{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:17:28Z","timestamp":1790317048298,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014358","name":"Second Affiliated Hospital of Soochow University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital, Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chinese Medical Journal Pulmonary and Critical Care Medicine"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.pccm.2023.04.005","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T11:26:55Z","timestamp":1686137215000},"page":"113-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Positive sputum culture of Candida spp. as a risk factor for 30-day mortality in patients with hospital-acquired pneumonia: A propensity-score matched retrospective clinical study"],"prefix":"10.1016","volume":"1","author":[{"given":"Yaopin","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binfeng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-6233","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pccm.2023.04.005_bib0001","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1093\/cid\/ciw353","article-title":"Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society","volume":"63","author":"Kalil","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pccm.2023.04.005_bib0002","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJMoa1306801","article-title":"Multistate point-prevalence survey of health care-associated infections","volume":"370","author":"Magill","year":"2014","journal-title":"New Engl J Med"},{"key":"10.1016\/j.pccm.2023.04.005_bib0003","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1473-3099(10)70258-9","article-title":"Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study","volume":"11","author":"Lambert","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.pccm.2023.04.005_bib0004","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.chest.2016.04.009","article-title":"A case-control study assessing the impact of nonventilated hospital-acquired pneumonia on patient outcomes","volume":"150","author":"Micek","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.pccm.2023.04.005_bib0005","first-page":"739","article-title":"Adult hospital acquired pneumonia: A multicenter study on microbiology and clinical characteristics of patients from 9 Chinese cities (in Chinese)","volume":"35","author":"Liu","year":"2012","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"10.1016\/j.pccm.2023.04.005_bib0006","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: a persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.pccm.2023.04.005_bib0007","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMra1315399","article-title":"Invasive candidiasis","volume":"373","author":"Kullberg","year":"2015","journal-title":"New Engl J Med"},{"key":"10.1016\/j.pccm.2023.04.005_bib0008","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00134-014-3281-0","article-title":"What's new in the clinical and diagnostic management of invasive candidiasis in critically ill patients","volume":"40","author":"Leon","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.pccm.2023.04.005_bib0009","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s00134-014-3364-y","article-title":"Candida colonization of respiratory tract: To treat or not to treat, will we ever get an answer?","volume":"40","author":"De Pascale","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.pccm.2023.04.005_bib0010","first-page":"131","article-title":"Impact of Candida species on clinical outcomes in patients with suspected ventilator-associated pneumonia","volume":"18","author":"Delisle","year":"2011","journal-title":"Can Respir J"},{"key":"10.1016\/j.pccm.2023.04.005_bib0011","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3390\/diagnostics13020323","article-title":"The clinical impact of metagenomic next-generation sequencing (mNGS) test in hospitalized patients with suspected sepsis: a multicenter prospective study","volume":"13","author":"Zuo","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.pccm.2023.04.005_bib0012","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.21037\/jtd.2019.06.09","article-title":"Chinese guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2018 Edition)","volume":"11","author":"Shi","year":"2019","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.pccm.2023.04.005_bib0013","series-title":"The national guide to clinical laboratory procedures (in Chinese)","first-page":"182","author":"Shang","year":"2014"},{"key":"10.1016\/j.pccm.2023.04.005_bib0014","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/eurheartj\/ehi890","article-title":"Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods","volume":"27","author":"Ahmed","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.pccm.2023.04.005_bib0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jcrc.2008.01.005","article-title":"The clinical significance of Candida colonization of respiratory tract secretions in critically ill patients","volume":"23","author":"Delisle","year":"2008","journal-title":"J Crit Care"},{"issue":"Suppl 2","key":"10.1016\/j.pccm.2023.04.005_bib0016","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1093\/cid\/ciy686","article-title":"Microbial etiology and prognostic factors of ventilator-associated pneumonia: a multicenter retrospective study in Shanghai","volume":"67","author":"Huang","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.pccm.2023.04.005_bib0017","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00582-2017","volume":"50","author":"Torres","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.pccm.2023.04.005_bib0018","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1590\/1807-3107bor-2017.vol31.0038","article-title":"Association between pathogens from tracheal aspirate and oral biofilm of patients on mechanical ventilation","volume":"31","author":"Souza","year":"2017","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.pccm.2023.04.005_bib0019","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0966-842X(02)00002-1","article-title":"Candida biofilms and their role in infection","volume":"11","author":"Douglas","year":"2003","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.pccm.2023.04.005_bib0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4187\/respcare.02722","article-title":"Description and microbiology of endotracheal tube biofilm in mechanically ventilated subjects","volume":"60","author":"Danin","year":"2015","journal-title":"Respir Care"},{"key":"10.1016\/j.pccm.2023.04.005_bib0021","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12630-010-9439-5","article-title":"The relationship between Candida species cultured from the respiratory tract and systemic inflammation in critically ill patients with ventilator-associated pneumonia","volume":"58","author":"Williamson","year":"2011","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.pccm.2023.04.005_bib0022","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pccm.2023.04.005_bib0023","article-title":"Albumin neutralizes hydrophobic toxins and modulates Candida albicans pathogenicity","volume":"12","author":"Austermeier","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.pccm.2023.04.005_bib0024","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3389\/fimmu.2020.01205","article-title":"Mechanisms of virus-induced airway immunity dysfunction in the pathogenesis of COPD disease, progression, and exacerbation","volume":"11","author":"Guo-Parke","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.pccm.2023.04.005_bib0025","article-title":"Candida colonization in the respiratory tract: what is the significance?","volume":"7","author":"Liu","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.pccm.2023.04.005_bib0026","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00134-012-2587-z","article-title":"Candida colonization in ventilated ICU patients: no longer a bystander!","volume":"38","author":"Ricard","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.pccm.2023.04.005_bib0027","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/mmy\/myw009","article-title":"Candida spp. airway colonization: a potential risk factor for Acinetobacter baumannii ventilator-associated pneumonia","volume":"54","author":"Tan","year":"2016","journal-title":"Med Mycol"},{"key":"10.1016\/j.pccm.2023.04.005_bib0028","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s00134-012-2584-2","article-title":"Candida spp. airway colonization could promote antibiotic-resistant bacteria selection in patients with suspected ventilator-associated pneumonia","volume":"38","author":"Hamet","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.pccm.2023.04.005_bib0029","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00134-006-0422-0","article-title":"Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study","volume":"33","author":"Nseir","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.pccm.2023.04.005_bib0030","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00134-005-0065-6","article-title":"Candida sp. isolated from bronchoalveolar lavage: clinical significance in critically ill trauma patients","volume":"32","author":"Wood","year":"2006","journal-title":"Intensive Care Med"}],"container-title":["Chinese Medical Journal Pulmonary and Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772558823000166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772558823000166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T23:54:22Z","timestamp":1762646062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772558823000166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2772558823000166"],"URL":"https:\/\/doi.org\/10.1016\/j.pccm.2023.04.005","relation":{},"ISSN":["2772-5588"],"issn-type":[{"value":"2772-5588","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positive sputum culture of Candida spp. as a risk factor for 30-day mortality in patients with hospital-acquired pneumonia: A propensity-score matched retrospective clinical study","name":"articletitle","label":"Article Title"},{"value":"Chinese Medical Journal Pulmonary and Critical Care Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pccm.2023.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of Chinese Medical Association.","name":"copyright","label":"Copyright"}]}}