2024","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2025.173958_bb0095","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bcp.2007.06.039","article-title":"Glutamatergic substrates of drug addiction and alcoholism","volume":"75","author":"Gass","year":"2008","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.pbb.2025.173958_bb0100","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00213-009-1490-y","article-title":"Role of protein kinase C epsilon (PKCe) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell","volume":"204","author":"Gass","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"issue":"22","key":"10.1016\/j.pbb.2025.173958_bb0105","doi-asserted-by":"crossref","first-page":"7562","DOI":"10.1523\/JNEUROSCI.5616-12.2014","article-title":"Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex","volume":"334","author":"Gass","year":"2014","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.pbb.2025.173958_bb0110","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications","volume":"12","author":"Goldstein","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.pbb.2025.173958_bb0115","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1038\/s41386-018-0050-8","article-title":"Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle","volume":"43","author":"Gonzalez-Cuevas","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2025.173958_bb0120","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejps.2017.07.031","article-title":"A phase I randomized clinical trial testing the safety, tolerability and preliminary pharmacokinetics of the mGluR5 negative allosteric modulator GET 73 following single and repeated doses in healthy volunteers","volume":"109","author":"Haass-Koffler","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.pbb.2025.173958_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/0269881117746904","article-title":"Administration of the metabotropic glutamate receptor subtype 5 allosteric modulator GET 73 with alcohol: a translational study in rats and humans","volume":"32","author":"Haass-Koffler","year":"2018","journal-title":"J. Psychopharmacol."},{"issue":"8","key":"10.1016\/j.pbb.2025.173958_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023885","article-title":"Shift in the intrinsic excitability of medial prefrontal cortex neurons following training in impulse control and cued-responding tasks","volume":"6","author":"Hayton","year":"2011","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.pbb.2025.173958_bb0135","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41386-020-00856-9","article-title":"Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence","volume":"46","author":"Hillmer","year":"2021","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.pbb.2025.173958_bb0140","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00213-005-0217-y","article-title":"The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL\/6J mice","volume":"183","author":"Hodge","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2025.173958_bb0145","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbr.2017.11.019","article-title":"Brain-derived neurotrophic factor (BDNF) determines a sex difference in cue-conditioned alcohol seeking in rats","volume":"339","author":"Hogarth","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"17","key":"10.1016\/j.pbb.2025.173958_bb0150","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1523\/JNEUROSCI.3383-16.2017","article-title":"Regulation of alcohol extinction and cue-induced reinstatement by specific projections among medial prefrontal cortex, nucleus accumbens, and basolateral amygdala","volume":"37","author":"Keistler","year":"2017","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.pbb.2025.173958_bb0155","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1177\/0269881119844180","article-title":"The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery","volume":"33","author":"Khoo","year":"2019","journal-title":"J. Psychopharmacol."},{"issue":"17","key":"10.1016\/j.pbb.2025.173958_bb0160","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1111\/bph.15854","article-title":"Compulsive alcohol seeking and relapse: central role of conditioning factors associated with alleviation of withdrawal states by alcohol","volume":"179","author":"Kozanian","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.pbb.2025.173958_bb0165","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2967\/jnumed.117.199422","article-title":"Lower limbic metabotropic glutamate receptor 5 availability in alcohol dependence","volume":"59","author":"Leurquin-Sterk","year":"2018","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.pbb.2025.173958_bb0170","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/adb.12542","article-title":"Cerebral dopaminergic and glutamatergic transmission relate to different subjective responses of acute alcohol intake: an in vivo multimodal imaging study","volume":"23","author":"Leurquin-Sterk","year":"2018","journal-title":"Addict. Biol."},{"issue":"3","key":"10.1016\/j.pbb.2025.173958_bb0175","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1124\/jpet.300.3.882","article-title":"Reversal of ethanol-seeking behavior by D1 and D2 antagonists in an animal model of relapse: differences in antagonist potency in previously ethanol-dependent versus nondependent rats","volume":"300","author":"Liu","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pbb.2025.173958_bb0180","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.drugalcdep.2006.04.003","article-title":"Behavioral and neurochemical interactions between group I mGluR antagonists and ethanol: potential insight into their anti-addictive properties","volume":"85","author":"Lominac","year":"2006","journal-title":"Drug Alcohol Depend."},{"issue":"3","key":"10.1016\/j.pbb.2025.173958_bb0185","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1037\/a0023515","article-title":"Dissociations between medial prefrontal cortical subregions in the modulation of learning and action","volume":"125","author":"Maddux","year":"2011","journal-title":"Behav. Neurosci."},{"issue":"30","key":"10.1016\/j.pbb.2025.173958_bb0190","doi-asserted-by":"crossref","first-page":"9472","DOI":"10.1073\/pnas.1507611112","article-title":"Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction","volume":"112","author":"Moorman","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.pbb.2025.173958_bb0195","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00213-022-06287-2","article-title":"Prelimbic and infralimbic medial prefrontal cortex neuron activity signals cocaine seeking variables across multiple timescales","volume":"240","author":"Moorman","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.pbb.2025.173958_bb0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbr.2017.03.037","article-title":"Female Sprague-Dawley rats display greater appetitive and consummatory responses to alcohol","volume":"327","author":"Nieto","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"11","key":"10.1016\/j.pbb.2025.173958_bb0205","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1111\/j.1530-0277.2009.01030.x","article-title":"Differential effects of chronic ethanol consumption and withdrawal on homer\/glutamate receptor expression in subregions of the accumbens and amygdala of P rats","volume":"33","author":"Obara","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.pbb.2025.173958_bb0210","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1124\/mol.104.003319","article-title":"The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase Ce-dependent mechanism","volume":"67","author":"Olive","year":"2005","journal-title":"Mol. Pharmacol."},{"year":"2014","author":"Paxinos","series-title":"The Rat Brain in Stereotaxic Coordinates","key":"10.1016\/j.pbb.2025.173958_bb0215"},{"issue":"20","key":"10.1016\/j.pbb.2025.173958_bb0220","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1111\/bph.12735","article-title":"Role of cues and contexts on drug-seeking behaviour","volume":"171","author":"Perry","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"30","key":"10.1016\/j.pbb.2025.173958_bb0225","doi-asserted-by":"crossref","first-page":"10750","DOI":"10.1523\/JNEUROSCI.0684-15.2015","article-title":"Losing control: excessive alcohol seeking after selective inactivation of cue-responsive neurons in the infralimbic cortex","volume":"35","author":"Pfarr","year":"2015","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.pbb.2025.173958_bb0230","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1038\/npp.2014.89","article-title":"Alterations in reward, fear and safety cue discrimination after inactivation of the rat prelimbic and infralimbic cortices","volume":"39","author":"Sangha","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.pbb.2025.173958_bb0235","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00213-005-2175-9","article-title":"The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats","volume":"179","author":"Schroeder","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2025.173958_bb0240","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.alcohol.2021.10.004","article-title":"The role of context on responding to an alcohol-predictive cue in female and male rats","volume":"99","author":"Segal","year":"2022","journal-title":"Alcohol"},{"issue":"9","key":"10.1016\/j.pbb.2025.173958_bb0245","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.biopsych.2010.01.005","article-title":"Effects of the mGlu2\/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence","volume":"67","author":"Sidhpura","year":"2010","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.pbb.2025.173958_bb0250","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.pbb.2012.01.014","article-title":"mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior","volume":"101","author":"Sinclair","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"5","key":"10.1016\/j.pbb.2025.173958_bb0255","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/acer.14816","article-title":"Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder","volume":"46","author":"Smart","year":"2022","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2025.173958_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114435","article-title":"Involvement of cortical projections to basolateral amygdala in context-induced reinstatement of ethanol-seeking in rats","volume":"448","author":"Tavares","year":"2023","journal-title":"Behav. Brain Res."},{"issue":"1\u20132","key":"10.1016\/j.pbb.2025.173958_bb0265","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbr.2003.09.028","article-title":"Do rats have a prefrontal cortex?","volume":"146","author":"Uylings","year":"2003","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.pbb.2025.173958_bb0270","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.npp.1301438","article-title":"Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence","volume":"33","author":"Walker","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"20","key":"10.1016\/j.pbb.2025.173958_bb0275","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1007\/s00213-015-4027-6","article-title":"Cue reactivity and its relation to craving and relapse in alcohol dependence: a combined laboratory and field study","volume":"232","author":"Witteman","year":"2015","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130572500005X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009130572500005X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:10:43Z","timestamp":1740377443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009130572500005X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":55,"alternative-id":["S009130572500005X"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2025.173958","relation":{},"ISSN":["0091-3057"],"issn-type":[{"type":"print","value":"0091-3057"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2025.173958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"173958"}}