{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:18:02Z","timestamp":1788952682125,"version":"build-2803163510"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100024018","name":"Programa de Desarrollo de las Ciencias B\u00e1sicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013697","name":"Direcci\u00f3n Nacional de Innovaci\u00f3n, Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["2021\/010"],"award-info":[{"award-number":["2021\/010"]}],"id":[{"id":"10.13039\/501100013697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.pbb.2026.174260","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:50:29Z","timestamp":1787813429000},"page":"174260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cannabigerol improves MK-801-induced long-term recognition memory deficit in male rats through cortical TrkB-R signaling independently of changes in BDNF"],"prefix":"10.1016","volume":"268","author":[{"given":"Ximena","family":"L\u00f3pez Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Marton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda","family":"Richeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fabius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessika","family":"Urbanavicius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Lima de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Echeverry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"S\u00e1nchez de Medina Baena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ferreiro-Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Castan\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Scorza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pbb.2026.174260_bb0005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cell.2008.05.045","article-title":"Distinct role of long 3\u2019 UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons","volume":"134","author":"An","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.pbb.2026.174260_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3565(24)35047-5","article-title":"Characterization of MK-801-induced behavior as a putative rat model of psychosis","volume":"290","author":"Andin\u00e9","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pbb.2026.174260_bb0015","first-page":"1","article-title":"Cannabis sativa: the plant of the thousand and one molecules","volume":"19","author":"Andre","year":"2016","journal-title":"Front. Plant Sci."},{"issue":"2","key":"10.1016\/j.pbb.2026.174260_bb0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"key":"10.1016\/j.pbb.2026.174260_bb0025","first-page":"937","article-title":"Cannabidiol and cannabigerol effect on cognitive deficit induced by intracerebroventricular administration of amyloid beta 42 in experimental Alzheimer's disease model","volume":"62","author":"Aydin","year":"2024","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.pbb.2026.174260_bb0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neubiorev.2021.03.028","article-title":"The effect of antipsychotics on the cognitive performance of individuals with psychotic disorders: network meta-analyses of randomized controlled trials","volume":"126","author":"Baldez","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.pbb.2026.174260_bb0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tics.2011.11.015","article-title":"Cognition in schizophrenia: core psychological and neural mechanisms","volume":"16","author":"Barch","year":"2012","journal-title":"Trends Cogn. Sci."},{"issue":"23","key":"10.1016\/j.pbb.2026.174260_bb0040","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1101\/gad.841400","article-title":"Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system","volume":"14","author":"Bibel","year":"2000","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.pbb.2026.174260_bb0045","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bcp.2013.01.017","article-title":"Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease","volume":"85","author":"Borrelli","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.pbb.2026.174260_bb0050","article-title":"Pharmacological aspects and biological effects of cannabigerol and its synthetic derivatives","volume":"8","author":"Calapai","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"14(8)","key":"10.1016\/j.pbb.2026.174260_bb0055","article-title":"Treatment of cognitive impairment associated with schizophrenia spectrum disorders: new evidence, challenges, and future perspectives","volume":"6","author":"Calzavara-Pinton","year":"2024","journal-title":"Brain Sci."},{"key":"10.1016\/j.pbb.2026.174260_bb0060","first-page":"3364","article-title":"Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders","volume":"367","author":"Campos","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"issue":"21","key":"10.1016\/j.pbb.2026.174260_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e39938","article-title":"Behavioral effects of two cannabidiol and cannabigerol-rich formulas on mice","volume":"10","author":"Carone","year":"2024","journal-title":"Heliyon"},{"issue":"3\u20134","key":"10.1016\/j.pbb.2026.174260_bb0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000324523","article-title":"Effects of risperidone on learning and memory in naive and MK-801-treated rats","volume":"87","author":"Celikyurt","year":"2011","journal-title":"Pharmacology"},{"key":"10.1016\/j.pbb.2026.174260_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their receptors: a convergence point for many signalling pathways","volume":"4","author":"Chao","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"10.1016\/j.pbb.2026.174260_bb0080","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/schbul\/sbab137","article-title":"Allosteric modulation of the Sigma-1 receptor elicits antipsychotic-like effects","volume":"48","author":"Chen","year":"2022","journal-title":"Schizophr. Bull."},{"issue":"82(5)","key":"10.1016\/j.pbb.2026.174260_bb0085","article-title":"Treatment-resistant schizophrenia: definition, predictors, and therapy options","volume":"7","author":"Correll","year":"2021","journal-title":"J. Clin. Psychiatry"},{"issue":"1","key":"10.1016\/j.pbb.2026.174260_bb0090","doi-asserted-by":"crossref","first-page":"16163","DOI":"10.1038\/s41598-024-66879-0","article-title":"Acute effects of cannabigerol on anxiety, stress, and mood: a double-blind, placebo-controlled, crossover, field trial","volume":"14","author":"Cuttler","year":"2024","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.pbb.2026.174260_bb0095","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neubiorev.2004.09.006","article-title":"Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates","volume":"28","author":"Dalley","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.pbb.2026.174260_bb0100","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbr.2004.05.016","article-title":"Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats","volume":"156","author":"De Lima","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.pbb.2026.174260_bb0105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/genetics\/163.1.335","article-title":"The inheritance of chemical phenotype in Cannabis sativa L","volume":"163","author":"de Meijer","year":"2003","journal-title":"Genetics"},{"issue":"1\u20132","key":"10.1016\/j.pbb.2026.174260_bb0110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00429-008-0186-0","article-title":"Sex differences and influence of gonadal hormones on MK801-induced neuronal degeneration in the granular retrosplenial cortex of the rat","volume":"213","author":"de Olmos","year":"2008","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.pbb.2026.174260_bb0115","article-title":"Neuroprotective and neuromodulatory effects induced by cannabidiol and cannabigerol in rat hypo-E22 cells and isolated hypothalamus","volume":"9","author":"di Giacomo","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.pbb.2026.174260_bb0120","series-title":"Cannabinoids and Sleep","first-page":"1","article-title":"Constituents of Cannabis sativa","volume":"1297","author":"Echeverry","year":"2021"},{"issue":"2","key":"10.1016\/j.pbb.2026.174260_bb0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s12640-020-00277-y","article-title":"A comparative in vitro study of the neuroprotective effect induced by cannabidiol, cannabigerol, and their respective acid forms: relevance of the 5-HT1A receptors","volume":"39","author":"Echeverry","year":"2021","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.pbb.2026.174260_bb0130","first-page":"1","article-title":"Phytochemistry of Cannabis sativa L.","volume":"103","author":"El-Sohly","year":"2017","journal-title":"Prog. Chem. Org. Nat. Prod."},{"key":"10.1016\/j.pbb.2026.174260_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.pbb.2026.174260_bb5000","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.brainresbull.2010.11.014","article-title":"The influence of N-desmethylclozapine and clozapine on recognition memory and BDNF expression in hippocampus","volume":"84","author":"Ertu\u011frul","year":"2011","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/j.pbb.2026.174260_bb0140","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s11596-017-1762-4","article-title":"\u03a9-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB\/BDNF\/TrkB pathway","volume":"37","author":"Fang","year":"2017","journal-title":"J. Huazhong Univ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.pbb.2026.174260_bb0145","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1055\/a-2421-2411","article-title":"Early treatment-resistance in first episode psychosis","volume":"58","author":"Fernando","year":"2025","journal-title":"Pharmacopsychiatry"},{"issue":"5","key":"10.1016\/j.pbb.2026.174260_bb0150","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/jnr.10609","article-title":"Effect of antipsychotic drugs on brain-derived neurotrophic factor expression under reduced N-methyl-D-aspartate receptor activity","volume":"72","author":"Fumagalli","year":"2003","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.pbb.2026.174260_bb0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12974-018-1060-5","article-title":"Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson\u2019s disease: possible involvement of different binding sites at the PPAR\u03b3 receptor","volume":"15","author":"Garc\u00eda","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.pbb.2026.174260_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/biom10111575","article-title":"Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders","volume":"10","author":"Garc\u00eda-Guti\u00e9rrez","year":"2020","journal-title":"Biomolecules"},{"issue":"11","key":"10.1016\/j.pbb.2026.174260_bb0165","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrneurol.2010.148","article-title":"Decision-making cognition in deurodegenerative diseases","volume":"6","author":"Gleichgerrcht","year":"2010","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.pbb.2026.174260_bb0170","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyu041","article-title":"Cannabidiol attenuates sensorimotor gating disruption and molecular changes induced by chronic antagonism of NMDA receptors in mice","volume":"18","author":"Gomes","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.pbb.2026.174260_bb0175","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1007\/s11481-012-9399-3","article-title":"A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis","volume":"7","author":"Granja","year":"2012","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.pbb.2026.174260_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.105110","article-title":"17\u03b2-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice","volume":"125","author":"Gross","year":"2021","journal-title":"Psychoneuroendocrinology"},{"issue":"7","key":"10.1016\/j.pbb.2026.174260_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19071992","article-title":"In vitro model of neuroinflammation: efficacy of cannabigerol, a non-psychoactive cannabinoid","volume":"19","author":"Gugliandolo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.pbb.2026.174260_bb0190","doi-asserted-by":"crossref","first-page":"227","DOI":"10.31887\/DCNS.2019.21.3\/pharvey","article-title":"Domains of cognition and their assessment","volume":"21","author":"Harvey","year":"2019","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.pbb.2026.174260_bb0195","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.physbeh.2015.05.013","article-title":"Measure of anxiety-related behaviors and hippocampal BDNF levels associated to the amnesic effect induced by MK-801 evaluated in the modified elevated plus-maze in rats","volume":"147","author":"Hill","year":"2015","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.pbb.2026.174260_bb0200","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.neuron.2007.11.026","article-title":"Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse","volume":"57","author":"Huang","year":"2008","journal-title":"Neuron"},{"issue":"14","key":"10.1016\/j.pbb.2026.174260_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23147929","article-title":"The origin and biomedical relevance of cannabigerol","volume":"23","author":"Jastrz\u0105b","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.pbb.2026.174260_bb0210","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1073\/pnas.0709102105","article-title":"Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect","volume":"105","author":"Jeanneteau","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.pbb.2026.174260_bb0215","doi-asserted-by":"crossref","first-page":"e2414","DOI":"10.1038\/cddis.2016.319","article-title":"Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons","volume":"7","author":"Ka","year":"2016","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.pbb.2026.174260_bb0220","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1001\/archpsyc.64.6.633","article-title":"Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial","volume":"64","author":"Keefe","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.pbb.2026.174260_bb0225","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neulet.2003.08.078","article-title":"Spatial learning is delayed and brain-derived neurotrophic factor mRNA expression inhibited by administration of MK-801 in rats","volume":"353","author":"Kesslak","year":"2003","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.pbb.2026.174260_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075760","article-title":"Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling","volume":"8","author":"Kimura","year":"2013","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.pbb.2026.174260_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26168056","article-title":"Cannabigerol attenuates memory impairments, neurodegeneration, and neuroinflammation caused by transient global cerebral ischemia in mice","volume":"26","author":"Kohara","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.pbb.2026.174260_bb0240","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.tins.2012.09.007","article-title":"The sigma-1 receptor: roles in neuronal plasticity and disease","volume":"35","author":"Kourrich","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.pbb.2026.174260_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114386","article-title":"GLP-1 agonist liraglutide prevents MK-801\u2013induced schizophrenia-like behaviors and BDNF, CREB, p-CREB, Trk-B expressions in the hippocampus and prefrontal cortex in Balb\/c mice","volume":"445","author":"Kutlu","year":"2023","journal-title":"Behav. Brain Res."},{"issue":"36","key":"10.1016\/j.pbb.2026.174260_bb0250","doi-asserted-by":"crossref","first-page":"15945","DOI":"10.1073\/pnas.1002929107","article-title":"Distinct 3\u2019UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)","volume":"107","author":"Lau","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.pbb.2026.174260_bb0255","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1073\/pnas.061020198","article-title":"Activation of Trk neurotrophin receptors in the absence of neurotrophins","volume":"98","author":"Lee","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"260","key":"10.1016\/j.pbb.2026.174260_bb0265","first-page":"1","article-title":"Olanzapine reverses MK-801-induced cognitive deficits and region-specific alterations of NMDA receptor subunits","volume":"11","author":"Liu","year":"2018","journal-title":"Front. Behav. Neurosci."},{"issue":"7","key":"10.1016\/j.pbb.2026.174260_bb0270","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.neuropharm.2012.01.025","article-title":"Role of the anterior thalamic nucleus in the motor hyperactivity induced by systemic MK-801 administration in rats","volume":"62","author":"L\u00f3pez Hill","year":"2012","journal-title":"Neuropharmacol"},{"key":"10.1016\/j.pbb.2026.174260_bb0275","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.physbeh.2017.07.016","article-title":"Clozapine blockade of MK-801-induced learning\/memory impairment in the mEPM: role of 5-HT1A receptors and hippocampal BDNF levels","volume":"179","author":"L\u00f3pez Hill","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.pbb.2026.174260_bb0280","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2019.05.005","article-title":"Neuro-behavioral effects after systemic administration of MK-801 and disinhibition of the anterior thalamic nucleus in rats: potential relevance in schizophrenia","volume":"1718","author":"L\u00f3pez Hill","year":"2019","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.pbb.2026.174260_bb0285","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.nlm.2007.08.018","article-title":"BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?","volume":"89","author":"Lu","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"issue":"4","key":"10.1016\/j.pbb.2026.174260_bb0290","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00213-011-2536-5","article-title":"Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models","volume":"220","author":"Lyon","year":"2012","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.pbb.2026.174260_bb0295","article-title":"Antipsychotics, metabolic adverse effects, and cognitive function in schizophrenia","volume":"9","author":"MacKenzie","year":"2018","journal-title":"Front. Psychol."},{"issue":"11","key":"10.1016\/j.pbb.2026.174260_bb0300","article-title":"Could the combination of two non-psychotropic cannabinoids counteract neuroinflammation? Effectiveness of cannabidiol associated with cannabigerol","volume":"55","author":"Mammana","year":"2019","journal-title":"Medicina (Kaunas)"},{"issue":"7","key":"10.1016\/j.pbb.2026.174260_bb0305","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ddr.21337","article-title":"Improving current treatments for schizophrenia","volume":"77","author":"Maric","year":"2016","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.pbb.2026.174260_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00193","article-title":"Ibogaine administration modifies GDNF and BDNF expression in brain regions involved in mesocorticolimbic and nigral dopaminergic circuits","volume":"10","author":"Marton","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.pbb.2026.174260_bb0315","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1038\/s41380-023-01984-6","article-title":"Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment","volume":"28","author":"McCutcheon","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"3945","key":"10.1016\/j.pbb.2026.174260_bb0320","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1126\/science.169.3945.611","article-title":"Chemical basis of hashish activity","volume":"169","author":"Mechoulam","year":"1970","journal-title":"Science"},{"key":"10.1016\/j.pbb.2026.174260_bb0325","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/mp.2012.47","article-title":"Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents","volume":"17","author":"Miyamoto","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pbb.2026.174260_bb0330","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1124\/jpet.120.000340","article-title":"The pharmacological case for cannabigerol","volume":"376","author":"Nachnani","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.pbb.2026.174260_bb0335","series-title":"Methods of Purifying Cannabinoids, Compositions and Kits Thereof. U.S. Patent. 9: 765,000","author":"Nadal","year":"2017"},{"issue":"3","key":"10.1016\/j.pbb.2026.174260_bb0340","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.pharmthera.2010.07.004","article-title":"Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism","volume":"128","author":"Neill","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.pbb.2026.174260_bb0345","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2174\/138161212799436476","article-title":"Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases","volume":"18","author":"Niitsu","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.pbb.2026.174260_bb0350","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2026.1755956","article-title":"Elucidating the putative role of cannabigerol: a hypothesis-generating review of neuroinflammatory and neuroprotective mechanisms with implications for drug-resistant epilepsy","volume":"17","author":"Patricio-Mart\u00ednez","year":"2026","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.pbb.2026.174260_bb0355","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0896-6273(00)80140-3","article-title":"Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice","volume":"6","author":"Patterson","year":"1996","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.pbb.2026.174260_bb0360","first-page":"466","article-title":"Visual spatial cognition in neurodegenerative disease","volume":"16","author":"Possin","year":"2010","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.pbb.2026.174260_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41537-019-0090-z","article-title":"The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research","volume":"6","author":"Potkin","year":"2020","journal-title":"NPJ Schizophr."},{"key":"10.1016\/j.pbb.2026.174260_bb0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2014.01.001","article-title":"Female mice liberated for inclusion in neuroscience and biomedical research","volume":"40","author":"Prendergast","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"17","key":"10.1016\/j.pbb.2026.174260_bb0375","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cub.2013.05.041","article-title":"Interplay of hippocampus and prefrontal cortex in memory","volume":"23","author":"Preston","year":"2013","journal-title":"Curr. Biol."},{"issue":"30","key":"10.1016\/j.pbb.2026.174260_bb0380","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1523\/JNEUROSCI.0010-04.2004","article-title":"Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes","volume":"24","author":"Rajagopal","year":"2004","journal-title":"J. Neurosci."},{"issue":"31","key":"10.1016\/j.pbb.2026.174260_bb0385","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.2174\/1381612819666131216114240","article-title":"The novel object recognition test in rodents in relation to cognitive impairment in schizophrenia","volume":"20","author":"Rajagopal","year":"2014","journal-title":"Curr. Pharm. Des."},{"issue":"3","key":"10.1016\/j.pbb.2026.174260_bb0390","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1503\/jpn.100048","article-title":"Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders","volume":"36","author":"Ray","year":"2011","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.pbb.2026.174260_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104749","article-title":"Cannabidiol attenuates behavioral changes in a rodent model of schizophrenia through 5-HT1A, but not CB1 and CB2 receptors","volume":"156","author":"Rodrigues da Silva","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.pbb.2026.174260_bb0400","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1017\/S1461145708008432","article-title":"Prefrontal cortex lesions cause only minor effects on the hyperlocomotion induced by MK-801 and its reversal by clozapine","volume":"11","author":"Scorza","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.pbb.2026.174260_bb0405","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuropharm.2010.04.012","article-title":"Clozapine does not require 5-HT1A receptors to block the locomotor hyperactivity induced by MK-801. Clz and MK-801 in KO1A mice","volume":"59","author":"Scorza","year":"2010","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.pbb.2026.174260_bb0410","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1176\/appi.ajp.161.8.1324","article-title":"Gender differences in the prescribing of antipsychotic drugs","volume":"161","author":"Seeman","year":"2004","journal-title":"Am. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.pbb.2026.174260_bb0415","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/WCO.0b013e32834cd42a","article-title":"Personality and social cognition in neurodegenerative disease","volume":"24","author":"Shany-Ur","year":"2011","journal-title":"Curr. Opin. Neurol."},{"issue":"10","key":"10.1016\/j.pbb.2026.174260_bb0420","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2165\/11586650-000000000-00000","article-title":"Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia","volume":"25","author":"Singh","year":"2011","journal-title":"CNS Drugs"},{"key":"10.1016\/j.pbb.2026.174260_bb0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2398212820925580","article-title":"Prefrontal\u2013hippocampal interaction during the encoding of new memories","volume":"4","author":"Takehara-Nishiuchi","year":"2020","journal-title":"Brain Neurosc. Adv."},{"key":"10.1016\/j.pbb.2026.174260_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2019.172839","article-title":"Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: role of BDNF-TrkB signaling","volume":"188","author":"Tan","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.pbb.2026.174260_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109079","article-title":"Discrimination of motor and sensorimotor effects of phencyclidine and MK-801: involvement of GluN2C-containing NMDA receptors in psychosis-like models","volume":"213","author":"Tarr\u00e9s-Gatius","year":"2022","journal-title":"Neuropharmacol"},{"issue":"1","key":"10.1016\/j.pbb.2026.174260_bb0440","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13311-014-0304-z","article-title":"Neuroprotective properties of cannabigerol in Huntington\u2019s disease: studies in R6\/2 mice and 3-nitropropionate-lesioned mice","volume":"12","author":"Valdeolivas","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.pbb.2026.174260_bb0445","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/sj.mp.4001308","article-title":"Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia","volume":"8","author":"Weickert","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.pbb.2026.174260_bb0450","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.641047","article-title":"Drugs based on NMDAR hypofunction hypothesis in schizophrenia","volume":"15","author":"Wu","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.pbb.2026.174260_bb0455","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1254\/jphs.91.267","article-title":"Brain-derived neurotrophic factor \/ TrkB signaling in memory processes","volume":"91","author":"Yamada","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.pbb.2026.174260_bb0460","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1672098","article-title":"Pharmacokinetics and pharmacodynamics of cannabigerol (CBG) in the C57BL\/6Crl mouse","volume":"16","author":"Zagzoog","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.pbb.2026.174260_bb0465","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1089\/can.2021.0027","article-title":"The cannabis constituent cannabigerol does not disrupt fear memory processes or stress-induced anxiety in mice","volume":"7","author":"Zhou","year":"2022","journal-title":"Cannabis Cannabinoid Res."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305726001152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091305726001152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:51:28Z","timestamp":1788951088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091305726001152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":93,"alternative-id":["S0091305726001152"],"URL":"https:\/\/doi.org\/10.1016\/j.pbb.2026.174260","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabigerol improves MK-801-induced long-term recognition memory deficit in male rats through cortical TrkB-R signaling independently of changes in BDNF","name":"articletitle","label":"Article Title"},{"value":"Pharmacology Biochemistry and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbb.2026.174260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"174260"}}