{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:42:10Z","timestamp":1774878130367,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"BRIDGES","award":["LT09-227"],"award-info":[{"award-number":["LT09-227"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","primary-care-diabetes.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Primary Care Diabetes"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.pcd.2018.07.010","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T10:58:14Z","timestamp":1534157894000},"page":"565-573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Roles of insulin resistance and beta cell dysfunction in macrosomia among Chinese women with gestational diabetes mellitus"],"prefix":"10.1016","volume":"12","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhong","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana C.N.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-8017","authenticated-orcid":false,"given":"Gang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-7992","authenticated-orcid":false,"given":"Xilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.pcd.2018.07.010_bib0005","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.2337\/dc13-S067","article-title":"Diagnosis and classification of diabetes mellitus","volume":"36","author":"American Diabetes Association,","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pcd.2018.07.010_bib0010","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2337\/diacare.25.5.847","article-title":"Gestational diabetes mellitus in women of single gravidity in Tianjin City, China","volume":"25","author":"Yang","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pcd.2018.07.010_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121029","article-title":"Prevalence of gestational diabetes mellitus and its risk factors in Chinese pregnant women: a prospective population-based study in Tianjin, China","volume":"10","author":"Leng","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.pcd.2018.07.010_bib0020","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"HAPO Study Cooperative Research Group","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pcd.2018.07.010_bib0025","doi-asserted-by":"crossref","first-page":"e1272","DOI":"10.1542\/peds.2010-2213","article-title":"Birth weight, postnatal weight change, and risk for high blood pressure among chinese children","volume":"127","author":"Bowers","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcd.2018.07.010_bib0030","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1056\/NEJMoa0902430","article-title":"A multicenter, randomized trial of treatment for mild gestational diabetes","volume":"361","author":"Landon","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.pcd.2018.07.010_bib0035","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa042973","article-title":"Effect of treatment of gestational diabetes mellitus on pregnancy outcomes","volume":"352","author":"Crowther","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"Suppl 2","key":"10.1016\/j.pcd.2018.07.010_bib0040","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000371628","article-title":"Gestational diabetes mellitus and macrosomia: a literature review","volume":"66","author":"Kc","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.pcd.2018.07.010_bib0045","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10995-015-1865-0","article-title":"Prepregnancy obesity and birth outcomes","volume":"20","author":"Averett","year":"2016","journal-title":"Matern. Child Health J."},{"key":"10.1016\/j.pcd.2018.07.010_bib0050","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/BF00403918","article-title":"Measurement of glucose metabolism and insulin secretion during normal pregnancy and pregnancy complicated by gestational diabetes","volume":"39","author":"Bowes","year":"1996","journal-title":"Diabetologia"},{"key":"10.1016\/j.pcd.2018.07.010_bib0055","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2337\/diacare.20.11.1717","article-title":"Pronounced insulin resistance and inadequate beta-cell secretion characterize lean gestational diabetes during and after pregnancy","volume":"20","author":"Kautzky-Willer","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pcd.2018.07.010_bib0060","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-014-0290-2","article-title":"A randomised translational trial of lifestyle intervention using a 3-tier shared care approach on pregnancy outcomes in Chinese women with gestational diabetes mellitus but without diabetes","volume":"12","author":"Yang","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.pcd.2018.07.010_bib0065","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc09-1848","article-title":"International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"International Association of Diabetes and Pregnancy Study Groups Consensus Panel","year":"2010","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"10.1016\/j.pcd.2018.07.010_bib0070","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","author":"American Diabetes Association,","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pcd.2018.07.010_bib0075","first-page":"1","article-title":"The guidelines for prevention and control of overweight and obesity in Chinese adults","volume":"17 Suppl","author":"Chen","year":"2004","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.pcd.2018.07.010_bib0080","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.2337\/diacare.24.9.1602","article-title":"Clinically useful estimates of insulin sensitivity during pregnancy: validation studies in women with normal glucose tolerance and gestational diabetes mellitus","volume":"24","author":"Kirwan","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pcd.2018.07.010_bib0085","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1056-8727(03)00030-8","article-title":"The effect of glucose levels on fetal birth weight: a study of Chinese gravidas in Tianjin China","volume":"18","author":"Yang","year":"2004","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.pcd.2018.07.010_bib0090","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2337\/dc08-1111","article-title":"Pregnancy insulin, glucose, and BMI contribute to birth outcomes in nondiabetic mothers","volume":"31","author":"Ong","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pcd.2018.07.010_bib0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000295710","article-title":"Insulin resistance, a link between maternal overweight and fetal macrosomia in nondiabetic pregnancies","volume":"74","author":"Ahlsson","year":"2010","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.pcd.2018.07.010_bib0100","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1507\/endocrj.EJ14-0163","article-title":"The association between maternal insulin resistance in mid-pregnancy and neonatal birthweight in uncomplicated pregnancies","volume":"61","author":"Yamashita","year":"2014","journal-title":"Endocr. J."},{"key":"10.1016\/j.pcd.2018.07.010_bib0105","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/14767050903121472","article-title":"Increased risk of macrosomia among overweight women with high gestational rise in fasting glucose","volume":"23","author":"Voldner","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.pcd.2018.07.010_bib0110","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1210\/jc.2014-2949","article-title":"Maternal fuels and metabolic measures during pregnancy and neonatal body composition: the healthy start study","volume":"100","author":"Crume","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.pcd.2018.07.010_bib0115","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0002-9378(99)70662-9","article-title":"Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus","volume":"180","author":"Catalano","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.pcd.2018.07.010_bib0120","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S2213-8587(15)00219-3","article-title":"Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised double-blind, placebo-controlled trial","volume":"3","author":"Chiswick","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.pcd.2018.07.010_bib0125","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.diabres.2013.11.003","article-title":"Global estimates of the prevalence of hyperglycaemia in pregnancy","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.pcd.2018.07.010_bib0130","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1542\/peds.101.2.e9","article-title":"Gestational diabetes and the risk of offspring obesity","volume":"101","author":"Whitaker","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcd.2018.07.010_bib0135","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1542\/peds.2008-0158","article-title":"Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero","volume":"122","author":"Tam","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcd.2018.07.010_bib0140","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2337\/dc14-2159","article-title":"Mild gestational diabetes mellitus and long-term child health","volume":"38","author":"Landon","year":"2014","journal-title":"Diabetes Care"}],"container-title":["Primary Care Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751991818302328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751991818302328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:56:49Z","timestamp":1761695809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751991818302328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S1751991818302328"],"URL":"https:\/\/doi.org\/10.1016\/j.pcd.2018.07.010","relation":{},"ISSN":["1751-9918"],"issn-type":[{"value":"1751-9918","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of insulin resistance and beta cell dysfunction in macrosomia among Chinese women with gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Primary Care Diabetes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pcd.2018.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}