{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:57:27Z","timestamp":1792303047909,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","progcardvascdis.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Progress in Cardiovascular Diseases"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.pcad.2015.09.006","type":"journal-article","created":{"date-parts":[[2015,10,10]],"date-time":"2015-10-10T18:26:34Z","timestamp":1444501594000},"page":"425-433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Role of Vasodilator Testing in Pulmonary Hypertension"],"prefix":"10.1016","volume":"58","author":[{"given":"Abhishek","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chukwudi","family":"Obiagwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenechukwu","family":"Mezue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakash","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Haythe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Einstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.pcad.2015.09.006_bb0005","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"Galie","year":"2009","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.pcad.2015.09.006_bb0010","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1378\/chest.11-1460","article-title":"An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the reveal registry","volume":"142","author":"Benza","year":"2012","journal-title":"Chest"},{"issue":"25 Suppl.","key":"10.1016\/j.pcad.2015.09.006_bb0015","doi-asserted-by":"crossref","first-page":"D34","DOI":"10.1016\/j.jacc.2013.10.029","article-title":"Updated clinical classification of pulmonary hypertension","volume":"62","author":"Simonneau","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.pcad.2015.09.006_bb0020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijcard.2006.01.067","article-title":"Evaluation of pulmonary vascular response to inhaled iloprost in heart transplant candidates with pulmonary venous hypertension","volume":"115","author":"Braun","year":"2007","journal-title":"Int J Cardiol"},{"issue":"3","key":"10.1016\/j.pcad.2015.09.006_bb0025","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.rmed.2003.09.019","article-title":"Clinical value of vasodilator test with inhaled nitric oxide for predicting long-term response to oral vasodilators in pulmonary hypertension","volume":"98","author":"Morales-Blanhir","year":"2004","journal-title":"Respir Med"},{"issue":"17","key":"10.1016\/j.pcad.2015.09.006_bb0030","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jacc.2009.01.004","volume":"53","author":"McLaughlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pcad.2015.09.006_bb0035","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jacc.2009.04.009","article-title":"Development and pathology of pulmonary hypertension","volume":"54","author":"Tuder","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"25 Suppl.","key":"10.1016\/j.pcad.2015.09.006_bb0040","doi-asserted-by":"crossref","first-page":"D42","DOI":"10.1016\/j.jacc.2013.10.032","article-title":"Definitions and diagnosis of pulmonary hypertension","volume":"62","author":"Hoeper","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.pcad.2015.09.006_bb0045","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1016\/j.jacc.2006.07.061","article-title":"Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers","volume":"48","author":"Hoeper","year":"2006","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.pcad.2015.09.006_bb0050","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.rmed.2009.11.015","article-title":"Pulmonary vasodilator testing and use of calcium channel blockers in pulmonary arterial hypertension","volume":"104","author":"Tonelli","year":"2010","journal-title":"Respir Med"},{"issue":"15","key":"10.1016\/j.pcad.2015.09.006_bb0055","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1093\/eurheartj\/ehq170","article-title":"Long-term response to calcium-channel blockers in non-idiopathic pulmonary arterial hypertension","volume":"31","author":"Montani","year":"2010","journal-title":"Eur Heart J"},{"issue":"10","key":"10.1016\/j.pcad.2015.09.006_bb0060","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1590\/S1806-37132008001000013","article-title":"Testing pulmonary vasoreactivity","volume":"34","author":"Oliveira","year":"2008","journal-title":"J Bras Pneumol"},{"issue":"7","key":"10.1016\/j.pcad.2015.09.006_bb0065","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/SMJ.0b013e3181e1a8af","article-title":"Prevalence of acute vasoresponsiveness in patients with pulmonary hypertension: treatment implications","volume":"103","author":"Arunthari","year":"2010","journal-title":"South Med J"},{"issue":"6","key":"10.1016\/j.pcad.2015.09.006_bb0070","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1164\/ajrccm\/140.6.1623","article-title":"The acute administration of vasodilators in primary pulmonary hypertension. Experience from the National Institutes of Health Registry on Primary Pulmonary Hypertension","volume":"140","author":"Weir","year":"1989","journal-title":"Am Rev Respir Dis"},{"issue":"25 Suppl.","key":"10.1016\/j.pcad.2015.09.006_bb0075","doi-asserted-by":"crossref","first-page":"D60","DOI":"10.1016\/j.jacc.2013.10.031","article-title":"Updated treatment algorithm of pulmonary arterial hypertension","volume":"62","author":"Galie","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"23","key":"10.1016\/j.pcad.2015.09.006_bb0080","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1161\/CIRCULATIONAHA.104.488486","article-title":"Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension","volume":"111","author":"Sitbon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.pcad.2015.09.006_bb0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1183\/09031936.98.12020265","article-title":"Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension","volume":"12","author":"Sitbon","year":"1998","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.pcad.2015.09.006_bb0090","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1254\/jphs.12114FP","article-title":"Acute vasoreactivity testing with nicardipine in patients with pulmonary arterial hypertension","volume":"120","author":"Saito","year":"2012","journal-title":"J Pharmacol Sci"},{"issue":"16","key":"10.1016\/j.pcad.2015.09.006_bb0095","first-page":"2826","article-title":"Acute responses to inhalation of Iloprost in patients with pulmonary hypertension","volume":"125","author":"Zhang","year":"2012","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"10.1016\/j.pcad.2015.09.006_bb0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0002-9149(85)90319-4","article-title":"Magnitude and implications of spontaneous hemodynamic variability in primary pulmonary hypertension","volume":"55","author":"Rich","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.pcad.2015.09.006_bb0105","first-page":"A2668","article-title":"Reponse to inhaled nitric oxide (iNO) does not predict long term mortality in pulmonary arterial hypertension (PAH)","volume":"179","author":"Rubenfire","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.pcad.2015.09.006_bb0115","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1172\/JCI33452","article-title":"Molecular pathogenesis of pulmonary arterial hypertension","volume":"118","author":"Rabinovitch","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pcad.2015.09.006_bb0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.vph.2005.05.004","article-title":"Acute vasodilator test in pulmonary arterial hypertension: evaluation of two response criteria","volume":"43","author":"Costa","year":"2005","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.pcad.2015.09.006_bb0125","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4103\/2045-8932.83449","article-title":"Vasoreactivity to inhaled nitric oxide with oxygen predicts long-term survival in pulmonary arterial hypertension","volume":"1","author":"Malhotra","year":"2011","journal-title":"Pulm Circ"},{"key":"10.1016\/j.pcad.2015.09.006_bb0130","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/01.CIR.93.3.484","article-title":"Clinical significance of the pulmonary vasodilator response during short-term infusion of prostacyclin in primary pulmonary hypertension","volume":"93","author":"Raffy","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.pcad.2015.09.006_bb0135","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.echo.2011.11.007","article-title":"Right-heart function related to the results of acute pulmonary vasodilator testing in patients with pulmonary arterial hypertension caused by connective tissue disease","volume":"25","author":"Liu","year":"2012","journal-title":"J Am Soc Echocardiogr"},{"issue":"5","key":"10.1016\/j.pcad.2015.09.006_bb0140","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0735-1097(91)90556-O","article-title":"High dose titration of calcium channel blocking agents for primary pulmonary hypertension: guidelines for short-term drug testing","volume":"18","author":"Rich","year":"1991","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.pcad.2015.09.006_bb0145","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM199207093270203","article-title":"The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension","volume":"327","author":"Rich","year":"1992","journal-title":"N Engl J Med"},{"issue":"2 Pt 1","key":"10.1016\/j.pcad.2015.09.006_bb0150","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1164\/ajrccm.151.2.7842196","article-title":"Inhaled nitric oxide as a screening vasodilator agent in primary pulmonary hypertension. A dose\u2013response study and comparison with prostacyclin","volume":"151","author":"Sitbon","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.pcad.2015.09.006_bb0155","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/2045-8932.109916","article-title":"Comparison of acute hemodynamic effects of inhaled nitric oxide and inhaled epoprostenol in patients with pulmonary hypertension","volume":"3","author":"Preston","year":"2013","journal-title":"Pulm Circ"},{"issue":"4","key":"10.1016\/j.pcad.2015.09.006_bb0160","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.rmed.2009.11.010","article-title":"Adenosine for vasoreactivity testing in pulmonary hypertension: a head-to-head comparison with inhaled nitric oxide","volume":"104","author":"Oliveira","year":"2010","journal-title":"Respir Med"},{"issue":"12","key":"10.1016\/j.pcad.2015.09.006_bb0165","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.amjcard.2012.02.026","article-title":"Usefulness of intravenous adenosine in idiopathic pulmonary arterial hypertension as a screening agent for identifying long-term responders to calcium channel blockers","volume":"109","author":"Zuo","year":"2012","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.pcad.2015.09.006_bb0170","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0735-1097(99)00494-5","article-title":"A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH Study Group","volume":"35","author":"Hoeper","year":"2000","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.pcad.2015.09.006_bb0175","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1183\/09031936.00169608","article-title":"Iloprost for pulmonary vasodilator testing in idiopathic pulmonary arterial hypertension","volume":"33","author":"Jing","year":"2009","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1016\/j.pcad.2015.09.006_bb0180","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1056\/NEJM199309093291117","article-title":"Death in a patient with primary pulmonary hypertension after 20mg of nifedipine","volume":"329","author":"Partanen","year":"1993","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.pcad.2015.09.006_bb0185","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.0954-6820.1978.tb08443.x","article-title":"Verapamil and pulmonary hypertension","volume":"204","author":"Landmark","year":"1978","journal-title":"Acta Med Scand"},{"issue":"5","key":"10.1016\/j.pcad.2015.09.006_bb0190","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/0735-1097(92)90295-X","article-title":"Comparison of the effects of adenosine and nifedipine in pulmonary hypertension","volume":"19","author":"Schrader","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pcad.2015.09.006_bb0195","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0735-1097(00)01102-5","article-title":"Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure","volume":"37","author":"Ghio","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.pcad.2015.09.006_bb0200","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1161\/01.CIR.92.12.3593","article-title":"Selection and treatment of candidates for heart transplantation. A statement for health professionals from the Committee on Heart Failure and Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association","volume":"92","author":"Costanzo","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.pcad.2015.09.006_bb0205","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/S0735-1097(96)00399-3","article-title":"Effect of bolus milrinone on hemodynamic variables and pulmonary vascular resistance in patients with severe left ventricular dysfunction: a rapid test for reversibility of pulmonary hypertension","volume":"28","author":"Givertz","year":"1996","journal-title":"J Am Coll Cardiol"},{"issue":"21","key":"10.1016\/j.pcad.2015.09.006_bb0210","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.jacc.2008.08.033","article-title":"Role of cardiac magnetic resonance imaging in the management of patients with pulmonary arterial hypertension","volume":"52","author":"Benza","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.pcad.2015.09.006_bb0215","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1056\/NEJM199801293380501","article-title":"Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension","volume":"338","author":"McLaughlin","year":"1998","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.pcad.2015.09.006_bb0220","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S0735-1097(98)00361-1","article-title":"Inhaled nitric oxide in primary pulmonary hypertension: a safe and effective agent for predicting response to nifedipine","volume":"32","author":"Ricciardi","year":"1998","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.pcad.2015.09.006_bb0225","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1183\/09031936.00042107","article-title":"A USA-based registry for pulmonary arterial hypertension: 1982\u20132006","volume":"30","author":"Thenappan","year":"2007","journal-title":"Eur Respir J"}],"container-title":["Progress in Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0033062015300177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0033062015300177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T18:23:05Z","timestamp":1718130185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0033062015300177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0033062015300177"],"URL":"https:\/\/doi.org\/10.1016\/j.pcad.2015.09.006","relation":{},"ISSN":["0033-0620"],"issn-type":[{"value":"0033-0620","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Vasodilator Testing in Pulmonary Hypertension","name":"articletitle","label":"Article Title"},{"value":"Progress in Cardiovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pcad.2015.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}