{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:16:34Z","timestamp":1768814194585,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Clinics of North America"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.pcl.2021.04.004","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T22:02:13Z","timestamp":1625781733000},"page":"759-773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Macrocephaly in the Primary Care Provider\u2019s Office"],"prefix":"10.1016","volume":"68","author":[{"given":"Jean-Paul","family":"Bryant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole E.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toba N.","family":"Niazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.pcl.2021.04.004_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-0035-1552622","article-title":"Megalencephaly and macrocephaly","volume":"35","author":"Winden","year":"2015","journal-title":"Semin Neurol"},{"key":"10.1016\/j.pcl.2021.04.004_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1542\/peds.41.1.106","article-title":"Head circumference from birth to 18 years. Practical composite international and interracial graphs","volume":"41","author":"Nellhaus","year":"1968","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcl.2021.04.004_bib3","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S0022-3476(80)80623-8","article-title":"Familial variation of head size and adjustment for parental head circumference","volume":"96","author":"Weaver","year":"1980","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.pcl.2021.04.004_bib4","series-title":"StatPearls","article-title":"Macrocephaly","author":"Jones","year":"2020"},{"key":"10.1016\/j.pcl.2021.04.004_bib5","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/adc.60.10.936","article-title":"Head circumference charts updated","volume":"60","author":"Ounsted","year":"1985","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.pcl.2021.04.004_bib6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jpeds.2010.01.009","article-title":"United States head circumference growth reference charts: birth to 21 years","volume":"156","author":"Rollins","year":"2010","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.pcl.2021.04.004_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3171\/2014.12.PEDS14251","article-title":"The value of head circumference measurements after 36\u00a0months of age: a clinical report and review of practice patterns","volume":"16","author":"James","year":"2015","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.pcl.2021.04.004_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pediatrneurol.2018.10.018","article-title":"Necessity of intracranial imaging in infants and children with macrocephaly","volume":"93","author":"Sampson","year":"2019","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.pcl.2021.04.004_bib9","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2214\/AJR.17.18693","article-title":"The child with macrocephaly: differential diagnosis and neuroimaging findings","volume":"210","author":"Orr\u00f9","year":"2018","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.pcl.2021.04.004_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jpeds.2016.11.033","article-title":"A\u00a0retrospective analysis of the utility of head computed tomography and\/or magnetic resonance imaging in the management of benign macrocrania","volume":"182","author":"Haws","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.pcl.2021.04.004_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3171\/2015.12.PEDS15600","article-title":"Macrocephaly in infancy: benign enlargement of the subarachnoid spaces and subdural collections","volume":"18","author":"Tucker","year":"2016","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.pcl.2021.04.004_bib12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/j.semperi.2009.10.002","article-title":"Cranial ultrasonography in neonates: role and limitations","volume":"34","author":"van Wezel-Meijler","year":"2010","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.pcl.2021.04.004_bib13","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3171\/PED.2008.2.12.438","article-title":"Quick-brain magnetic resonance imaging for nonhydrocephalus indications","volume":"2","author":"Missios","year":"2008","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.pcl.2021.04.004_bib14","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/ajmg.a.32434","article-title":"Genetic disorders associated with macrocephaly","volume":"146a","author":"Williams","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.pcl.2021.04.004_bib15","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1542\/peds.77.6.901","article-title":"Idiopathic external hydrocephalus: natural history and relationship to benign familial macrocephaly","volume":"77","author":"Alvarez","year":"1986","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcl.2021.04.004_bib16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0887-8994(86)90072-X","article-title":"Megalencephaly: types, clinical syndromes, and management","volume":"2","author":"DeMyer","year":"1986","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.pcl.2021.04.004_bib17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1212\/WNL.24.3.232","article-title":"Familial megalencephaly or hydrocephalus?","volume":"24","author":"Schreier","year":"1974","journal-title":"Neurology"},{"key":"10.1016\/j.pcl.2021.04.004_bib18","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1542\/peds.57.4.535","article-title":"Benign familial macrocephaly: report of a family and review of the literature","volume":"57","author":"Asch","year":"1976","journal-title":"Pediatrics"},{"key":"10.1016\/j.pcl.2021.04.004_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/1817-1745.139309","article-title":"Benign enlargement of sub-arachnoid spaces in infancy","volume":"9","author":"Kuruvilla","year":"2014","journal-title":"J\u00a0Pediatr Neurosci"},{"key":"10.1016\/j.pcl.2021.04.004_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00342987","article-title":"Benign communicating hydrocephalus in children","volume":"21","author":"Kendall","year":"1981","journal-title":"Neuroradiology"},{"key":"10.1016\/j.pcl.2021.04.004_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mehy.2013.09.017","article-title":"The pathogenesis of retinal and subdural haemorrhage in non-accidental head injury in infancy: assessment using Bradford Hill criteria","volume":"82","author":"Acres","year":"2014","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.pcl.2021.04.004_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.nec.2011.09.006","article-title":"Vein of Galen malformations: epidemiology, clinical presentations, management","volume":"23","author":"Recinos","year":"2012","journal-title":"Neurosurg Clin N Am"},{"key":"10.1016\/j.pcl.2021.04.004_bib23","doi-asserted-by":"crossref","first-page":"E205","DOI":"10.1093\/neuros\/nyz172","article-title":"Genetic drivers of vein of galen malformations","volume":"85","author":"Starke","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.pcl.2021.04.004_bib24","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.3171\/2009.8.FOCUS09168","article-title":"Vein of Galen malformation","volume":"27","author":"Hoang","year":"2009","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.pcl.2021.04.004_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nic.2007.02.005","article-title":"Vein of Galen aneurysmal malformations","volume":"17","author":"Alvarez","year":"2007","journal-title":"Neuroimaging Clin N Am"},{"key":"10.1016\/j.pcl.2021.04.004_bib26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/01.DBP.0000257518.60083.2d","article-title":"Early acceleration of head circumference in children with fragile x syndrome and autism","volume":"28","author":"Chiu","year":"2007","journal-title":"J\u00a0Dev Behav Pediatr"},{"key":"10.1016\/j.pcl.2021.04.004_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/B978-0-444-62702-5.00004-4","article-title":"Neurofibromatosis type 1","volume":"132","author":"Anderson","year":"2015","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.pcl.2021.04.004_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/0045-9380(92)90053-2","article-title":"Type 1 neurofibromatosis and the pediatric patient","volume":"22","author":"Riccardi","year":"1992","journal-title":"Curr Probl Pediatr"},{"key":"10.1016\/j.pcl.2021.04.004_bib29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/RMR.0000000000000170","article-title":"Macrocephaly: solving the diagnostic dilemma","volume":"27","author":"Tan","year":"2018","journal-title":"Top Magn Reson Imaging"},{"key":"10.1016\/j.pcl.2021.04.004_bib30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/jmg.2004.024646","article-title":"Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations","volume":"42","author":"Butler","year":"2005","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.pcl.2021.04.004_bib31","doi-asserted-by":"crossref","first-page":"e6814","DOI":"10.1097\/MD.0000000000006814","article-title":"A\u00a0clinical review on megalencephaly: a large brain as a possible sign of cerebral impairment","volume":"96","author":"Pavone","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.pcl.2021.04.004_bib32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/humu.21197","article-title":"An overview of L-2-hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype-phenotype study","volume":"31","author":"Steenweg","year":"2010","journal-title":"Hum Mutat"},{"key":"10.1016\/j.pcl.2021.04.004_bib33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ymgme.2011.08.027","article-title":"The unsolved puzzle of neuropathogenesis in glutaric aciduria type I","volume":"104","author":"Jafari","year":"2011","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.pcl.2021.04.004_bib34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/088307389501000216","article-title":"D-2-hydroxyglutaric aciduria","volume":"10","author":"Nyhan","year":"1995","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.pcl.2021.04.004_bib35","series-title":"GeneReviews\u00ae[Internet]","article-title":"Canavan disease","author":"Matalon","year":"2015"}],"container-title":["Pediatric Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003139552100050X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003139552100050X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:24:21Z","timestamp":1758475461000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003139552100050X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S003139552100050X"],"URL":"https:\/\/doi.org\/10.1016\/j.pcl.2021.04.004","relation":{},"ISSN":["0031-3955"],"issn-type":[{"value":"0031-3955","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrocephaly in the Primary Care Provider\u2019s Office","name":"articletitle","label":"Article Title"},{"value":"Pediatric Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pcl.2021.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}