{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:15:20Z","timestamp":1789503320859,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","pediatric.theclinics.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Clinics of North America"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.pcl.2017.01.005","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T09:32:42Z","timestamp":1494581562000},"page":"577-591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Pediatric Inflammatory Bowel Disease"],"prefix":"10.1016","volume":"64","author":[{"given":"M\u00e1ire A.","family":"Conrad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel R.","family":"Rosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.pcl.2017.01.005_bib1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/jpc.12685","article-title":"Crohn disease and ulcerative colitis in children: an update for 2014","volume":"51","author":"Lemberg","year":"2015","journal-title":"J\u00a0Paediatr Child Health"},{"issue":"3","key":"10.1016\/j.pcl.2017.01.005_bib2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00005176-200409000-00006","article-title":"Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease","volume":"39","author":"Castellaneta","year":"2004","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"5","key":"10.1016\/j.pcl.2017.01.005_bib3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1097\/MPG.0b013e31805563f3","article-title":"Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America","volume":"44","author":"North American Society for Pediatric Gastroenterology Hepatology, Nutrition","year":"2007","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"8","key":"10.1016\/j.pcl.2017.01.005_bib4","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1172\/JCI75436","article-title":"Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature","volume":"124","author":"Haberman","year":"2014","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib5","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1053\/j.gastro.2004.03.024","article-title":"Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics","volume":"126","author":"Sartor","year":"2004","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.pcl.2017.01.005_bib6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pcl.2017.01.005_bib7","doi-asserted-by":"crossref","first-page":"904307","DOI":"10.1155\/2014\/904307","article-title":"Incidence and Paris classification of pediatric inflammatory bowel disease","volume":"2014","author":"Eszter Muller","year":"2014","journal-title":"Gastroenterol Res Pract"},{"issue":"8","key":"10.1016\/j.pcl.2017.01.005_bib8","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/00054725-200608000-00002","article-title":"Incidence of inflammatory bowel disease in Finnish children, 1987-2003","volume":"12","author":"Turunen","year":"2006","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.crohns.2011.05.009","article-title":"Emigration to western industrialized countries: a risk factor for developing inflammatory bowel disease","volume":"5","author":"Barreiro-de Acosta","year":"2011","journal-title":"J\u00a0Crohns Colitis"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/ajg.2015.52","article-title":"Inflammatory bowel disease in immigrants to Canada and their children: a population-based cohort study","volume":"110","author":"Benchimol","year":"2015","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10620-012-2371-5","article-title":"Recent trends in the prevalence of Crohn's disease and ulcerative colitis in a commercially insured US population","volume":"58","author":"Kappelman","year":"2013","journal-title":"Dig Dis Sci"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib12","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1053\/j.gastro.2015.07.006","article-title":"Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease","volume":"149","author":"Kelsen","year":"2015","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.pcl.2017.01.005_bib13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrgastro.2014.102","article-title":"Growth problems in children with IBD","volume":"11","author":"Sanderson","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.pcl.2017.01.005_bib14","first-page":"554","article-title":"Very-early-onset inflammatory bowel disease","volume":"11","author":"Snapper","year":"2015","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"3","key":"10.1016\/j.pcl.2017.01.005_bib15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ibd.20767","article-title":"Course and treatment of perianal disease in children newly diagnosed with Crohn's disease","volume":"15","author":"Keljo","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib16","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1542\/peds.2009-1936","article-title":"Shortcomings of the inflammatory bowel disease Serology 7 panel","volume":"125","author":"Benor","year":"2010","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib17","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00005176-199708000-00003","article-title":"Antineutrophil cytoplasmic antibodies in children with inflammatory bowel disease: prevalence and diagnostic value","volume":"25","author":"Olives","year":"1997","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib18","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0016-5085(98)70252-5","article-title":"Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease","volume":"115","author":"Ruemmele","year":"1998","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.pcl.2017.01.005_bib19","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00054725-200209000-00003","article-title":"Role of serology and routine laboratory tests in childhood inflammatory bowel disease","volume":"8","author":"Khan","year":"2002","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.pcl.2017.01.005_bib20","doi-asserted-by":"crossref","first-page":"c3369","DOI":"10.1136\/bmj.c3369","article-title":"Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis","volume":"341","author":"van Rheenen","year":"2010","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.pcl.2017.01.005_bib21","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ajg.2013.131","article-title":"The diagnostic accuracy of fecal calprotectin during the investigation of suspected pediatric inflammatory bowel disease: a systematic review and meta-analysis","volume":"109","author":"Henderson","year":"2014","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.pcl.2017.01.005_bib22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/00365521.2014.987809","article-title":"Fecal calprotectin in diagnosis and clinical assessment of inflammatory bowel disease","volume":"50","author":"Sipponen","year":"2015","journal-title":"Scand J Gastroenterol"},{"issue":"5","key":"10.1016\/j.pcl.2017.01.005_bib23","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1053\/j.gastro.2014.07.023","article-title":"The diagnostic approach to monogenic very early onset inflammatory bowel disease","volume":"147","author":"Uhlig","year":"2014","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib24","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/MPG.0000000000000239","article-title":"ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents","volume":"58","author":"Levine","year":"2014","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/MPG.0000000000000475","article-title":"Imaging in the evaluation of the young patient with inflammatory bowel disease: what the gastroenterologist needs to know","volume":"59","author":"Anupindi","year":"2014","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"9","key":"10.1016\/j.pcl.2017.01.005_bib26","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/ibd.20927","article-title":"Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn's disease","volume":"15","author":"Schnitzler","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1053\/j.gastro.2013.10.027","article-title":"Increased effectiveness of early therapy with anti-tumor necrosis factor-alpha vs an immunomodulator in children with Crohn's disease","volume":"146","author":"Walters","year":"2014","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib28","article-title":"Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis","author":"Sutherland","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib29","article-title":"Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis","author":"Sutherland","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib30","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/MCG.0b013e3181595b56","article-title":"Oral 5-ASA therapy in ulcerative colitis: what are the implications of the new formulations?","volume":"42","author":"Sandborn","year":"2008","journal-title":"J\u00a0Clin Gastroenterol"},{"issue":"1","key":"10.1016\/j.pcl.2017.01.005_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/MPG.0b013e31826ac41a","article-title":"Outcome following aminosalicylate therapy in children newly diagnosed as having ulcerative colitis","volume":"56","author":"Zeisler","year":"2013","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib32","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3892\/etm.2012.718","article-title":"Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease","volume":"4","author":"Wang","year":"2012","journal-title":"Exp Ther Med"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1055\/s-0033-1348043","article-title":"Medical management of crohn disease","volume":"26","author":"Scott","year":"2013","journal-title":"Clin Colon Rectal Surg"},{"issue":"3","key":"10.1016\/j.pcl.2017.01.005_bib34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1053\/j.gastro.2011.11.032","article-title":"Rifaximin-extended intestinal release induces remission in patients with moderately active Crohn's disease","volume":"142","author":"Prantera","year":"2012","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib35","first-page":"58","article-title":"Use of antibiotics in patients with Crohn's disease: a systematic review and meta-analysis","volume":"16","author":"Su","year":"2015","journal-title":"J\u00a0Dig Dis"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/MIB.0000000000000377","article-title":"Guidelines for medical treatment of Crohn's perianal fistulas: critical evaluation of therapeutic trials","volume":"21","author":"Schwartz","year":"2015","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"10.1016\/j.pcl.2017.01.005_bib37","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.crohns.2011.01.006","article-title":"Combined azithromycin and metronidazole therapy is effective in inducing remission in pediatric Crohn's disease","volume":"5","author":"Levine","year":"2011","journal-title":"J\u00a0Crohns Colitis"},{"issue":"11","key":"10.1016\/j.pcl.2017.01.005_bib38","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.crohns.2014.05.010","article-title":"Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: a preliminary report","volume":"8","author":"Turner","year":"2014","journal-title":"J\u00a0Crohns Colitis"},{"issue":"12","key":"10.1016\/j.pcl.2017.01.005_bib39","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1038\/ajg.2010.303","article-title":"Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease","volume":"105","author":"Margolis","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.chom.2015.09.008","article-title":"Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn's disease","volume":"18","author":"Lewis","year":"2015","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib41","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/gut.2003.025239","article-title":"Antibiotic use and the development of Crohn's disease","volume":"53","author":"Card","year":"2004","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.pcl.2017.01.005_bib42","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jpeds.2012.08.037","article-title":"Association between early childhood otitis media and pediatric inflammatory bowel disease: an exploratory population-based analysis","volume":"162","author":"Shaw","year":"2013","journal-title":"J\u00a0Pediatr"},{"issue":"7","key":"10.1016\/j.pcl.2017.01.005_bib43","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1097\/MIB.0b013e318281321b","article-title":"A\u00a0novel enteral nutrition protocol for the treatment of pediatric Crohn's disease","volume":"19","author":"Gupta","year":"2013","journal-title":"Inflamm Bowel Dis"},{"issue":"8","key":"10.1016\/j.pcl.2017.01.005_bib44","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1097\/MIB.0000000000000426","article-title":"Comparative effectiveness of nutritional and biological therapy in North American children with active Crohn's disease","volume":"21","author":"Lee","year":"2015","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib45","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1053\/gast.2000.18144","article-title":"A\u00a0multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease","volume":"119","author":"Markowitz","year":"2000","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.pcl.2017.01.005_bib46","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1111\/j.1572-0241.2007.01474.x","article-title":"Methotrexate following unsuccessful thiopurine therapy in pediatric Crohn's disease","volume":"102","author":"Turner","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"10.1016\/j.pcl.2017.01.005_bib47","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1097\/MIB.0000000000000102","article-title":"Retrospective cohort study of methotrexate use in the treatment of pediatric Crohn's disease","volume":"20","author":"Sunseri","year":"2014","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib48","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00005176-200302000-00017","article-title":"A\u00a0comparison of budesonide and prednisone for the treatment of active pediatric Crohn disease","volume":"36","author":"Levine","year":"2003","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib49","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/ajg.2011.70","article-title":"Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis","volume":"106","author":"Ford","year":"2011","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.pcl.2017.01.005_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002913","article-title":"Budesonide for maintenance of remission in Crohn's disease","author":"Simms","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"issue":"15","key":"10.1016\/j.pcl.2017.01.005_bib51","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM199710093371502","article-title":"A\u00a0short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's disease cA2 study group","volume":"337","author":"Targan","year":"1997","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib52","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cgh.2011.11.026","article-title":"Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis","volume":"10","author":"Hyams","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.pcl.2017.01.005_bib53","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1185\/03007995.2010.547575","article-title":"Safety and efficacy of maintenance infliximab therapy for moderate-to-severe Crohn's disease in children: REACH open-label extension","volume":"27","author":"Hyams","year":"2011","journal-title":"Curr Med Res Opin"},{"issue":"12","key":"10.1016\/j.pcl.2017.01.005_bib54","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1038\/ajg.2009.493","article-title":"Retrospective evaluation of the safety and effect of adalimumab therapy (RESEAT) in pediatric Crohn's disease","volume":"104","author":"Rosh","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib55","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1053\/j.gastro.2012.04.046","article-title":"Safety and efficacy of adalimumab for moderate to severe Crohn's disease in children","volume":"143","author":"Hyams","year":"2012","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib56","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/ibd.20069","article-title":"Linear growth improves during infliximab therapy in children with chronically active severe Crohn's disease","volume":"13","author":"Walters","year":"2007","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"10.1016\/j.pcl.2017.01.005_bib57","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1097\/MIB.0000000000000865","article-title":"Multi-center experience of vedolizumab effectiveness in pediatric inflammatory bowel disease","volume":"22","author":"Singh","year":"2016","journal-title":"Inflamm Bowel Dis"},{"issue":"10","key":"10.1016\/j.pcl.2017.01.005_bib58","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1097\/MIB.0000000000000918","article-title":"vedolizumab therapy in severe pediatric inflammatory bowel disease","volume":"22","author":"Conrad","year":"2016","journal-title":"Inflamm Bowel Dis"},{"issue":"10","key":"10.1016\/j.pcl.2017.01.005_bib59","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cgh.2006.06.025","article-title":"Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn's disease","volume":"4","author":"Maser","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.pcl.2017.01.005_bib60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/gut.2009.183095","article-title":"Trough serum infliximab: a predictive factor of clinical outcome for infliximab treatment in acute ulcerative colitis","volume":"59","author":"Seow","year":"2010","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib61","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1053\/j.gastro.2014.08.035","article-title":"Association between serum concentration of infliximab and efficacy in adult patients with ulcerative colitis","volume":"147","author":"Adedokun","year":"2014","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.pcl.2017.01.005_bib62","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1136\/gutjnl-2014-307883","article-title":"The relationship between infliximab concentrations, antibodies to infliximab and disease activity in Crohn's disease","volume":"64","author":"Vande Casteele","year":"2015","journal-title":"Gut"},{"issue":"20","key":"10.1016\/j.pcl.2017.01.005_bib63","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.3748\/wjg.v21.i20.6101","article-title":"Surgical strategies in paediatric inflammatory bowel disease","volume":"21","author":"Baillie","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"10","key":"10.1016\/j.pcl.2017.01.005_bib64","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1002\/ibd.21585","article-title":"Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease","volume":"17","author":"Long","year":"2011","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"10.1016\/j.pcl.2017.01.005_bib65","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jpeds.2007.04.004","article-title":"Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts","volume":"151","author":"Kugathasan","year":"2007","journal-title":"J\u00a0Pediatr"},{"issue":"8","key":"10.1016\/j.pcl.2017.01.005_bib66","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1097\/MIB.0b013e318281f5b5","article-title":"Health maintenance and vaccination strategies in pediatric inflammatory bowel disease","volume":"19","author":"Breglio","year":"2013","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.pcl.2017.01.005_bib67","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MPG.0b013e31825959b8","article-title":"Health supervision in the management of children and adolescents with IBD: NASPGHAN recommendations","volume":"55","author":"Rufo","year":"2012","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib68","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/ajg.2009.733","article-title":"A\u00a0practical guide to vaccinating the inflammatory bowel disease patient","volume":"105","author":"Wasan","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.pcl.2017.01.005_bib69","first-page":"355","article-title":"Immunizations in children with inflammatory bowel disease treated with immunosuppressive therapy","volume":"10","author":"Lu","year":"2014","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"8","key":"10.1016\/j.pcl.2017.01.005_bib70","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/08880010701640499","article-title":"Systemic type Epstein-Barr virus-related lymphoproliferative diseases in children and young adults: challenges for pediatric hemato-oncologists and infectious disease specialists","volume":"24","author":"Imashuku","year":"2007","journal-title":"Pediatr Hematol Oncol"},{"issue":"5","key":"10.1016\/j.pcl.2017.01.005_bib71","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1542\/peds.2006-0841","article-title":"Vitamin D status in children and young adults with inflammatory bowel disease","volume":"118","author":"Pappa","year":"2006","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.pcl.2017.01.005_bib72","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ajg.2016.53","article-title":"Association of vitamin D level with clinical status in inflammatory bowel disease: a 5-year longitudinal study","volume":"111","author":"Kabbani","year":"2016","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1016\/j.pcl.2017.01.005_bib73","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1172\/JCI65842","article-title":"Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis","volume":"123","author":"Liu","year":"2013","journal-title":"J\u00a0Clin Invest"},{"issue":"1","key":"10.1016\/j.pcl.2017.01.005_bib74","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3945\/ajcn.115.123786","article-title":"Serum 25-hydroxy vitamin D concentration is inversely associated with mucosal inflammation in patients with ulcerative colitis","volume":"104","author":"Meckel","year":"2016","journal-title":"Am J Clin Nutr"},{"issue":"10","key":"10.1016\/j.pcl.2017.01.005_bib75","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1080\/00365521.2016.1185463","article-title":"Vitamin D regulates the tight-junction protein expression in active ulcerative colitis","volume":"51","author":"Stio","year":"2016","journal-title":"Scand J Gastroenterol"},{"issue":"4","key":"10.1016\/j.pcl.2017.01.005_bib76","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00005176-200410000-00017","article-title":"Depressive symptoms and inflammatory bowel disease in children and adolescents: a cross-sectional study","volume":"39","author":"Szigethy","year":"2004","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"2","key":"10.1016\/j.pcl.2017.01.005_bib77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chc.2010.01.007","article-title":"Inflammatory bowel disease","volume":"19","author":"Szigethy","year":"2010","journal-title":"Child Adolesc Psychiatr Clin N Am"}],"container-title":["Pediatric Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031395517300056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031395517300056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T14:30:31Z","timestamp":1659018631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031395517300056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0031395517300056"],"URL":"https:\/\/doi.org\/10.1016\/j.pcl.2017.01.005","relation":{},"ISSN":["0031-3955"],"issn-type":[{"value":"0031-3955","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pediatric Inflammatory Bowel Disease","name":"articletitle","label":"Article Title"},{"value":"Pediatric Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pcl.2017.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}