{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:29:37Z","timestamp":1692851377865},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cancer with high rate to local relapse and metastasis. Its connection to immunosuppression is well known, with reported association to human immunodeficiency virus (HIV).<\/jats:p>\n            <jats:p>The authors present an 87-year-old woman, infected by HIV type 2 at advanced stage of the disease, whom presented a painless papule on left cheek in 2011. After its total excision, the histopathology confirmed MCC \u201cin situ,\u201d with no regional or distant metastases. Simultaneously, she revealed a viral load of 2220\u200acopies\/mL and 224\u200aCD4\/mm<jats:sup>3<\/jats:sup>. Five months later, the patient presented a local and distance relapse with an aggressive behavior and positive regional lymph node. Stage IV disease was confirmed due to presence of liver metastases. Concurrently to the relapse, it was detected low CD4 levels.<\/jats:p>\n            <jats:p>In our multidisciplinary team decision meeting, it has been decided conservative treatment due to low Karnofsky status, comorbidities, and stage of disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1016\/j.pbj.0000000000000011","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T17:34:42Z","timestamp":1538501682000},"page":"e11","source":"Crossref","is-referenced-by-count":1,"title":["Merkel cell carcinoma and the challenge in its approach: a review based on a clinical context of immunosuppression"],"prefix":"10.1097","volume":"3","author":[{"given":"Filipe","family":"Coutinho","sequence":"first","affiliation":[{"name":"Service of Medical Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Horta","sequence":"additional","affiliation":[{"name":"Service of Dermatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estrela","family":"Rocha","sequence":"additional","affiliation":[{"name":"Service of Medical Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Unit of Clinical Immunology; Centro Hospitalar do Porto, Oporto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Service of Medical Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R2-20230824","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(02)07668-7","article-title":"Merkel cell carcinoma and HIV infection","volume":"359","author":"Engels","year":"2002","journal-title":"Lancet"},{"key":"R3-20230824","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/dsu.12079","article-title":"The Merkel cell polyomavirus and its involvement in Merkel cell carcinoma","volume":"39","author":"Amber","year":"2013","journal-title":"Dermatol Surg"},{"key":"R4-20230824","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.sder.2011.02.001","article-title":"Merkel cell carcinoma: update and review","volume":"30","author":"Wang","year":"2011","journal-title":"Semin Cutan Med Surg"},{"key":"R5-20230824","doi-asserted-by":"crossref","first-page":"84\u201c","DOI":"10.1186\/1743-422X-10-84","article-title":"Frequent detection of Merkel cell polyomavirus DNA in sera of HIV-1-positive patients","volume":"10","author":"Fukumoto","year":"2013","journal-title":"Virol J"},{"key":"R6-20230824","first-page":"1","article-title":"A review of carcinomas arising in the head and neck region in HIV-positive patients","author":"Purgina","year":"2011","journal-title":"Pathol Res Int"},{"key":"R7-20230824","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/archdermatol.2011.42","article-title":"Merkel cell polyomavirus infection in HIV-positive men","volume":"147","author":"Wieland","year":"2011","journal-title":"Arch Dermatol"},{"key":"R8-20230824","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.critrevonc.2015.10.008","article-title":"Merkel cell carcinoma: an algorithm for multidisciplinary management and decision-making","volume":"98","author":"Prieto","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"key":"R9-20230824","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1200\/JCO.2005.02.329","article-title":"Merkel cell carcinoma: prognosis and treatment of patients from a single institution","volume":"23","author":"Allen","year":"2005","journal-title":"J Clin Oncol"},{"key":"R10-20230824","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/014107680309600512","article-title":"Sustained remission of metastatic Merkel cell carcinoma with treatment of HIV infection","volume":"96","author":"Burack","year":"2003","journal-title":"J R Soc Med"},{"key":"R11-20230824","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/jid.2012.388","article-title":"Systemic immune suppression as a stage-independent predictor of diminished Merkel cell carcinoma-specific survival","volume":"133","author":"Paulson","year":"2013","journal-title":"J Invest Dermatol"}],"container-title":["Porto Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/02054639-201808000-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:53:29Z","timestamp":1692842009000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/02054639-201808000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1016\/j.pbj.0000000000000011","relation":{},"ISSN":["2444-8664"],"issn-type":[{"value":"2444-8664","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}