{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:37:03Z","timestamp":1758926223543,"version":"3.44.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":4759,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Biophysics and Molecular Biology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.pbiomolbio.2007.07.013","type":"journal-article","created":{"date-parts":[[2007,8,14]],"date-time":"2007-08-14T07:23:25Z","timestamp":1187076205000},"page":"132-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Simulation of spontaneous action potentials of cardiomyocytes in pulmonary veins of rabbits"],"prefix":"10.1016","volume":"96","author":[{"given":"Chang Ahn","family":"Seol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Mi","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Choe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon Jin","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Bo","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Boum","family":"Youm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung E.","family":"Earm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae Hun","family":"Leem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib1","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/hh2401.101375","article-title":"HERG K(+) channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate","volume":"89","author":"Bian","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib2","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1161\/01.CIR.101.18.2200","article-title":"Gadolinium decreases stretch-induced vulnerability to atrial fibrillation","volume":"101","author":"Bode","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/35051165","article-title":"Tarantula peptide inhibits atrial fibrillation","volume":"409","author":"Bode","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF00374750","article-title":"Ultra-slow voltage-dependent inactivation of the calcium current in guinea-pig and ferret ventricular myocytes","volume":"428","author":"Boyett","year":"1994","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib5","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/s004240050240","article-title":"Inhibition of IKs in guinea pig cardiac myocytes and guinea pig IsK channels by the chromanol 293B","volume":"432","author":"Busch","year":"1996","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1540-8167.2004.03399.x","article-title":"T-type calcium current in electrical activity of cardiomyocytes isolated from rabbit pulmonary vein","volume":"15","author":"Chen","year":"2004","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib7","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1161\/hc4801.099736","article-title":"Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins: implication in initiation of atrial fibrillation","volume":"104","author":"Chen","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s395-002-8384-6","article-title":"Electrophysiology of single cardiomyocytes isolated from rabbit pulmonary veins: implication in initiation of focal atrial fibrillation","volume":"97","author":"Chen","year":"2002","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1113\/jphysiol.1981.sp013718","article-title":"Electrical activity of the pulmonary vein and its interaction with the right atrium in the guinea pig","volume":"314","author":"Cheung","year":"1981","journal-title":"J. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/294582a0","article-title":"Pulmonary vein as an ectopic focus in digitalis-induced arrhythmia","volume":"294","author":"Cheung","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4070\/kcj.2001.31.1.94","article-title":"The characteristics of spontaneous action potential of cardiac myocytes in rabbit pulmonary veins","volume":"31","author":"Choi","year":"2001","journal-title":"Kor. Circulation J."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1113\/jphysiol.1986.sp016177","article-title":"Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial node","volume":"377","author":"DiFrancesco","year":"1986","journal-title":"J. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0079-6107(84)90009-9","article-title":"Inactivation of Ca channels","volume":"44","author":"Eckert","year":"1984","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib15","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1113\/jphysiol.2003.046417","article-title":"Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties","volume":"551","author":"Ehrlich","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1113\/jphysiol.2004.061119","article-title":"Characterization of a hyperpolarization-activated time-dependent potassium current in canine cardiomyocytes from pulmonary vein myocardial sleeves and left atrium","volume":"557","author":"Ehrlich","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1113\/jphysiol.1991.sp018789","article-title":"Regional variations in action potentials and transient outward current in myocytes isolated from rabbit left ventricle","volume":"442","author":"Fedida","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1113\/jphysiol.1985.sp015856","article-title":"A transient outward current in isolated cells from the crista terminalis of rabbit heart","volume":"368","author":"Giles","year":"1985","journal-title":"J. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00001573-199701000-00004","article-title":"Role of catheter ablation for atrial fibrillation","volume":"12","author":"Haissaguerre","year":"1997","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","article-title":"Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins","volume":"339","author":"Haissaguerre","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib21","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1161\/01.CIR.0000062645.38670.BD","article-title":"Pacing-induced spontaneous activity in myocardial sleeves of pulmonary veins after treatment with ryanodine","volume":"107","author":"Honjo","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF00584963","article-title":"Calcium tolerant ventricular myocytes prepared by preincubation in a \u201cKB medium\u201d","volume":"395","author":"Isenberg","year":"1982","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib24","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1016\/S0006-3495(01)75903-6","article-title":"Activation and propagation of Ca(2+) release during excitation-contraction coupling in atrial myocytes","volume":"81","author":"Kockskamper","year":"2001","journal-title":"Biophys. J."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib25","first-page":"1223","article-title":"Simulation of Ca(2+)-activated Cl(\u2212) current of cardiomyocytes in rabbit pulmonary vein: implications of subsarcolemmal Ca(2+) dynamics","volume":"364","author":"Leem","year":"2006","journal-title":"Philos. Trans. A Math. Phys. Eng. Sci."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib54","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0008-6363(00)00036-5","article-title":"Characterisation of the transient outward K+ current in rabbit sinoatrial node cells","volume":"46","author":"Lei","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib26","first-page":"H1666","article-title":"A model of the action potential and underlying membrane currents in a rabbit atrial cell","volume":"271","author":"Lindblad","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib28","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/01.RES.74.6.1071","article-title":"A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes","volume":"74","author":"Luo","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bpc.2005.04.017","article-title":"Analysis of the modal hypothesis of Ca2+-dependent inactivation of L-type Ca2+ channels","volume":"117","author":"Markevich","year":"2005","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2170\/jjphysiol.53.105","article-title":"Role of individual ionic current systems in ventricular cells hypothesized by a model study","volume":"53","author":"Matsuoka","year":"2003","journal-title":"Jpn. J. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.1994.74.2.365","article-title":"Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells","volume":"74","author":"McDonald","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1113\/expphysiol.1996.sp003959","article-title":"Comparison of ultra-slow, voltage-dependent inactivation of the cardiac L-type Ca2+ channel with Ca2+ or Ba2+ as the charge carrier in ferret ventricular myocytes","volume":"81","author":"McMorn","year":"1996","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib33","article-title":"The characteristics of spontaneous action potentials if myocytes in rabbit pulmonary vein: implication initiation mechanism of focal atrial fibrillation","volume":"23","author":"Nam","year":"2000","journal-title":"PACE"},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib34","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.CIR.34.3.412","article-title":"The junction between the left atrium and the pulmonary veins. An anatomic study of human hearts","volume":"34","author":"Nathan","year":"1966","journal-title":"Circulation"},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/415219a","article-title":"New ideas about atrial fibrillation 50 years on","volume":"415","author":"Nattel","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib36","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1046\/j.1540-8167.2003.03445.x","article-title":"Basic electrophysiology of the pulmonary veins and their role in atrial fibrillation: precipitators, perpetuators, and perplexers","volume":"14","author":"Nattel","year":"2003","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.physiol.62.1.51","article-title":"Basic mechanisms of atrial fibrillation\u2013very new insights into very old ideas","volume":"62","author":"Nattel","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1098\/rspb.1992.0150","article-title":"Reciprocal role of the inward currents ib, Na and i(f) in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells","volume":"250","author":"Noble","year":"1992","journal-title":"Proc. R Soc. London B Biol. Sci."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib39","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1046\/j.1540-8167.2002.01131.x","article-title":"Mathematical model of the rapidly activating delayed rectifier potassium current I(Kr) in rabbit sinoatrial node","volume":"13","author":"Oehmen","year":"2002","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib40","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1085\/jgp.96.1.195","article-title":"Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents","volume":"96","author":"Sanguinetti","year":"1990","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib42","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1085\/jgp.102.6.1005","article-title":"Ca(2+)-dependent inactivation of cardiac L-type Ca2+ channels does not affect their voltage sensor","volume":"102","author":"Shirokov","year":"1993","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib43","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0146-2806(00)80003-1","article-title":"Atrial fibrillation: epidemiology, mechanisms, and management","volume":"25","author":"Sra","year":"2000","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib44","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1253\/jcj.33.1087","article-title":"Electrophysiological study of the striated muscle cells of the extrapulmonary vein of the guinea pig","volume":"33","author":"Tasaki","year":"1969","journal-title":"Jpn. Circ. J."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib45","doi-asserted-by":"crossref","first-page":"27457","DOI":"10.1074\/jbc.274.39.27457","article-title":"Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A","volume":"274","author":"Thomas","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib46","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0008-6363(03)00386-9","article-title":"Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein","volume":"59","author":"Thomas","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0167-5273(02)00474-6","article-title":"Homogenous distribution of fast response action potentials in canine pulmonary vein sleeves: a contradictory report","volume":"89","author":"Wang","year":"2003","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib48","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/01.RES.0000071747.61468.7F","article-title":"Cardiac submembrane [Na+] transients sensed by Na+-Ca2+ exchange current","volume":"92","author":"Weber","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1085\/jgp.117.2.119","article-title":"Allosteric regulation of Na\/Ca exchange current by cytosolic Ca in intact cardiac myocytes","volume":"117","author":"Weber","year":"2001","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib50","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cardiores.2006.07.026","article-title":"Extended atrial conduction system characterised by the expression of the HCN4 channel and connexin45","volume":"72","author":"Yamamoto","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib51","doi-asserted-by":"crossref","first-page":"C330","DOI":"10.1152\/ajpcell.00272.2003","article-title":"Activation of calcium release assessed by calcium release-induced inactivation of calcium current in rat cardiac myocytes","volume":"286","author":"Zahradnikova","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib52","doi-asserted-by":"crossref","first-page":"H397","DOI":"10.1152\/ajpheart.2000.279.1.H397","article-title":"Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node","volume":"279","author":"Zhang","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.pbiomolbio.2007.07.013_bib53","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0006-3495(98)77782-3","article-title":"Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature","volume":"74","author":"Zhou","year":"1998","journal-title":"Biophys. J."}],"container-title":["Progress in Biophysics and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079610707000752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0079610707000752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T21:39:57Z","timestamp":1758749997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0079610707000752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":50,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0079610707000752"],"URL":"https:\/\/doi.org\/10.1016\/j.pbiomolbio.2007.07.013","relation":{},"ISSN":["0079-6107"],"issn-type":[{"type":"print","value":"0079-6107"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simulation of spontaneous action potentials of cardiomyocytes in pulmonary veins of rabbits","name":"articletitle","label":"Article Title"},{"value":"Progress in Biophysics and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pbiomolbio.2007.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}