{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:14:07Z","timestamp":1778667247501,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004039","name":"Juntendo University Juntendo Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004039","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.pbb.2025.174041","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T19:10:12Z","timestamp":1748286612000},"page":"174041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Administration of paroxetine during pregnancy affects behavioral changes and hippocampal cell proliferation in male offspring in rats"],"prefix":"10.1016","volume":"253","author":[{"given":"Junko","family":"Horie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Kinjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihito","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.901940102","article-title":"Development of the brain stem in the rat. I. Thymidine-radiographic study of the time of origin of neurons of the lower medulla","volume":"194","author":"Altman","year":"1980","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.pbb.2025.174041_bb0010","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn.2017.45","article-title":"Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood","volume":"18","author":"Anacker","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000096645","article-title":"Developmental and behavioral consequences of prenatal fluoxetine","volume":"79","author":"Bairy","year":"2007","journal-title":"Pharmacology"},{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/bdrb.20099","article-title":"First trimester exposure to paroxetine and risk of cardiac malformations in infants: the importance of dosage","volume":"80","author":"B\u00e9rard","year":"2007","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13034-023-00624-9","article-title":"Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study","volume":"17","author":"Bliddal","year":"2023","journal-title":"Child Adolesc. Psychiatry Ment. Health"},{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1503\/jpn.140099","article-title":"Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology","volume":"40","author":"Booij","year":"2015","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.pbb.2025.174041_bb0035","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neuroscience.2016.02.037","article-title":"Developmental changes in serotonin signaling: implications for early brain function, behavior and adaptation","volume":"342","author":"Brummelte","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2025.174041_bb0040","doi-asserted-by":"crossref","first-page":"1042858","DOI":"10.3389\/fnsyn.2023.1042858","article-title":"Inhibitory hippocampus-medial septum projection controls locomotion and exploratory behavior","volume":"15","author":"Chen","year":"2023","journal-title":"Front. Synaptic Neurosci."},{"issue":"5","key":"10.1016\/j.pbb.2025.174041_bb0045","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0892-0362(00)00099-4","article-title":"Chronic prenatal exposure to paroxetine (Paxil) and cognitive development of mice offspring","volume":"22","author":"Christensen","year":"2000","journal-title":"Neurotoxicol. Teratol."},{"issue":"5 Pt 1","key":"10.1016\/j.pbb.2025.174041_bb0050","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0002-9378(99)70102-X","article-title":"Behavioral changes in developing mice after prenatal exposure to paroxetine (Paxil)","volume":"181","author":"Coleman","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"11","key":"10.1016\/j.pbb.2025.174041_bb0055","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/archgenpsychiatry.2011.73","article-title":"Antidepressant use during pregnancy and childhood autism spectrum disorders","volume":"68","author":"Croen","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.pbb.2025.174041_bb0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbr.2013.05.064","article-title":"Fluoxetine exposure during pregnancy and lactation: effects on acute stress response and behavior in the novelty-suppressed feeding are age and gender-dependent in rats","volume":"252","author":"Francis-Oliveira","year":"2013","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12916-018-1193-5","article-title":"Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births","volume":"16","author":"Gao","year":"2018","journal-title":"BMC Med."},{"key":"10.1016\/j.pbb.2025.174041_bb0070","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijdevneu.2016.04.008","article-title":"Of rodents and humans: a comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research","volume":"51","author":"Glover","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.pbb.2025.174041_bb0075","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.neuroscience.2014.10.044","article-title":"Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety\/depression-prone rats","volume":"284","author":"Glover","year":"2015","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.pbb.2025.174041_bb0080","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1111\/ejn.14315","article-title":"Perinatal exposure to the SSRI paroxetine alters the methylome landscape of the developing dentate gyrus","volume":"50","author":"Glover","year":"2019","journal-title":"Eur. J. Neurosci."},{"issue":"10","key":"10.1016\/j.pbb.2025.174041_bb0085","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1248\/bpb.31.1928","article-title":"Effects of repeated electroconvulsive seizures on spontaneous alternation behavior and locomotor activity in rats","volume":"31","author":"Hidaka","year":"2008","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.pbb.2025.174041_bb0090","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bbr.2003.10.028","article-title":"Responsiveness to brightness change in male and female rats following treatment with the partial agonist of the N-methyl-D-aspartate receptor, D-cycloserine","volume":"152","author":"Hughes","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.pbb.2025.174041_bb0095","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpsychires.2022.06.054","article-title":"Antidepressant prescriptions and therapy intensification in men and women newly diagnosed with depression in the UK","volume":"154","author":"John","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.pbb.2025.174041_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146403","article-title":"Prenatal exposure to valproic acid is associated with altered neurocognitive function and neurogenesis in the dentate gyrus of male offspring rats","volume":"1723","author":"Kinjo","year":"2019","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.pbb.2025.174041_bb0105","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1159\/000363102","article-title":"Increased aggression, improved spatial memory, and reduced anxiety-like behaviour in adult male mice exposed to fluoxetine early in life","volume":"36","author":"Kiryanova","year":"2014","journal-title":"Dev. Neurosci."},{"issue":"6","key":"10.1016\/j.pbb.2025.174041_bb0110","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2174\/1570159X19666210303121059","volume":"19","author":"Leshem","year":"2021","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/sj.npp.1300823","article-title":"Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry","volume":"31","author":"Maciag","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.pbb.2025.174041_bb0120","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neubiorev.2014.11.020","article-title":"Exposure to selective serotonin reuptake inhibitors during pregnancy and risk of autism spectrum disorder in children: a systematic review and meta-analysis of observational studies","volume":"49","author":"Man","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pbb.2025.174041_bb0125","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.neuroscience.2012.09.024","article-title":"Behavioural outcomes of perinatal maternal fluoxetine treatment","volume":"226","author":"McAllister","year":"2012","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2011.02.029","article-title":"Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008","volume":"205","author":"Mitchell","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.pbb.2025.174041_bb0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jad.2019.12.014","article-title":"The international prevalence of antidepressant use before, during, and after pregnancy: a systematic review and meta-analysis of timing, type of prescriptions and geographical variability","volume":"264","author":"Molenaar","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.pbb.2025.174041_bb0140","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.pbb.2025.174041_bb0145","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainres.2012.10.052","article-title":"Effects of single and repeated electroconvulsive stimulation on hippocampal cell proliferation and spontaneous behaviors in the rat","volume":"1491","author":"Nakamura","year":"2013","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.pbb.2025.174041_bb0150","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s42000-018-0011-y","article-title":"Perinatal SSRI medications and offspring hippocampal plasticity: interaction with maternal stress and sex","volume":"17","author":"Pawluski","year":"2018","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.pbb.2025.174041_bb0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neubiorev.2020.04.010","article-title":"Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: a systematic review and meta-analyses of animal studies","volume":"114","author":"Ramsteijn","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5634","key":"10.1016\/j.pbb.2025.174041_bb0160","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"issue":"26","key":"10.1016\/j.pbb.2025.174041_bb0165","doi-asserted-by":"crossref","first-page":"14731","DOI":"10.1073\/pnas.97.26.14731","article-title":"Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors","volume":"97","author":"Sarnyai","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"23","key":"10.1016\/j.pbb.2025.174041_bb0170","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"van Praag","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.pbb.2025.174041_bb0175","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/ar.21245","article-title":"Neonatal exposure to citalopram selectively alters the expression of the serotonin transporter in the hippocampus: dose-dependent effects","volume":"293","author":"Weaver","year":"2010","journal-title":"Anat. Rec."},{"issue":"5","key":"10.1016\/j.pbb.2025.174041_bb0180","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/hipo.450040507","article-title":"\u201cshort-stops\u201d in rats with fimbria-fornix lesions: evidence for change in the mobility gradient","volume":"4","author":"Whishaw","year":"1994","journal-title":"Hippocampus"},{"issue":"Suppl. 1","key":"10.1016\/j.pbb.2025.174041_bb0185","first-page":"S115","article-title":"Antidepressants and antipsychotics in human pregnancy: transfer across the placenta and opportunities for modeling studies","volume":"62","author":"Zheng","year":"2022","journal-title":"J. Clin. Pharmacol."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305725000887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305725000887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:30:59Z","timestamp":1778664659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305725000887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"alternative-id":["S0091305725000887"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2025.174041","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Administration of paroxetine during pregnancy affects behavioral changes and hippocampal cell proliferation in male offspring in rats","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2025.174041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"174041"}}