{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:39:30Z","timestamp":1786995570127,"version":"build-2736575974"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.pbb.2025.173982","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T11:21:01Z","timestamp":1740223261000},"page":"173982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Efficacy of minocycline in substance use disorder: A systematic review of preclinical and clinical studies"],"prefix":"10.1016","volume":"250","author":[{"given":"Sahar","family":"Eshrati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Nikbakhtzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Arezoomandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azin","family":"Fattahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbb.2025.173982_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13011-020-00300-7","article-title":"Individualized approach to primary prevention of substance use disorder: age-related risks","volume":"15","author":"Afuseh","year":"2020","journal-title":"Subst. Abuse Treat. Prev. Policy"},{"key":"10.1016\/j.pbb.2025.173982_bb0010","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1016\/j.bbi.2011.03.002","article-title":"Minocycline reduces ethanol drinking","volume":"25 Suppl 1(Suppl 1)","author":"Agrawal","year":"2011","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.pbb.2025.173982_bb0015","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acer.12288","article-title":"Bioinformatics analyses reveal age-specific neuroimmune modulation as a target for treatment of high ethanol drinking","volume":"38","author":"Agrawal","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.pbb.2025.173982_bb0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ajp.2019.10.007","article-title":"Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats","volume":"46","author":"Arezoomandan","year":"2019","journal-title":"Asian J. Psychiatr."},{"issue":"3","key":"10.1016\/j.pbb.2025.173982_bb0025","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1139\/cjpp-2015-0209","article-title":"Administration of the glial cell modulator, minocycline, in the nucleus accumbens attenuated the maintenance and reinstatement of morphine-seeking behavior","volume":"94","author":"Arezoomandan","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"10","key":"10.1016\/j.pbb.2025.173982_bb0030","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1007\/s00213-018-5146-7","article-title":"Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients","volume":"236","author":"Arout","year":"2019","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2025.173982_bb0035","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pnpbp.2014.04.008","article-title":"Minocycline, an antibiotic with inhibitory effect on microglial activation, attenuates the maintenance and reinstatement of methamphetamine-seeking behavior in rat [article]","volume":"53","author":"Attarzadeh-Yazdi","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.pbb.2025.173982_bb5010","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/13543784.2021.1854725","article-title":"Cholangiocarcinoma: bridging the translational gap from preclinical to clinical development and implications for future therapy","volume":"30","author":"Baiocchi","year":"2021","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"5","key":"10.1016\/j.pbb.2025.173982_bb5015","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.3390\/ijms23052618","article-title":"More than addiction\u2014the nucleus accumbens contribution to development of mental disorders and neurodegenerative diseases","volume":"23","author":"Bayassi-Jakowicka","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.pbb.2025.173982_bb0040","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2174\/1567205013666160819124206","article-title":"The anti-inflammatory role of minocycline in Alzheimer\u2019s disease","volume":"13","author":"Budni","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.pbb.2025.173982_bb0045","doi-asserted-by":"crossref","DOI":"10.7573\/dic.212553","article-title":"The therapeutic role of minocycline in Parkinson\u2019s disease","volume":"8","author":"Cankaya","year":"2019","journal-title":"Drugs in context"},{"issue":"3","key":"10.1016\/j.pbb.2025.173982_bb0050","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.neulet.2009.01.078","article-title":"Minocycline affects cocaine sensitization in mice","volume":"452","author":"Chen","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pbb.2025.173982_bb0055","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuroscience.2012.06.046","article-title":"Minocycline inhibits d-amphetamine-elicited action potential bursts in a central snail neuron [article]","volume":"223","author":"Chen","year":"2012","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.pbb.2025.173982_bb5025","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2174\/1570159X21666221208142151","article-title":"Role of microglia in psychostimulant addiction","volume":"21","author":"da Silva","year":"2023","journal-title":"Curr. Neuropharmacol."},{"issue":"12","key":"10.1016\/j.pbb.2025.173982_bb0060","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1097\/j.pain.0000000000001688","article-title":"Withdrawal from an opioid induces a transferable memory trace in the cerebrospinal fluid","volume":"160","author":"Drdla-Schutting","year":"2019","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.pbb.2025.173982_bb0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/glia.20268","article-title":"Inhibitory effect of minocycline on amyloid \u03b2 fibril formation and human microglial activation","volume":"53","author":"Familian","year":"2006","journal-title":"Glia"},{"issue":"5","key":"10.1016\/j.pbb.2025.173982_bb0070","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/j.1471-4159.2006.03799.x","article-title":"Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury","volume":"97","author":"Festoff","year":"2006","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb0075","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/add.14764","article-title":"Are animal models of addiction useful?","volume":"115","author":"Field","year":"2020","journal-title":"Addiction"},{"issue":"2","key":"10.1016\/j.pbb.2025.173982_bb0080","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pbb.2012.01.005","article-title":"The antibiotic minocycline prevents methamphetamine-induced rewarding effects in mice","volume":"101","author":"Fujita","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00540-012-1469-4","article-title":"Microglial activation involved in morphine tolerance is not mediated by toll-like receptor 4","volume":"27","author":"Fukagawa","year":"2013","journal-title":"J. Anesth."},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb0090","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1574884713666180228110310","article-title":"Minocycline in alcohol withdrawal induced anxiety and alcohol relapse in rats [article]","volume":"13","author":"Gajbhiye","year":"2018","journal-title":"Curr. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.pbb.2025.173982_bb0095","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/bph.12139","article-title":"Minocycline: far beyond an antibiotic","volume":"169","author":"Garrido-Mesa","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.pbb.2025.173982_bb0100","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1080\/01480545.2021.1942484","article-title":"The effects of minocycline in improving of methamphetamine withdrawal syndrome in male mice","volume":"45","author":"Ghavimi","year":"2022","journal-title":"Drug Chem. Toxicol."},{"issue":"21","key":"10.1016\/j.pbb.2025.173982_bb5030","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.3390\/jcm12216734","article-title":"Advances in stroke neurorehabilitation","volume":"12","author":"Gunduz","year":"2023","journal-title":"J. Clin. Med."},{"issue":"3","key":"10.1016\/j.pbb.2025.173982_bb0105","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1213\/ane.0b013e3181ae5f13","article-title":"Central administration of minocycline and riluzole prevents morphine-induced tolerance in rats","volume":"109","author":"Habibi-Asl","year":"2009","journal-title":"Anesth. Analg."},{"issue":"8","key":"10.1016\/j.pbb.2025.173982_bb0110","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/1440-1681.13090","article-title":"Effect of pretreatment with intracerebroventricular injection of minocycline on morphine-induced memory impairment in passive avoidance test: role of P-CREB and c-Fos expression in the dorsal hippocampus and basolateral amygdala regions","volume":"46","author":"Hamidkhaniha","year":"2019","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"5","key":"10.1016\/j.pbb.2025.173982_bb0115","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.biopsych.2006.03.019","article-title":"Protective effects of minocycline on the reduction of dopamine transporters in the striatum after Administration of Methamphetamine: a positron emission tomography study in conscious monkeys [article]","volume":"61","author":"Hashimoto","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.pbb.2025.173982_bb0120","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s12640-010-9212-0","article-title":"Minocycline prevents morphine-induced apoptosis in rat cerebral cortex and lumbar spinal cord: a possible mechanism for attenuating morphine tolerance","volume":"19","author":"Hassanzadeh","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.pbb.2025.173982_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108054","article-title":"Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice","volume":"170","author":"Hu","year":"2020","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.pbb.2025.173982_bb0130","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.bbi.2008.07.008","article-title":"Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia","volume":"22","author":"Hutchinson","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.pbb.2025.173982_bb0135","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbi.2018.01.012","article-title":"Minocycline blocks traumatic brain injury-induced alcohol consumption and nucleus accumbens inflammation in adolescent male mice","volume":"69","author":"Karelina","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.pbb.2025.173982_bb0140","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0091-3057(90)90006-4","article-title":"Inhibition by antibiotic tetracyclines of rat cortical noradrenergic adenylate cyclase and amphetamine-induced hyperactivity [article]","volume":"37","author":"Kofman","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb5035","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41467-019-14173-3","article-title":"Microglial activation increases cocaine self-administration following adolescent nicotine exposure","volume":"11","author":"Linker","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.pbb.2025.173982_bb0145","doi-asserted-by":"crossref","unstructured":"Kuehn, B. M. (2012). WHO documents worldwide need for better drug abuse treatment--and access to it. Jama, 308(5), 442\u2013443. doi:https:\/\/doi.org\/10.1001\/jama.2012.8882.","DOI":"10.1001\/jama.2012.8882"},{"key":"10.1016\/j.pbb.2025.173982_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135825","article-title":"Minocycline alleviates the symptoms of morphine withdrawal via the CaMKII-Ras-ERK signaling pathway","volume":"752","author":"Liu","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.pbb.2025.173982_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135283","article-title":"Injection of minocycline into the periaqueductal gray attenuates morphine withdrawal signs","volume":"736","author":"Liu","year":"2020","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.pbb.2025.173982_bb0160","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00213-007-0955-0","article-title":"Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice","volume":"196","author":"Mizoguchi","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.pbb.2025.173982_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173241","article-title":"Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users","volume":"209","author":"Mogali","year":"2021","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pbb.2025.173982_bb5040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112597","article-title":"Molecular, histological and behavioral evidences for neuroprotective effects of minocycline against nicotine-induced neurodegeneration and cognition impairment: possible role of CREB-BDNF signaling pathway","volume":"386","author":"Motaghinejad","year":"2020","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb0170","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/fcp.12584","article-title":"The possible role of CREB-BDNF signaling pathway in neuroprotective effects of minocycline against alcohol-induced neurodegeneration: molecular and behavioral evidences","volume":"35","author":"Motaghinejad","year":"2021","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"9","key":"10.1016\/j.pbb.2025.173982_bb0175","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1523\/JNEUROSCI.4847-03.2004","article-title":"Role of tumor necrosis factor-\u03b1 in methamphetamine-induced drug dependence and neurotoxicity","volume":"24","author":"Nakajima","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.pbb.2025.173982_bb5045","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuroscience.2014.05.028","article-title":"Neurotrophins in the ventral tegmental area: role in social stress, mood disorders and drug abuse","volume":"282","author":"Nikulina","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2025.173982_bb0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2014.03.005","article-title":"Minocycline mitigates motor impairments and cortical neuronal loss induced by focal ischemia in rats chronically exposed to ethanol during adolescence","volume":"1561","author":"Oliveira","year":"2014","journal-title":"Brain Res."},{"issue":"6733","key":"10.1016\/j.pbb.2025.173982_bb0185","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/20446","article-title":"Inhibition of caspase-1 slows disease progression in a mouse model of Huntington\u2019s disease","volume":"399","author":"Ona","year":"1999","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.pbb.2025.173982_bb0190","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1007\/s00213-019-05205-3","article-title":"Targeting neuroinflammation with minocycline in heavy drinkers [article]","volume":"236","author":"Petrakis","year":"2019","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb0195","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1017\/S1092852918001426","article-title":"Cognitive impairment in substance use disorders","volume":"24","author":"Ramey","year":"2019","journal-title":"CNS Spectr."},{"key":"10.1016\/j.pbb.2025.173982_bb0200","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.alcohol.2018.12.002","article-title":"Minocycline attenuates ethanol-induced cell death and microglial activation in the developing spinal cord [article]","volume":"79","author":"Ren","year":"2019","journal-title":"Alcohol"},{"issue":"7","key":"10.1016\/j.pbb.2025.173982_bb0205","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1037\/abn0000191","article-title":"Age at first use and later substance use disorder: shared genetic and environmental pathways for nicotine, alcohol, and cannabis","volume":"125","author":"Richmond-Rakerd","year":"2016","journal-title":"J. Abnorm. Psychol."},{"issue":"2","key":"10.1016\/j.pbb.2025.173982_bb0210","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000519886","article-title":"Indicators of drug-related community impacts of open drug scenes: a scoping review","volume":"28","author":"Saberi Zafarghandi","year":"2022","journal-title":"Eur. Addict. Res."},{"issue":"3","key":"10.1016\/j.pbb.2025.173982_bb0215","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1523\/JNEUROSCI.2516-12.2013","article-title":"Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction","volume":"33","author":"Schwarz","year":"2013","journal-title":"J. Neurosci."},{"issue":"1\u20133","key":"10.1016\/j.pbb.2025.173982_bb0220","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejphar.2013.01.016","article-title":"Glial cell modulators attenuate methamphetamine self-administration in the rat","volume":"701","author":"Snider","year":"2013","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb0225","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00213-010-2014-5","article-title":"Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans","volume":"213","author":"Sofuoglu","year":"2011","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb0230","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pbb.2008.11.004","article-title":"Minocycline reduced craving for cigarettes but did not affect smoking or intravenous nicotine responses in humans","volume":"92","author":"Sofuoglu","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.pbb.2025.173982_bb0235","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/npp.2015.221","article-title":"Neuroimmune regulation of GABAergic neurons within the ventral tegmental area during withdrawal from chronic morphine","volume":"41","author":"Taylor","year":"2016","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.pbb.2025.173982_bb0240","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2174\/1381612043453162","article-title":"Minocycline: neuroprotective mechanisms in Parkinson\u2019s disease","volume":"10","author":"Thomas","year":"2004","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.pbb.2025.173982_bb5050","first-page":"415","article-title":"Focus: personalized medicine: precision in addiction care: does it make a difference?","volume":"88","author":"Van Der Stel","year":"2015","journal-title":"Yale J. Biol. Med."},{"issue":"1","key":"10.1016\/j.pbb.2025.173982_bb5055","article-title":"Novel advances and recent updates in the crosstalk between neuroplasticity and addiction","volume":"1","author":"Varghese","year":"2022","journal-title":"Clin. Chem."},{"key":"10.1016\/j.pbb.2025.173982_bb5060","series-title":"Cognition and Addiction","first-page":"405","article-title":"Synergistic opportunities in combined interventions for addiction treatment","author":"Verdejo-Garcia","year":"2020"},{"key":"10.1016\/j.pbb.2025.173982_bb0245","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuropharm.2017.11.019","article-title":"Minocycline protects developing brain against ethanol-induced damage","volume":"129","author":"Wang","year":"2018","journal-title":"Neuropharmacology"},{"issue":"9","key":"10.1016\/j.pbb.2025.173982_bb0250","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1176\/ps.62.9.pss6209_1007","article-title":"Substance use disorder among people with first-episode psychosis: a systematic review of course and treatment","volume":"62","author":"Wisdom","year":"2011","journal-title":"Psychiatr. Serv."},{"issue":"26","key":"10.1016\/j.pbb.2025.173982_bb0255","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrj\u00e4nheikki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.pbb.2025.173982_bb0260","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.pnpbp.2006.05.015","article-title":"Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine [article]","volume":"30","author":"Zhang","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.pbb.2025.173982_bb0265","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbi.2011.09.017","article-title":"Activation of p38 signaling in the microglia in the nucleus accumbens contributes to the acquisition and maintenance of morphine-induced conditioned place preference","volume":"26","author":"Zhang","year":"2012","journal-title":"Brain Behav. Immun."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305725000292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305725000292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T07:34:05Z","timestamp":1744011245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305725000292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":63,"alternative-id":["S0091305725000292"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2025.173982","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of minocycline in substance use disorder: A systematic review of preclinical and clinical studies","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2025.173982","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"173982"}}