{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:37:55Z","timestamp":1786120675419,"version":"build-2736575974"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Foundation for Research Support of Rio Grande do Sul State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010432","name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Cat\u00e1lise em Sistemas Moleculares e Nanoestruturados","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010432","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.pbb.2026.174244","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:19:55Z","timestamp":1784301595000},"page":"174244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Antiseizure properties of new selenobenzimidazole derivatives: A pre-clinical study in a neonatal model of epilepsy"],"prefix":"10.1016","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-145X","authenticated-orcid":false,"given":"Fernanda","family":"Feuerharmel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2721-321X","authenticated-orcid":false,"given":"Rodrigo Borges","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-7152","authenticated-orcid":false,"given":"Paulo Henrique","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2555-9754","authenticated-orcid":false,"given":"Rodrigo","family":"Ligabue-Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-9220","authenticated-orcid":false,"given":"Juliana Maria Forain Miolo","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-7732","authenticated-orcid":false,"given":"Helena Maria Tannhauser","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.pbb.2026.174244_bb0005","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-3908","article-title":"Incidence and prevalence of childhood epilepsy: a nationwide cohort study","volume":"139","author":"Aaberg","year":"2017","journal-title":"Pediatrics"},{"issue":"W1","key":"10.1016\/j.pbb.2026.174244_bb0010","doi-asserted-by":"crossref","first-page":"W530","DOI":"10.1093\/nar\/gkab294","article-title":"PLIP 2021: expanding the scope of the protein-ligand interaction profiler to DNA and RNA","volume":"49","author":"Adasme","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.pbb.2026.174244_bb0015","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.emc.2013.04.001","article-title":"Pediatric seizures","volume":"31","author":"Agarwal","year":"2013","journal-title":"Emerg. Med. Clin. North Am."},{"issue":"8","key":"10.1016\/j.pbb.2026.174244_bb0020","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1016\/j.bmc.2017.03.013","article-title":"Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors","volume":"25","author":"Angeli","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"4","key":"10.1016\/j.pbb.2026.174244_bb0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1382-6689(01)00078-3","article-title":"The biochemistry of selenium and the glutathione system","volume":"10","author":"Arteel","year":"2001","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.pbb.2026.174244_bb0030","first-page":"60","article-title":"Pharmacological profile of oxazine and its derivatives: a mini review","volume":"7","author":"Asif","year":"2020","journal-title":"Int. J. New Chem."},{"issue":"W1","key":"10.1016\/j.pbb.2026.174244_bb0035","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: a webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.pbb.2026.174244_bb0040","first-page":"53","article-title":"Anticonvulsant evaluation of some newer benzimidazole derivatives: design and synthesis","volume":"69","author":"Bhrigu","year":"2012","journal-title":"Acta Pol. Pharm."},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1684\/epd.2015.0736","article-title":"Incidence, prevalence and aetiology of seizures and epilepsy in children","volume":"17","author":"Camfield","year":"2015","journal-title":"Epileptic Disord."},{"key":"10.1016\/j.pbb.2026.174244_bb0050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neulet.2013.04.031","article-title":"Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy","volume":"546","author":"Carletti","year":"2013","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.pbb.2026.174244_bb0055","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.yrtph.2013.03.001","article-title":"Pharmaceutical toxicology: designing studies to reduce animal use, while maximizing human translation","volume":"66","author":"Chapman","year":"2013","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.pbb.2026.174244_bb0060","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/jamaneurol.2017.3949","article-title":"Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study","volume":"75","author":"Chen","year":"2018","journal-title":"JAMA Neurol."},{"issue":"8","key":"10.1016\/j.pbb.2026.174244_bb0065","first-page":"749","article-title":"Design and synthesis of novel substituted benzimidazole analogs as potent anticonvulsant agents","volume":"4","author":"Chikkula","year":"2017","journal-title":"Eur. J. Biomed. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0070","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/prot.20417","article-title":"Cation-\u03c0 interactions in protein-protein interfaces","volume":"59","author":"Crowley","year":"2005","journal-title":"Proteins"},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0075","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0306-4522(99)00468-6","article-title":"Reciprocal modulation of glutamate and GABA release may underlie the anticonvulsant effect of phenytoin","volume":"95","author":"Cunningham","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.pbb.2026.174244_bb0080","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.lfs.2015.09.008","article-title":"On the anticonvulsant effect of allopregnanolone (a neurosteroid) in neonatal rats","volume":"143","author":"Dhir","year":"2015","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.pbb.2026.174244_bb0085","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.eplepsyres.2014.04.001","article-title":"Physiological bases of the K+ and the glutamate\/GABA hypotheses of epilepsy","volume":"108","author":"DiNuzzo","year":"2014","journal-title":"Epilepsy Res."},{"issue":"22","key":"10.1016\/j.pbb.2026.174244_bb0090","first-page":"6730","article-title":"Pharmacology profile of recently developed multi-functional azoles; SAR-based predictive structural modification","volume":"5","author":"Dorababu","year":"2020","journal-title":"Chem. Sel."},{"issue":"4","key":"10.1016\/j.pbb.2026.174244_bb0095","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1021\/ar300265y","article-title":"The cation-\u03c0 interaction","volume":"46","author":"Dougherty","year":"2013","journal-title":"Acc. Chem. Res."},{"issue":"8","key":"10.1016\/j.pbb.2026.174244_bb0100","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"4","key":"10.1016\/j.pbb.2026.174244_bb0105","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"issue":"21","key":"10.1016\/j.pbb.2026.174244_bb0110","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1016\/j.bmc.2010.08.053","article-title":"Synthesis and biological evaluation of radio-iodinated benzimidazoles as SPECT imaging agents for NR2B subtype of NMDA receptor","volume":"18","author":"Fuchigami","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"7","key":"10.1016\/j.pbb.2026.174244_bb0115","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2174\/1568026614666140202210424","article-title":"Trifluoromethylated heterocycles","volume":"14","author":"Gakh","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"issue":"17","key":"10.1016\/j.pbb.2026.174244_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202400063","article-title":"Organoselenium compounds in medicinal chemistry","volume":"19","author":"Gallo-Rodriguez","year":"2024","journal-title":"ChemMedChem"},{"issue":"9","key":"10.1016\/j.pbb.2026.174244_bb0125","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00415-017-8465-4","article-title":"Phenytoin: a step by step insight into its multiple mechanisms of action-80 years of mechanistic studies in neuropharmacology","volume":"264","author":"Keppel Hesselink","year":"2017","journal-title":"J. Neurol."},{"issue":"1","key":"10.1016\/j.pbb.2026.174244_bb0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/cbdd.12462","article-title":"Comprehensive review in current developments of benzimidazole-based medicinal chemistry","volume":"86","author":"Keri","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"issue":"3","key":"10.1016\/j.pbb.2026.174244_bb0135","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0031-9384(00)00425-X","article-title":"+\u2212induced seizures in rats: effects of age and strain","volume":"72","author":"Klioueva","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.pbb.2026.174244_bb0140","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ejmech.2016.02.031","article-title":"Thiazolo[4,5-d]pyrimidines as a privileged scaffold in drug discovery","volume":"113","author":"Kuppast","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.pbb.2026.174244_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25010091","article-title":"The significance of halogen bonding in ligand-receptor interactions: the lesson learned from molecular dynamic simulations of the D4 receptor","volume":"25","author":"Kurczab","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.pbb.2026.174244_bb0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1476-5381.1995.tb16320.x","article-title":"Electrophysiological actions of phenytoin on N-methyl-D-aspartate receptor-mediated responses in rat hippocampus in vitro","volume":"115","author":"Laffling","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"23","key":"10.1016\/j.pbb.2026.174244_bb0155","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1212\/WNL.0000000000002740","article-title":"Delineating the GRIN1 phenotypic spectrum: a distinct genetic NMDA receptor encephalopathy","volume":"86","author":"Lemke","year":"2016","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.pbb.2026.174244_bb0160","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00702-014-1193-3","volume":"121","author":"Levite","year":"2014","journal-title":"J. Neural Transm."},{"issue":"13","key":"10.1016\/j.pbb.2026.174244_bb0165","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1021\/acs.jafc.8b00758","article-title":"\u03a0-Cation interactions in molecular recognition: perspectives on pharmaceuticals and pesticides","volume":"66","author":"Liang","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0170","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.3390\/molecules17022000","article-title":"Impact of halogen substituents on interactions between 2-phenyl-2,3-dihydroquinazolin-4(1H)-one derivatives and human serum albumin","volume":"17","author":"Liu","year":"2012","journal-title":"Molecules"},{"issue":"15","key":"10.1016\/j.pbb.2026.174244_bb0175","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1093\/bioinformatics\/btt303","article-title":"HitPick: a web server for hit identification and target prediction of chemical screenings","volume":"29","author":"Liu","year":"2013","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.pbb.2026.174244_bb0180","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.pbb.2026.174244_bb0185","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrd4126","article-title":"New avenues for anti-epileptic drug discovery and development","volume":"12","author":"Loscher","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.pbb.2026.174244_bb0190","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/293689","article-title":"Oxidative stress associated with neuronal apoptosis in experimental models of epilepsy","volume":"2014","author":"Mendez-Armenta","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.pbb.2026.174244_bb0195","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1039\/a908114c","article-title":"Synthetic organoselenium compounds as antioxidants: glutathione peroxidase activity","volume":"29","author":"Mugesh","year":"2000","journal-title":"Chem. Soc. Rev."},{"issue":"15","key":"10.1016\/j.pbb.2026.174244_bb0200","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1016\/j.ica.2006.05.032","article-title":"Synthesis of pure aromatic, aliphatic, and araliphatic diselenides","volume":"359","author":"M\u00fcller","year":"2006","journal-title":"Inorg. Chim. Acta"},{"issue":"5","key":"10.1016\/j.pbb.2026.174244_bb0205","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10571-013-9936-5","article-title":"Effects of antiepileptic drugs on antioxidant and oxidant molecular pathways: focus on trace elements","volume":"33","author":"Naziroglu","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.pbb.2026.174244_bb0210","article-title":"Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data","volume":"6","author":"Nevitt","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"12","key":"10.1016\/j.pbb.2026.174244_bb0215","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1021\/cr0406559","article-title":"Organoselenium and organotellurium compounds: toxicology and pharmacology","volume":"104","author":"Nogueira","year":"2004","journal-title":"Chem. Rev."},{"issue":"6","key":"10.1016\/j.pbb.2026.174244_bb0220","doi-asserted-by":"crossref","first-page":"805","DOI":"10.32598\/bcn.2022.3025.1","article-title":"Menthol dissolved in dimethyl sulfoxide protects against epileptiform activity induced by Pentylenetetrazol in male rats","volume":"14","author":"Panahi","year":"2023","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.pbb.2026.174244_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2016.00015","article-title":"How reliable are ligand-centric methods for target fishing?","volume":"4","author":"Pe\u00f3n","year":"2016","journal-title":"Front. Chem."},{"issue":"4","key":"10.1016\/j.pbb.2026.174244_bb0230","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/iub.1262","article-title":"Selenium and selenoprotein function in brain disorders","volume":"66","author":"Pillai","year":"2014","journal-title":"IUBMB Life"},{"issue":"10","key":"10.1016\/j.pbb.2026.174244_bb0235","doi-asserted-by":"crossref","first-page":"7292","DOI":"10.3390\/molecules15107292","article-title":"Antioxidant-prooxidant properties of a new organoselenium compound library","volume":"15","author":"Plano","year":"2010","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0240","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00894-006-0154-7","article-title":"An overview of halogen bonding","volume":"13","author":"Politzer","year":"2007","journal-title":"J. Mol. Model."},{"issue":"19","key":"10.1016\/j.pbb.2026.174244_bb0245","doi-asserted-by":"crossref","first-page":"12468","DOI":"10.1021\/acs.joc.0c01697","article-title":"Modeling biologically important NH\u00b7\u00b7\u00b7\u03c0 interactions using peri-disubstituted naphthalenes","volume":"85","author":"Pozharskii","year":"2020","journal-title":"J. Organomet. Chem."},{"issue":"1","key":"10.1016\/j.pbb.2026.174244_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12013-010-9088-x","article-title":"Antioxidant and anticancer properties and mechanisms of inorganic selenium, oxo-sulfur, and oxo-selenium compounds","volume":"58","author":"Ramoutar","year":"2010","journal-title":"Cell Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0255","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1542\/peds.2010-1371","article-title":"A national profile of childhood epilepsy and seizure disorder","volume":"129","author":"Russ","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.pbb.2026.174244_bb0260","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bioorg.2013.07.003","article-title":"Evaluating the antioxidative activity of diselenide containing compounds in human blood","volume":"50","author":"Saluk","year":"2013","journal-title":"Bioorg. Chem."},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0265","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/pro.2201","article-title":"Halogen bonding (X-bonding): a biological perspective","volume":"22","author":"Scholfield","year":"2013","journal-title":"Protein Sci."},{"issue":"5","key":"10.1016\/j.pbb.2026.174244_bb0270","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.ejmech.2010.01.007","article-title":"Derivatives of benzimidazole pharmacophore: synthesis, anticonvulsant, antidiabetic and DNA cleavage studies","volume":"45","author":"Shingalapur","year":"2010","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.pbb.2026.174244_bb0275","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s00044-016-1570-6","article-title":"Synthesis of new benzimidazole and phenylhydrazinecarbothiomide hybrids and their anticonvulsant activity","volume":"25","author":"Siddiqui","year":"2016","journal-title":"Med. Chem. Res."},{"issue":"29","key":"10.1016\/j.pbb.2026.174244_bb0280","doi-asserted-by":"crossref","first-page":"11596","DOI":"10.1039\/C9NJ01948K","article-title":"Straightforward synthesis of photoactive chalcogen functionalized benzimidazo[1,2-a]quinolines","volume":"43","author":"da Silva","year":"2019","journal-title":"New J. Chem."},{"key":"10.1016\/j.pbb.2026.174244_bb0285","doi-asserted-by":"crossref","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.pbb.2026.174244_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2017.00712","article-title":"The burden of severely drug-refractory epilepsy: a comparative longitudinal evaluation of mortality, morbidity, resource use, and cost using German health insurance data","volume":"8","author":"Strzelczyk","year":"2017","journal-title":"Front. Neurol."},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0295","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1021\/jm00176a022","article-title":"Cannabidiol and phenytoin: a structural comparison","volume":"23","author":"Tamir","year":"1980","journal-title":"J. Med. Chem."},{"issue":"46","key":"10.1016\/j.pbb.2026.174244_bb0300","doi-asserted-by":"crossref","first-page":"11450","DOI":"10.1021\/ja001901a","article-title":"Origin of the attraction and directionality of the NH\/\u03c0 interaction: comparison with OH\/\u03c0 and CH\/\u03c0 interactions","volume":"122","author":"Tsuzuki","year":"2000","journal-title":"J. Am. Chem. Soc."},{"issue":"7873","key":"10.1016\/j.pbb.2026.174244_bb0305","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-021-03828-1","article-title":"Highly accurate protein structure prediction for the human proteome","volume":"596","author":"Tunyasuvunakool","year":"2021","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.pbb.2026.174244_bb0310","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/BF00169017","article-title":"Pentylenetetrazol-induced seizures in rats: an ontogenetic study","volume":"346","author":"Velisek","year":"1992","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"11","key":"10.1016\/j.pbb.2026.174244_bb0315","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s40263-016-0383-y","article-title":"Clinical drug development in epilepsy revisited: a proposal for a new paradigm streamlined using extrapolation","volume":"30","author":"Wadsworth","year":"2016","journal-title":"CNS Drugs"},{"issue":"2","key":"10.1016\/j.pbb.2026.174244_bb0320","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1476-5381.2009.00549.x","article-title":"Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor","volume":"159","author":"Wee","year":"2010","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.pbb.2026.174244_bb0325","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.brainresbull.2009.03.006","article-title":"Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures","volume":"79","author":"Wilhelm","year":"2009","journal-title":"Brain Res. Bull."},{"issue":"17\u201318","key":"10.1016\/j.pbb.2026.174244_bb0330","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.lfs.2012.03.005","article-title":"Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: protective effect of 3-alkynyl selenophene","volume":"90","author":"Wilhelm","year":"2012","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.pbb.2026.174244_bb0335","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12264-017-0191-5","article-title":"Mutations of N-methyl-D-aspartate receptor subunits in epilepsy","volume":"34","author":"Xu","year":"2018","journal-title":"Neurosci. Bull."},{"issue":"1","key":"10.1016\/j.pbb.2026.174244_bb0340","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci400539q","article-title":"Halogen bond: its role beyond drug-target binding affinity for drug discovery and development","volume":"54","author":"Xu","year":"2014","journal-title":"J. Chem. Inf. Model."},{"issue":"20","key":"10.1016\/j.pbb.2026.174244_bb0345","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/bioinformatics\/btt447","article-title":"Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment","volume":"29","author":"Yang","year":"2013","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.pbb.2026.174244_bb0350","doi-asserted-by":"crossref","first-page":"W291","DOI":"10.1093\/nar\/gkx366","article-title":"COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information","volume":"45","author":"Zhang","year":"2017","journal-title":"Nucleic Acids Res."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305726000997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305726000997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:36:54Z","timestamp":1786063014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305726000997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":70,"alternative-id":["S0091305726000997"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2026.174244","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiseizure properties of new selenobenzimidazole derivatives: A pre-clinical study in a neonatal model of epilepsy","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2026.174244","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"174244"}}