{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:25:15Z","timestamp":1780471515538,"version":"3.54.1"},"reference-count":90,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Clinics of North America"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.pcl.2013.09.004","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T23:35:32Z","timestamp":1384299332000},"page":"1443-1462","source":"Crossref","is-referenced-by-count":31,"title":["Pediatric Thrombophilia"],"prefix":"10.1016","volume":"60","author":[{"given":"Janet Y.K.","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony K.C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pcl.2013.09.004_bib1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1542\/peds.96.5.939","article-title":"Neonatal thrombosis: report of a prospective Canadian and international registry","volume":"96","author":"Schmidt","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcl.2013.09.004_bib2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1182\/blood.V83.5.1251.1251","article-title":"Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE","volume":"83","author":"Andrew","year":"1994","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.pcl.2013.09.004_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM200108093450604","article-title":"Cerebral sinovenous thrombosis in children","volume":"345","author":"deVeber","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pcl.2013.09.004_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1052-5149(02)00064-3","article-title":"Sinovenous thrombosis in children","volume":"13","author":"Shroff","year":"2003","journal-title":"Neuroimaging Clin N Am"},{"key":"10.1016\/j.pcl.2013.09.004_bib5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00008480-200112000-00002","article-title":"Epidemiology of perinatal stroke","volume":"13","author":"Lynch","year":"2001","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.pcl.2013.09.004_bib6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1474-4422(04)00679-9","article-title":"Stroke in newborn infants","volume":"3","author":"Nelson","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.pcl.2013.09.004_bib7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1515\/JPM.2005.032","article-title":"Incidence and diagnosis of unilateral arterial cerebral infarction in newborn infants","volume":"33","author":"Schulzke","year":"2005","journal-title":"J\u00a0Perinat Med"},{"key":"10.1016\/j.pcl.2013.09.004_bib8","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1542\/peds.109.1.116","article-title":"Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke","volume":"109","author":"Lynch","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcl.2013.09.004_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-2007-994930","article-title":"Protein C and S deficiency","volume":"25","author":"Nizzi","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00043426-200401000-00008","article-title":"Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency","volume":"26","author":"Manco-Johnson","year":"2004","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"key":"10.1016\/j.pcl.2013.09.004_bib11","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1538-7836.2003.00158.x","article-title":"Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease","volume":"1","author":"Revel-Vilk","year":"2003","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib12","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1067\/mpd.2001.118192","article-title":"Venous thromboembolism in childhood: a prospective two-year registry in the Netherlands","volume":"139","author":"van Ommen","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.pcl.2013.09.004_bib13","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/CIRCULATIONAHA.109.913673","article-title":"Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous in neonates and children. A systematic review and meta-analysis of observational studies","volume":"121","author":"Kenet","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.pcl.2013.09.004_bib14","doi-asserted-by":"crossref","first-page":"e737S","DOI":"10.1378\/chest.11-2308","article-title":"Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Monagle","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.pcl.2013.09.004_bib15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1055\/s-0037-1614593","article-title":"Long-term management of homozygous protein C deficiency: replacement therapy with subcutaneous purified protein C concentrate","volume":"81","author":"Sanz-Rodriguez","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1046\/j.1365-2141.1996.4691021.x","article-title":"Treatment of homozygous protein C deficiency with subcutaneous protein C concentrate","volume":"93","author":"Minford","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.pcl.2013.09.004_bib17","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1055\/s-0037-1616525","article-title":"Homozygous antithrombin deficiency type II (99 Leu to Phe mutation) and childhood thromboembolism","volume":"86","author":"Kuhle","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1055\/s-0038-1648838","article-title":"Homozygous antithrombin deficiency: report of two new cases (99 Leu toPhe) associated with arterial and venous thrombosis","volume":"72","author":"Chowdhury","year":"1994","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/107602960000600312","article-title":"Rapid genetic diagnosis in neonatal pulmonary artery thrombosis caused by homozygous antithrombin Budapest 3","volume":"6","author":"Brown","year":"2000","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib20","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1182\/blood.V79.5.1206.1206","article-title":"Antithrombin III Budapest: a single amino acid substitution (429Pro to Leu) in a region highly conserved in the serpin family","volume":"79","author":"Olds","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.pcl.2013.09.004_bib21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0049-3848(83)90333-X","article-title":"Antithrombin III Toyama: a hereditary abnormal antithrombin III of a patient with recurrent thrombophlebitis","volume":"31","author":"Sakuragawa","year":"1983","journal-title":"Thromb Res"},{"key":"10.1016\/j.pcl.2013.09.004_bib22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1055\/s-0038-1661525","article-title":"Antithrombin III Alger: a new homozygous AT III variant","volume":"55","author":"Fischer","year":"1986","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-0038-1646520","article-title":"Homozygous variant of antithrombin III that lacks affinity for heparin, AT III Kumamoto","volume":"61","author":"Okajima","year":"1989","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib24","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/00001721-199610000-00008","article-title":"Homozygous variant of antithrombin with lack of affinity for heparin: management of severe thrombotic complications associated with intrauterine fetal demise","volume":"7","author":"Bauters","year":"1996","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.pcl.2013.09.004_bib25","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1182\/blood.V69.5.1275.1275","article-title":"Heparin binding defects in a new antithrombin III variant: Rouen, 47 Arg to His","volume":"69","author":"Owen","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.pcl.2013.09.004_bib26","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0021-9258(17)36071-4","article-title":"Antithrombin III basel. Identification of a Pro-Leu substitution in a hereditary abnormal antithrombin with impaired heparin cofactor activity","volume":"261","author":"Chang","year":"1986","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.pcl.2013.09.004_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1203\/00006450-198403000-00012","article-title":"Low antithrombin III levels in neonates with idiopathic respiratory distress syndrome: poor prognosis","volume":"18","author":"Peters","year":"1984","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pcl.2013.09.004_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1203\/00006450-198502000-00020","article-title":"Dysfunctional antithrombin III in sick premature infants","volume":"19","author":"Andrew","year":"1985","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pcl.2013.09.004_bib29","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood.V72.5.1651.1651","article-title":"Development of the human coagulation system in the healthy premature infant","volume":"72","author":"Andrew","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.pcl.2013.09.004_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1182\/blood.V70.1.165.165","article-title":"Development of the human coagulation system in the full-term infant","volume":"70","author":"Andrew","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.pcl.2013.09.004_bib31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1160\/TH05-01-0047","article-title":"Developmental haemostasis: impact for clinical haemostasis laboratories","volume":"95","author":"Monagle","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1136\/jcp.44.6.477","article-title":"Screening for heparin binding variants of antithrombin","volume":"44","author":"Harper","year":"1991","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.pcl.2013.09.004_bib33","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1538-7836.2007.02395.x","article-title":"Detecting antithrombin deficiency may be a difficult task-more than one test is necessary","volume":"5","author":"Kristensen","year":"2007","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib34","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1161\/CIRCULATIONAHA.108.789008","article-title":"Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies","volume":"118","author":"Young","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.pcl.2013.09.004_bib35","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/ehm.09.43","article-title":"Antithrombin-\u03b1 for the prophylaxis of venous thrombosis in congenital antithrombin deficiency","volume":"2","author":"Fyfe","year":"2009","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.pcl.2013.09.004_bib36","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1160\/TH07-08-0489","article-title":"Antithrombin alfa in hereditary antithrombin deficient patients: a Phase III study of prophylactic intravenous administration in high-risk situations","volume":"99","author":"Tiede","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib37","first-page":"1095","article-title":"Screening for inherited thrombophilia: indication and therapeutic implications","volume":"87","author":"De Stefano","year":"2002","journal-title":"Haematologica"},{"key":"10.1016\/j.pcl.2013.09.004_bib38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1017\/S0012162201000421","article-title":"Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: a potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood","volume":"43","author":"Prengler","year":"2001","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.pcl.2013.09.004_bib39","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1161\/01.CIR.99.16.2070","article-title":"Hyperhomocysteinemia: a risk factor for ischemic stroke in children","volume":"99","author":"van Beynum","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.pcl.2013.09.004_bib40","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1182\/blood.V96.10.3364","article-title":"Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism","volume":"96","author":"von Depka","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.pcl.2013.09.004_bib41","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/01.CIR.100.7.743","article-title":"Increased lipoprotein (a) is an important risk factor for venous thromboembolism in childhood","volume":"100","author":"Nowak-G\u00f6ttl","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.pcl.2013.09.004_bib42","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1365-2141.2007.06662.x","article-title":"Hemizygous antithrombin-deficiency (Budapest III) in a newborn presenting with a thrombosis at birth","volume":"138","author":"Kristensen","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.pcl.2013.09.004_bib43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jacc.2012.08.1023","article-title":"Factors associated with thrombotic complications after the Fontan procedure: a secondary analysis of a multicenter, randomized trial of primary thromboprophylaxis for 2 years after the Fontan procedure","volume":"61","author":"McCrindle","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.pcl.2013.09.004_bib44","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1203\/00006450-200006000-00013","article-title":"Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia Registry","volume":"47","author":"Monagle","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pcl.2013.09.004_bib45","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1182\/blood-2002-09-2731","article-title":"Central venous line-related thrombosis in children: associated with central venous line location and insertion technique","volume":"101","author":"Male","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.pcl.2013.09.004_bib46","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.thromres.2007.10.001","article-title":"Association between thrombosis and bloodstream infection in neonates with peripherally inserted catheters","volume":"122","author":"Thornburg","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.pcl.2013.09.004_bib47","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0022-3476(95)70369-1","article-title":"Treatment of purpura fulminans in meningococcemia with protein C concentrate","volume":"126","author":"Rivard","year":"1995","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.pcl.2013.09.004_bib48","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s001340051184","article-title":"Meningococcal septicaemia: treatment with protein C concentrate","volume":"26","author":"Clarke","year":"2000","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.pcl.2013.09.004_bib49","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/014860710803200188","article-title":"Thromboembolism in infants and children with gastrointestinal failure receiving long term parenteral nutrition","volume":"32","author":"Kakzanov","year":"2008","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.pcl.2013.09.004_bib50","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/0961203307079039","article-title":"Infant perinatal thrombosis and antiphospholipid antibodies: a review","volume":"16","author":"Boffa","year":"2007","journal-title":"Lupus"},{"key":"10.1016\/j.pcl.2013.09.004_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pediatrneurol.2007.04.007","article-title":"Risk factors for perinatal arterial stroke: a study of 60 mother-child pairs","volume":"37","author":"Curry","year":"2007","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.pcl.2013.09.004_bib52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000097462","article-title":"Congenital prothrombotic disorders in children with peripheral venous and arterial thromboses","volume":"117","author":"Albisetti","year":"2007","journal-title":"Acta Haematol"},{"key":"10.1016\/j.pcl.2013.09.004_bib53","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1055\/s-0037-1614553","article-title":"Increased levels of factor VIII and fibrinogen in patients with venous thrombosis are not caused by acute phase reactions","volume":"81","author":"Kamphuisen","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1055\/s-0037-1613748","article-title":"Elevation of FVIII: C in venous thromboembolism is persistent and independent of the acute phase response","volume":"83","author":"O\u2019Donnell","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib55","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1161\/01.ATV.0000227510.36653.ed","article-title":"Familial elevated factor VIII in children with symptomatic venous thrombosis and post-thrombotic syndrome: results of a multicenter study","volume":"26","author":"Kreuz","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.pcl.2013.09.004_bib56","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1182\/blood.V97.4.858","article-title":"Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors","volume":"97","author":"Nowak-G\u00f6ttl","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.pcl.2013.09.004_bib57","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/archneur.55.12.1539","article-title":"Prothrombotic disorders in infants and children with cerebral thromboembolism","volume":"55","author":"deVeber","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1016\/j.pcl.2013.09.004_bib58","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/01.STR.31.6.1283","article-title":"Factor V Leiden and antiphospholipid antibodies are significant risk factors of ischemic stroke in children","volume":"31","author":"Kenet","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.pcl.2013.09.004_bib59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/pbc.21486","article-title":"Deep venous thrombosis in adolescents due to anatomic causes","volume":"51","author":"Bruins","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.pcl.2013.09.004_bib60","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(00)04010-1","article-title":"Congenital absence of the inferior vena cava: a rare risk factor for idiopathic deep-vein thrombosis","volume":"357","author":"Ruggeri","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.pcl.2013.09.004_bib61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1742-1241.1999.tb11665.x","article-title":"Deep vein thrombosis as a presenting symptoms of congenital interruption of the inferior vena cava","volume":"53","author":"Timmers","year":"1999","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.pcl.2013.09.004_bib62","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/0003-4819-136-1-200201010-00009","article-title":"Anomalies of the inferior vena cava in patients with iliac venous thrombosis","volume":"136","author":"Obernosterer","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.pcl.2013.09.004_bib63","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/pbc.20728","article-title":"May-Thurner syndrome (iliac vein compression) and thrombosis in adolescents","volume":"47","author":"Raffini","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.pcl.2013.09.004_bib64","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ejrad.2004.11.002","article-title":"Computed tomography findings in 10 cases of iliac vein compression (May-Thurner) syndrome","volume":"55","author":"Oguzkurt","year":"2005","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.pcl.2013.09.004_bib65","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/01.RVI.0000109402.52762.8D","article-title":"Acute iliofemoral deep vein thrombosis: evaluation of underlying anatomic abnormalities by spiral CT venography","volume":"15","author":"Chung","year":"2004","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.pcl.2013.09.004_bib66","doi-asserted-by":"crossref","first-page":"e1100","DOI":"10.1542\/peds.2008-1209","article-title":"Pediatric antiphospholipid syndrome: clinical and immunologic features of 121 patients in an international registry","volume":"122","author":"Avcin","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcl.2013.09.004_bib67","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/art.10187","article-title":"Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients","volume":"46","author":"Cervera","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.pcl.2013.09.004_bib68","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/0961203307077108","article-title":"Antiphospholipid syndrome in Latin American patients: clinical and immunological characteristics and comparison with European patients","volume":"16","author":"Garc\u00eda-Carrasco","year":"2007","journal-title":"Lupus"},{"key":"10.1016\/j.pcl.2013.09.004_bib69","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/ard.2005.045443","article-title":"Infectious origin of the antiphospholipid syndrome","volume":"65","author":"Shoenfeld","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.pcl.2013.09.004_bib70","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s11926-007-0034-x","article-title":"Antiphospholipid antibodies in response to infection","volume":"9","author":"Avcin","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.pcl.2013.09.004_bib71","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1200\/JCO.2005.05.5343","article-title":"Catheter-related deep vein thrombosis and other catheter complications in children with cancer","volume":"24","author":"Journeycake","year":"2006","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.pcl.2013.09.004_bib72","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/pbc.21734","article-title":"Epidemiology and clinical risk factors predisposing to thromboembolism in children with cancer","volume":"51","author":"Athale","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.pcl.2013.09.004_bib73","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1055\/s-2007-976177","article-title":"Thromboembolic complications in pediatric hematologic malignancies","volume":"33","author":"Athale","year":"2007","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib74","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/s-2007-996100","article-title":"Thromboembolic risks and complications in nephrotic children","volume":"23","author":"Schlegel","year":"1997","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpeds.2009.01.070","article-title":"Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome: a Midwest Pediatric Nephrology Consortium (MWPNC) study","volume":"155","author":"Kerlin","year":"2009","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.pcl.2013.09.004_bib76","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/00003246-200009001-00006","article-title":"Tissue factor pathway of coagulation in sepsis","volume":"28","author":"Hack","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pcl.2013.09.004_bib77","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1097\/00003246-200009001-00010","article-title":"The protein C pathway","volume":"28","author":"Esmon","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pcl.2013.09.004_bib78","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1097\/00003246-200107001-00013","article-title":"Vascular bed-specific hemostasis: role of endothelium in sepsis pathogenesis","volume":"29","author":"Aird","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pcl.2013.09.004_bib79","first-page":"72","article-title":"Cerebral vasculitis and obsessive-compulsive disorder following varicella infection in childhood","volume":"51","author":"Yaramis","year":"2009","journal-title":"Turk J Pediatr"},{"key":"10.1016\/j.pcl.2013.09.004_bib80","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1161\/01.STR.32.6.1257","article-title":"Chickenpox and stroke in childhood: a study of frequency and causation","volume":"32","author":"Askalan","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.pcl.2013.09.004_bib81","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1203\/00006450-200109000-00009","article-title":"The varicella autoantibody syndrome","volume":"50","author":"Josephson","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1016\/j.pcl.2013.09.004_bib82","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/adc.76.6.522","article-title":"Mechanisms of ischemic stroke after chickenpox","volume":"76","author":"Ganesan","year":"1997","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.pcl.2013.09.004_bib83","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1090-3798(02)90622-7","article-title":"Focal cerebral vasculitis and stroke after chickenpox","volume":"6","author":"Alehan","year":"2002","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.pcl.2013.09.004_bib84","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1111\/j.1468-1331.2008.02267.x","article-title":"Stroke and multiple peripheral thrombotic events in an adult with varicella","volume":"15","author":"Massano","year":"2008","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.pcl.2013.09.004_bib85","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0022-3476(95)70063-3","article-title":"Postinfectious purpura fulminans caused by an autoantibody directed against protein S","volume":"127","author":"Levin","year":"1995","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.pcl.2013.09.004_bib86","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1056\/NEJM199306173282405","article-title":"Brief report: autoimmune protein S deficiency in a boy with severe thromboembolic disease","volume":"328","author":"D\u2019Angelo","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.pcl.2013.09.004_bib87","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-0037-1613169","article-title":"Laboratory testing for thrombophilia in pediatric patients. On behalf of the Subcommittee for Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis (ISTH)","volume":"88","author":"Manco-Johnson","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.pcl.2013.09.004_bib88","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1182\/asheducation-2008.1.228","article-title":"Thrombophilia in children: who to test, how, when and why?","author":"Raffini","year":"2008","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.pcl.2013.09.004_bib89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta10110","article-title":"Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study","volume":"10","author":"Wu","year":"2006","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.pcl.2013.09.004_bib90","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1055\/s-0037-1616207","article-title":"Oral contraceptives, hormone replacement therapy and thrombosis","volume":"86","author":"Rosendaal","year":"2001","journal-title":"Thromb Haemost"}],"container-title":["Pediatric Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031395513001272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031395513001272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T12:31:46Z","timestamp":1688646706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031395513001272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0031395513001272"],"URL":"https:\/\/doi.org\/10.1016\/j.pcl.2013.09.004","relation":{},"ISSN":["0031-3955"],"issn-type":[{"value":"0031-3955","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}