{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:42:31Z","timestamp":1697236951673},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Clinics of North America"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.pcl.2006.05.002","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T14:28:34Z","timestamp":1168439314000},"page":"715-725","source":"Crossref","is-referenced-by-count":4,"title":["Genetic Aspects of the Etiology and Treatment of Asthma"],"prefix":"10.1016","volume":"53","author":[{"given":"John R.","family":"Meurer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James V.","family":"Lustig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard J.","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pcl.2006.05.002_bib1","series-title":"Pediatric asthma: promoting best practice, guide for managing asthma in children","author":"American Academy of Allergy, Asthma, and Immunology","year":"1999"},{"issue":"3 Suppl","key":"10.1016\/j.pcl.2006.05.002_bib2","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1378\/chest.121.3_suppl.7S-a","article-title":"Asthma genetics","volume":"121","author":"Cookson","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.pcl.2006.05.002_bib3","series-title":"Pediatric allergy: principles and practice","first-page":"23","article-title":"The genetics of allergic disease and asthma","author":"Holloway","year":"2003"},{"issue":"4","key":"10.1016\/j.pcl.2006.05.002_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ng0497-389","article-title":"A genome-wide search for asthma susceptibility loci in ethnically diverse populations","volume":"15","year":"1997","journal-title":"Nat Genet"},{"issue":"Suppl 6","key":"10.1016\/j.pcl.2006.05.002_bib5","first-page":"S521","article-title":"Issues in understanding pediatric asthma: epidemiology and genetics","volume":"109","author":"Lemanske","year":"2002","journal-title":"JACI"},{"issue":"5","key":"10.1016\/j.pcl.2006.05.002_bib6","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0025-7125(02)00028-7","article-title":"Genetics of asthma","volume":"86","author":"Blumenthal","year":"2002","journal-title":"Med Clinics N Am"},{"key":"10.1016\/j.pcl.2006.05.002_bib7","first-page":"185","article-title":"Genetics of asthma: current research paving the way for development of personalized drugs","volume":"117","author":"Ghosh","year":"2003","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.pcl.2006.05.002_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jaci.2005.11.030","article-title":"Genetic epidemiology of health disparities in allergy and clinical immunology","volume":"117","author":"Barnes","year":"2006","journal-title":"J Allergy Clin Immunol"},{"issue":"3 Suppl","key":"10.1016\/j.pcl.2006.05.002_bib9","first-page":"S799","article-title":"Mechanisms of asthma","volume":"111","author":"Busse","year":"2003","journal-title":"JACI"},{"issue":"1","key":"10.1016\/j.pcl.2006.05.002_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1183\/09031936.99.13100899","article-title":"Genetic and environment in asthma: the answer of twin studies","volume":"13","author":"Koppelman","year":"1999","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.pcl.2006.05.002_bib11","first-page":"67","article-title":"Decreased prevalence of asthma among farm-reared children compared with those who are rural but not farm-reared","volume":"115","author":"Adler","year":"2005","journal-title":"JACI"},{"issue":"10","key":"10.1016\/j.pcl.2006.05.002_bib12","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1056\/NEJMra012479","article-title":"Genomics as a probe for disease biology","volume":"349","author":"Burke","year":"2003","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.pcl.2006.05.002_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/aje\/kwg148","article-title":"Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma","volume":"158","author":"Belanger","year":"2003","journal-title":"Am J Epid"},{"issue":"3","key":"10.1016\/j.pcl.2006.05.002_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1289\/ehp.7242","article-title":"Home dampness and molds, parental atopy, and asthma in childhood: a 6-year population-based cohort study","volume":"113","author":"Jaakkola","year":"2005","journal-title":"Environ Health Perspect"},{"issue":"9","key":"10.1016\/j.pcl.2006.05.002_bib15","first-page":"1239","article-title":"Day care attendance in early life, maternal history of asthma, and asthma at age of 6 years","volume":"167","author":"Celedon","year":"2003","journal-title":"AJRCCM"},{"issue":"2 Suppl","key":"10.1016\/j.pcl.2006.05.002_bib16","doi-asserted-by":"crossref","first-page":"105S","DOI":"10.1378\/chest.126.2_suppl_1.105S","article-title":"Genetics of asthma and COPD: similar results for different phenotypes","volume":"126","author":"Meyers","year":"2004","journal-title":"Chest"},{"issue":"Suppl 2","key":"10.1016\/j.pcl.2006.05.002_bib17","doi-asserted-by":"crossref","first-page":"96S","DOI":"10.1378\/chest.126.2_suppl_1.96S","article-title":"Rationale for the Dutch hypothesis: allergy and airway hyper-responsiveness as genetic factors and their interaction with environment in the development of asthma and COPD","volume":"126","author":"Postma","year":"2004","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.pcl.2006.05.002_bib18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1165\/rcmb.F303","article-title":"Genetic studies seek to advance our knowledge by identifying the differences in our genetic make-up that cause us to be susceptible","volume":"33","author":"Lilly","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"10.1016\/j.pcl.2006.05.002_bib19","first-page":"953","article-title":"Allergy and asthma","volume":"15","author":"Bochner","year":"2005","journal-title":"JACI"},{"issue":"2","key":"10.1016\/j.pcl.2006.05.002_bib20","first-page":"227","article-title":"Chemokines in asthma: cooperative interaction between chemokines and IL-13","volume":"111","author":"Zimmermann","year":"2003","journal-title":"JACI"},{"issue":"6597","key":"10.1016\/j.pcl.2006.05.002_bib21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/383247a0","article-title":"A genome-wide search for quantitative trait loci underlying asthma","volume":"383","author":"Daniels","year":"1996","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.pcl.2006.05.002_bib22","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJMcibr022144","article-title":"ADAM-33 surfaces as an asthma gene","volume":"347","author":"Shapiro","year":"2002","journal-title":"N Engl J Med"},{"issue":"Spec 1","key":"10.1016\/j.pcl.2006.05.002_bib23","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1093\/hmg\/ddh080","article-title":"Asthma genetics 2003","volume":"13","author":"Weiss","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"Suppl 6","key":"10.1016\/j.pcl.2006.05.002_bib24","doi-asserted-by":"crossref","first-page":"320S","DOI":"10.1378\/chest.122.6_suppl.320S","article-title":"Goblet cell and mucin gene abnormalities in asthma","volume":"122","author":"Fahy","year":"2002","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.pcl.2006.05.002_bib25","first-page":"213","article-title":"Epidemiology and genetics of asthma risk associated with air pollution","volume":"115","author":"Peden","year":"2005","journal-title":"JACI"},{"key":"10.1016\/j.pcl.2006.05.002_bib26","first-page":"12","article-title":"How pharmacogenetics will play a role in the management of asthma","volume":"172","author":"Wechsler","year":"2005","journal-title":"AJRCCM"},{"issue":"4","key":"10.1016\/j.pcl.2006.05.002_bib27","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.pcl.2006.05.008","article-title":"Pharmacogenetics and the future of drug therapy","volume":"53","author":"Hines","year":"2006","journal-title":"Pediatr Clin North Am"},{"issue":"1","key":"10.1016\/j.pcl.2006.05.002_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.0306-5251.2001.01509.x","article-title":"Pharmacogenetics of asthma","volume":"53","author":"Fenech","year":"2002","journal-title":"Br J Clin Pharm"},{"issue":"1\u20133","key":"10.1016\/j.pcl.2006.05.002_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000053705","article-title":"Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma","volume":"124","author":"Israel","year":"2001","journal-title":"Int Arch All Immunol"},{"key":"10.1016\/j.pcl.2006.05.002_bib30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1067\/S0022-3476(03)00493-1","article-title":"Comparison of racemic albuterol and levalbuterol for treatment of acute asthma","volume":"143","author":"Carl","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.pcl.2006.05.002_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1398-9995.2006.00979.x","article-title":"ALOX5 promotor genotype, asthma severity and LTC4 production by eosinophils","volume":"61","author":"Kalayci","year":"2006","journal-title":"Allergy"},{"issue":"12","key":"10.1016\/j.pcl.2006.05.002_bib32","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1046\/j.1365-2362.2002.01088.x","article-title":"Clinical and genetic features underlying the response of patients with bronchial asthma to of the treatment with a leukotriene receptor antagonist","volume":"32","author":"Mastalerz","year":"2002","journal-title":"Eur J Clin Invest"},{"issue":"3","key":"10.1016\/j.pcl.2006.05.002_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2165\/00151829-200403030-00004","article-title":"Therapeutic response to asthma medications: genotype predictors","volume":"3","author":"Wallace","year":"2004","journal-title":"Treat Respir Med"},{"issue":"4","key":"10.1016\/j.pcl.2006.05.002_bib34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1513\/pats.200409-043MS","article-title":"Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses","volume":"1","author":"Weiss","year":"2004","journal-title":"Proc Am Thor Soc"},{"issue":"13","key":"10.1016\/j.pcl.2006.05.002_bib35","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/hmg\/ddh149","article-title":"Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids","volume":"13","author":"Tantisira","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"52","key":"10.1016\/j.pcl.2006.05.002_bib36","doi-asserted-by":"crossref","first-page":"18099","DOI":"10.1073\/pnas.0408532102","article-title":"TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids","volume":"101","author":"Tantisira","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.pcl.2006.05.002_bib37","first-page":"683","article-title":"Future research directions in asthma: an NHLBI working group report","volume":"170","author":"Busse","year":"2004","journal-title":"ARJCCM"},{"issue":"3","key":"10.1016\/j.pcl.2006.05.002_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1677\/joe.0.1780347","article-title":"Corticosteroid-insensitive asthma: molecular mechanisms","volume":"178","author":"Adcock","year":"2003","journal-title":"J Endocrinol"},{"issue":"11","key":"10.1016\/j.pcl.2006.05.002_bib39","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1001\/jama.294.11.1399","article-title":"Realizing the promise of genomics in biomedical research","volume":"294","author":"Guttmacher","year":"2005","journal-title":"JAMA"}],"container-title":["Pediatric Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031395506000654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031395506000654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T04:51:31Z","timestamp":1547095891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031395506000654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0031395506000654"],"URL":"https:\/\/doi.org\/10.1016\/j.pcl.2006.05.002","relation":{},"ISSN":["0031-3955"],"issn-type":[{"value":"0031-3955","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}